Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KPCD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed, PubMed). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction . Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed, PubMed). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed, PubMed). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed, PubMed). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation . Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways . Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion . Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed). Phosphorylates mitochondrial phospolipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001919 CLV_C14_Caspase3-7 CLV 326 330 -
ELMI001919 CLV_C14_Caspase3-7 CLV 326 330 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KPCD_HUMAN
GO:0043168 anion binding 48.0000 4 yes
GO:0000166 nucleotide binding 41.3333 4 yes
GO:0017076 purine nucleotide binding 41.3333 5 yes
GO:0032555 purine ribonucleotide binding 41.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 41.3333 4 yes
GO:0005524 ATP binding 34.6667 5 yes
GO:0030554 adenyl nucleotide binding 34.6667 6 yes
GO:0032559 adenyl ribonucleotide binding 34.6667 5 yes
GO:0019900 kinase binding 32.0000 4 yes
GO:0019901 protein kinase binding 32.0000 5 yes
GO:0043169 cation binding 30.6667 4 yes
GO:0046872 metal ion binding 29.3333 5 yes
GO:0016301 kinase activity 26.6667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 26.6667 4 yes
GO:0003723 RNA binding 22.6667 4 no
GO:0004674 protein serine/threonine kinase activity 21.3333 4 yes
GO:0106310 protein serine kinase activity 18.6667 4 yes
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 9.3333 5 yes
GO:0004713 protein tyrosine kinase activity 9.3333 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 9.3333 5 yes
GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KPCD_HUMAN
GO:0048522 positive regulation of cellular process 73.3333 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 65.3333 4 yes
GO:0080090 regulation of primary metabolic process 64.0000 4 yes
GO:0009966 regulation of signal transduction 64.0000 4 yes
GO:0009889 regulation of biosynthetic process 57.3333 4 yes
GO:0009893 positive regulation of metabolic process 56.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 56.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 56.0000 5 yes
GO:0048584 positive regulation of response to stimulus 54.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 54.6667 5 yes
GO:0010468 regulation of gene expression 53.3333 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 53.3333 5 yes
GO:0023056 positive regulation of signaling 50.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 50.6667 5 yes
GO:0051246 regulation of protein metabolic process 49.3333 5 yes
GO:0009892 negative regulation of metabolic process 49.3333 4 yes
GO:0010647 positive regulation of cell communication 49.3333 5 yes
GO:0051128 regulation of cellular component organization 48.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 45.3333 5 yes
GO:0051240 positive regulation of multicellular organismal process 45.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 45.3333 5 yes
GO:0009967 positive regulation of signal transduction 44.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.0000 5 yes
GO:0042981 regulation of apoptotic process 41.3333 5 yes
GO:0043067 regulation of programmed cell death 41.3333 4 yes
GO:0048585 negative regulation of response to stimulus 41.3333 4 yes
GO:0051247 positive regulation of protein metabolic process 41.3333 6 yes
GO:0010648 negative regulation of cell communication 41.3333 5 yes
GO:0023057 negative regulation of signaling 41.3333 4 yes
GO:0006996 organelle organization 40.0000 4 no
GO:0051049 regulation of transport 38.6667 4 yes
GO:0051174 regulation of phosphorus metabolic process 38.6667 5 yes
GO:0009891 positive regulation of biosynthetic process 38.6667 5 yes
GO:0009968 negative regulation of signal transduction 38.6667 5 yes
GO:0019220 regulation of phosphate metabolic process 38.6667 6 yes
GO:0031399 regulation of protein modification process 38.6667 6 yes
GO:0036211 protein modification process 37.3333 4 yes
GO:0043412 macromolecule modification 37.3333 4 yes
GO:0051252 regulation of RNA metabolic process 37.3333 5 yes
GO:0071310 cellular response to organic substance 37.3333 4 yes
GO:0008104 protein localization 37.3333 4 no
GO:0031328 positive regulation of cellular biosynthetic process 37.3333 6 yes
GO:0042325 regulation of phosphorylation 36.0000 7 yes
GO:0001932 regulation of protein phosphorylation 36.0000 7 yes
GO:0002684 positive regulation of immune system process 36.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 36.0000 4 yes
GO:0022607 cellular component assembly 36.0000 4 no
GO:0032101 regulation of response to external stimulus 36.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 34.6667 4 yes
GO:0042127 regulation of cell population proliferation 34.6667 4 no
GO:0045595 regulation of cell differentiation 34.6667 4 no
GO:0051094 positive regulation of developmental process 34.6667 4 no
GO:1902533 positive regulation of intracellular signal transduction 34.6667 6 no
GO:0080134 regulation of response to stress 33.3333 4 yes
GO:0010243 response to organonitrogen compound 33.3333 4 yes
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0044087 regulation of cellular component biogenesis 32.0000 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 32.0000 4 no
GO:0043085 positive regulation of catalytic activity 30.6667 4 yes
GO:0060341 regulation of cellular localization 30.6667 4 yes
GO:0009894 regulation of catabolic process 30.6667 4 yes
GO:0016310 phosphorylation 30.6667 5 yes
GO:0006355 regulation of DNA-templated transcription 30.6667 7 no
GO:2001141 regulation of RNA biosynthetic process 30.6667 6 no
GO:0031401 positive regulation of protein modification process 30.6667 7 yes
GO:0045937 positive regulation of phosphate metabolic process 29.3333 7 yes
GO:0006915 apoptotic process 29.3333 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 29.3333 6 yes
GO:0009890 negative regulation of biosynthetic process 29.3333 5 no
GO:0030155 regulation of cell adhesion 29.3333 4 yes
GO:0042327 positive regulation of phosphorylation 28.0000 8 yes
GO:0043066 negative regulation of apoptotic process 28.0000 6 yes
GO:0043069 negative regulation of programmed cell death 28.0000 5 yes
GO:0043408 regulation of MAPK cascade 28.0000 6 yes
GO:0050776 regulation of immune response 28.0000 4 yes
GO:0051338 regulation of transferase activity 28.0000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.0000 6 yes
GO:0001934 positive regulation of protein phosphorylation 28.0000 8 yes
GO:0030334 regulation of cell migration 28.0000 5 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:2000145 regulation of cell motility 28.0000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.0000 6 no
GO:0010628 positive regulation of gene expression 28.0000 7 no
GO:0031327 negative regulation of cellular biosynthetic process 28.0000 6 no
GO:0031344 regulation of cell projection organization 28.0000 5 yes
GO:0051248 negative regulation of protein metabolic process 26.6667 6 yes
GO:0006468 protein phosphorylation 26.6667 5 yes
GO:0071702 organic substance transport 26.6667 4 no
GO:0071705 nitrogen compound transport 26.6667 4 no
GO:0141124 intracellular signaling cassette 26.6667 4 no
GO:0031347 regulation of defense response 26.6667 5 yes
GO:0043549 regulation of kinase activity 25.3333 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.3333 5 yes
GO:0050778 positive regulation of immune response 25.3333 5 yes
GO:0051336 regulation of hydrolase activity 25.3333 4 yes
GO:0008284 positive regulation of cell population proliferation 25.3333 5 no
GO:0032103 positive regulation of response to external stimulus 25.3333 5 no
GO:0060284 regulation of cell development 25.3333 5 no
GO:0032880 regulation of protein localization 24.0000 5 yes
GO:0045859 regulation of protein kinase activity 24.0000 6 yes
GO:0051050 positive regulation of transport 24.0000 4 yes
GO:0030335 positive regulation of cell migration 24.0000 6 no
GO:0040017 positive regulation of locomotion 24.0000 4 no
GO:2000147 positive regulation of cell motility 24.0000 5 no
GO:0050865 regulation of cell activation 22.6667 4 yes
GO:0071417 cellular response to organonitrogen compound 22.6667 4 yes
GO:1901699 cellular response to nitrogen compound 22.6667 4 yes
GO:1902532 negative regulation of intracellular signal transduction 22.6667 6 yes
GO:0045597 positive regulation of cell differentiation 22.6667 5 no
GO:0033043 regulation of organelle organization 21.3333 5 yes
GO:0001817 regulation of cytokine production 21.3333 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.3333 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.3333 5 no
GO:0018193 peptidyl-amino acid modification 21.3333 5 yes
GO:0022407 regulation of cell-cell adhesion 21.3333 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.3333 8 no
GO:0015031 protein transport 21.3333 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.3333 5 no
GO:0007010 cytoskeleton organization 21.3333 5 no
GO:0031400 negative regulation of protein modification process 21.3333 7 yes
GO:0043065 positive regulation of apoptotic process 20.0000 6 yes
GO:0043068 positive regulation of programmed cell death 20.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 20.0000 4 yes
GO:0051345 positive regulation of hydrolase activity 20.0000 5 yes
GO:0032870 cellular response to hormone stimulus 18.6667 4 yes
GO:0043254 regulation of protein-containing complex assembly 18.6667 5 yes
GO:0045936 negative regulation of phosphate metabolic process 18.6667 7 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 18.6667 8 yes
GO:0051347 positive regulation of transferase activity 18.6667 5 yes
GO:0051493 regulation of cytoskeleton organization 18.6667 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 18.6667 6 yes
GO:0033674 positive regulation of kinase activity 17.3333 6 yes
GO:0042326 negative regulation of phosphorylation 17.3333 8 yes
GO:0043086 negative regulation of catalytic activity 17.3333 4 yes
GO:0043434 response to peptide hormone 17.3333 4 yes
GO:0045860 positive regulation of protein kinase activity 17.3333 7 yes
GO:0001933 negative regulation of protein phosphorylation 17.3333 8 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 17.3333 4 yes
GO:1902903 regulation of supramolecular fiber organization 17.3333 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 17.3333 4 yes
GO:1903829 positive regulation of protein localization 17.3333 5 yes
GO:0009896 positive regulation of catabolic process 17.3333 5 yes
GO:0010608 post-transcriptional regulation of gene expression 17.3333 7 yes
GO:0031329 regulation of cellular catabolic process 17.3333 5 yes
GO:0032970 regulation of actin filament-based process 16.0000 4 yes
GO:0051129 negative regulation of cellular component organization 16.0000 5 yes
GO:0051348 negative regulation of transferase activity 16.0000 5 yes
GO:0061024 membrane organization 16.0000 4 yes
GO:0070201 regulation of establishment of protein localization 16.0000 6 yes
GO:0032956 regulation of actin cytoskeleton organization 14.6667 5 yes
GO:0043687 post-translational protein modification 14.6667 5 yes
GO:0051223 regulation of protein transport 14.6667 5 yes
GO:0062197 cellular response to chemical stress 14.6667 4 yes
GO:0071375 cellular response to peptide hormone stimulus 14.6667 5 yes
GO:0110053 regulation of actin filament organization 14.6667 6 yes
GO:0032386 regulation of intracellular transport 13.3333 5 yes
GO:0033673 negative regulation of kinase activity 13.3333 6 yes
GO:0034599 cellular response to oxidative stress 13.3333 4 yes
GO:0038093 Fc receptor signaling pathway 13.3333 5 yes
GO:0006974 DNA damage response 13.3333 4 yes
GO:0018105 peptidyl-serine phosphorylation 13.3333 6 yes
GO:0018209 peptidyl-serine modification 13.3333 6 yes
GO:0032102 negative regulation of response to external stimulus 13.3333 5 yes
GO:0050727 regulation of inflammatory response 12.0000 5 yes
GO:0051052 regulation of DNA metabolic process 12.0000 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 12.0000 7 yes
GO:0000302 response to reactive oxygen species 12.0000 4 yes
GO:0006469 negative regulation of protein kinase activity 12.0000 7 yes
GO:1904951 positive regulation of establishment of protein localization 12.0000 6 yes
GO:2000377 regulation of reactive oxygen species metabolic process 12.0000 5 yes
GO:0031348 negative regulation of defense response 12.0000 5 yes
GO:0032271 regulation of protein polymerization 12.0000 6 yes
GO:0032535 regulation of cellular component size 10.6667 4 yes
GO:0038094 Fc-gamma receptor signaling pathway 10.6667 6 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 10.6667 4 yes
GO:0042542 response to hydrogen peroxide 10.6667 4 yes
GO:0050821 protein stabilization 10.6667 4 yes
GO:0051222 positive regulation of protein transport 10.6667 5 yes
GO:0060491 regulation of cell projection assembly 10.6667 5 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 10.6667 5 yes
GO:0007162 negative regulation of cell adhesion 10.6667 5 yes
GO:0032388 positive regulation of intracellular transport 9.3333 5 yes
GO:0034614 cellular response to reactive oxygen species 9.3333 5 yes
GO:0042113 B cell activation 9.3333 4 yes
GO:0043393 regulation of protein binding 9.3333 4 yes
GO:0043409 negative regulation of MAPK cascade 9.3333 7 yes
GO:0050728 negative regulation of inflammatory response 9.3333 6 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 9.3333 6 yes
GO:1900180 regulation of protein localization to nucleus 9.3333 6 yes
GO:2001233 regulation of apoptotic signaling pathway 9.3333 5 yes
GO:0010639 negative regulation of organelle organization 9.3333 6 yes
GO:0031331 positive regulation of cellular catabolic process 9.3333 6 yes
GO:0032147 activation of protein kinase activity 9.3333 8 yes
GO:0046626 regulation of insulin receptor signaling pathway 8.0000 5 yes
GO:0051054 positive regulation of DNA metabolic process 8.0000 6 yes
GO:0070301 cellular response to hydrogen peroxide 8.0000 5 yes
GO:0097193 intrinsic apoptotic signaling pathway 8.0000 4 yes
GO:1900076 regulation of cellular response to insulin stimulus 8.0000 4 yes
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8.0000 4 yes
GO:1903311 regulation of mRNA metabolic process 8.0000 6 yes
GO:0018107 peptidyl-threonine phosphorylation 8.0000 6 yes
GO:0018210 peptidyl-threonine modification 8.0000 6 yes
GO:0019216 regulation of lipid metabolic process 8.0000 5 yes
GO:0022408 negative regulation of cell-cell adhesion 8.0000 6 yes
GO:0032943 mononuclear cell proliferation 6.6667 4 yes
GO:0043488 regulation of mRNA stability 6.6667 4 yes
GO:0045834 positive regulation of lipid metabolic process 6.6667 5 yes
GO:0046627 negative regulation of insulin receptor signaling pathway 6.6667 6 yes
GO:0046651 lymphocyte proliferation 6.6667 4 yes
GO:0051494 negative regulation of cytoskeleton organization 6.6667 7 yes
GO:0061013 regulation of mRNA catabolic process 6.6667 5 yes
GO:1900077 negative regulation of cellular response to insulin stimulus 6.6667 5 yes
GO:1900182 positive regulation of protein localization to nucleus 6.6667 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 6.6667 6 yes
GO:1903034 regulation of response to wounding 6.6667 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 6.6667 6 yes
GO:0030832 regulation of actin filament length 6.6667 5 yes
GO:0030833 regulation of actin filament polymerization 6.6667 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 6.6667 6 yes
GO:0034110 regulation of homotypic cell-cell adhesion 5.3333 6 yes
GO:0034248 regulation of amide metabolic process 5.3333 4 yes
GO:0034350 regulation of glial cell apoptotic process 5.3333 6 yes
GO:0034351 negative regulation of glial cell apoptotic process 5.3333 7 yes
GO:0035303 regulation of dephosphorylation 5.3333 7 yes
GO:0035306 positive regulation of dephosphorylation 5.3333 8 yes
GO:0043405 regulation of MAP kinase activity 5.3333 8 yes
GO:0046822 regulation of nucleocytoplasmic transport 5.3333 6 yes
GO:0046824 positive regulation of nucleocytoplasmic transport 5.3333 6 yes
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 5.3333 9 yes
GO:0050866 negative regulation of cell activation 5.3333 5 yes
GO:0050994 regulation of lipid catabolic process 5.3333 5 yes
GO:0050996 positive regulation of lipid catabolic process 5.3333 6 yes
GO:0051489 regulation of filopodium assembly 5.3333 7 yes
GO:0061041 regulation of wound healing 5.3333 6 yes
GO:0071478 cellular response to radiation 5.3333 4 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 5.3333 8 yes
GO:0090330 regulation of platelet aggregation 5.3333 6 yes
GO:0009416 response to light stimulus 5.3333 4 yes
GO:2000379 positive regulation of reactive oxygen species metabolic process 5.3333 6 yes
GO:0010543 regulation of platelet activation 5.3333 5 yes
GO:0031345 negative regulation of cell projection organization 5.3333 6 yes
GO:0032411 positive regulation of transporter activity 4.0000 4 yes
GO:0033157 regulation of intracellular protein transport 4.0000 6 yes
GO:0034644 cellular response to UV 4.0000 6 yes
GO:0035304 regulation of protein dephosphorylation 4.0000 7 yes
GO:0035307 positive regulation of protein dephosphorylation 4.0000 8 yes
GO:0042100 B cell proliferation 4.0000 5 yes
GO:0042306 regulation of protein import into nucleus 4.0000 7 yes
GO:0042307 positive regulation of protein import into nucleus 4.0000 7 yes
GO:0042742 defense response to bacterium 4.0000 4 yes
GO:0043407 negative regulation of MAP kinase activity 4.0000 8 yes
GO:0046889 positive regulation of lipid biosynthetic process 4.0000 6 yes
GO:0046890 regulation of lipid biosynthetic process 4.0000 5 yes
GO:0060326 cell chemotaxis 4.0000 4 yes
GO:0071482 cellular response to light stimulus 4.0000 5 yes
GO:0090316 positive regulation of intracellular protein transport 4.0000 6 yes
GO:0090322 regulation of superoxide metabolic process 4.0000 6 yes
GO:1903035 negative regulation of response to wounding 4.0000 5 yes
GO:1905952 regulation of lipid localization 4.0000 4 yes
GO:0009411 response to UV 4.0000 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 4.0000 6 yes
GO:0032272 negative regulation of protein polymerization 4.0000 7 yes
GO:0032368 regulation of lipid transport 4.0000 5 yes
GO:0032370 positive regulation of lipid transport 2.6667 5 yes
GO:0032928 regulation of superoxide anion generation 2.6667 7 yes
GO:0032930 positive regulation of superoxide anion generation 2.6667 7 yes
GO:0033194 response to hydroperoxide 2.6667 4 yes
GO:0034111 negative regulation of homotypic cell-cell adhesion 2.6667 7 yes
GO:0034250 positive regulation of amide metabolic process 2.6667 5 yes
GO:0036230 granulocyte activation 2.6667 4 yes
GO:0042119 neutrophil activation 2.6667 5 yes
GO:0050818 regulation of coagulation 2.6667 4 yes
GO:0050819 negative regulation of coagulation 2.6667 5 yes
GO:0051100 negative regulation of binding 2.6667 4 yes
GO:0051490 negative regulation of filopodium assembly 2.6667 8 yes
GO:0060696 regulation of phospholipid catabolic process 2.6667 6 yes
GO:0060697 positive regulation of phospholipid catabolic process 2.6667 7 yes
GO:0061045 negative regulation of wound healing 2.6667 6 yes
GO:0061091 regulation of phospholipid translocation 2.6667 4 yes
GO:0071447 cellular response to hydroperoxide 2.6667 5 yes
GO:0090153 regulation of sphingolipid biosynthetic process 2.6667 5 yes
GO:0090154 positive regulation of sphingolipid biosynthetic process 2.6667 6 yes
GO:0090331 negative regulation of platelet aggregation 2.6667 7 yes
GO:0110112 regulation of lipid transporter activity 2.6667 4 yes
GO:0110113 positive regulation of lipid transporter activity 2.6667 5 yes
GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 2.6667 7 yes
GO:1900047 negative regulation of hemostasis 2.6667 4 yes
GO:1900161 regulation of phospholipid scramblase activity 2.6667 5 yes
GO:1900163 positive regulation of phospholipid scramblase activity 2.6667 6 yes
GO:0002449 lymphocyte mediated immunity 2.6667 4 yes
GO:1903725 regulation of phospholipid metabolic process 2.6667 6 yes
GO:1903727 positive regulation of phospholipid metabolic process 2.6667 6 yes
GO:1903729 regulation of plasma membrane organization 2.6667 5 yes
GO:1904385 cellular response to angiotensin 2.6667 6 yes
GO:1905038 regulation of membrane lipid metabolic process 2.6667 5 yes
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 2.6667 5 yes
GO:1905954 positive regulation of lipid localization 2.6667 4 yes
GO:1990776 response to angiotensin 2.6667 5 yes
GO:2000303 regulation of ceramide biosynthetic process 2.6667 5 yes
GO:2000304 positive regulation of ceramide biosynthetic process 2.6667 6 yes
GO:2000752 regulation of glucosylceramide catabolic process 2.6667 5 yes
GO:2000753 positive regulation of glucosylceramide catabolic process 2.6667 6 yes
GO:2000754 regulation of sphingomyelin catabolic process 2.6667 5 yes
GO:2000755 positive regulation of sphingomyelin catabolic process 2.6667 6 yes
GO:2001138 regulation of phospholipid transport 2.6667 6 yes
GO:0010544 negative regulation of platelet activation 2.6667 6 yes
GO:0016064 immunoglobulin mediated immune response 2.6667 6 yes
GO:0019724 B cell mediated immunity 2.6667 5 yes
GO:0023021 termination of signal transduction 2.6667 6 yes
GO:0030193 regulation of blood coagulation 2.6667 4 yes
GO:0030195 negative regulation of blood coagulation 2.6667 5 yes
GO:0030837 negative regulation of actin filament polymerization 2.6667 7 yes
GO:0032069 regulation of nuclease activity 2.6667 5 yes
GO:0032070 regulation of deoxyribonuclease activity 2.6667 6 yes
GO:0032071 regulation of endodeoxyribonuclease activity 2.6667 7 yes
GO:0032075 positive regulation of nuclease activity 2.6667 6 yes
GO:0032077 positive regulation of deoxyribonuclease activity 2.6667 7 yes
GO:0032079 positive regulation of endodeoxyribonuclease activity 2.6667 8 yes
GO:0032091 negative regulation of protein binding 2.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDCP1_HUMAN [view interactions] Low throughput no yes
LDB3_HUMAN [view interactions] Low throughput no no
SPI1_HUMAN [view interactions] Low throughput no no
RIPK4_HUMAN [view interactions] Low throughput no no
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
TOP2A_HUMAN [view interactions] Low throughput no no
P63_HUMAN [view interactions] Low throughput no no
CAR11_HUMAN [view interactions] Low throughput no no
MALT1_HUMAN [view interactions] Low throughput no no
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
LIMK1_HUMAN [view entry] [view interactions] Low throughput yes yes
NLRC4_HUMAN [view interactions] Low throughput no no
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
TROP_HUMAN [view interactions] Low throughput no no
DBLOH_HUMAN [view interactions] Low throughput no no
TOP2B_HUMAN [view interactions] Low throughput no yes
T53I1_HUMAN [view interactions] Low throughput no yes
NCF2_HUMAN [view interactions] Low throughput no no
NCF1_HUMAN [view interactions] Low throughput no no
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
GLRB_HUMAN [view entry] [view interactions] Low throughput yes no
PTN22_HUMAN [view interactions] Low throughput no yes
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
BCLF1_HUMAN [view interactions] Low throughput no yes
PDPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRP3_HUMAN [view interactions] Low throughput no no
SHIP1_HUMAN [view interactions] Low throughput no no
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
ADAM9_HUMAN [view interactions] Low throughput no no
INSR_HUMAN [view interactions] Low throughput no yes
PDP1_HUMAN [view interactions] Low throughput no yes
PDP2_HUMAN [view interactions] Low throughput no yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PK3CB_HUMAN [view interactions] Low throughput no yes
PTN6_HUMAN [view interactions] Low throughput no no
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
PLD2_HUMAN [view interactions] Low throughput no yes
IL6RB_HUMAN [view interactions] Low throughput no no
MUC1_HUMAN [view interactions] Low throughput no no
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI41_HUMAN [view interactions] Low throughput no yes
SQSTM_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
IKKB_HUMAN [view interactions] Low throughput no yes
IKKA_HUMAN [view interactions] Low throughput no yes
SP1_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] Low throughput yes no
KLF4_HUMAN [view interactions] Low throughput no no
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
IBTK_HUMAN [view interactions] Low throughput no yes
IRAK1_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
TNR1A_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
S38A3_HUMAN [view interactions] Low throughput no no
PAI1_HUMAN [view interactions] Low throughput no no
RBP10_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
IL32_HUMAN [view interactions] Low throughput no no
FLI1_HUMAN [view interactions] Low throughput no no
NOTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] Low throughput yes yes
P73_HUMAN [view interactions] Low throughput no no
SPY2_HUMAN [view interactions] Low throughput no yes
MYC_HUMAN [view interactions] Low throughput no yes
ATG7_HUMAN [view interactions] Low throughput no yes
AFAP1_HUMAN [view interactions] Low throughput no yes
PLS3_HUMAN [view interactions] Low throughput no yes
GNA12_HUMAN [view interactions] Low throughput no no
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HMGB1_HUMAN [view interactions] Low throughput no yes
HDAC5_HUMAN [view interactions] Low throughput no yes
H11_HUMAN [view interactions] Low throughput no no
H15_HUMAN [view interactions] Low throughput no no
MARCS_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
GSK3A_HUMAN [view interactions] Low throughput no yes
OCLN_HUMAN [view interactions] Low throughput no no
EP300_HUMAN [view interactions] Low throughput no yes
DAB2_HUMAN [view interactions] Low throughput no yes
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
PTOV1_HUMAN [view interactions] Low throughput no yes
HAKAI_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
ACTBL_HUMAN [view interactions] High throughput no no
PRP4B_HUMAN [view interactions] High throughput no yes
PIP30_HUMAN [view interactions] High throughput no yes
ZN131_HUMAN [view interactions] High throughput no yes
H2B1K_HUMAN [view interactions] High throughput no yes
LYSM2_HUMAN [view interactions] High throughput no yes
RL37A_HUMAN [view entry] [view interactions] High throughput yes yes
CWC15_HUMAN [view interactions] High throughput no yes
DHX16_HUMAN [view interactions] High throughput no yes
BUD13_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
RMC1_HUMAN [view interactions] High throughput no no
PGM1_HUMAN [view interactions] High throughput no no
P85A_HUMAN [view interactions] High throughput no yes
BCAP_HUMAN [view interactions] High throughput no no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
KPCT_HUMAN [view interactions] High throughput no no
MCM7_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
GRM5_HUMAN [view entry] [view interactions] High throughput yes no
FCERG_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
PPRC1_HUMAN [view interactions] High throughput no yes
TPC13_HUMAN [view interactions] High throughput no yes
CHD9_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TLR9_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
IL27B_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
BEX4_HUMAN [view interactions] High throughput no no
DUX3_HUMAN [view interactions] High throughput no no
MED17_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
INSRR_HUMAN [view interactions] High throughput no no
SERB1_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
FOXC1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC6_HUMAN [view interactions] High throughput no yes
GOLI_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
MPIP1_HUMAN [view interactions] High throughput no no
MPIP2_HUMAN [view interactions] High throughput no no
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
SPHK1_HUMAN [view interactions] High throughput no yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
LTC4S_HUMAN [view interactions] High throughput no no
CSF3R_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
NAR3_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1B_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
TM1L1_HUMAN [view interactions] High throughput no yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
PYGB_HUMAN [view entry] [view interactions] High throughput yes no
PLST_HUMAN [view interactions] High throughput no yes
IDE_HUMAN [view interactions] High throughput no yes
SYDC_HUMAN [view interactions] High throughput no yes
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
THOP1_HUMAN [view interactions] High throughput no yes
BIEA_HUMAN [view interactions] High throughput no yes
WDR4_HUMAN [view interactions] High throughput no no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGG_HUMAN [view interactions] High throughput no yes
KCTD9_HUMAN [view interactions] High throughput no no
GGA1_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
ERGI1_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes