PYGB_HUMAN
Evidence for PS localization
Functions
Glycogen phosphorylase that regulates glycogen mobilization (PubMed). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed). However, all known phosphorylases share catalytic and structural properties (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PYGB_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.7869 | 4 | yes |
| GO:0003723 | RNA binding | 32.7869 | 4 | no |
| GO:0000166 | nucleotide binding | 31.1475 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.5082 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 27.8689 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 27.8689 | 4 | no |
| GO:0019900 | kinase binding | 26.2295 | 4 | no |
| GO:0043169 | cation binding | 26.2295 | 4 | no |
| GO:0046872 | metal ion binding | 26.2295 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.2295 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.5902 | 4 | no |
| GO:0019901 | protein kinase binding | 22.9508 | 5 | no |
| GO:0005524 | ATP binding | 22.9508 | 5 | no |
| GO:0016758 | hexosyltransferase activity | 6.5574 | 4 | yes |
| GO:0004645 | 1,4-alpha-oligoglucan phosphorylase activity | 4.9180 | 5 | yes |
| GO:0008184 | glycogen phosphorylase activity | 4.9180 | 6 | yes |
| GO:0030170 | pyridoxal phosphate binding | 4.9180 | 4 | yes |
| GO:0102250 | linear malto-oligosaccharide phosphorylase activity | 4.9180 | 5 | yes |
| GO:0102499 | SHG alpha-glucan phosphorylase activity | 4.9180 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PYGB_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 60.6557 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 59.0164 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 55.7377 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.7377 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 49.1803 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.2623 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 42.6230 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.6230 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.6230 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 42.6230 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.6230 | 5 | no |
| GO:0010468 | regulation of gene expression | 40.9836 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.9836 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.3443 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 39.3443 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.7049 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 37.7049 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.0656 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.0656 | 5 | no |
| GO:0022607 | cellular component assembly | 36.0656 | 4 | no |
| GO:0006996 | organelle organization | 32.7869 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.7869 | 5 | no |
| GO:0043933 | protein-containing complex organization | 32.7869 | 4 | no |
| GO:0051049 | regulation of transport | 31.1475 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 29.5082 | 5 | no |
| GO:0009894 | regulation of catabolic process | 29.5082 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 29.5082 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.5082 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.5082 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.8689 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.8689 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.2295 | 5 | no |
| GO:0043412 | macromolecule modification | 26.2295 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.2295 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.2295 | 6 | no |
| GO:0008104 | protein localization | 26.2295 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 24.5902 | 7 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.5902 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.5902 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.5902 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.5902 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.5902 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 24.5902 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.9508 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.9508 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 22.9508 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.9508 | 4 | no |
| GO:0036211 | protein modification process | 22.9508 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.9508 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.9508 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.9508 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9508 | 6 | no |
| GO:0051726 | regulation of cell cycle | 22.9508 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.9508 | 5 | no |
| GO:0071702 | organic substance transport | 22.9508 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 21.3115 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 21.3115 | 4 | no |
| GO:0051338 | regulation of transferase activity | 21.3115 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.3115 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.3115 | 5 | no |
| GO:0071705 | nitrogen compound transport | 21.3115 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.3115 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.3115 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.3115 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.3115 | 4 | no |
| GO:0016052 | carbohydrate catabolic process | 9.8361 | 4 | yes |
| GO:0005976 | polysaccharide metabolic process | 8.1967 | 4 | yes |
| GO:0005977 | glycogen metabolic process | 8.1967 | 6 | yes |
| GO:0006112 | energy reserve metabolic process | 8.1967 | 5 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 8.1967 | 4 | yes |
| GO:0044042 | glucan metabolic process | 8.1967 | 5 | yes |
| GO:0000272 | polysaccharide catabolic process | 6.5574 | 5 | yes |
| GO:0005980 | glycogen catabolic process | 6.5574 | 7 | yes |
| GO:0009251 | glucan catabolic process | 6.5574 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF24_HUMAN | [view interactions] | High throughput | no | no |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYG2_HUMAN | [view interactions] | High throughput | no | no |
| PPR3F_HUMAN | [view interactions] | High throughput | no | yes |
| CTSRE_HUMAN | [view interactions] | High throughput | no | no |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| FYB1_HUMAN | [view interactions] | High throughput | no | no |
| NDST3_HUMAN | [view interactions] | High throughput | no | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| CDHR3_HUMAN | [view interactions] | High throughput | no | no |
| GDE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| PPR3D_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP53_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| SKI8_HUMAN | [view interactions] | High throughput | no | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNRE_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PBDC1_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD69_HUMAN | [view interactions] | High throughput | no | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| ZFP41_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| BIN3_HUMAN | [view interactions] | High throughput | no | yes |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| TMA16_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| NTF3_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPR3B_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY2B_HUMAN | [view interactions] | High throughput | no | no |
| AMYP_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| LIN37_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| DHB3_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |