KPCD_HUMAN
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed, PubMed). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction . Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed, PubMed). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed, PubMed). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed, PubMed). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation . Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways . Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion . Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed). Phosphorylates mitochondrial phospolipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI001919 | CLV_C14_Caspase3-7 | CLV | 326 | 330 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KPCD_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 45.4545 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 45.4545 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 45.4545 | 4 | yes |
GO:0005524 | ATP binding | 38.6364 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 38.6364 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 38.6364 | 5 | yes |
GO:0019900 | kinase binding | 37.5000 | 4 | yes |
GO:0019901 | protein kinase binding | 36.3636 | 5 | yes |
GO:0016301 | kinase activity | 30.6818 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 30.6818 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 28.4091 | 4 | yes |
GO:0046872 | metal ion binding | 27.2727 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 22.7273 | 4 | yes |
GO:0003723 | RNA binding | 20.4545 | 4 | no |
GO:0106310 | protein serine kinase activity | 19.3182 | 4 | yes |
GO:0004713 | protein tyrosine kinase activity | 13.6364 | 4 | yes |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 11.3636 | 5 | yes |
GO:0004697 | protein kinase C activity | 6.8182 | 5 | yes |
GO:0004698 | calcium-dependent protein kinase C activity | 6.8182 | 6 | yes |
GO:0009931 | calcium-dependent protein serine/threonine kinase activity | 6.8182 | 5 | yes |
GO:0010857 | calcium-dependent protein kinase activity | 6.8182 | 4 | yes |
GO:0004699 | calcium-independent protein kinase C activity | 3.4091 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KPCD_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 78.4091 | 4 | yes |
GO:0010646 | regulation of cell communication | 71.5909 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 69.3182 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 69.3182 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 68.1818 | 4 | yes |
GO:0009966 | regulation of signal transduction | 68.1818 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 67.0455 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 67.0455 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 63.6364 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 60.2273 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 56.8182 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 56.8182 | 5 | yes |
GO:0010468 | regulation of gene expression | 56.8182 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 55.6818 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 54.5455 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 52.2727 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 52.2727 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 52.2727 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 51.1364 | 6 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 48.8636 | 5 | yes |
GO:0023056 | positive regulation of signaling | 48.8636 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 47.7273 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 47.7273 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 47.7273 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 46.5909 | 7 | yes |
GO:0043085 | positive regulation of catalytic activity | 45.4545 | 4 | yes |
GO:0071310 | cellular response to organic substance | 45.4545 | 4 | yes |
GO:0031399 | regulation of protein modification process | 45.4545 | 6 | yes |
GO:0051252 | regulation of RNA metabolic process | 44.3182 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 44.3182 | 4 | yes |
GO:0051049 | regulation of transport | 43.1818 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 43.1818 | 7 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 43.1818 | 4 | yes |
GO:0010941 | regulation of cell death | 43.1818 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 42.0455 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 42.0455 | 5 | yes |
GO:0009967 | positive regulation of signal transduction | 42.0455 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 42.0455 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 40.9091 | 7 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 40.9091 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 40.9091 | 6 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 40.9091 | 5 | yes |
GO:0036211 | protein modification process | 39.7727 | 4 | yes |
GO:0042327 | positive regulation of phosphorylation | 39.7727 | 8 | yes |
GO:0043412 | macromolecule modification | 39.7727 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 39.7727 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 38.6364 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 38.6364 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 38.6364 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 38.6364 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 38.6364 | 7 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 37.5000 | 5 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 37.5000 | 8 | yes |
GO:0002684 | positive regulation of immune system process | 37.5000 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 37.5000 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 37.5000 | 5 | yes |
GO:0023057 | negative regulation of signaling | 37.5000 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 37.5000 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 37.5000 | 6 | yes |
GO:0051338 | regulation of transferase activity | 36.3636 | 4 | yes |
GO:0080134 | regulation of response to stress | 36.3636 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 36.3636 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 35.2273 | 5 | yes |
GO:0006996 | organelle organization | 35.2273 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 34.0909 | 4 | yes |
GO:0045595 | regulation of cell differentiation | 34.0909 | 4 | no |
GO:0051094 | positive regulation of developmental process | 34.0909 | 4 | no |
GO:2000145 | regulation of cell motility | 34.0909 | 4 | no |
GO:0043549 | regulation of kinase activity | 32.9545 | 5 | yes |
GO:0016310 | phosphorylation | 32.9545 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.9545 | 6 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 32.9545 | 6 | no |
GO:0022607 | cellular component assembly | 32.9545 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 32.9545 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 31.8182 | 5 | yes |
GO:0030334 | regulation of cell migration | 31.8182 | 5 | no |
GO:0030155 | regulation of cell adhesion | 31.8182 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 31.8182 | 5 | no |
GO:0033043 | regulation of organelle organization | 31.8182 | 5 | yes |
GO:0043408 | regulation of MAPK cascade | 30.6818 | 6 | yes |
GO:0044087 | regulation of cellular component biogenesis | 30.6818 | 4 | yes |
GO:0045859 | regulation of protein kinase activity | 30.6818 | 6 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.6818 | 6 | yes |
GO:0006468 | protein phosphorylation | 30.6818 | 5 | yes |
GO:0009894 | regulation of catabolic process | 30.6818 | 4 | yes |
GO:0010628 | positive regulation of gene expression | 30.6818 | 6 | no |
GO:0051345 | positive regulation of hydrolase activity | 29.5455 | 5 | yes |
GO:0060341 | regulation of cellular localization | 29.5455 | 4 | yes |
GO:0060548 | negative regulation of cell death | 29.5455 | 5 | yes |
GO:0032101 | regulation of response to external stimulus | 29.5455 | 4 | yes |
GO:0033674 | positive regulation of kinase activity | 28.4091 | 6 | yes |
GO:0050776 | regulation of immune response | 28.4091 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.4091 | 6 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 28.4091 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 28.4091 | 4 | no |
GO:0031344 | regulation of cell projection organization | 28.4091 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 27.2727 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 27.2727 | 6 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 27.2727 | 5 | no |
GO:0008284 | positive regulation of cell population proliferation | 27.2727 | 5 | no |
GO:0030335 | positive regulation of cell migration | 27.2727 | 6 | no |
GO:0040017 | positive regulation of locomotion | 27.2727 | 4 | no |
GO:2000147 | positive regulation of cell motility | 27.2727 | 5 | no |
GO:0051050 | positive regulation of transport | 26.1364 | 4 | yes |
GO:0071417 | cellular response to organonitrogen compound | 26.1364 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 26.1364 | 4 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 26.1364 | 7 | no |
GO:0045597 | positive regulation of cell differentiation | 26.1364 | 5 | no |
GO:0045860 | positive regulation of protein kinase activity | 25.0000 | 7 | yes |
GO:0050865 | regulation of cell activation | 25.0000 | 4 | yes |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | yes |
GO:0006915 | apoptotic process | 25.0000 | 4 | yes |
GO:0018193 | peptidyl-amino acid modification | 25.0000 | 5 | yes |
GO:0008104 | protein localization | 25.0000 | 4 | no |
GO:0050778 | positive regulation of immune response | 23.8636 | 5 | yes |
GO:1901652 | response to peptide | 23.8636 | 4 | yes |
GO:0014070 | response to organic cyclic compound | 23.8636 | 4 | no |
GO:0045785 | positive regulation of cell adhesion | 23.8636 | 5 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 23.8636 | 7 | no |
GO:0051254 | positive regulation of RNA metabolic process | 23.8636 | 6 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 23.8636 | 7 | no |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 23.8636 | 8 | no |
GO:0031329 | regulation of cellular catabolic process | 23.8636 | 5 | yes |
GO:0007010 | cytoskeleton organization | 23.8636 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 22.7273 | 6 | yes |
GO:0010942 | positive regulation of cell death | 22.7273 | 5 | yes |
GO:0080135 | regulation of cellular response to stress | 21.5909 | 4 | yes |
GO:0033993 | response to lipid | 21.5909 | 4 | no |
GO:0022407 | regulation of cell-cell adhesion | 21.5909 | 5 | yes |
GO:0031347 | regulation of defense response | 21.5909 | 5 | yes |
GO:0071702 | organic substance transport | 21.5909 | 4 | no |
GO:0071705 | nitrogen compound transport | 21.5909 | 4 | no |
GO:0032880 | regulation of protein localization | 21.5909 | 5 | yes |
GO:0043065 | positive regulation of apoptotic process | 20.4545 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 20.4545 | 6 | yes |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 20.4545 | 8 | yes |
GO:0001817 | regulation of cytokine production | 20.4545 | 4 | no |
GO:0002694 | regulation of leukocyte activation | 20.4545 | 4 | no |
GO:0030030 | cell projection organization | 20.4545 | 4 | no |
GO:0043933 | protein-containing complex organization | 20.4545 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 20.4545 | 5 | no |
GO:0051241 | negative regulation of multicellular organismal process | 19.3182 | 4 | yes |
GO:1901653 | cellular response to peptide | 19.3182 | 5 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 19.3182 | 6 | yes |
GO:0032970 | regulation of actin filament-based process | 19.3182 | 4 | yes |
GO:0034248 | regulation of cellular amide metabolic process | 18.1818 | 5 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 18.1818 | 5 | yes |
GO:0043434 | response to peptide hormone | 18.1818 | 4 | yes |
GO:0032870 | cellular response to hormone stimulus | 18.1818 | 4 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 18.1818 | 5 | yes |
GO:0051129 | negative regulation of cellular component organization | 17.0455 | 5 | yes |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 17.0455 | 4 | yes |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 17.0455 | 4 | yes |
GO:0031400 | negative regulation of protein modification process | 17.0455 | 7 | yes |
GO:0051223 | regulation of protein transport | 15.9091 | 5 | yes |
GO:0061024 | membrane organization | 15.9091 | 4 | yes |
GO:0070201 | regulation of establishment of protein localization | 15.9091 | 6 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 15.9091 | 5 | yes |
GO:1903829 | positive regulation of protein localization | 15.9091 | 5 | yes |
GO:0018105 | peptidyl-serine phosphorylation | 15.9091 | 6 | yes |
GO:0018209 | peptidyl-serine modification | 15.9091 | 6 | yes |
GO:0032386 | regulation of intracellular transport | 15.9091 | 5 | yes |
GO:0042326 | negative regulation of phosphorylation | 14.7727 | 8 | yes |
GO:0043086 | negative regulation of catalytic activity | 14.7727 | 4 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 14.7727 | 7 | yes |
GO:0051222 | positive regulation of protein transport | 14.7727 | 5 | yes |
GO:0071900 | regulation of protein serine/threonine kinase activity | 14.7727 | 7 | yes |
GO:0000302 | response to reactive oxygen species | 14.7727 | 4 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 14.7727 | 6 | yes |
GO:0009896 | positive regulation of catabolic process | 14.7727 | 5 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 14.7727 | 6 | yes |
GO:0010608 | post-transcriptional regulation of gene expression | 14.7727 | 6 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 14.7727 | 5 | yes |
GO:0050727 | regulation of inflammatory response | 13.6364 | 5 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 13.6364 | 5 | yes |
GO:0110053 | regulation of actin filament organization | 13.6364 | 6 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 13.6364 | 8 | yes |
GO:0032147 | activation of protein kinase activity | 13.6364 | 8 | yes |
GO:0032271 | regulation of protein polymerization | 13.6364 | 6 | yes |
GO:0042542 | response to hydrogen peroxide | 12.5000 | 4 | yes |
GO:0062197 | cellular response to chemical stress | 12.5000 | 4 | yes |
GO:2000377 | regulation of reactive oxygen species metabolic process | 12.5000 | 5 | yes |
GO:0034250 | positive regulation of cellular amide metabolic process | 11.3636 | 6 | yes |
GO:0034599 | cellular response to oxidative stress | 11.3636 | 4 | yes |
GO:0043393 | regulation of protein binding | 11.3636 | 4 | yes |
GO:0051052 | regulation of DNA metabolic process | 11.3636 | 5 | yes |
GO:0051348 | negative regulation of transferase activity | 11.3636 | 5 | yes |
GO:0060491 | regulation of cell projection assembly | 11.3636 | 5 | yes |
GO:0019216 | regulation of lipid metabolic process | 11.3636 | 5 | yes |
GO:0031331 | positive regulation of cellular catabolic process | 11.3636 | 6 | yes |
GO:0031348 | negative regulation of defense response | 11.3636 | 5 | yes |
GO:0032102 | negative regulation of response to external stimulus | 11.3636 | 5 | yes |
GO:0032535 | regulation of cellular component size | 11.3636 | 4 | yes |
GO:0033673 | negative regulation of kinase activity | 10.2273 | 6 | yes |
GO:0038093 | Fc receptor signaling pathway | 10.2273 | 5 | yes |
GO:0045834 | positive regulation of lipid metabolic process | 10.2273 | 5 | yes |
GO:0097193 | intrinsic apoptotic signaling pathway | 10.2273 | 4 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 10.2273 | 6 | yes |
GO:0006469 | negative regulation of protein kinase activity | 10.2273 | 7 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 10.2273 | 6 | yes |
GO:0030832 | regulation of actin filament length | 10.2273 | 5 | yes |
GO:0032388 | positive regulation of intracellular transport | 10.2273 | 5 | yes |
GO:0034614 | cellular response to reactive oxygen species | 9.0909 | 5 | yes |
GO:0038094 | Fc-gamma receptor signaling pathway | 9.0909 | 6 | yes |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 9.0909 | 4 | yes |
GO:0043409 | negative regulation of MAPK cascade | 9.0909 | 7 | yes |
GO:0050728 | negative regulation of inflammatory response | 9.0909 | 6 | yes |
GO:0050821 | protein stabilization | 9.0909 | 4 | yes |
GO:0051054 | positive regulation of DNA metabolic process | 9.0909 | 6 | yes |
GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 9.0909 | 5 | yes |
GO:0007162 | negative regulation of cell adhesion | 9.0909 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 9.0909 | 6 | yes |
GO:0018107 | peptidyl-threonine phosphorylation | 9.0909 | 6 | yes |
GO:0018210 | peptidyl-threonine modification | 9.0909 | 6 | yes |
GO:0030833 | regulation of actin filament polymerization | 9.0909 | 7 | yes |
GO:0043405 | regulation of MAP kinase activity | 7.9545 | 8 | yes |
GO:1900180 | regulation of protein localization to nucleus | 7.9545 | 6 | yes |
GO:1903034 | regulation of response to wounding | 7.9545 | 5 | yes |
GO:1903311 | regulation of mRNA metabolic process | 7.9545 | 6 | yes |
GO:0031345 | negative regulation of cell projection organization | 7.9545 | 6 | yes |
GO:0035303 | regulation of dephosphorylation | 6.8182 | 7 | yes |
GO:0035306 | positive regulation of dephosphorylation | 6.8182 | 8 | yes |
GO:0042113 | B cell activation | 6.8182 | 4 | yes |
GO:0046626 | regulation of insulin receptor signaling pathway | 6.8182 | 5 | yes |
GO:0061041 | regulation of wound healing | 6.8182 | 6 | yes |
GO:0070301 | cellular response to hydrogen peroxide | 6.8182 | 5 | yes |
GO:0071478 | cellular response to radiation | 6.8182 | 4 | yes |
GO:0090316 | positive regulation of intracellular protein transport | 6.8182 | 6 | yes |
GO:1900076 | regulation of cellular response to insulin stimulus | 6.8182 | 4 | yes |
GO:2000379 | positive regulation of reactive oxygen species metabolic process | 6.8182 | 6 | yes |
GO:2001020 | regulation of response to DNA damage stimulus | 6.8182 | 5 | yes |
GO:2001235 | positive regulation of apoptotic signaling pathway | 6.8182 | 6 | yes |
GO:0022408 | negative regulation of cell-cell adhesion | 6.8182 | 6 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 6.8182 | 6 | yes |
GO:0033157 | regulation of intracellular protein transport | 6.8182 | 6 | yes |
GO:0034110 | regulation of homotypic cell-cell adhesion | 5.6818 | 6 | yes |
GO:0035304 | regulation of protein dephosphorylation | 5.6818 | 7 | yes |
GO:0035307 | positive regulation of protein dephosphorylation | 5.6818 | 8 | yes |
GO:0043488 | regulation of mRNA stability | 5.6818 | 4 | yes |
GO:0046627 | negative regulation of insulin receptor signaling pathway | 5.6818 | 6 | yes |
GO:0046651 | lymphocyte proliferation | 5.6818 | 4 | yes |
GO:0051100 | negative regulation of binding | 5.6818 | 4 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 5.6818 | 7 | yes |
GO:0061013 | regulation of mRNA catabolic process | 5.6818 | 6 | yes |
GO:0090330 | regulation of platelet aggregation | 5.6818 | 6 | yes |
GO:1900077 | negative regulation of cellular response to insulin stimulus | 5.6818 | 5 | yes |
GO:1900182 | positive regulation of protein localization to nucleus | 5.6818 | 6 | yes |
GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 5.6818 | 4 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 5.6818 | 6 | yes |
GO:0009416 | response to light stimulus | 5.6818 | 4 | yes |
GO:0010543 | regulation of platelet activation | 5.6818 | 5 | yes |
GO:0032943 | mononuclear cell proliferation | 5.6818 | 4 | yes |
GO:0042742 | defense response to bacterium | 4.5455 | 4 | yes |
GO:0046822 | regulation of nucleocytoplasmic transport | 4.5455 | 6 | yes |
GO:0046824 | positive regulation of nucleocytoplasmic transport | 4.5455 | 6 | yes |
GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation | 4.5455 | 9 | yes |
GO:0050866 | negative regulation of cell activation | 4.5455 | 5 | yes |
GO:0050994 | regulation of lipid catabolic process | 4.5455 | 5 | yes |
GO:0050996 | positive regulation of lipid catabolic process | 4.5455 | 6 | yes |
GO:0051489 | regulation of filopodium assembly | 4.5455 | 7 | yes |
GO:0071901 | negative regulation of protein serine/threonine kinase activity | 4.5455 | 8 | yes |
GO:0090322 | regulation of superoxide metabolic process | 4.5455 | 6 | yes |
GO:0009411 | response to UV | 4.5455 | 5 | yes |
GO:2001022 | positive regulation of response to DNA damage stimulus | 4.5455 | 5 | yes |
GO:0032091 | negative regulation of protein binding | 4.5455 | 5 | yes |
GO:0034350 | regulation of glial cell apoptotic process | 3.4091 | 7 | yes |
GO:0034351 | negative regulation of glial cell apoptotic process | 3.4091 | 8 | yes |
GO:0034644 | cellular response to UV | 3.4091 | 6 | yes |
GO:0042100 | B cell proliferation | 3.4091 | 5 | yes |
GO:0042306 | regulation of protein import into nucleus | 3.4091 | 7 | yes |
GO:0042307 | positive regulation of protein import into nucleus | 3.4091 | 7 | yes |
GO:0043407 | negative regulation of MAP kinase activity | 3.4091 | 8 | yes |
GO:0046889 | positive regulation of lipid biosynthetic process | 3.4091 | 6 | yes |
GO:0046890 | regulation of lipid biosynthetic process | 3.4091 | 5 | yes |
GO:0060326 | cell chemotaxis | 3.4091 | 4 | yes |
GO:0061045 | negative regulation of wound healing | 3.4091 | 6 | yes |
GO:0071482 | cellular response to light stimulus | 3.4091 | 5 | yes |
GO:1903035 | negative regulation of response to wounding | 3.4091 | 5 | yes |
GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 3.4091 | 5 | yes |
GO:1904385 | cellular response to angiotensin | 3.4091 | 6 | yes |
GO:1990776 | response to angiotensin | 3.4091 | 5 | yes |
GO:0032272 | negative regulation of protein polymerization | 3.4091 | 7 | yes |
GO:0032411 | positive regulation of transporter activity | 3.4091 | 4 | yes |
GO:0032928 | regulation of superoxide anion generation | 3.4091 | 7 | yes |
GO:0032930 | positive regulation of superoxide anion generation | 3.4091 | 7 | yes |
GO:0033194 | response to hydroperoxide | 3.4091 | 4 | yes |
GO:0034111 | negative regulation of homotypic cell-cell adhesion | 2.2727 | 7 | yes |
GO:0036230 | granulocyte activation | 2.2727 | 4 | yes |
GO:0042119 | neutrophil activation | 2.2727 | 5 | yes |
GO:0050818 | regulation of coagulation | 2.2727 | 4 | yes |
GO:0050819 | negative regulation of coagulation | 2.2727 | 5 | yes |
GO:0051490 | negative regulation of filopodium assembly | 2.2727 | 8 | yes |
GO:0060696 | regulation of phospholipid catabolic process | 2.2727 | 6 | yes |
GO:0060697 | positive regulation of phospholipid catabolic process | 2.2727 | 7 | yes |
GO:0061091 | regulation of phospholipid translocation | 2.2727 | 4 | yes |
GO:0071447 | cellular response to hydroperoxide | 2.2727 | 5 | yes |
GO:0090153 | regulation of sphingolipid biosynthetic process | 2.2727 | 5 | yes |
GO:0090154 | positive regulation of sphingolipid biosynthetic process | 2.2727 | 6 | yes |
GO:0090331 | negative regulation of platelet aggregation | 2.2727 | 7 | yes |
GO:0110112 | regulation of lipid transporter activity | 2.2727 | 4 | yes |
GO:0110113 | positive regulation of lipid transporter activity | 2.2727 | 5 | yes |
GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 2.2727 | 7 | yes |
GO:1900047 | negative regulation of hemostasis | 2.2727 | 4 | yes |
GO:1900161 | regulation of phospholipid scramblase activity | 2.2727 | 5 | yes |
GO:1900163 | positive regulation of phospholipid scramblase activity | 2.2727 | 6 | yes |
GO:0002449 | lymphocyte mediated immunity | 2.2727 | 4 | yes |
GO:1903725 | regulation of phospholipid metabolic process | 2.2727 | 6 | yes |
GO:1903727 | positive regulation of phospholipid metabolic process | 2.2727 | 6 | yes |
GO:1903729 | regulation of plasma membrane organization | 2.2727 | 5 | yes |
GO:1905038 | regulation of membrane lipid metabolic process | 2.2727 | 5 | yes |
GO:1905952 | regulation of lipid localization | 2.2727 | 4 | yes |
GO:1905954 | positive regulation of lipid localization | 2.2727 | 4 | yes |
GO:2000303 | regulation of ceramide biosynthetic process | 2.2727 | 6 | yes |
GO:2000304 | positive regulation of ceramide biosynthetic process | 2.2727 | 7 | yes |
GO:2000752 | regulation of glucosylceramide catabolic process | 2.2727 | 6 | yes |
GO:0010544 | negative regulation of platelet activation | 2.2727 | 6 | yes |
GO:2000753 | positive regulation of glucosylceramide catabolic process | 2.2727 | 7 | yes |
GO:2000754 | regulation of sphingomyelin catabolic process | 2.2727 | 6 | yes |
GO:2000755 | positive regulation of sphingomyelin catabolic process | 2.2727 | 7 | yes |
GO:2001138 | regulation of phospholipid transport | 2.2727 | 6 | yes |
GO:0016064 | immunoglobulin mediated immune response | 2.2727 | 6 | yes |
GO:0019724 | B cell mediated immunity | 2.2727 | 5 | yes |
GO:0023021 | termination of signal transduction | 2.2727 | 6 | yes |
GO:0030193 | regulation of blood coagulation | 2.2727 | 4 | yes |
GO:0030195 | negative regulation of blood coagulation | 2.2727 | 5 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 2.2727 | 7 | yes |
GO:0032069 | regulation of nuclease activity | 2.2727 | 5 | yes |
GO:0032070 | regulation of deoxyribonuclease activity | 2.2727 | 6 | yes |
GO:0032071 | regulation of endodeoxyribonuclease activity | 2.2727 | 7 | yes |
GO:0032075 | positive regulation of nuclease activity | 2.2727 | 6 | yes |
GO:0032077 | positive regulation of deoxyribonuclease activity | 2.2727 | 7 | yes |
GO:0032079 | positive regulation of endodeoxyribonuclease activity | 2.2727 | 8 | yes |
GO:0032368 | regulation of lipid transport | 2.2727 | 5 | yes |
GO:0032370 | positive regulation of lipid transport | 2.2727 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KPCD_HUMAN |
---|---|---|---|---|
DOID:612 | primary immunodeficiency disease | 5.6818 | 3 | no |
DOID:0111962 | combined immunodeficiency | 3.4091 | 4 | no |
DOID:0050686 | organ system cancer | 2.2727 | 3 | no |
DOID:1289 | neurodegenerative disease | 2.2727 | 4 | no |
DOID:331 | central nervous system disease | 2.2727 | 3 | no |
DOID:627 | severe combined immunodeficiency | 2.2727 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CDCP1_HUMAN | [view interactions] | Low throughput | no | yes |
LDB3_HUMAN | [view interactions] | Low throughput | no | no |
SPI1_HUMAN | [view interactions] | Low throughput | no | no |
RIPK4_HUMAN | [view interactions] | Low throughput | no | no |
TOP2A_HUMAN | [view interactions] | Low throughput | no | no |
PRKDC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P63_HUMAN | [view interactions] | Low throughput | no | no |
CAR11_HUMAN | [view interactions] | Low throughput | no | no |
MALT1_HUMAN | [view interactions] | Low throughput | no | no |
TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
LIMK1_HUMAN | [view interactions] | Low throughput | no | yes |
NLRC4_HUMAN | [view interactions] | Low throughput | no | no |
SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
C1QBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P53_HUMAN | [view interactions] | Low throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TROP_HUMAN | [view interactions] | Low throughput | no | no |
DBLOH_HUMAN | [view interactions] | Low throughput | no | no |
TOP2B_HUMAN | [view interactions] | Low throughput | no | yes |
T53I1_HUMAN | [view interactions] | Low throughput | no | yes |
NCF2_HUMAN | [view interactions] | Low throughput | no | no |
NCF1_HUMAN | [view interactions] | Low throughput | no | no |
KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PTN22_HUMAN | [view interactions] | Low throughput | no | yes |
SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FLOT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
BCLF1_HUMAN | [view interactions] | Low throughput | no | yes |
PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRP3_HUMAN | [view interactions] | Low throughput | no | no |
SHIP1_HUMAN | [view interactions] | Low throughput | no | no |
1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ADAM9_HUMAN | [view interactions] | Low throughput | no | no |
INSR_HUMAN | [view interactions] | Low throughput | no | yes |
PDP1_HUMAN | [view interactions] | Low throughput | no | yes |
PDP2_HUMAN | [view interactions] | Low throughput | no | yes |
IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PK3CB_HUMAN | [view interactions] | Low throughput | no | yes |
PTN6_HUMAN | [view interactions] | Low throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
MUC1_HUMAN | [view interactions] | Low throughput | no | no |
GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRI41_HUMAN | [view interactions] | Low throughput | no | yes |
SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
SP1_HUMAN | [view interactions] | Low throughput | no | yes |
STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HSPB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KLF4_HUMAN | [view interactions] | Low throughput | no | no |
VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IBTK_HUMAN | [view interactions] | Low throughput | no | yes |
IRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
S38A3_HUMAN | [view interactions] | Low throughput | no | no |
PAI1_HUMAN | [view interactions] | Low throughput | no | no |
RBP10_HUMAN | [view interactions] | Low throughput | no | no |
RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IL32_HUMAN | [view interactions] | Low throughput | no | no |
FLI1_HUMAN | [view interactions] | Low throughput | no | no |
NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P73_HUMAN | [view interactions] | Low throughput | no | no |
SPY2_HUMAN | [view interactions] | Low throughput | no | yes |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
ATG7_HUMAN | [view interactions] | Low throughput | no | yes |
AFAP1_HUMAN | [view interactions] | Low throughput | no | yes |
PLS3_HUMAN | [view interactions] | Low throughput | no | yes |
GNA12_HUMAN | [view interactions] | Low throughput | no | no |
GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HMGB1_HUMAN | [view interactions] | Low throughput | no | yes |
HDAC5_HUMAN | [view interactions] | Low throughput | no | yes |
H11_HUMAN | [view interactions] | Low throughput | no | no |
H15_HUMAN | [view interactions] | Low throughput | no | no |
MARCS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITB2_HUMAN | [view interactions] | Low throughput | no | no |
GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
OCLN_HUMAN | [view interactions] | Low throughput | no | no |
EP300_HUMAN | [view interactions] | Low throughput | no | yes |
DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HAKAI_HUMAN | [view interactions] | High throughput | no | yes |
PIP30_HUMAN | [view interactions] | High throughput | no | yes |
PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
ACTBL_HUMAN | [view interactions] | High throughput | no | no |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BUD13_HUMAN | [view interactions] | High throughput | no | yes |
DHX16_HUMAN | [view interactions] | High throughput | no | yes |
CWC15_HUMAN | [view interactions] | High throughput | no | yes |
RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYSM2_HUMAN | [view interactions] | High throughput | no | yes |
H2B1K_HUMAN | [view interactions] | High throughput | no | yes |
ZN131_HUMAN | [view interactions] | High throughput | no | yes |
NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGM1_HUMAN | [view interactions] | High throughput | no | no |
BCAP_HUMAN | [view interactions] | High throughput | no | no |
P85A_HUMAN | [view interactions] | High throughput | no | yes |
KPCT_HUMAN | [view interactions] | High throughput | no | no |
KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCM7_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FCERG_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPRC1_HUMAN | [view interactions] | High throughput | no | yes |
TPC13_HUMAN | [view interactions] | High throughput | no | yes |
CHD9_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TLR9_HUMAN | [view interactions] | High throughput | no | no |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
RMC1_HUMAN | [view interactions] | High throughput | no | no |
IL27B_HUMAN | [view interactions] | High throughput | no | no |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
BEX4_HUMAN | [view interactions] | High throughput | no | no |
DUX3_HUMAN | [view interactions] | High throughput | no | no |
MED17_HUMAN | [view interactions] | High throughput | no | no |
OPALI_HUMAN | [view interactions] | High throughput | no | yes |
INSRR_HUMAN | [view interactions] | High throughput | no | no |
PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
POTE1_HUMAN | [view interactions] | High throughput | no | no |
MPIP1_HUMAN | [view interactions] | High throughput | no | no |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LTC4S_HUMAN | [view interactions] | High throughput | no | no |
CSF3R_HUMAN | [view interactions] | High throughput | no | yes |
DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAR3_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEBP_HUMAN | [view interactions] | High throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
RACK1_HUMAN | [view interactions] | High throughput | no | yes |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SC61B_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KPCE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FGR_HUMAN | [view interactions] | Computational | no | no |
CY24A_HUMAN | [view interactions] | Computational | no | no |
PIN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SDC2_HUMAN | [view interactions] | Computational | no | yes |
ADCY8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PK3CD_HUMAN | [view interactions] | Computational | no | no |
CY24B_HUMAN | [view interactions] | Computational | no | no |
CASP3_HUMAN | [view interactions] | Computational | no | yes |
PLPL9_HUMAN | [view interactions] | Computational | no | yes |
JAK1_HUMAN | [view interactions] | Computational | no | yes |
MRP_HUMAN | [view entry] [view interactions] | Computational | yes | no |
P85B_HUMAN | [view interactions] | Computational | no | yes |
ADCY6_HUMAN | [view interactions] | Computational | no | yes |
ADCY7_HUMAN | [view interactions] | Computational | no | yes |
RASA1_HUMAN | [view interactions] | Computational | no | yes |
DAG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NCF4_HUMAN | [view interactions] | Computational | no | no |
KPCZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MP2K4_HUMAN | [view interactions] | Computational | no | yes |
MLRS_HUMAN | [view interactions] | Computational | no | no |
MK08_HUMAN | [view interactions] | Computational | no | yes |
IRS2_HUMAN | [view interactions] | Computational | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NFKB1_HUMAN | [view interactions] | Computational | no | yes |
TF65_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
P55G_HUMAN | [view interactions] | Computational | no | yes |
RAF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CARD9_HUMAN | [view interactions] | Computational | no | no |
ADCY1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IKBA_HUMAN | [view interactions] | Computational | no | yes |
HNRPK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADCY3_HUMAN | [view interactions] | Computational | no | yes |
RHG35_HUMAN | [view interactions] | Computational | no | yes |
ARBK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
INGR1_HUMAN | [view interactions] | Computational | no | no |
BLK_HUMAN | [view interactions] | Computational | no | no |
BCAR1_HUMAN | [view interactions] | Computational | no | yes |
RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TRPV4_HUMAN | [view interactions] | Computational | no | yes |
ADCY4_HUMAN | [view interactions] | Computational | no | yes |
INGR2_HUMAN | [view interactions] | Computational | no | yes |
YES_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SDC4_HUMAN | [view interactions] | Computational | no | yes |
IGF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
BAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NOS3_HUMAN | [view interactions] | Computational | no | no |
MP2K2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADCY2_HUMAN | [view interactions] | Computational | no | yes |
ADCY5_HUMAN | [view interactions] | Computational | no | no |
GLI2_HUMAN | [view interactions] | Computational | no | yes |
TA2R_HUMAN | [view interactions] | Computational | no | no |
MK09_HUMAN | [view interactions] | Computational | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CRK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SHH_HUMAN | [view interactions] | Computational | no | no |
LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SRC8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IFNG_HUMAN | [view interactions] | Computational | no | no |
PLCG2_HUMAN | [view interactions] | Computational | no | yes |
ADCY9_HUMAN | [view interactions] | Computational | no | yes |
CABIN_HUMAN | [view interactions] | Computational | no | yes |
PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TRAF2_HUMAN | [view interactions] | Computational | no | yes |