Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM5_HUMAN
GO:0046872 metal ion binding 34.4262 4 no
GO:0001664 G protein-coupled receptor binding 24.5902 4 yes
GO:0019900 kinase binding 22.9508 4 yes
GO:0019901 protein kinase binding 21.3115 5 yes
GO:0035254 glutamate receptor binding 21.3115 4 no
GO:0017076 purine nucleotide binding 21.3115 4 no
GO:0032555 purine ribonucleotide binding 21.3115 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.3115 4 no
GO:0098960 postsynaptic neurotransmitter receptor activity 18.0328 4 yes
GO:0008066 glutamate receptor activity 14.7541 4 yes
GO:0004930 G protein-coupled receptor activity 13.1148 4 yes
GO:0019209 kinase activator activity 9.8361 4 yes
GO:0019887 protein kinase regulator activity 9.8361 4 yes
GO:0030295 protein kinase activator activity 9.8361 5 yes
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 6.5574 5 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 4.9180 6 yes
GO:0098988 G protein-coupled glutamate receptor activity 4.9180 5 yes
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 4.9180 5 yes
GO:0030296 protein tyrosine kinase activator activity 3.2787 6 yes
GO:0031685 adenosine receptor binding 3.2787 5 yes
GO:0031687 A2A adenosine receptor binding 3.2787 6 yes
GO:1990782 protein tyrosine kinase binding 3.2787 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM5_HUMAN
GO:0010646 regulation of cell communication 63.9344 4 yes
GO:0048522 positive regulation of cellular process 60.6557 4 yes
GO:0048523 negative regulation of cellular process 52.4590 4 yes
GO:0051049 regulation of transport 52.4590 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.8197 4 yes
GO:0009966 regulation of signal transduction 50.8197 4 yes
GO:0050804 modulation of chemical synaptic transmission 45.9016 5 yes
GO:0099177 regulation of trans-synaptic signaling 45.9016 4 yes
GO:0080090 regulation of primary metabolic process 44.2623 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 42.6230 4 yes
GO:0031323 regulation of cellular metabolic process 40.9836 4 yes
GO:0043269 regulation of ion transport 40.9836 5 yes
GO:0051128 regulation of cellular component organization 40.9836 4 no
GO:0051246 regulation of protein metabolic process 39.3443 5 yes
GO:0098916 anterograde trans-synaptic signaling 39.3443 5 yes
GO:0099537 trans-synaptic signaling 39.3443 4 yes
GO:0022607 cellular component assembly 39.3443 4 no
GO:0007268 chemical synaptic transmission 39.3443 6 yes
GO:0010647 positive regulation of cell communication 36.0656 5 yes
GO:0023056 positive regulation of signaling 36.0656 4 yes
GO:0034330 cell junction organization 36.0656 4 yes
GO:0044057 regulation of system process 36.0656 4 no
GO:0019220 regulation of phosphate metabolic process 34.4262 6 yes
GO:0031399 regulation of protein modification process 34.4262 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 34.4262 5 yes
GO:0051174 regulation of phosphorus metabolic process 34.4262 5 yes
GO:0051247 positive regulation of protein metabolic process 34.4262 6 yes
GO:0009893 positive regulation of metabolic process 34.4262 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 34.4262 5 yes
GO:0043085 positive regulation of catalytic activity 32.7869 4 yes
GO:0050890 cognition 32.7869 4 yes
GO:1902531 regulation of intracellular signal transduction 32.7869 5 yes
GO:0010468 regulation of gene expression 32.7869 5 yes
GO:0031325 positive regulation of cellular metabolic process 31.1475 5 yes
GO:0034762 regulation of transmembrane transport 31.1475 4 yes
GO:0034765 regulation of ion transmembrane transport 31.1475 5 yes
GO:0042325 regulation of phosphorylation 31.1475 7 yes
GO:0048584 positive regulation of response to stimulus 31.1475 4 yes
GO:0050808 synapse organization 31.1475 5 yes
GO:0008104 protein localization 31.1475 4 no
GO:0051050 positive regulation of transport 31.1475 4 no
GO:0009892 negative regulation of metabolic process 31.1475 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.1475 5 no
GO:0001932 regulation of protein phosphorylation 31.1475 7 yes
GO:0022898 regulation of transmembrane transporter activity 29.5082 4 yes
GO:0031401 positive regulation of protein modification process 29.5082 7 yes
GO:0032412 regulation of ion transmembrane transporter activity 29.5082 5 yes
GO:0045937 positive regulation of phosphate metabolic process 29.5082 7 yes
GO:0051336 regulation of hydrolase activity 29.5082 4 no
GO:0009967 positive regulation of signal transduction 29.5082 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 29.5082 6 yes
GO:0042327 positive regulation of phosphorylation 27.8689 8 yes
GO:0051338 regulation of transferase activity 27.8689 4 yes
GO:0010941 regulation of cell death 27.8689 4 no
GO:0001934 positive regulation of protein phosphorylation 27.8689 8 yes
GO:0010648 negative regulation of cell communication 26.2295 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.2295 5 yes
GO:0023057 negative regulation of signaling 26.2295 4 yes
GO:0036211 protein modification process 26.2295 4 yes
GO:0043412 macromolecule modification 26.2295 4 yes
GO:0043549 regulation of kinase activity 26.2295 5 yes
GO:0045859 regulation of protein kinase activity 26.2295 6 yes
GO:0010959 regulation of metal ion transport 26.2295 6 no
GO:0051924 regulation of calcium ion transport 26.2295 7 no
GO:0034329 cell junction assembly 26.2295 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.2295 5 no
GO:0031326 regulation of cellular biosynthetic process 24.5902 5 yes
GO:0051240 positive regulation of multicellular organismal process 24.5902 4 yes
GO:0051252 regulation of RNA metabolic process 24.5902 5 yes
GO:0051347 positive regulation of transferase activity 24.5902 5 yes
GO:0060341 regulation of cellular localization 24.5902 4 no
GO:0031344 regulation of cell projection organization 24.5902 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.5902 6 no
GO:1904062 regulation of cation transmembrane transport 24.5902 6 no
GO:0051248 negative regulation of protein metabolic process 24.5902 6 no
GO:0042981 regulation of apoptotic process 24.5902 6 no
GO:0043067 regulation of programmed cell death 24.5902 5 no
GO:0007612 learning 24.5902 4 yes
GO:0009889 regulation of biosynthetic process 24.5902 4 yes
GO:0010243 response to organonitrogen compound 24.5902 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 24.5902 5 yes
GO:0033674 positive regulation of kinase activity 22.9508 6 yes
GO:0045860 positive regulation of protein kinase activity 22.9508 7 yes
GO:0048585 negative regulation of response to stimulus 22.9508 4 yes
GO:0051094 positive regulation of developmental process 22.9508 4 yes
GO:0050807 regulation of synapse organization 22.9508 5 no
GO:0031324 negative regulation of cellular metabolic process 22.9508 5 no
GO:0030030 cell projection organization 22.9508 4 no
GO:0006796 phosphate-containing compound metabolic process 22.9508 4 yes
GO:0007215 glutamate receptor signaling pathway 22.9508 4 yes
GO:0016310 phosphorylation 21.3115 5 yes
GO:0045595 regulation of cell differentiation 21.3115 4 yes
GO:2000026 regulation of multicellular organismal development 21.3115 4 yes
GO:0006811 ion transport 21.3115 4 no
GO:0031644 regulation of nervous system process 21.3115 5 no
GO:2001257 regulation of cation channel activity 21.3115 6 no
GO:0051345 positive regulation of hydrolase activity 21.3115 5 no
GO:0007416 synapse assembly 21.3115 6 no
GO:0006468 protein phosphorylation 21.3115 5 yes
GO:0009968 negative regulation of signal transduction 21.3115 5 yes
GO:0043408 regulation of MAPK cascade 19.6721 6 yes
GO:0071310 cellular response to organic substance 19.6721 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 19.6721 7 yes
GO:2001141 regulation of RNA biosynthetic process 19.6721 6 yes
GO:0006355 regulation of DNA-templated transcription 19.6721 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 18.0328 6 yes
GO:1901699 cellular response to nitrogen compound 18.0328 4 yes
GO:0019722 calcium-mediated signaling 16.3934 5 yes
GO:0019932 second-messenger-mediated signaling 16.3934 4 yes
GO:0051960 regulation of nervous system development 16.3934 5 yes
GO:0043410 positive regulation of MAPK cascade 14.7541 7 yes
GO:0045597 positive regulation of cell differentiation 14.7541 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 14.7541 4 yes
GO:0071417 cellular response to organonitrogen compound 14.7541 4 yes
GO:1901701 cellular response to oxygen-containing compound 14.7541 4 yes
GO:1902533 positive regulation of intracellular signal transduction 14.7541 6 yes
GO:0034248 regulation of cellular amide metabolic process 13.1148 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 13.1148 8 yes
GO:0050767 regulation of neurogenesis 13.1148 6 yes
GO:0051962 positive regulation of nervous system development 13.1148 5 yes
GO:0060284 regulation of cell development 13.1148 5 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 11.4754 5 yes
GO:1901652 response to peptide 11.4754 4 yes
GO:1901653 cellular response to peptide 11.4754 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 11.4754 5 yes
GO:0010608 post-transcriptional regulation of gene expression 11.4754 6 yes
GO:0010720 positive regulation of cell development 9.8361 6 yes
GO:0040013 negative regulation of locomotion 9.8361 4 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 9.8361 9 yes
GO:0050769 positive regulation of neurogenesis 9.8361 6 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 9.8361 4 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 9.8361 4 yes
GO:0044070 regulation of anion transport 8.1967 6 yes
GO:0061097 regulation of protein tyrosine kinase activity 8.1967 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 8.1967 8 yes
GO:1904645 response to amyloid-beta 8.1967 5 yes
GO:1904646 cellular response to amyloid-beta 8.1967 6 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 8.1967 6 yes
GO:0006417 regulation of translation 8.1967 6 yes
GO:0035584 calcium-mediated signaling using intracellular calcium source 6.5574 6 yes
GO:1903959 regulation of anion transmembrane transport 6.5574 6 yes
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 6.5574 4 yes
GO:0010359 regulation of anion channel activity 6.5574 6 yes
GO:0048170 positive regulation of long-term neuronal synaptic plasticity 4.9180 6 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 4.9180 6 yes
GO:1902938 regulation of intracellular calcium activated chloride channel activity 4.9180 7 yes
GO:1903795 regulation of inorganic anion transmembrane transport 4.9180 7 yes
GO:2001225 regulation of chloride transport 4.9180 7 yes
GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 4.9180 5 yes
GO:0022401 negative adaptation of signaling pathway 3.2787 6 yes
GO:0023058 adaptation of signaling pathway 3.2787 5 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 3.2787 6 yes
GO:0099541 trans-synaptic signaling by lipid 3.2787 5 yes
GO:0099542 trans-synaptic signaling by endocannabinoid 3.2787 6 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 3.2787 5 yes
GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission 3.2787 6 yes
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 3.2787 7 yes
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 3.2787 7 yes
GO:0006448 regulation of translational elongation 3.2787 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in GRM5_HUMAN
DOID:0050700 cardiomyopathy 3.2787 4 no
DOID:0060036 intrinsic cardiomyopathy 3.2787 5 no
DOID:114 heart disease 3.2787 3 no
DOID:2843 long QT syndrome 3.2787 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
NECA2_HUMAN [view interactions] Low throughput no yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
PIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
MET_HUMAN [view interactions] Low throughput no yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME2_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS4_HUMAN [view interactions] Low throughput no no
NCDN_HUMAN [view entry] [view interactions] Low throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
DYN3_HUMAN [view entry] [view interactions] Low throughput yes no
NHRF2_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
CE104_HUMAN [view interactions] High throughput no yes
LBN_HUMAN [view interactions] High throughput no yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
GRM1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
DLGP3_HUMAN [view entry] [view interactions] Computational yes yes
CNR1_HUMAN [view interactions] Computational no yes
FMR1_HUMAN [view entry] [view interactions] Computational yes yes
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
AQP4_HUMAN [view entry] [view interactions] Computational yes no
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
ESR1_HUMAN [view interactions] Computational no no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
CASR_HUMAN [view interactions] Computational no no
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
DLGP1_HUMAN [view entry] [view interactions] Computational yes no
NRX3A_HUMAN [view entry] [view interactions] Computational yes yes
ACM5_HUMAN [view entry] [view interactions] Computational yes no
SHAN1_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
NLGN3_HUMAN [view entry] [view interactions] Computational yes yes
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes
DRD2_HUMAN [view entry] [view interactions] Computational yes no
ACM3_HUMAN [view entry] [view interactions] Computational yes yes