CAP1_HUMAN
Evidence for PS localization
Functions
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAP1_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 40.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 28.8889 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.6667 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0019900 | kinase binding | 26.6667 | 4 | no |
| GO:0005524 | ATP binding | 24.4444 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.4444 | 5 | no |
| GO:0046872 | metal ion binding | 24.4444 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0008179 | adenylate cyclase binding | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.8889 | 4 | no |
| GO:0006996 | organelle organization | 64.4444 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 51.1111 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.4444 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.4444 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0007010 | cytoskeleton organization | 42.2222 | 5 | yes |
| GO:0022607 | cellular component assembly | 42.2222 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.2222 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.7778 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 31.1111 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.1111 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.1111 | 5 | no |
| GO:0010941 | regulation of cell death | 31.1111 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.1111 | 5 | no |
| GO:0060341 | regulation of cellular localization | 31.1111 | 4 | no |
| GO:0051049 | regulation of transport | 31.1111 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.1111 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.1111 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.8889 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 28.8889 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.8889 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 28.8889 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.8889 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.8889 | 4 | no |
| GO:0036211 | protein modification process | 28.8889 | 4 | no |
| GO:0043412 | macromolecule modification | 28.8889 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.8889 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.8889 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.8889 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.8889 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.8889 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 28.8889 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.8889 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.6667 | 7 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.6667 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.6667 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 26.6667 | 4 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0007015 | actin filament organization | 24.4444 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.4444 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 24.4444 | 4 | no |
| GO:0051338 | regulation of transferase activity | 24.4444 | 4 | no |
| GO:0080134 | regulation of response to stress | 24.4444 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.4444 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.2222 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 22.2222 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 22.2222 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 22.2222 | 5 | no |
| GO:0043549 | regulation of kinase activity | 22.2222 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.2222 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.2222 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.2222 | 6 | no |
| GO:0060548 | negative regulation of cell death | 22.2222 | 5 | no |
| GO:0006897 | endocytosis | 13.3333 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 13.3333 | 4 | yes |
| GO:0001667 | ameboidal-type cell migration | 11.1111 | 4 | yes |
| GO:0019932 | second-messenger-mediated signaling | 11.1111 | 4 | yes |
| GO:0019933 | cAMP-mediated signaling | 8.8889 | 6 | yes |
| GO:0019935 | cyclic-nucleotide-mediated signaling | 8.8889 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 6.6667 | 6 | yes |
| GO:0007190 | activation of adenylate cyclase activity | 6.6667 | 7 | yes |
| GO:0031279 | regulation of cyclase activity | 6.6667 | 4 | yes |
| GO:0031281 | positive regulation of cyclase activity | 6.6667 | 5 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 6.6667 | 5 | yes |
| GO:0045762 | positive regulation of adenylate cyclase activity | 6.6667 | 6 | yes |
| GO:0051339 | regulation of lyase activity | 6.6667 | 4 | yes |
| GO:0051349 | positive regulation of lyase activity | 6.6667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TWF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAG6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYOC_HUMAN | [view interactions] | Low throughput | no | no |
| PLCG2_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAL12_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| BCL7A_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| DNAL4_HUMAN | [view interactions] | High throughput | no | yes |
| OXLA_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| PSME2_HUMAN | [view interactions] | High throughput | no | no |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| NEK9_HUMAN | [view interactions] | High throughput | no | yes |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| DPH2_HUMAN | [view interactions] | High throughput | no | no |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| RNH2C_HUMAN | [view interactions] | High throughput | no | yes |
| TTC38_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INO1_HUMAN | [view interactions] | High throughput | no | no |
| MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCY1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PHLP1_HUMAN | [view interactions] | Computational | no | yes |
| RETN_HUMAN | [view interactions] | Computational | no | no |
| PHLP2_HUMAN | [view interactions] | Computational | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |