Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FAK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at Tyr-9, Tyr-373, and Tyr-376. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000806 LIG_SH2_GRB2like LIG 881 884 -
ELMI000806 LIG_SH2_GRB2like LIG 881 884 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FAK2_HUMAN
GO:0043168 anion binding 44.0678 4 yes
GO:0019900 kinase binding 42.3729 4 yes
GO:0032555 purine ribonucleotide binding 37.2881 4 yes
GO:0000166 nucleotide binding 37.2881 4 yes
GO:0017076 purine nucleotide binding 37.2881 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.5932 4 yes
GO:0019901 protein kinase binding 35.5932 5 yes
GO:0032559 adenyl ribonucleotide binding 33.8983 5 yes
GO:0043169 cation binding 33.8983 4 no
GO:0046872 metal ion binding 33.8983 5 no
GO:0030554 adenyl nucleotide binding 33.8983 6 yes
GO:0005524 ATP binding 32.2034 5 yes
GO:0016301 kinase activity 27.1186 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 27.1186 4 yes
GO:0004713 protein tyrosine kinase activity 20.3390 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 16.9492 5 yes
GO:0044389 ubiquitin-like protein ligase binding 15.2542 4 yes
GO:0031625 ubiquitin protein ligase binding 15.2542 5 yes
GO:0004674 protein serine/threonine kinase activity 13.5593 4 yes
GO:0008066 glutamate receptor activity 11.8644 4 yes
GO:0046943 carboxylic acid transmembrane transporter activity 10.1695 4 yes
GO:0005216 monoatomic ion channel activity 10.1695 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 10.1695 5 yes
GO:0015267 channel activity 10.1695 4 yes
GO:0022832 voltage-gated channel activity 10.1695 6 yes
GO:0022836 gated channel activity 10.1695 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 10.1695 4 yes
GO:0004970 glutamate-gated receptor activity 8.4746 4 yes
GO:0004972 NMDA glutamate receptor activity 8.4746 5 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 8.4746 6 yes
GO:0015276 ligand-gated monoatomic ion channel activity 8.4746 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 8.4746 5 yes
GO:0022834 ligand-gated channel activity 8.4746 6 yes
GO:0022835 transmitter-gated channel activity 8.4746 4 yes
GO:0004683 calmodulin-dependent protein kinase activity 5.0847 5 yes
GO:0043423 3-phosphoinositide-dependent protein kinase binding 3.3898 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FAK2_HUMAN
GO:0048522 positive regulation of cellular process 74.5763 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.1017 4 yes
GO:0080090 regulation of primary metabolic process 66.1017 4 yes
GO:0048523 negative regulation of cellular process 64.4068 4 yes
GO:0010646 regulation of cell communication 64.4068 4 yes
GO:0009966 regulation of signal transduction 62.7119 4 yes
GO:0031323 regulation of cellular metabolic process 61.0169 4 yes
GO:0051246 regulation of protein metabolic process 57.6271 5 yes
GO:0009893 positive regulation of metabolic process 57.6271 4 yes
GO:0048584 positive regulation of response to stimulus 55.9322 4 yes
GO:0051128 regulation of cellular component organization 55.9322 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 54.2373 5 yes
GO:0051247 positive regulation of protein metabolic process 52.5424 6 yes
GO:0051049 regulation of transport 49.1525 4 yes
GO:0010647 positive regulation of cell communication 49.1525 5 yes
GO:0023056 positive regulation of signaling 49.1525 4 yes
GO:0031399 regulation of protein modification process 47.4576 6 yes
GO:0051174 regulation of phosphorus metabolic process 47.4576 5 yes
GO:1902531 regulation of intracellular signal transduction 47.4576 5 yes
GO:0009967 positive regulation of signal transduction 47.4576 5 yes
GO:0019220 regulation of phosphate metabolic process 47.4576 6 yes
GO:0031325 positive regulation of cellular metabolic process 45.7627 5 yes
GO:0031326 regulation of cellular biosynthetic process 44.0678 5 yes
GO:0042325 regulation of phosphorylation 44.0678 7 yes
GO:0009889 regulation of biosynthetic process 44.0678 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 44.0678 5 yes
GO:0022607 cellular component assembly 44.0678 4 yes
GO:0043085 positive regulation of catalytic activity 42.3729 4 yes
GO:0001932 regulation of protein phosphorylation 42.3729 7 yes
GO:0031401 positive regulation of protein modification process 40.6780 7 yes
GO:0006996 organelle organization 40.6780 4 yes
GO:0036211 protein modification process 38.9831 4 yes
GO:0042327 positive regulation of phosphorylation 38.9831 8 yes
GO:0042981 regulation of apoptotic process 38.9831 5 yes
GO:0043067 regulation of programmed cell death 38.9831 4 yes
GO:0043412 macromolecule modification 38.9831 4 yes
GO:0045937 positive regulation of phosphate metabolic process 38.9831 7 yes
GO:0010468 regulation of gene expression 38.9831 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 38.9831 6 yes
GO:0001934 positive regulation of protein phosphorylation 37.2881 8 yes
GO:0006796 phosphate-containing compound metabolic process 37.2881 4 yes
GO:0060341 regulation of cellular localization 37.2881 4 no
GO:0051240 positive regulation of multicellular organismal process 35.5932 4 yes
GO:0051338 regulation of transferase activity 35.5932 4 yes
GO:0002684 positive regulation of immune system process 35.5932 4 yes
GO:0043549 regulation of kinase activity 33.8983 5 yes
GO:0050804 modulation of chemical synaptic transmission 33.8983 5 yes
GO:0099177 regulation of trans-synaptic signaling 33.8983 4 yes
GO:0120036 plasma membrane bounded cell projection organization 33.8983 5 yes
GO:1902533 positive regulation of intracellular signal transduction 33.8983 6 yes
GO:0030030 cell projection organization 33.8983 4 yes
GO:0042127 regulation of cell population proliferation 32.2034 4 yes
GO:0045859 regulation of protein kinase activity 32.2034 6 yes
GO:0009894 regulation of catabolic process 32.2034 4 yes
GO:0009892 negative regulation of metabolic process 32.2034 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.2034 5 no
GO:0008104 protein localization 32.2034 4 no
GO:0032880 regulation of protein localization 32.2034 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.2034 5 yes
GO:0030155 regulation of cell adhesion 30.5085 4 yes
GO:0032101 regulation of response to external stimulus 30.5085 4 yes
GO:0043933 protein-containing complex organization 30.5085 4 yes
GO:0045595 regulation of cell differentiation 30.5085 4 yes
GO:0051130 positive regulation of cellular component organization 30.5085 5 yes
GO:0051347 positive regulation of transferase activity 30.5085 5 yes
GO:0065003 protein-containing complex assembly 30.5085 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 30.5085 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 30.5085 5 yes
GO:0034762 regulation of transmembrane transport 28.8136 4 yes
GO:0043066 negative regulation of apoptotic process 28.8136 6 yes
GO:0043069 negative regulation of programmed cell death 28.8136 5 yes
GO:0043408 regulation of MAPK cascade 28.8136 6 yes
GO:0044087 regulation of cellular component biogenesis 28.8136 4 yes
GO:0071310 cellular response to organic substance 28.8136 4 yes
GO:0010243 response to organonitrogen compound 28.8136 4 yes
GO:0080134 regulation of response to stress 28.8136 4 no
GO:0016310 phosphorylation 28.8136 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.8136 4 yes
GO:0030334 regulation of cell migration 27.1186 5 yes
GO:0033674 positive regulation of kinase activity 27.1186 6 yes
GO:0034330 cell junction organization 27.1186 4 yes
GO:0044057 regulation of system process 27.1186 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 27.1186 8 yes
GO:0051094 positive regulation of developmental process 27.1186 4 yes
GO:0006468 protein phosphorylation 27.1186 5 yes
GO:2000145 regulation of cell motility 27.1186 4 yes
GO:0050776 regulation of immune response 27.1186 4 no
GO:0051336 regulation of hydrolase activity 27.1186 4 no
GO:0010648 negative regulation of cell communication 27.1186 5 yes
GO:0023057 negative regulation of signaling 27.1186 4 yes
GO:0030162 regulation of proteolysis 25.4237 6 yes
GO:0031175 neuron projection development 25.4237 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.4237 6 yes
GO:0031344 regulation of cell projection organization 25.4237 5 yes
GO:0033043 regulation of organelle organization 25.4237 5 yes
GO:0043269 regulation of monoatomic ion transport 25.4237 5 yes
GO:0045860 positive regulation of protein kinase activity 25.4237 7 yes
GO:1901701 cellular response to oxygen-containing compound 25.4237 4 yes
GO:2000026 regulation of multicellular organismal development 25.4237 4 yes
GO:0009891 positive regulation of biosynthetic process 25.4237 5 yes
GO:0031324 negative regulation of cellular metabolic process 25.4237 5 no
GO:0051050 positive regulation of transport 25.4237 4 no
GO:0018193 peptidyl-amino acid modification 25.4237 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 23.7288 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.7288 6 yes
GO:0141124 intracellular signaling cassette 23.7288 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 23.7288 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 23.7288 6 yes
GO:0048585 negative regulation of response to stimulus 23.7288 4 no
GO:0050778 positive regulation of immune response 23.7288 5 no
GO:0051248 negative regulation of protein metabolic process 23.7288 6 no
GO:0071702 organic substance transport 23.7288 4 no
GO:0050890 cognition 23.7288 4 no
GO:1903829 positive regulation of protein localization 23.7288 5 no
GO:0045862 positive regulation of proteolysis 22.0339 7 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.0339 9 yes
GO:0051093 negative regulation of developmental process 22.0339 4 yes
GO:0051493 regulation of cytoskeleton organization 22.0339 6 yes
GO:0006915 apoptotic process 22.0339 4 yes
GO:0007010 cytoskeleton organization 22.0339 5 yes
GO:0008284 positive regulation of cell population proliferation 22.0339 5 yes
GO:0009968 negative regulation of signal transduction 22.0339 5 no
GO:0071705 nitrogen compound transport 22.0339 4 no
GO:0098657 import into cell 22.0339 4 no
GO:0010959 regulation of metal ion transport 22.0339 6 yes
GO:0030335 positive regulation of cell migration 20.3390 6 yes
GO:0034329 cell junction assembly 20.3390 5 yes
GO:0040017 positive regulation of locomotion 20.3390 4 yes
GO:0043254 regulation of protein-containing complex assembly 20.3390 5 yes
GO:0043410 positive regulation of MAPK cascade 20.3390 7 yes
GO:0045785 positive regulation of cell adhesion 20.3390 5 yes
GO:0051241 negative regulation of multicellular organismal process 20.3390 4 yes
GO:0008285 negative regulation of cell population proliferation 20.3390 5 yes
GO:2000147 positive regulation of cell motility 20.3390 5 yes
GO:0031347 regulation of defense response 20.3390 5 no
GO:0050865 regulation of cell activation 20.3390 4 no
GO:0051345 positive regulation of hydrolase activity 20.3390 5 no
GO:0051252 regulation of RNA metabolic process 20.3390 5 no
GO:0032103 positive regulation of response to external stimulus 18.6441 5 yes
GO:0038127 ERBB signaling pathway 18.6441 6 yes
GO:0045596 negative regulation of cell differentiation 18.6441 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 18.6441 5 yes
GO:0009896 positive regulation of catabolic process 18.6441 5 yes
GO:0010638 positive regulation of organelle organization 18.6441 6 yes
GO:0032271 regulation of protein polymerization 16.9492 6 yes
GO:0032535 regulation of cellular component size 16.9492 4 yes
GO:0044089 positive regulation of cellular component biogenesis 16.9492 5 yes
GO:0046777 protein autophosphorylation 16.9492 6 yes
GO:0050807 regulation of synapse organization 16.9492 5 yes
GO:0051051 negative regulation of transport 16.9492 4 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 16.9492 6 yes
GO:0051924 regulation of calcium ion transport 16.9492 7 yes
GO:0060284 regulation of cell development 16.9492 5 yes
GO:1902903 regulation of supramolecular fiber organization 16.9492 5 yes
GO:0010628 positive regulation of gene expression 16.9492 7 yes
GO:0010810 regulation of cell-substrate adhesion 16.9492 5 yes
GO:0010975 regulation of neuron projection development 16.9492 7 yes
GO:0018108 peptidyl-tyrosine phosphorylation 16.9492 6 yes
GO:0018212 peptidyl-tyrosine modification 16.9492 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 15.2542 6 yes
GO:0031644 regulation of nervous system process 15.2542 5 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 15.2542 5 yes
GO:0050806 positive regulation of synaptic transmission 15.2542 5 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 15.2542 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 15.2542 7 yes
GO:0097435 supramolecular fiber organization 15.2542 4 yes
GO:1902905 positive regulation of supramolecular fiber organization 15.2542 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 15.2542 7 yes
GO:0007173 epidermal growth factor receptor signaling pathway 15.2542 7 yes
GO:0014070 response to organic cyclic compound 15.2542 4 yes
GO:0022604 regulation of cell morphogenesis 15.2542 5 yes
GO:0022898 regulation of transmembrane transporter activity 15.2542 4 yes
GO:0031346 positive regulation of cell projection organization 13.5593 6 yes
GO:0032273 positive regulation of protein polymerization 13.5593 7 yes
GO:0032956 regulation of actin cytoskeleton organization 13.5593 5 yes
GO:0032970 regulation of actin filament-based process 13.5593 4 yes
GO:0051495 positive regulation of cytoskeleton organization 13.5593 7 yes
GO:0098815 modulation of excitatory postsynaptic potential 13.5593 4 yes
GO:0007215 glutamate receptor signaling pathway 13.5593 4 yes
GO:0007229 integrin-mediated signaling pathway 13.5593 4 yes
GO:0010632 regulation of epithelial cell migration 13.5593 4 yes
GO:0030832 regulation of actin filament length 11.8644 5 yes
GO:0030833 regulation of actin filament polymerization 11.8644 7 yes
GO:0033993 response to lipid 11.8644 4 yes
GO:0045471 response to ethanol 11.8644 5 yes
GO:0045927 positive regulation of growth 11.8644 4 yes
GO:0051052 regulation of DNA metabolic process 11.8644 5 yes
GO:0051282 regulation of sequestering of calcium ion 11.8644 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 11.8644 6 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 11.8644 8 yes
GO:0071396 cellular response to lipid 11.8644 5 yes
GO:0071675 regulation of mononuclear cell migration 11.8644 5 yes
GO:0000302 response to reactive oxygen species 11.8644 4 yes
GO:0001558 regulation of cell growth 11.8644 4 yes
GO:0097305 response to alcohol 11.8644 4 yes
GO:0001952 regulation of cell-matrix adhesion 11.8644 6 yes
GO:0110053 regulation of actin filament organization 11.8644 6 yes
GO:0002685 regulation of leukocyte migration 11.8644 4 yes
GO:1901888 regulation of cell junction assembly 11.8644 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 11.8644 6 yes
GO:2000377 regulation of reactive oxygen species metabolic process 11.8644 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 11.8644 5 yes
GO:0010634 positive regulation of epithelial cell migration 11.8644 5 yes
GO:0019221 cytokine-mediated signaling pathway 11.8644 4 yes
GO:0030307 positive regulation of cell growth 10.1695 5 yes
GO:0032147 activation of protein kinase activity 10.1695 8 yes
GO:0035235 ionotropic glutamate receptor signaling pathway 10.1695 4 yes
GO:0043266 regulation of potassium ion transport 10.1695 7 yes
GO:0043271 negative regulation of monoatomic ion transport 10.1695 5 yes
GO:0045765 regulation of angiogenesis 10.1695 5 yes
GO:0050920 regulation of chemotaxis 10.1695 4 yes
GO:0051054 positive regulation of DNA metabolic process 10.1695 6 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 10.1695 5 yes
GO:0071677 positive regulation of mononuclear cell migration 10.1695 6 yes
GO:0099175 regulation of postsynapse organization 10.1695 6 yes
GO:0002687 positive regulation of leukocyte migration 10.1695 5 yes
GO:0150115 cell-substrate junction organization 10.1695 5 yes
GO:1901342 regulation of vasculature development 10.1695 5 yes
GO:0007015 actin filament organization 10.1695 5 yes
GO:0007044 cell-substrate junction assembly 10.1695 6 yes
GO:2000278 regulation of DNA biosynthetic process 10.1695 6 yes
GO:2000379 positive regulation of reactive oxygen species metabolic process 10.1695 6 yes
GO:0010038 response to metal ion 10.1695 4 yes
GO:0010608 post-transcriptional regulation of gene expression 10.1695 7 yes
GO:0030838 positive regulation of actin filament polymerization 8.4746 7 yes
GO:0031032 actomyosin structure organization 8.4746 4 yes
GO:0036293 response to decreased oxygen levels 8.4746 4 yes
GO:0042542 response to hydrogen peroxide 8.4746 4 yes
GO:0043523 regulation of neuron apoptotic process 8.4746 6 yes
GO:0043524 negative regulation of neuron apoptotic process 8.4746 7 yes
GO:0045428 regulation of nitric oxide biosynthetic process 8.4746 5 yes
GO:0045429 positive regulation of nitric oxide biosynthetic process 8.4746 6 yes
GO:0045766 positive regulation of angiogenesis 8.4746 6 yes
GO:0048010 vascular endothelial growth factor receptor signaling pathway 8.4746 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 8.4746 6 yes
GO:0060291 long-term synaptic potentiation 8.4746 4 yes
GO:0000165 MAPK cascade 8.4746 5 yes
GO:0080164 regulation of nitric oxide metabolic process 8.4746 4 yes
GO:0001667 ameboidal-type cell migration 8.4746 4 yes
GO:0001894 tissue homeostasis 8.4746 4 yes
GO:0002521 leukocyte differentiation 8.4746 4 yes
GO:0002688 regulation of leukocyte chemotaxis 8.4746 5 yes
GO:0006417 regulation of translation 8.4746 6 yes
GO:1902115 regulation of organelle assembly 8.4746 5 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 8.4746 7 yes
GO:1903131 mononuclear cell differentiation 8.4746 5 yes
GO:1903706 regulation of hemopoiesis 8.4746 4 yes
GO:1904018 positive regulation of vasculature development 8.4746 5 yes
GO:1904407 positive regulation of nitric oxide metabolic process 8.4746 5 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 8.4746 5 yes
GO:2000573 positive regulation of DNA biosynthetic process 8.4746 7 yes
GO:0010594 regulation of endothelial cell migration 8.4746 5 yes
GO:0010660 regulation of muscle cell apoptotic process 8.4746 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 8.4746 6 yes
GO:0030098 lymphocyte differentiation 6.7797 4 yes
GO:0030278 regulation of ossification 6.7797 4 yes
GO:0030865 cortical cytoskeleton organization 6.7797 6 yes
GO:0042113 B cell activation 6.7797 4 yes
GO:0043279 response to alkaloid 6.7797 5 yes
GO:0048041 focal adhesion assembly 6.7797 7 yes
GO:0050921 positive regulation of chemotaxis 6.7797 5 yes
GO:0099601 regulation of neurotransmitter receptor activity 6.7797 4 yes
GO:0002690 positive regulation of leukocyte chemotaxis 6.7797 6 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 6.7797 8 yes
GO:0007172 signal complex assembly 6.7797 5 yes
GO:1905521 regulation of macrophage migration 6.7797 6 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 6.7797 6 yes
GO:2000310 regulation of NMDA receptor activity 6.7797 5 yes
GO:2000401 regulation of lymphocyte migration 6.7797 6 yes
GO:2000403 positive regulation of lymphocyte migration 6.7797 7 yes
GO:0010595 positive regulation of endothelial cell migration 6.7797 6 yes
GO:0010631 epithelial cell migration 6.7797 5 yes
GO:0010656 negative regulation of muscle cell apoptotic process 6.7797 7 yes
GO:0010758 regulation of macrophage chemotaxis 6.7797 6 yes
GO:0010976 positive regulation of neuron projection development 6.7797 7 yes
GO:0030183 B cell differentiation 5.0847 5 yes
GO:0032526 response to retinoic acid 5.0847 4 yes
GO:0033209 tumor necrosis factor-mediated signaling pathway 5.0847 5 yes
GO:0038083 peptidyl-tyrosine autophosphorylation 5.0847 7 yes
GO:0042220 response to cocaine 5.0847 4 yes
GO:0042976 activation of Janus kinase activity 5.0847 7 yes
GO:0043149 stress fiber assembly 5.0847 5 yes
GO:0043267 negative regulation of potassium ion transport 5.0847 6 yes
GO:0043534 blood vessel endothelial cell migration 5.0847 7 yes
GO:0043542 endothelial cell migration 5.0847 6 yes
GO:0045453 bone resorption 5.0847 5 yes
GO:0045637 regulation of myeloid cell differentiation 5.0847 5 yes
GO:0045638 negative regulation of myeloid cell differentiation 5.0847 6 yes
GO:0045727 positive regulation of translation 5.0847 7 yes
GO:0046328 regulation of JNK cascade 5.0847 7 yes
GO:0046330 positive regulation of JNK cascade 5.0847 8 yes
GO:0051017 actin filament bundle assembly 5.0847 5 yes
GO:0051592 response to calcium ion 5.0847 5 yes
GO:0051963 regulation of synapse assembly 5.0847 6 yes
GO:0061572 actin filament bundle organization 5.0847 6 yes
GO:0070098 chemokine-mediated signaling pathway 5.0847 4 yes
GO:0071300 cellular response to retinoic acid 5.0847 5 yes
GO:0071498 cellular response to fluid shear stress 5.0847 4 yes
GO:0001954 positive regulation of cell-matrix adhesion 5.0847 7 yes
GO:0006968 cellular defense response 5.0847 4 yes
GO:0009651 response to salt stress 5.0847 4 yes
GO:0009743 response to carbohydrate 5.0847 4 yes
GO:0030038 contractile actin filament bundle assembly 5.0847 6 yes
GO:0030279 negative regulation of ossification 3.3898 5 yes
GO:0030500 regulation of bone mineralization 3.3898 5 yes
GO:0030502 negative regulation of bone mineralization 3.3898 6 yes
GO:0034284 response to monosaccharide 3.3898 5 yes
GO:0043157 response to cation stress 3.3898 5 yes
GO:0046683 response to organophosphorus 3.3898 4 yes
GO:0050805 negative regulation of synaptic transmission 3.3898 5 yes
GO:0051591 response to cAMP 3.3898 4 yes
GO:0060292 long-term synaptic depression 3.3898 4 yes
GO:0070167 regulation of biomineral tissue development 3.3898 5 yes
GO:0070168 negative regulation of biomineral tissue development 3.3898 5 yes
GO:0086100 endothelin receptor signaling pathway 3.3898 4 yes
GO:0099150 regulation of postsynaptic specialization assembly 3.3898 6 yes
GO:0099151 regulation of postsynaptic density assembly 3.3898 7 yes
GO:0002040 sprouting angiogenesis 3.3898 4 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 3.3898 6 yes
GO:0002285 lymphocyte activation involved in immune response 3.3898 4 yes
GO:0002312 B cell activation involved in immune response 3.3898 5 yes
GO:0002313 mature B cell differentiation involved in immune response 3.3898 6 yes
GO:0002315 marginal zone B cell differentiation 3.3898 7 yes
GO:0002335 mature B cell differentiation 3.3898 6 yes
GO:0140131 positive regulation of lymphocyte chemotaxis 3.3898 7 yes
GO:1901623 regulation of lymphocyte chemotaxis 3.3898 6 yes
GO:1904889 regulation of excitatory synapse assembly 3.3898 7 yes
GO:1905874 regulation of postsynaptic density organization 3.3898 6 yes
GO:0009746 response to hexose 3.3898 6 yes
GO:0009749 response to glucose 3.3898 7 yes
GO:2000537 regulation of B cell chemotaxis 3.3898 7 yes
GO:2000538 positive regulation of B cell chemotaxis 3.3898 8 yes
GO:0014074 response to purine-containing compound 3.3898 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ASAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOU_HUMAN [view interactions] Low throughput no no
NPHP1_HUMAN [view interactions] Low throughput no yes
PAXI_HUMAN [view interactions] Low throughput no yes
ARFG1_HUMAN [view interactions] Low throughput no no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
MATK_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG10_HUMAN [view interactions] Low throughput no no
TGFI1_HUMAN [view interactions] Low throughput no no
M3K4_HUMAN [view interactions] Low throughput no yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
MYD88_HUMAN [view interactions] Low throughput no yes
DOCK8_HUMAN [view interactions] Low throughput no yes
NPHP4_HUMAN [view interactions] Low throughput no yes
TRAF4_HUMAN [view interactions] Low throughput no yes
NCF1_HUMAN [view interactions] Low throughput no no
SKAP2_HUMAN [view interactions] Low throughput no no
LPXN_HUMAN [view interactions] Low throughput no yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
GELS_HUMAN [view entry] [view interactions] Low throughput yes no
PITM3_HUMAN [view interactions] Low throughput no no
PITM1_HUMAN [view interactions] Low throughput no yes
PITM2_HUMAN [view interactions] Low throughput no yes
RBCC1_HUMAN [view interactions] Low throughput no no
SOCS3_HUMAN [view interactions] Low throughput no yes
MBD2_HUMAN [view interactions] Low throughput no yes
SOCS2_HUMAN [view interactions] Low throughput no yes
BCAR1_HUMAN [view interactions] Low throughput no yes
M4K4_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
KSYK_HUMAN [view interactions] Low throughput no no
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
JAK3_HUMAN [view interactions] Low throughput no no
JAK1_HUMAN [view interactions] Low throughput no yes
IL7RA_HUMAN [view interactions] Low throughput no no
KCNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
CASL_HUMAN [view interactions] Low throughput no yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GTR1_HUMAN [view entry] [view interactions] Low throughput yes no
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP2_HUMAN [view interactions] Low throughput no yes
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
TLN1_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
EWS_HUMAN [view interactions] Low throughput no yes
RASA1_HUMAN [view interactions] Low throughput no yes
PK3CB_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DOK1_HUMAN [view interactions] Low throughput no yes
PLD2_HUMAN [view interactions] Low throughput no yes
CBLB_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB3_HUMAN [view interactions] Low throughput no yes
NED4L_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRO_HUMAN [view entry] [view interactions] Low throughput yes no
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
EFS_HUMAN [view interactions] Low throughput no no
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
VAV_HUMAN [view interactions] Low throughput no no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN12_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
CF418_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
ZFHX2_HUMAN [view interactions] High throughput no no
CPVL_HUMAN [view interactions] High throughput no no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SATB2_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
EXC6B_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
PAX6_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS1_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
ALG2_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
GPVI_HUMAN [view interactions] High throughput no no
GP1BB_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
BFAR_HUMAN [view interactions] High throughput no no
PEAK3_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RD23B_HUMAN [view interactions] High throughput no yes
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
GUAD_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX19_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes