CAP1_HUMAN
Evidence for PS localization
Functions
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAP1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.2500 | 4 | no |
| GO:0000166 | nucleotide binding | 36.2500 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.7500 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.2500 | 4 | no |
| GO:0003779 | actin binding | 27.5000 | 4 | yes |
| GO:0003723 | RNA binding | 27.5000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.2500 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
| GO:0005524 | ATP binding | 23.7500 | 5 | no |
| GO:0019900 | kinase binding | 23.7500 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.7500 | 5 | no |
| GO:0043169 | cation binding | 22.5000 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.2500 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.2500 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.2500 | 6 | no |
| GO:0046872 | metal ion binding | 21.2500 | 5 | no |
| GO:0008179 | adenylate cyclase binding | 3.7500 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.2500 | 4 | no |
| GO:0006996 | organelle organization | 52.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7500 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.2500 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 45.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 38.7500 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.7500 | 5 | no |
| GO:0010646 | regulation of cell communication | 38.7500 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.7500 | 4 | no |
| GO:0022607 | cellular component assembly | 38.7500 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.2500 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.2500 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.2500 | 5 | no |
| GO:0010468 | regulation of gene expression | 35.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.7500 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.5000 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.2500 | 5 | no |
| GO:0031399 | regulation of protein modification process | 31.2500 | 6 | no |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 28.7500 | 4 | yes |
| GO:0008104 | protein localization | 28.7500 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.5000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.5000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.2500 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.2500 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.2500 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.2500 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.7500 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.7500 | 6 | no |
| GO:0051049 | regulation of transport | 23.7500 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.7500 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.7500 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.7500 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.7500 | 5 | no |
| GO:0007015 | actin filament organization | 22.5000 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.5000 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.5000 | 5 | no |
| GO:0043412 | macromolecule modification | 22.5000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.5000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.5000 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.2500 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.2500 | 5 | no |
| GO:0036211 | protein modification process | 21.2500 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.2500 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.2500 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.2500 | 5 | no |
| GO:0080134 | regulation of response to stress | 21.2500 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.2500 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.0000 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 16.2500 | 4 | yes |
| GO:0098657 | import into cell | 10.0000 | 4 | yes |
| GO:0001667 | ameboidal-type cell migration | 5.0000 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 5.0000 | 4 | yes |
| GO:0007190 | activation of adenylate cyclase activity | 3.7500 | 7 | yes |
| GO:0019933 | cAMP-mediated signaling | 3.7500 | 5 | yes |
| GO:0031279 | regulation of cyclase activity | 3.7500 | 4 | yes |
| GO:0031281 | positive regulation of cyclase activity | 3.7500 | 5 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 3.7500 | 5 | yes |
| GO:0045762 | positive regulation of adenylate cyclase activity | 3.7500 | 6 | yes |
| GO:0051339 | regulation of lyase activity | 3.7500 | 4 | yes |
| GO:0051349 | positive regulation of lyase activity | 3.7500 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BAG6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYOC_HUMAN | [view interactions] | Low throughput | no | no |
| TWF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| BCL7A_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| DNAL4_HUMAN | [view interactions] | High throughput | no | yes |
| OXLA_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| PSME2_HUMAN | [view interactions] | High throughput | no | no |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| NEK9_HUMAN | [view interactions] | High throughput | no | yes |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| DPH2_HUMAN | [view interactions] | High throughput | no | no |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| RNH2C_HUMAN | [view interactions] | High throughput | no | yes |
| TTC38_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INO1_HUMAN | [view interactions] | High throughput | no | no |
| MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEPD_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| TPD53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| VAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
| RISC_HUMAN | [view interactions] | High throughput | no | yes |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG2_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAL12_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |