GBRG2_HUMAN
Evidence for PS localization
Functions
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed, PubMed). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRG2_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 32.3529 | 4 | yes |
| GO:0015267 | channel activity | 32.3529 | 4 | yes |
| GO:0016917 | GABA receptor activity | 29.4118 | 4 | yes |
| GO:0022836 | gated channel activity | 29.4118 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 29.4118 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 26.4706 | 6 | yes |
| GO:0008509 | anion transmembrane transporter activity | 26.4706 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 26.4706 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 26.4706 | 5 | yes |
| GO:0015276 | ligand-gated ion channel activity | 26.4706 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 26.4706 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 26.4706 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 26.4706 | 4 | yes |
| GO:0004890 | GABA-A receptor activity | 23.5294 | 5 | yes |
| GO:0005253 | anion channel activity | 23.5294 | 5 | yes |
| GO:0005254 | chloride channel activity | 23.5294 | 6 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 23.5294 | 5 | yes |
| GO:0099095 | ligand-gated anion channel activity | 23.5294 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 23.5294 | 5 | yes |
| GO:0046872 | metal ion binding | 23.5294 | 4 | no |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 20.5882 | 6 | yes |
| GO:0017076 | purine nucleotide binding | 20.5882 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.5882 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.5882 | 4 | no |
| GO:0005237 | inhibitory extracellular ligand-gated ion channel activity | 17.6471 | 7 | yes |
| GO:0008503 | benzodiazepine receptor activity | 8.8235 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRG2_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 41.1765 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 41.1765 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 41.1765 | 4 | yes |
| GO:0006811 | ion transport | 38.2353 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.2353 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 38.2353 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 32.3529 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 32.3529 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 32.3529 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 32.3529 | 4 | no |
| GO:0051049 | regulation of transport | 32.3529 | 4 | no |
| GO:0006820 | anion transport | 26.4706 | 5 | yes |
| GO:0006821 | chloride transport | 26.4706 | 7 | yes |
| GO:0015698 | inorganic anion transport | 26.4706 | 6 | yes |
| GO:0022607 | cellular component assembly | 26.4706 | 4 | yes |
| GO:0098656 | anion transmembrane transport | 26.4706 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 26.4706 | 5 | yes |
| GO:1902476 | chloride transmembrane transport | 26.4706 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.4706 | 4 | no |
| GO:0036211 | protein modification process | 26.4706 | 4 | no |
| GO:0043412 | macromolecule modification | 26.4706 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.4706 | 4 | no |
| GO:0034330 | cell junction organization | 23.5294 | 4 | yes |
| GO:0050808 | synapse organization | 23.5294 | 5 | yes |
| GO:0008104 | protein localization | 23.5294 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.5294 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.5294 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.5294 | 4 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 20.5882 | 4 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 20.5882 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.5882 | 5 | no |
| GO:0015031 | protein transport | 20.5882 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.5882 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.5882 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.5882 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.5882 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.5882 | 4 | no |
| GO:0050890 | cognition | 20.5882 | 4 | no |
| GO:0007416 | synapse assembly | 17.6471 | 6 | yes |
| GO:0034329 | cell junction assembly | 17.6471 | 5 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 17.6471 | 7 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 17.6471 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 17.6471 | 4 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 14.7059 | 5 | yes |
| GO:1904862 | inhibitory synapse assembly | 14.7059 | 7 | yes |
| GO:0034776 | response to histamine | 11.7647 | 5 | yes |
| GO:0071420 | cellular response to histamine | 11.7647 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GBRG2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 8.8235 | 3 | no |
| DOID:936 | brain disease | 5.8824 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| NOVA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CUL1_HUMAN | [view interactions] | Low throughput | no | yes |
| KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MFN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| TBB1_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| GBRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT5_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| LCLT1_HUMAN | [view interactions] | High throughput | no | no |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP33_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| AT131_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCN1B_HUMAN | [view interactions] | Computational | no | no |
| GBRL1_HUMAN | [view interactions] | Computational | no | yes |
| GABR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARHG9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCN2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| S12A5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCN1A_HUMAN | [view interactions] | Computational | no | no |