Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLSL_HUMAN

GO
G2C
SynGO

Actin-binding protein (PubMed, PubMed, PubMed). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

ELM instance Name Type Start End Partner
ELMI001420 MOD_PKA_2 MOD 2 8 -
ELMI001420 MOD_PKA_2 MOD 2 8 -

Molecular function

Term Name % Distance from the top of the tree Annotated in PLSL_HUMAN
GO:0003779 actin binding 50.0000 4 yes
GO:0043169 cation binding 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 5 yes
GO:0043168 anion binding 33.3333 4 no
GO:0000166 nucleotide binding 23.3333 4 no
GO:0017076 purine nucleotide binding 23.3333 5 no
GO:0032555 purine ribonucleotide binding 23.3333 4 no
GO:0019900 kinase binding 23.3333 4 no
GO:0005509 calcium ion binding 13.3333 6 yes
GO:0051020 GTPase binding 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLSL_HUMAN
GO:0048522 positive regulation of cellular process 63.3333 4 yes
GO:0051128 regulation of cellular component organization 60.0000 4 yes
GO:0006996 organelle organization 53.3333 4 yes
GO:0044087 regulation of cellular component biogenesis 53.3333 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0009893 positive regulation of metabolic process 43.3333 4 no
GO:0031323 regulation of cellular metabolic process 43.3333 4 no
GO:0022607 cellular component assembly 43.3333 4 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0007010 cytoskeleton organization 40.0000 5 yes
GO:0009966 regulation of signal transduction 36.6667 4 no
GO:0010468 regulation of gene expression 36.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.6667 5 no
GO:0010646 regulation of cell communication 36.6667 4 no
GO:0051246 regulation of protein metabolic process 36.6667 5 no
GO:0032880 regulation of protein localization 36.6667 5 yes
GO:0060341 regulation of cellular localization 36.6667 4 yes
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0032970 regulation of actin filament-based process 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0043254 regulation of protein-containing complex assembly 33.3333 5 yes
GO:0051049 regulation of transport 33.3333 4 yes
GO:0032535 regulation of cellular component size 33.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.0000 6 no
GO:0008104 protein localization 30.0000 4 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 30.0000 5 no
GO:0051493 regulation of cytoskeleton organization 30.0000 6 no
GO:0010628 positive regulation of gene expression 26.6667 7 no
GO:1901701 cellular response to oxygen-containing compound 26.6667 4 no
GO:0030030 cell projection organization 26.6667 4 no
GO:0110053 regulation of actin filament organization 26.6667 6 no
GO:1902903 regulation of supramolecular fiber organization 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0051130 positive regulation of cellular component organization 26.6667 5 yes
GO:0097435 supramolecular fiber organization 26.6667 4 yes
GO:0048584 positive regulation of response to stimulus 23.3333 4 no
GO:0051240 positive regulation of multicellular organismal process 23.3333 4 no
GO:0008064 regulation of actin polymerization or depolymerization 23.3333 6 no
GO:0030832 regulation of actin filament length 23.3333 5 no
GO:0043933 protein-containing complex organization 23.3333 4 no
GO:0007015 actin filament organization 23.3333 5 yes
GO:0032386 regulation of intracellular transport 23.3333 5 yes
GO:0010638 positive regulation of organelle organization 20.0000 6 yes
GO:0044089 positive regulation of cellular component biogenesis 20.0000 5 yes
GO:1902115 regulation of organelle assembly 20.0000 5 yes
GO:0010737 protein kinase A signaling 16.6667 4 yes
GO:0070201 regulation of establishment of protein localization 16.6667 6 yes
GO:0022411 cellular component disassembly 13.3333 4 yes
GO:0030865 cortical cytoskeleton organization 13.3333 6 yes
GO:0030866 cortical actin cytoskeleton organization 13.3333 4 yes
GO:0031334 positive regulation of protein-containing complex assembly 13.3333 6 yes
GO:0051223 regulation of protein transport 13.3333 5 yes
GO:0071801 regulation of podosome assembly 13.3333 6 yes
GO:0030198 extracellular matrix organization 10.0000 5 yes
GO:0033157 regulation of intracellular protein transport 10.0000 6 yes
GO:0042110 T cell activation 10.0000 4 yes
GO:0043062 extracellular structure organization 10.0000 4 yes
GO:0045229 external encapsulating structure organization 10.0000 4 yes
GO:0051017 actin filament bundle assembly 10.0000 5 yes
GO:0061572 actin filament bundle organization 10.0000 6 yes
GO:0071803 positive regulation of podosome assembly 10.0000 7 yes
GO:1902117 positive regulation of organelle assembly 10.0000 6 yes
GO:0002285 lymphocyte activation involved in immune response 6.6667 4 yes
GO:0002286 T cell activation involved in immune response 6.6667 5 yes
GO:0022617 extracellular matrix disassembly 6.6667 5 yes
GO:0031100 animal organ regeneration 6.6667 4 yes
GO:0051639 actin filament network formation 6.6667 6 yes
GO:0051764 actin crosslink formation 6.6667 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ATX2_HUMAN [view interactions] Low throughput no yes
AIF1_HUMAN [view interactions] Low throughput no no
GRAN_HUMAN [view interactions] Low throughput no no
ITB2_HUMAN [view interactions] Low throughput no no
MK14_HUMAN [view interactions] High throughput no yes
PLST_HUMAN [view interactions] High throughput no yes
PLSI_HUMAN [view interactions] High throughput no no
TTL_HUMAN [view interactions] High throughput no no
RNF41_HUMAN [view interactions] High throughput no yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
TAGL_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
MED23_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
CXCR2_HUMAN [view interactions] High throughput no no
CNN3_HUMAN [view entry] [view interactions] High throughput yes yes
PLSL_HUMAN [view entry] [view interactions] High throughput yes no
TIFAB_HUMAN [view interactions] High throughput no no
RET_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
DD19B_HUMAN [view interactions] High throughput no yes
GLYR1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
PPME1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
REQU_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
PPARG_HUMAN [view interactions] High throughput no yes
EYA1_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
OR2A4_HUMAN [view interactions] High throughput no no
GCYA1_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
GBG8_HUMAN [view interactions] High throughput no no
ELOA2_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
FRMD1_HUMAN [view interactions] High throughput no no
LHPL4_HUMAN [view entry] [view interactions] High throughput yes no
SGTB_HUMAN [view interactions] High throughput no yes
COE2_HUMAN [view interactions] High throughput no no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
PTSS1_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
DKK2_HUMAN [view interactions] High throughput no no
SSBP2_HUMAN [view interactions] High throughput no yes
EGFL8_HUMAN [view interactions] High throughput no no
CP343_HUMAN [view interactions] High throughput no no
PRKX_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
SARAF_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
KLK10_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
SMIM8_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FKB14_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC1_HUMAN [view interactions] High throughput no no
URP2_HUMAN [view interactions] High throughput no no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
PNPH_HUMAN [view interactions] High throughput no no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
PLEK_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
COT2_HUMAN [view interactions] High throughput no no
MET2B_HUMAN [view interactions] High throughput no no
DPP9_HUMAN [view interactions] High throughput no yes
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
DCA15_HUMAN [view interactions] High throughput no no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes