GBRB1_HUMAN
Evidence for PS localization
Functions
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRB1_HUMAN |
|---|---|---|---|---|
| GO:0016917 | GABA receptor activity | 66.6667 | 4 | yes |
| GO:0004890 | GABA-A receptor activity | 58.3333 | 5 | yes |
| GO:0005216 | ion channel activity | 58.3333 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 58.3333 | 6 | yes |
| GO:0005253 | anion channel activity | 58.3333 | 5 | yes |
| GO:0005254 | chloride channel activity | 58.3333 | 6 | yes |
| GO:0008509 | anion transmembrane transporter activity | 58.3333 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 58.3333 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 58.3333 | 5 | yes |
| GO:0015267 | channel activity | 58.3333 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 58.3333 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 58.3333 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 58.3333 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 58.3333 | 4 | yes |
| GO:0022836 | gated channel activity | 58.3333 | 5 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 58.3333 | 5 | yes |
| GO:0099095 | ligand-gated anion channel activity | 58.3333 | 6 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated ion channel activity | 33.3333 | 7 | no |
| GO:0050811 | GABA receptor binding | 25.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRB1_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 75.0000 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 75.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 75.0000 | 4 | yes |
| GO:0006811 | ion transport | 58.3333 | 4 | yes |
| GO:0006820 | anion transport | 58.3333 | 5 | yes |
| GO:0006821 | chloride transport | 58.3333 | 7 | yes |
| GO:0014070 | response to organic cyclic compound | 58.3333 | 4 | yes |
| GO:0015698 | inorganic anion transport | 58.3333 | 6 | yes |
| GO:0098656 | anion transmembrane transport | 58.3333 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 58.3333 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 58.3333 | 5 | yes |
| GO:1902476 | chloride transmembrane transport | 58.3333 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 50.0000 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 50.0000 | 4 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 50.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
| GO:0034776 | response to histamine | 41.6667 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 41.6667 | 4 | yes |
| GO:0071420 | cellular response to histamine | 41.6667 | 5 | yes |
| GO:1901699 | cellular response to nitrogen compound | 41.6667 | 4 | yes |
| GO:0007416 | synapse assembly | 41.6667 | 6 | no |
| GO:0034329 | cell junction assembly | 41.6667 | 5 | no |
| GO:0034330 | cell junction organization | 41.6667 | 4 | no |
| GO:0050808 | synapse organization | 41.6667 | 5 | no |
| GO:1904862 | inhibitory synapse assembly | 41.6667 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0051932 | synaptic transmission, GABAergic | 33.3333 | 7 | no |
| GO:0033993 | response to lipid | 25.0000 | 4 | yes |
| GO:0048545 | response to steroid hormone | 25.0000 | 4 | yes |
| GO:0048666 | neuron development | 25.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0060078 | regulation of postsynaptic membrane potential | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
| GO:0021954 | central nervous system neuron development | 16.6667 | 5 | yes |
| GO:0032570 | response to progesterone | 16.6667 | 5 | yes |
| GO:1901654 | response to ketone | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOD1_HUMAN | [view interactions] | High throughput | no | no |
| NDF4_HUMAN | [view interactions] | High throughput | no | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COMD8_HUMAN | [view interactions] | Computational | no | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |