PYGB_HUMAN
Evidence for PS localization
Functions
Glycogen phosphorylase that regulates glycogen mobilization (PubMed). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed). However, all known phosphorylases share catalytic and structural properties (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PYGB_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 37.1429 | 4 | no |
| GO:0019900 | kinase binding | 25.7143 | 4 | no |
| GO:0016758 | hexosyltransferase activity | 11.4286 | 4 | yes |
| GO:0004645 | 1,4-alpha-oligoglucan phosphorylase activity | 8.5714 | 5 | yes |
| GO:0008184 | glycogen phosphorylase activity | 8.5714 | 6 | yes |
| GO:0030170 | pyridoxal phosphate binding | 8.5714 | 4 | yes |
| GO:0102250 | linear malto-oligosaccharide phosphorylase activity | 8.5714 | 5 | yes |
| GO:0102499 | SHG alpha-glucan phosphorylase activity | 8.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PYGB_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 45.7143 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.7143 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.1429 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 34.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.2857 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.2857 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 31.4286 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.4286 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.4286 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.4286 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.4286 | 5 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0010941 | regulation of cell death | 28.5714 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0010468 | regulation of gene expression | 25.7143 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.7143 | 5 | no |
| GO:0043412 | macromolecule modification | 25.7143 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.7143 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.7143 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 25.7143 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.7143 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:0051049 | regulation of transport | 25.7143 | 4 | no |
| GO:0036211 | protein modification process | 22.8571 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.8571 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.8571 | 5 | no |
| GO:0006996 | organelle organization | 22.8571 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 22.8571 | 6 | no |
| GO:0043549 | regulation of kinase activity | 22.8571 | 5 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 22.8571 | 7 | no |
| GO:0051338 | regulation of transferase activity | 22.8571 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.8571 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.8571 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.8571 | 7 | no |
| GO:0051726 | regulation of cell cycle | 22.8571 | 4 | no |
| GO:0005976 | polysaccharide metabolic process | 17.1429 | 4 | yes |
| GO:0005977 | glycogen metabolic process | 17.1429 | 6 | yes |
| GO:0006073 | cellular glucan metabolic process | 17.1429 | 5 | yes |
| GO:0006112 | energy reserve metabolic process | 17.1429 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 17.1429 | 4 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 17.1429 | 4 | yes |
| GO:0044042 | glucan metabolic process | 17.1429 | 5 | yes |
| GO:0044264 | cellular polysaccharide metabolic process | 17.1429 | 4 | yes |
| GO:0016052 | carbohydrate catabolic process | 14.2857 | 4 | yes |
| GO:0000272 | polysaccharide catabolic process | 11.4286 | 5 | yes |
| GO:0005980 | glycogen catabolic process | 11.4286 | 6 | yes |
| GO:0009251 | glucan catabolic process | 11.4286 | 6 | yes |
| GO:0044247 | cellular polysaccharide catabolic process | 11.4286 | 5 | yes |
| GO:0044275 | cellular carbohydrate catabolic process | 11.4286 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PYGB_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.7143 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.7143 | 5 | no |
| DOID:114 | heart disease | 5.7143 | 3 | no |
| DOID:2843 | long QT syndrome | 5.7143 | 6 | no |
| DOID:331 | central nervous system disease | 5.7143 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD69_HUMAN | [view interactions] | High throughput | no | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| ZFP41_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| BIN3_HUMAN | [view interactions] | High throughput | no | yes |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| TMA16_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| NTF3_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPR3B_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY2B_HUMAN | [view interactions] | High throughput | no | no |
| AMYP_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| LIN37_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| DHB3_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF24_HUMAN | [view interactions] | High throughput | no | no |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYG2_HUMAN | [view interactions] | High throughput | no | no |
| PPR3F_HUMAN | [view interactions] | High throughput | no | yes |
| CTSRE_HUMAN | [view interactions] | High throughput | no | no |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| FYB1_HUMAN | [view interactions] | High throughput | no | no |
| NDST3_HUMAN | [view interactions] | High throughput | no | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| CDHR3_HUMAN | [view interactions] | High throughput | no | no |
| GDE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| PPR3D_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| WDR61_HUMAN | [view interactions] | High throughput | no | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNRE_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| KPB1_HUMAN | [view interactions] | Computational | no | yes |
| MGA_HUMAN | [view interactions] | Computational | no | no |
| PHKG1_HUMAN | [view interactions] | Computational | no | no |
| RIPK3_HUMAN | [view interactions] | Computational | no | no |
| UGPA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PGM2L_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPBB_HUMAN | [view interactions] | Computational | no | no |
| MGAL_HUMAN | [view interactions] | Computational | no | no |
| AMY1C_HUMAN | [view interactions] | Computational | no | no |
| AMY1A_HUMAN | [view interactions] | Computational | no | no |
| PGM1_HUMAN | [view interactions] | Computational | no | no |
| GYS2_HUMAN | [view interactions] | Computational | no | no |
| PGM2_HUMAN | [view interactions] | Computational | no | no |
| ENPP3_HUMAN | [view interactions] | Computational | no | no |