Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FAK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at Tyr-9, Tyr-373, and Tyr-376. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000806 LIG_SH2_GRB2like LIG 881 884 -
ELMI000463 LIG_SH2_SRC LIG 402 405 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FAK2_HUMAN
GO:0017076 purine nucleotide binding 44.8718 4 yes
GO:0032555 purine ribonucleotide binding 44.8718 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.5897 4 yes
GO:0019900 kinase binding 41.0256 4 yes
GO:0019901 protein kinase binding 37.1795 5 yes
GO:0030554 adenyl nucleotide binding 34.6154 5 yes
GO:0032559 adenyl ribonucleotide binding 34.6154 5 yes
GO:0005524 ATP binding 33.3333 5 yes
GO:0046872 metal ion binding 29.4872 4 no
GO:0016301 kinase activity 29.4872 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 29.4872 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 28.2051 4 yes
GO:0004713 protein tyrosine kinase activity 17.9487 4 yes
GO:0004674 protein serine/threonine kinase activity 15.3846 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 12.8205 5 yes
GO:0031625 ubiquitin protein ligase binding 11.5385 5 yes
GO:0044389 ubiquitin-like protein ligase binding 11.5385 4 yes
GO:0022836 gated channel activity 8.9744 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 8.9744 4 yes
GO:0005216 ion channel activity 8.9744 4 yes
GO:0005261 cation channel activity 8.9744 5 yes
GO:0008066 glutamate receptor activity 8.9744 4 yes
GO:0008324 cation transmembrane transporter activity 8.9744 4 yes
GO:0015267 channel activity 8.9744 4 yes
GO:0022824 transmitter-gated ion channel activity 7.6923 5 yes
GO:0022832 voltage-gated channel activity 7.6923 6 yes
GO:0022834 ligand-gated channel activity 7.6923 6 yes
GO:0022835 transmitter-gated channel activity 7.6923 4 yes
GO:0022843 voltage-gated cation channel activity 7.6923 5 yes
GO:0099094 ligand-gated cation channel activity 7.6923 6 yes
GO:0005230 extracellular ligand-gated ion channel activity 7.6923 6 yes
GO:0005244 voltage-gated ion channel activity 7.6923 4 yes
GO:0015276 ligand-gated ion channel activity 7.6923 5 yes
GO:0004970 ionotropic glutamate receptor activity 6.4103 5 yes
GO:0004972 NMDA glutamate receptor activity 6.4103 6 yes
GO:0004683 calmodulin-dependent protein kinase activity 5.1282 5 yes
GO:0043423 3-phosphoinositide-dependent protein kinase binding 2.5641 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FAK2_HUMAN
GO:0048522 positive regulation of cellular process 78.2051 4 yes
GO:0010646 regulation of cell communication 70.5128 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.8205 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.8205 4 yes
GO:0080090 regulation of primary metabolic process 62.8205 4 yes
GO:0009966 regulation of signal transduction 62.8205 4 yes
GO:0048523 negative regulation of cellular process 60.2564 4 yes
GO:0031323 regulation of cellular metabolic process 58.9744 4 yes
GO:0009893 positive regulation of metabolic process 55.1282 4 yes
GO:0051128 regulation of cellular component organization 53.8462 4 yes
GO:0051246 regulation of protein metabolic process 53.8462 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 52.5641 5 yes
GO:1902531 regulation of intracellular signal transduction 52.5641 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 51.2821 5 yes
GO:0010647 positive regulation of cell communication 51.2821 5 yes
GO:0023056 positive regulation of signaling 51.2821 4 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0043085 positive regulation of catalytic activity 48.7179 4 yes
GO:0051247 positive regulation of protein metabolic process 47.4359 6 yes
GO:0031325 positive regulation of cellular metabolic process 47.4359 5 yes
GO:0051174 regulation of phosphorus metabolic process 46.1538 5 yes
GO:0010468 regulation of gene expression 46.1538 5 yes
GO:0019220 regulation of phosphate metabolic process 46.1538 6 yes
GO:0031399 regulation of protein modification process 46.1538 6 yes
GO:0009967 positive regulation of signal transduction 44.8718 5 yes
GO:0042325 regulation of phosphorylation 44.8718 7 yes
GO:0051049 regulation of transport 43.5897 4 yes
GO:0001932 regulation of protein phosphorylation 42.3077 7 yes
GO:0071310 cellular response to organic substance 39.7436 4 yes
GO:0009889 regulation of biosynthetic process 38.4615 4 yes
GO:1902533 positive regulation of intracellular signal transduction 38.4615 6 yes
GO:0010941 regulation of cell death 38.4615 4 yes
GO:0022607 cellular component assembly 38.4615 4 yes
GO:0045937 positive regulation of phosphate metabolic process 37.1795 7 yes
GO:0051336 regulation of hydrolase activity 37.1795 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.1795 6 yes
GO:0031326 regulation of cellular biosynthetic process 37.1795 5 yes
GO:0031401 positive regulation of protein modification process 37.1795 7 yes
GO:0042327 positive regulation of phosphorylation 37.1795 8 yes
GO:0001934 positive regulation of protein phosphorylation 35.8974 8 yes
GO:0006796 phosphate-containing compound metabolic process 35.8974 4 yes
GO:0006996 organelle organization 35.8974 4 yes
GO:0030030 cell projection organization 35.8974 4 yes
GO:0036211 protein modification process 35.8974 4 yes
GO:0043412 macromolecule modification 35.8974 4 yes
GO:0050804 modulation of chemical synaptic transmission 34.6154 5 yes
GO:0051338 regulation of transferase activity 34.6154 4 yes
GO:0099177 regulation of trans-synaptic signaling 34.6154 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.6154 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.6154 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 34.6154 4 yes
GO:0042981 regulation of apoptotic process 34.6154 6 yes
GO:0043067 regulation of programmed cell death 34.6154 5 yes
GO:2000145 regulation of cell motility 33.3333 4 yes
GO:0030334 regulation of cell migration 33.3333 5 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0051130 positive regulation of cellular component organization 32.0513 5 yes
GO:0051345 positive regulation of hydrolase activity 32.0513 5 yes
GO:0010243 response to organonitrogen compound 32.0513 4 yes
GO:0120036 plasma membrane bounded cell projection organization 32.0513 5 yes
GO:0060341 regulation of cellular localization 32.0513 4 no
GO:0030155 regulation of cell adhesion 32.0513 4 yes
GO:0043408 regulation of MAPK cascade 32.0513 6 yes
GO:0043549 regulation of kinase activity 32.0513 5 yes
GO:0045595 regulation of cell differentiation 32.0513 4 yes
GO:0051347 positive regulation of transferase activity 30.7692 5 yes
GO:0002684 positive regulation of immune system process 30.7692 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 30.7692 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 30.7692 5 yes
GO:0080134 regulation of response to stress 30.7692 4 yes
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 yes
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0032101 regulation of response to external stimulus 30.7692 4 yes
GO:0051094 positive regulation of developmental process 29.4872 4 yes
GO:0016310 phosphorylation 29.4872 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.4872 5 no
GO:0031344 regulation of cell projection organization 29.4872 5 yes
GO:0033043 regulation of organelle organization 29.4872 5 yes
GO:0045859 regulation of protein kinase activity 28.2051 6 yes
GO:0006468 protein phosphorylation 28.2051 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.2051 6 yes
GO:0032880 regulation of protein localization 28.2051 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.2051 5 no
GO:0033674 positive regulation of kinase activity 28.2051 6 yes
GO:0042127 regulation of cell population proliferation 28.2051 4 yes
GO:0060548 negative regulation of cell death 26.9231 5 yes
GO:0031175 neuron projection development 26.9231 6 yes
GO:0034330 cell junction organization 26.9231 4 yes
GO:0045785 positive regulation of cell adhesion 25.6410 5 yes
GO:0051240 positive regulation of multicellular organismal process 25.6410 4 yes
GO:0009894 regulation of catabolic process 25.6410 4 yes
GO:0010648 negative regulation of cell communication 25.6410 5 yes
GO:2000147 positive regulation of cell motility 25.6410 5 yes
GO:0023057 negative regulation of signaling 25.6410 4 yes
GO:0051252 regulation of RNA metabolic process 25.6410 5 no
GO:0030335 positive regulation of cell migration 25.6410 6 yes
GO:0040017 positive regulation of locomotion 25.6410 4 yes
GO:0043933 protein-containing complex organization 25.6410 4 yes
GO:0051493 regulation of cytoskeleton organization 24.3590 6 yes
GO:0065003 protein-containing complex assembly 24.3590 5 yes
GO:2000026 regulation of multicellular organismal development 24.3590 4 yes
GO:0050776 regulation of immune response 24.3590 4 no
GO:0030162 regulation of proteolysis 24.3590 6 yes
GO:0048585 negative regulation of response to stimulus 24.3590 4 no
GO:0043066 negative regulation of apoptotic process 24.3590 7 yes
GO:0043069 negative regulation of programmed cell death 24.3590 6 yes
GO:0043410 positive regulation of MAPK cascade 24.3590 7 yes
GO:0044089 positive regulation of cellular component biogenesis 24.3590 5 yes
GO:0045860 positive regulation of protein kinase activity 23.0769 7 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.0769 8 yes
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 yes
GO:0018193 peptidyl-amino acid modification 23.0769 5 yes
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0050865 regulation of cell activation 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 6 no
GO:1903506 regulation of nucleic acid-templated transcription 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0045862 positive regulation of proteolysis 21.7949 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.7949 6 yes
GO:0007010 cytoskeleton organization 21.7949 5 yes
GO:0008284 positive regulation of cell population proliferation 21.7949 5 yes
GO:0009891 positive regulation of biosynthetic process 21.7949 5 yes
GO:0010942 positive regulation of cell death 21.7949 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.7949 6 yes
GO:0043254 regulation of protein-containing complex assembly 21.7949 5 yes
GO:0043269 regulation of ion transport 21.7949 5 yes
GO:0051093 negative regulation of developmental process 20.5128 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 20.5128 6 yes
GO:0010810 regulation of cell-substrate adhesion 20.5128 5 yes
GO:0022604 regulation of cell morphogenesis 20.5128 5 yes
GO:0051129 negative regulation of cellular component organization 20.5128 5 no
GO:0051248 negative regulation of protein metabolic process 20.5128 6 no
GO:1903829 positive regulation of protein localization 20.5128 5 no
GO:0050890 cognition 20.5128 4 no
GO:0046777 protein autophosphorylation 19.2308 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 19.2308 9 yes
GO:0071396 cellular response to lipid 19.2308 5 yes
GO:0010638 positive regulation of organelle organization 19.2308 6 yes
GO:0010975 regulation of neuron projection development 19.2308 7 yes
GO:0014070 response to organic cyclic compound 19.2308 4 yes
GO:0033993 response to lipid 19.2308 4 yes
GO:0034762 regulation of transmembrane transport 19.2308 4 yes
GO:0044057 regulation of system process 19.2308 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 17.9487 7 yes
GO:0097435 supramolecular fiber organization 17.9487 4 yes
GO:1901214 regulation of neuron death 17.9487 5 yes
GO:0010628 positive regulation of gene expression 17.9487 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 17.9487 6 yes
GO:0034329 cell junction assembly 17.9487 5 yes
GO:0006915 apoptotic process 16.6667 4 yes
GO:0080135 regulation of cellular response to stress 16.6667 4 yes
GO:0032103 positive regulation of response to external stimulus 16.6667 5 yes
GO:0034765 regulation of ion transmembrane transport 16.6667 5 yes
GO:0045596 negative regulation of cell differentiation 16.6667 5 yes
GO:0002685 regulation of leukocyte migration 15.3846 4 yes
GO:0008360 regulation of cell shape 15.3846 6 yes
GO:1902903 regulation of supramolecular fiber organization 15.3846 5 yes
GO:0010632 regulation of epithelial cell migration 15.3846 4 yes
GO:0010959 regulation of metal ion transport 15.3846 6 yes
GO:2000377 regulation of reactive oxygen species metabolic process 15.3846 5 yes
GO:0031329 regulation of cellular catabolic process 15.3846 5 yes
GO:0031346 positive regulation of cell projection organization 15.3846 6 yes
GO:0032956 regulation of actin cytoskeleton organization 15.3846 5 yes
GO:0032970 regulation of actin filament-based process 15.3846 4 yes
GO:0050806 positive regulation of synaptic transmission 14.1026 5 yes
GO:0051051 negative regulation of transport 14.1026 4 yes
GO:0007015 actin filament organization 14.1026 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 14.1026 8 yes
GO:0071900 regulation of protein serine/threonine kinase activity 14.1026 7 yes
GO:0008285 negative regulation of cell population proliferation 14.1026 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 14.1026 6 yes
GO:1904062 regulation of cation transmembrane transport 14.1026 6 yes
GO:0032271 regulation of protein polymerization 14.1026 6 yes
GO:0043087 regulation of GTPase activity 14.1026 5 yes
GO:0045834 positive regulation of lipid metabolic process 12.8205 5 yes
GO:0051495 positive regulation of cytoskeleton organization 12.8205 7 yes
GO:0051924 regulation of calcium ion transport 12.8205 7 yes
GO:0097305 response to alcohol 12.8205 4 yes
GO:0009896 positive regulation of catabolic process 12.8205 5 yes
GO:1901215 negative regulation of neuron death 12.8205 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 12.8205 6 yes
GO:0018108 peptidyl-tyrosine phosphorylation 12.8205 6 yes
GO:0018212 peptidyl-tyrosine modification 12.8205 6 yes
GO:0019216 regulation of lipid metabolic process 12.8205 5 yes
GO:0032535 regulation of cellular component size 12.8205 4 yes
GO:0038127 ERBB signaling pathway 12.8205 6 yes
GO:0043523 regulation of neuron apoptotic process 12.8205 6 yes
GO:0050920 regulation of chemotaxis 11.5385 4 yes
GO:0000302 response to reactive oxygen species 11.5385 4 yes
GO:0007173 epidermal growth factor receptor signaling pathway 11.5385 7 yes
GO:0071675 regulation of mononuclear cell migration 11.5385 5 yes
GO:0007229 integrin-mediated signaling pathway 11.5385 4 yes
GO:0110053 regulation of actin filament organization 11.5385 6 yes
GO:0010594 regulation of endothelial cell migration 11.5385 5 yes
GO:0010608 post-transcriptional regulation of gene expression 11.5385 6 yes
GO:0010634 positive regulation of epithelial cell migration 11.5385 5 yes
GO:0031644 regulation of nervous system process 11.5385 5 yes
GO:0032273 positive regulation of protein polymerization 11.5385 7 yes
GO:0043547 positive regulation of GTPase activity 11.5385 6 yes
GO:0045765 regulation of angiogenesis 10.2564 5 yes
GO:0045927 positive regulation of growth 10.2564 4 yes
GO:0051052 regulation of DNA metabolic process 10.2564 5 yes
GO:0051054 positive regulation of DNA metabolic process 10.2564 6 yes
GO:0001558 regulation of cell growth 10.2564 4 yes
GO:0001952 regulation of cell-matrix adhesion 10.2564 6 yes
GO:0002687 positive regulation of leukocyte migration 10.2564 5 yes
GO:0002688 regulation of leukocyte chemotaxis 10.2564 5 yes
GO:0006109 regulation of carbohydrate metabolic process 10.2564 5 yes
GO:0007215 glutamate receptor signaling pathway 10.2564 4 yes
GO:0080164 regulation of nitric oxide metabolic process 10.2564 5 yes
GO:0090218 positive regulation of lipid kinase activity 10.2564 6 yes
GO:1901342 regulation of vasculature development 10.2564 5 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 10.2564 6 yes
GO:0022898 regulation of transmembrane transporter activity 10.2564 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 10.2564 5 yes
GO:0043405 regulation of MAP kinase activity 10.2564 8 yes
GO:0043524 negative regulation of neuron apoptotic process 10.2564 7 yes
GO:0043550 regulation of lipid kinase activity 10.2564 6 yes
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 10.2564 7 yes
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 10.2564 7 yes
GO:0045428 regulation of nitric oxide biosynthetic process 10.2564 6 yes
GO:0045471 response to ethanol 10.2564 5 yes
GO:0050921 positive regulation of chemotaxis 8.9744 5 yes
GO:0001667 ameboidal-type cell migration 8.9744 4 yes
GO:0060291 long-term synaptic potentiation 8.9744 4 yes
GO:0002690 positive regulation of leukocyte chemotaxis 8.9744 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 8.9744 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 8.9744 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 8.9744 8 yes
GO:0010038 response to metal ion 8.9744 4 yes
GO:0010595 positive regulation of endothelial cell migration 8.9744 6 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 8.9744 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 8.9744 7 yes
GO:1903706 regulation of hemopoiesis 8.9744 4 yes
GO:2000379 positive regulation of reactive oxygen species metabolic process 8.9744 6 yes
GO:0019221 cytokine-mediated signaling pathway 8.9744 4 yes
GO:0030832 regulation of actin filament length 8.9744 5 yes
GO:0030833 regulation of actin filament polymerization 8.9744 7 yes
GO:0031331 positive regulation of cellular catabolic process 8.9744 6 yes
GO:0032147 activation of protein kinase activity 8.9744 8 yes
GO:0034248 regulation of cellular amide metabolic process 8.9744 5 yes
GO:0036293 response to decreased oxygen levels 8.9744 4 yes
GO:0042542 response to hydrogen peroxide 8.9744 4 yes
GO:0045766 positive regulation of angiogenesis 7.6923 6 yes
GO:0000165 MAPK cascade 7.6923 4 yes
GO:0051282 regulation of sequestering of calcium ion 7.6923 4 yes
GO:0001894 tissue homeostasis 7.6923 5 yes
GO:0060249 anatomical structure homeostasis 7.6923 4 yes
GO:0062012 regulation of small molecule metabolic process 7.6923 4 yes
GO:0006417 regulation of translation 7.6923 6 yes
GO:0098815 modulation of excitatory postsynaptic potential 7.6923 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 7.6923 4 yes
GO:0010631 epithelial cell migration 7.6923 5 yes
GO:1904018 positive regulation of vasculature development 7.6923 5 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 7.6923 5 yes
GO:1904407 positive regulation of nitric oxide metabolic process 7.6923 6 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 7.6923 6 yes
GO:2000278 regulation of DNA biosynthetic process 7.6923 6 yes
GO:2000401 regulation of lymphocyte migration 7.6923 6 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 7.6923 5 yes
GO:2000573 positive regulation of DNA biosynthetic process 7.6923 7 yes
GO:0030307 positive regulation of cell growth 7.6923 5 yes
GO:0031032 actomyosin structure organization 7.6923 4 yes
GO:0032872 regulation of stress-activated MAPK cascade 7.6923 6 yes
GO:0045429 positive regulation of nitric oxide biosynthetic process 7.6923 7 yes
GO:0046328 regulation of JNK cascade 6.4103 7 yes
GO:0048010 vascular endothelial growth factor receptor signaling pathway 6.4103 6 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 6.4103 5 yes
GO:0002521 leukocyte differentiation 6.4103 4 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 6.4103 6 yes
GO:0007044 cell-substrate junction assembly 6.4103 6 yes
GO:0071300 cellular response to retinoic acid 6.4103 5 yes
GO:0009743 response to carbohydrate 6.4103 4 yes
GO:0150115 cell-substrate junction organization 6.4103 5 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 6.4103 8 yes
GO:1903131 mononuclear cell differentiation 6.4103 5 yes
GO:0010660 regulation of muscle cell apoptotic process 6.4103 7 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 6.4103 7 yes
GO:0010976 positive regulation of neuron projection development 6.4103 7 yes
GO:2001257 regulation of cation channel activity 6.4103 6 yes
GO:0030838 positive regulation of actin filament polymerization 6.4103 7 yes
GO:0032526 response to retinoic acid 6.4103 4 yes
GO:0034250 positive regulation of cellular amide metabolic process 6.4103 6 yes
GO:0043279 response to alkaloid 6.4103 5 yes
GO:0043406 positive regulation of MAP kinase activity 6.4103 8 yes
GO:0043542 endothelial cell migration 6.4103 6 yes
GO:0045727 positive regulation of translation 5.1282 7 yes
GO:0046330 positive regulation of JNK cascade 5.1282 8 yes
GO:0046683 response to organophosphorus 5.1282 4 yes
GO:0050805 negative regulation of synaptic transmission 5.1282 5 yes
GO:0050848 regulation of calcium-mediated signaling 5.1282 6 yes
GO:0051017 actin filament bundle assembly 5.1282 5 yes
GO:0001954 positive regulation of cell-matrix adhesion 5.1282 7 yes
GO:0051591 response to cAMP 5.1282 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 5.1282 6 yes
GO:0061572 actin filament bundle organization 5.1282 6 yes
GO:0007172 signal complex assembly 5.1282 5 yes
GO:0071677 positive regulation of mononuclear cell migration 5.1282 6 yes
GO:0090630 activation of GTPase activity 5.1282 7 yes
GO:0010656 negative regulation of muscle cell apoptotic process 5.1282 8 yes
GO:0010758 regulation of macrophage chemotaxis 5.1282 6 yes
GO:1905521 regulation of macrophage migration 5.1282 5 yes
GO:2000114 regulation of establishment of cell polarity 5.1282 5 yes
GO:0014074 response to purine-containing compound 5.1282 5 yes
GO:2000310 regulation of NMDA receptor activity 5.1282 5 yes
GO:2000403 positive regulation of lymphocyte migration 5.1282 7 yes
GO:0030038 contractile actin filament bundle assembly 5.1282 6 yes
GO:0030098 lymphocyte differentiation 5.1282 4 yes
GO:0030278 regulation of ossification 5.1282 4 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 5.1282 7 yes
GO:0032878 regulation of establishment or maintenance of cell polarity 5.1282 4 yes
GO:0035235 ionotropic glutamate receptor signaling pathway 5.1282 4 yes
GO:0042113 B cell activation 5.1282 4 yes
GO:0043149 stress fiber assembly 5.1282 5 yes
GO:0043255 regulation of carbohydrate biosynthetic process 5.1282 5 yes
GO:0043266 regulation of potassium ion transport 5.1282 7 yes
GO:0043271 negative regulation of ion transport 5.1282 5 yes
GO:0045637 regulation of myeloid cell differentiation 5.1282 5 yes
GO:0045638 negative regulation of myeloid cell differentiation 3.8462 6 yes
GO:0048041 focal adhesion assembly 3.8462 7 yes
GO:0051592 response to calcium ion 3.8462 5 yes
GO:0006968 cellular defense response 3.8462 4 yes
GO:0071498 cellular response to fluid shear stress 3.8462 4 yes
GO:0009746 response to hexose 3.8462 6 yes
GO:0086100 endothelin receptor signaling pathway 3.8462 4 yes
GO:0009749 response to glucose 3.8462 7 yes
GO:0030183 B cell differentiation 3.8462 5 yes
GO:0033209 tumor necrosis factor-mediated signaling pathway 3.8462 5 yes
GO:0034284 response to monosaccharide 3.8462 5 yes
GO:0038083 peptidyl-tyrosine autophosphorylation 3.8462 7 yes
GO:0042220 response to cocaine 3.8462 4 yes
GO:0042976 activation of Janus kinase activity 3.8462 7 yes
GO:0043534 blood vessel endothelial cell migration 3.8462 7 yes
GO:0045453 bone resorption 3.8462 6 yes
GO:0050999 regulation of nitric-oxide synthase activity 2.5641 6 yes
GO:0051000 positive regulation of nitric-oxide synthase activity 2.5641 7 yes
GO:0051341 regulation of oxidoreductase activity 2.5641 4 yes
GO:0051353 positive regulation of oxidoreductase activity 2.5641 5 yes
GO:0002040 sprouting angiogenesis 2.5641 4 yes
GO:0002285 lymphocyte activation involved in immune response 2.5641 4 yes
GO:0002312 B cell activation involved in immune response 2.5641 5 yes
GO:0002313 mature B cell differentiation involved in immune response 2.5641 6 yes
GO:0002315 marginal zone B cell differentiation 2.5641 7 yes
GO:0002335 mature B cell differentiation 2.5641 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 2.5641 6 yes
GO:0060292 long-term synaptic depression 2.5641 4 yes
GO:0070098 chemokine-mediated signaling pathway 2.5641 5 yes
GO:0070167 regulation of biomineral tissue development 2.5641 4 yes
GO:0070168 negative regulation of biomineral tissue development 2.5641 5 yes
GO:0110150 negative regulation of biomineralization 2.5641 4 yes
GO:0010226 response to lithium ion 2.5641 5 yes
GO:0140131 positive regulation of lymphocyte chemotaxis 2.5641 7 yes
GO:1901623 regulation of lymphocyte chemotaxis 2.5641 6 yes
GO:1902930 regulation of alcohol biosynthetic process 2.5641 5 yes
GO:0010752 regulation of cGMP-mediated signaling 2.5641 6 yes
GO:0010919 regulation of inositol phosphate biosynthetic process 2.5641 6 yes
GO:2000249 regulation of actin cytoskeleton reorganization 2.5641 6 yes
GO:2000537 regulation of B cell chemotaxis 2.5641 7 yes
GO:2000538 positive regulation of B cell chemotaxis 2.5641 8 yes
GO:0030279 negative regulation of ossification 2.5641 5 yes
GO:0030500 regulation of bone mineralization 2.5641 5 yes
GO:0030502 negative regulation of bone mineralization 2.5641 6 yes
GO:0032768 regulation of monooxygenase activity 2.5641 5 yes
GO:0032770 positive regulation of monooxygenase activity 2.5641 6 yes
GO:0032960 regulation of inositol trisphosphate biosynthetic process 2.5641 7 yes
GO:0043267 negative regulation of potassium ion transport 2.5641 6 yes
GO:0043506 regulation of JUN kinase activity 2.5641 9 yes
GO:0043507 positive regulation of JUN kinase activity 2.5641 9 yes

Disease

Term Name % Distance from top the of the tree Annotated in FAK2_HUMAN
DOID:331 central nervous system disease 5.1282 3 no
DOID:0050686 organ system cancer 5.1282 3 no
DOID:1289 neurodegenerative disease 2.5641 4 no
DOID:0111962 combined immunodeficiency 2.5641 4 no
DOID:612 primary immunodeficiency disease 2.5641 3 no
DOID:120 female reproductive organ cancer 2.5641 5 no
DOID:193 reproductive organ cancer 2.5641 4 no
DOID:2531 hematologic cancer 2.5641 4 no
DOID:3635 congenital myasthenic syndrome 2.5641 7 no
DOID:439 neuromuscular junction disease 2.5641 6 no
DOID:440 neuromuscular disease 2.5641 5 no
DOID:574 peripheral nervous system disease 2.5641 3 no
DOID:870 neuropathy 2.5641 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
GELS_HUMAN [view entry] [view interactions] Low throughput yes no
PITM3_HUMAN [view interactions] Low throughput no no
PITM1_HUMAN [view interactions] Low throughput no yes
PITM2_HUMAN [view interactions] Low throughput no yes
RBCC1_HUMAN [view interactions] Low throughput no no
SOCS3_HUMAN [view interactions] Low throughput no yes
MBD2_HUMAN [view interactions] Low throughput no yes
SOCS2_HUMAN [view interactions] Low throughput no yes
BCAR1_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
KSYK_HUMAN [view interactions] Low throughput no no
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
JAK3_HUMAN [view interactions] Low throughput no no
JAK1_HUMAN [view interactions] Low throughput no yes
IL7RA_HUMAN [view interactions] Low throughput no no
KCNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
CASL_HUMAN [view interactions] Low throughput no yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GTR1_HUMAN [view entry] [view interactions] Low throughput yes no
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP2_HUMAN [view interactions] Low throughput no yes
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
TLN1_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
EWS_HUMAN [view interactions] Low throughput no yes
RASA1_HUMAN [view interactions] Low throughput no yes
PK3CB_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DOK1_HUMAN [view interactions] Low throughput no yes
PLD2_HUMAN [view interactions] Low throughput no yes
CBLB_HUMAN [view interactions] Low throughput no yes
ERBB3_HUMAN [view interactions] Low throughput no yes
NED4L_HUMAN [view interactions] Low throughput no yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRO_HUMAN [view entry] [view interactions] Low throughput yes no
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
EFS_HUMAN [view interactions] Low throughput no no
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
VAV_HUMAN [view interactions] Low throughput no no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN12_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOU_HUMAN [view interactions] Low throughput no no
NPHP1_HUMAN [view interactions] Low throughput no yes
PAXI_HUMAN [view interactions] Low throughput no yes
ARFG1_HUMAN [view interactions] Low throughput no no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
MATK_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG10_HUMAN [view interactions] Low throughput no no
TGFI1_HUMAN [view interactions] Low throughput no no
M3K4_HUMAN [view interactions] Low throughput no yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
MYD88_HUMAN [view entry] [view interactions] Low throughput yes yes
DOCK8_HUMAN [view interactions] Low throughput no yes
NPHP4_HUMAN [view interactions] Low throughput no yes
TRAF4_HUMAN [view interactions] Low throughput no yes
NCF1_HUMAN [view interactions] Low throughput no no
SKAP2_HUMAN [view interactions] Low throughput no no
LPXN_HUMAN [view interactions] Low throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
ALG2_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
GPVI_HUMAN [view interactions] High throughput no no
GP1BB_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
ACK1_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
BFAR_HUMAN [view interactions] High throughput no no
GUAD_HUMAN [view interactions] High throughput no yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX19_HUMAN [view interactions] High throughput no yes
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
2ABB_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
CPVL_HUMAN [view interactions] High throughput no no
ZFHX2_HUMAN [view interactions] High throughput no no
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SATB2_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
EXC6B_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
PAX6_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
STA5B_HUMAN [view interactions] Computational no yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
VGFR2_HUMAN [view interactions] Computational no no
VCAM1_HUMAN [view interactions] Computational no no
ARHGC_HUMAN [view interactions] Computational no yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
RAPSN_HUMAN [view entry] [view interactions] Computational yes no
DLGP3_HUMAN [view entry] [view interactions] Computational yes yes
ITA2B_HUMAN [view interactions] Computational no no
SHC1_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
MK14_HUMAN [view interactions] Computational no yes
RAC1_HUMAN [view entry] [view interactions] Computational yes no
VTNC_HUMAN [view interactions] Computational no no
SHB_HUMAN [view interactions] Computational no yes
CRKL_HUMAN [view entry] [view interactions] Computational yes yes
ARHG1_HUMAN [view interactions] Computational no no
KPCL_HUMAN [view interactions] Computational no yes
KPCT_HUMAN [view interactions] Computational no no
BLK_HUMAN [view interactions] Computational no no
PI4KA_HUMAN [view entry] [view interactions] Computational yes yes
OCLN_HUMAN [view interactions] Computational no no
ITA4_HUMAN [view interactions] Computational no no
IL2RB_HUMAN [view interactions] Computational no no
IL2RA_HUMAN [view interactions] Computational no no
ARG28_HUMAN [view interactions] Computational no yes
ITA5_HUMAN [view entry] [view interactions] Computational yes no
GBG1_HUMAN [view interactions] Computational no no
FGFR3_HUMAN [view interactions] Computational no yes
RAP1B_HUMAN [view entry] [view interactions] Computational yes no
SHPS1_HUMAN [view entry] [view interactions] Computational yes yes
RAC3_HUMAN [view entry] [view interactions] Computational yes no
MK08_HUMAN [view interactions] Computational no yes
ITAL_HUMAN [view interactions] Computational no no
ACHB_HUMAN [view entry] [view interactions] Computational yes yes
GNA12_HUMAN [view interactions] Computational no no
OSTP_HUMAN [view interactions] Computational no yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
ITAV_HUMAN [view interactions] Computational no yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
CADH5_HUMAN [view interactions] Computational no yes
MEF2C_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
LPAR2_HUMAN [view interactions] Computational no yes
MUSK_HUMAN [view entry] [view interactions] Computational yes no
FGF23_HUMAN [view interactions] Computational no no
IL2_HUMAN [view interactions] Computational no no
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
FGR_HUMAN [view interactions] Computational no no
IL2RG_HUMAN [view interactions] Computational no no
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
CRK_HUMAN [view entry] [view interactions] Computational yes no
MP2K3_HUMAN [view entry] [view interactions] Computational yes yes
RHOA_HUMAN [view entry] [view interactions] Computational yes yes