Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM5_HUMAN
GO:0043169 cation binding 38.0952 4 no
GO:0046872 metal ion binding 38.0952 5 no
GO:0019900 kinase binding 35.7143 4 yes
GO:0019901 protein kinase binding 35.7143 5 yes
GO:0043168 anion binding 26.1905 4 no
GO:0001664 G protein-coupled receptor binding 23.8095 4 yes
GO:0000166 nucleotide binding 21.4286 4 no
GO:0017076 purine nucleotide binding 21.4286 5 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0035254 glutamate receptor binding 21.4286 4 no
GO:0098960 postsynaptic neurotransmitter receptor activity 16.6667 4 yes
GO:0008066 glutamate receptor activity 14.2857 4 yes
GO:0019209 kinase activator activity 14.2857 4 yes
GO:0019887 protein kinase regulator activity 14.2857 4 yes
GO:0030295 protein kinase activator activity 14.2857 5 yes
GO:0004930 G protein-coupled receptor activity 9.5238 4 yes
GO:0031687 A2A adenosine receptor binding 7.1429 6 yes
GO:0098988 G protein-coupled glutamate receptor activity 7.1429 5 yes
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 7.1429 5 yes
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 7.1429 5 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 7.1429 6 yes
GO:0031685 adenosine receptor binding 7.1429 5 yes
GO:1990782 protein tyrosine kinase binding 4.7619 6 yes
GO:0030296 protein tyrosine kinase activator activity 4.7619 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM5_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0009966 regulation of signal transduction 61.9048 4 yes
GO:0048523 negative regulation of cellular process 61.9048 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.5238 4 yes
GO:0051049 regulation of transport 59.5238 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 yes
GO:0080090 regulation of primary metabolic process 52.3810 4 yes
GO:0010647 positive regulation of cell communication 47.6190 5 yes
GO:0023056 positive regulation of signaling 47.6190 4 yes
GO:0009967 positive regulation of signal transduction 45.2381 5 yes
GO:0048584 positive regulation of response to stimulus 45.2381 4 yes
GO:0050804 modulation of chemical synaptic transmission 45.2381 5 yes
GO:0099177 regulation of trans-synaptic signaling 45.2381 4 yes
GO:1902531 regulation of intracellular signal transduction 45.2381 5 yes
GO:0051128 regulation of cellular component organization 45.2381 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 yes
GO:0009889 regulation of biosynthetic process 40.4762 4 yes
GO:0009893 positive regulation of metabolic process 40.4762 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 40.4762 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.4762 5 yes
GO:0031326 regulation of cellular biosynthetic process 40.4762 5 yes
GO:0010468 regulation of gene expression 38.0952 6 yes
GO:0031325 positive regulation of cellular metabolic process 38.0952 5 yes
GO:0031399 regulation of protein modification process 38.0952 6 yes
GO:0022607 cellular component assembly 38.0952 4 no
GO:0010243 response to organonitrogen compound 35.7143 4 yes
GO:0019220 regulation of phosphate metabolic process 35.7143 6 yes
GO:0034330 cell junction organization 35.7143 4 yes
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 yes
GO:0051247 positive regulation of protein metabolic process 35.7143 6 yes
GO:0043269 regulation of monoatomic ion transport 35.7143 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 yes
GO:0031401 positive regulation of protein modification process 33.3333 7 yes
GO:0042325 regulation of phosphorylation 33.3333 7 yes
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0001934 positive regulation of protein phosphorylation 30.9524 8 yes
GO:0007268 chemical synaptic transmission 30.9524 7 yes
GO:0010648 negative regulation of cell communication 30.9524 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.9524 5 yes
GO:0023057 negative regulation of signaling 30.9524 4 yes
GO:0042327 positive regulation of phosphorylation 30.9524 8 yes
GO:0043085 positive regulation of catalytic activity 30.9524 4 yes
GO:0071310 cellular response to organic substance 30.9524 4 yes
GO:0098916 anterograde trans-synaptic signaling 30.9524 6 yes
GO:0099536 synaptic signaling 30.9524 4 yes
GO:0099537 trans-synaptic signaling 30.9524 5 yes
GO:0042981 regulation of apoptotic process 30.9524 5 no
GO:0043067 regulation of programmed cell death 30.9524 4 no
GO:0043408 regulation of MAPK cascade 28.5714 6 yes
GO:0048585 negative regulation of response to stimulus 28.5714 4 yes
GO:0050808 synapse organization 28.5714 5 yes
GO:0051252 regulation of RNA metabolic process 28.5714 5 yes
GO:0008104 protein localization 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0010959 regulation of metal ion transport 28.5714 6 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0051924 regulation of calcium ion transport 28.5714 7 no
GO:0009968 negative regulation of signal transduction 26.1905 5 yes
GO:0043549 regulation of kinase activity 26.1905 5 yes
GO:0045595 regulation of cell differentiation 26.1905 4 yes
GO:0045859 regulation of protein kinase activity 26.1905 6 yes
GO:0051338 regulation of transferase activity 26.1905 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 26.1905 6 yes
GO:0006996 organelle organization 26.1905 4 no
GO:0060341 regulation of cellular localization 26.1905 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 26.1905 5 no
GO:0031324 negative regulation of cellular metabolic process 26.1905 5 no
GO:0034329 cell junction assembly 26.1905 5 no
GO:0051248 negative regulation of protein metabolic process 26.1905 6 no
GO:0006355 regulation of DNA-templated transcription 23.8095 7 yes
GO:0007215 glutamate receptor signaling pathway 23.8095 4 yes
GO:0033674 positive regulation of kinase activity 23.8095 6 yes
GO:0045860 positive regulation of protein kinase activity 23.8095 7 yes
GO:0050890 cognition 23.8095 4 yes
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 yes
GO:0051347 positive regulation of transferase activity 23.8095 5 yes
GO:2000026 regulation of multicellular organismal development 23.8095 4 yes
GO:2001141 regulation of RNA biosynthetic process 23.8095 6 yes
GO:0030030 cell projection organization 23.8095 4 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 yes
GO:0048168 regulation of neuronal synaptic plasticity 21.4286 4 yes
GO:0060284 regulation of cell development 21.4286 5 yes
GO:0071417 cellular response to organonitrogen compound 21.4286 4 yes
GO:1901699 cellular response to nitrogen compound 21.4286 4 yes
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 yes
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 21.4286 6 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0007612 learning 19.0476 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 19.0476 8 yes
GO:1901701 cellular response to oxygen-containing compound 19.0476 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 16.6667 5 yes
GO:0051094 positive regulation of developmental process 16.6667 4 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 14.2857 4 yes
GO:0010608 post-transcriptional regulation of gene expression 14.2857 7 yes
GO:0010720 positive regulation of cell development 14.2857 6 yes
GO:0045597 positive regulation of cell differentiation 14.2857 5 yes
GO:0050767 regulation of neurogenesis 14.2857 6 yes
GO:0051960 regulation of nervous system development 14.2857 5 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 11.9048 5 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 11.9048 9 yes
GO:0061097 regulation of protein tyrosine kinase activity 11.9048 7 yes
GO:1904645 response to amyloid-beta 11.9048 4 yes
GO:1904646 cellular response to amyloid-beta 11.9048 5 yes
GO:0006417 regulation of translation 9.5238 6 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 9.5238 4 yes
GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 9.5238 5 yes
GO:0050769 positive regulation of neurogenesis 9.5238 6 yes
GO:0051962 positive regulation of nervous system development 9.5238 5 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 9.5238 8 yes
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 7.1429 4 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 7.1429 6 yes
GO:0048170 positive regulation of long-term neuronal synaptic plasticity 7.1429 6 yes
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 4.7619 7 yes
GO:0006448 regulation of translational elongation 4.7619 7 yes
GO:0022401 negative adaptation of signaling pathway 4.7619 6 yes
GO:0023058 adaptation of signaling pathway 4.7619 5 yes
GO:0099541 trans-synaptic signaling by lipid 4.7619 6 yes
GO:0099542 trans-synaptic signaling by endocannabinoid 4.7619 7 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 4.7619 6 yes
GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission 4.7619 7 yes
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 4.7619 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
NECA2_HUMAN [view entry] [view interactions] Low throughput yes yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
PIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
MET_HUMAN [view interactions] Low throughput no yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME2_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS4_HUMAN [view entry] [view interactions] Low throughput yes no
NCDN_HUMAN [view entry] [view interactions] Low throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
DYN3_HUMAN [view entry] [view interactions] Low throughput yes no
NHRF2_HUMAN [view interactions] Low throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
CE104_HUMAN [view interactions] High throughput no yes
LBN_HUMAN [view interactions] High throughput no yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
GRM1_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes