Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRB1_HUMAN
GO:0004890 GABA-A receptor activity 50.0000 5 yes
GO:0005216 monoatomic ion channel activity 50.0000 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 50.0000 6 yes
GO:0005253 monoatomic anion channel activity 50.0000 5 yes
GO:0005254 chloride channel activity 50.0000 6 yes
GO:0008509 monoatomic anion transmembrane transporter activity 50.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 50.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 50.0000 5 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 50.0000 5 yes
GO:0016917 GABA receptor activity 50.0000 4 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 50.0000 5 yes
GO:0022834 ligand-gated channel activity 50.0000 6 yes
GO:0022835 transmitter-gated channel activity 50.0000 4 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0022851 GABA-gated chloride ion channel activity 50.0000 6 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 50.0000 4 yes
GO:0099095 ligand-gated monoatomic anion channel activity 50.0000 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 50.0000 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 50.0000 6 yes
GO:0050811 GABA receptor binding 30.0000 4 yes
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 30.0000 6 yes
GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity 30.0000 7 no
GO:0001664 G protein-coupled receptor binding 30.0000 4 no
GO:0004930 G protein-coupled receptor activity 20.0000 4 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 20.0000 4 yes
GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential 20.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GBRB1_HUMAN
GO:0006811 monoatomic ion transport 50.0000 4 yes
GO:0006820 monoatomic anion transport 50.0000 5 yes
GO:0006821 chloride transport 50.0000 5 yes
GO:0007214 gamma-aminobutyric acid signaling pathway 50.0000 4 yes
GO:0014070 response to organic cyclic compound 50.0000 4 yes
GO:0015698 inorganic anion transport 50.0000 4 yes
GO:0098656 monoatomic anion transmembrane transport 50.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 50.0000 4 yes
GO:1902476 chloride transmembrane transport 50.0000 5 yes
GO:0007268 chemical synaptic transmission 50.0000 7 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 50.0000 6 no
GO:0099536 synaptic signaling 50.0000 4 no
GO:0099537 trans-synaptic signaling 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0010243 response to organonitrogen compound 40.0000 4 yes
GO:0071310 cellular response to organic substance 40.0000 4 yes
GO:0071407 cellular response to organic cyclic compound 40.0000 5 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0031323 regulation of cellular metabolic process 40.0000 4 no
GO:0048522 positive regulation of cellular process 40.0000 4 no
GO:0048523 negative regulation of cellular process 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0033993 response to lipid 30.0000 4 yes
GO:0034776 response to histamine 30.0000 5 yes
GO:0048545 response to steroid hormone 30.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 30.0000 4 yes
GO:0071420 cellular response to histamine 30.0000 5 yes
GO:1901699 cellular response to nitrogen compound 30.0000 4 yes
GO:0007416 synapse assembly 30.0000 6 no
GO:0034329 cell junction assembly 30.0000 5 no
GO:0034330 cell junction organization 30.0000 4 no
GO:0050808 synapse organization 30.0000 5 no
GO:0051932 synaptic transmission, GABAergic 30.0000 8 no
GO:0060078 regulation of postsynaptic membrane potential 30.0000 4 no
GO:1904862 inhibitory synapse assembly 30.0000 7 no
GO:0006996 organelle organization 30.0000 4 no
GO:0009889 regulation of biosynthetic process 30.0000 4 no
GO:0009892 negative regulation of metabolic process 30.0000 4 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0010468 regulation of gene expression 30.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 30.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0051246 regulation of protein metabolic process 30.0000 5 no
GO:0008104 protein localization 30.0000 4 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0021954 central nervous system neuron development 20.0000 5 yes
GO:0032570 response to progesterone 20.0000 5 yes
GO:0048666 neuron development 20.0000 4 yes
GO:1901654 response to ketone 20.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BIG2_HUMAN [view entry] [view interactions] Low throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
UBQL1_HUMAN [view interactions] Low throughput no yes
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
RACK1_HUMAN [view interactions] Low throughput no yes
GBRB1_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
NOD1_HUMAN [view interactions] High throughput no no
NDF4_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no