PLSL_HUMAN
Actin-binding protein (PubMed, PubMed, PubMed). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI001420 | MOD_PKA_2 | MOD | 2 | 8 | - |
ELMI001420 | MOD_PKA_2 | MOD | 2 | 8 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PLSL_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 50.0000 | 4 | yes |
GO:0043169 | cation binding | 33.3333 | 4 | yes |
GO:0046872 | metal ion binding | 33.3333 | 5 | yes |
GO:0043168 | anion binding | 33.3333 | 4 | no |
GO:0000166 | nucleotide binding | 23.3333 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.3333 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 23.3333 | 4 | no |
GO:0019900 | kinase binding | 23.3333 | 4 | no |
GO:0005509 | calcium ion binding | 13.3333 | 6 | yes |
GO:0051020 | GTPase binding | 13.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PLSL_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 63.3333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
GO:0006996 | organelle organization | 53.3333 | 4 | yes |
GO:0044087 | regulation of cellular component biogenesis | 53.3333 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 50.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 43.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 43.3333 | 4 | no |
GO:0022607 | cellular component assembly | 43.3333 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 40.0000 | 5 | yes |
GO:0009966 | regulation of signal transduction | 36.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 36.6667 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.6667 | 5 | no |
GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 36.6667 | 5 | no |
GO:0032880 | regulation of protein localization | 36.6667 | 5 | yes |
GO:0060341 | regulation of cellular localization | 36.6667 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 33.3333 | 6 | no |
GO:0032970 | regulation of actin filament-based process | 33.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 33.3333 | 5 | yes |
GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
GO:0032535 | regulation of cellular component size | 33.3333 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | no |
GO:0008104 | protein localization | 30.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 30.0000 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 30.0000 | 6 | no |
GO:0010628 | positive regulation of gene expression | 26.6667 | 7 | no |
GO:1901701 | cellular response to oxygen-containing compound | 26.6667 | 4 | no |
GO:0030030 | cell projection organization | 26.6667 | 4 | no |
GO:0110053 | regulation of actin filament organization | 26.6667 | 6 | no |
GO:1902903 | regulation of supramolecular fiber organization | 26.6667 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | yes |
GO:0097435 | supramolecular fiber organization | 26.6667 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 23.3333 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 23.3333 | 4 | no |
GO:0008064 | regulation of actin polymerization or depolymerization | 23.3333 | 6 | no |
GO:0030832 | regulation of actin filament length | 23.3333 | 5 | no |
GO:0043933 | protein-containing complex organization | 23.3333 | 4 | no |
GO:0007015 | actin filament organization | 23.3333 | 5 | yes |
GO:0032386 | regulation of intracellular transport | 23.3333 | 5 | yes |
GO:0010638 | positive regulation of organelle organization | 20.0000 | 6 | yes |
GO:0044089 | positive regulation of cellular component biogenesis | 20.0000 | 5 | yes |
GO:1902115 | regulation of organelle assembly | 20.0000 | 5 | yes |
GO:0010737 | protein kinase A signaling | 16.6667 | 4 | yes |
GO:0070201 | regulation of establishment of protein localization | 16.6667 | 6 | yes |
GO:0022411 | cellular component disassembly | 13.3333 | 4 | yes |
GO:0030865 | cortical cytoskeleton organization | 13.3333 | 6 | yes |
GO:0030866 | cortical actin cytoskeleton organization | 13.3333 | 4 | yes |
GO:0031334 | positive regulation of protein-containing complex assembly | 13.3333 | 6 | yes |
GO:0051223 | regulation of protein transport | 13.3333 | 5 | yes |
GO:0071801 | regulation of podosome assembly | 13.3333 | 6 | yes |
GO:0030198 | extracellular matrix organization | 10.0000 | 5 | yes |
GO:0033157 | regulation of intracellular protein transport | 10.0000 | 6 | yes |
GO:0042110 | T cell activation | 10.0000 | 4 | yes |
GO:0043062 | extracellular structure organization | 10.0000 | 4 | yes |
GO:0045229 | external encapsulating structure organization | 10.0000 | 4 | yes |
GO:0051017 | actin filament bundle assembly | 10.0000 | 5 | yes |
GO:0061572 | actin filament bundle organization | 10.0000 | 6 | yes |
GO:0071803 | positive regulation of podosome assembly | 10.0000 | 7 | yes |
GO:1902117 | positive regulation of organelle assembly | 10.0000 | 6 | yes |
GO:0002285 | lymphocyte activation involved in immune response | 6.6667 | 4 | yes |
GO:0002286 | T cell activation involved in immune response | 6.6667 | 5 | yes |
GO:0022617 | extracellular matrix disassembly | 6.6667 | 5 | yes |
GO:0031100 | animal organ regeneration | 6.6667 | 4 | yes |
GO:0051639 | actin filament network formation | 6.6667 | 6 | yes |
GO:0051764 | actin crosslink formation | 6.6667 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ATX2_HUMAN | [view interactions] | Low throughput | no | yes |
AIF1_HUMAN | [view interactions] | Low throughput | no | no |
GRAN_HUMAN | [view interactions] | Low throughput | no | no |
ITB2_HUMAN | [view interactions] | Low throughput | no | no |
MK14_HUMAN | [view interactions] | High throughput | no | yes |
PLST_HUMAN | [view interactions] | High throughput | no | yes |
PLSI_HUMAN | [view interactions] | High throughput | no | no |
TTL_HUMAN | [view interactions] | High throughput | no | no |
RNF41_HUMAN | [view interactions] | High throughput | no | yes |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MED23_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
CXCR2_HUMAN | [view interactions] | High throughput | no | no |
CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TIFAB_HUMAN | [view interactions] | High throughput | no | no |
RET_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
FOXP3_HUMAN | [view interactions] | High throughput | no | no |
DD19B_HUMAN | [view interactions] | High throughput | no | yes |
GLYR1_HUMAN | [view interactions] | High throughput | no | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
PPME1_HUMAN | [view interactions] | High throughput | no | yes |
U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
REQU_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
PPARG_HUMAN | [view interactions] | High throughput | no | yes |
EYA1_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OR2A4_HUMAN | [view interactions] | High throughput | no | no |
GCYA1_HUMAN | [view interactions] | High throughput | no | yes |
2ABB_HUMAN | [view interactions] | High throughput | no | yes |
GBG8_HUMAN | [view interactions] | High throughput | no | no |
ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
FRMD1_HUMAN | [view interactions] | High throughput | no | no |
LHPL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SGTB_HUMAN | [view interactions] | High throughput | no | yes |
COE2_HUMAN | [view interactions] | High throughput | no | no |
FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTSS1_HUMAN | [view interactions] | High throughput | no | no |
STX17_HUMAN | [view interactions] | High throughput | no | yes |
DKK2_HUMAN | [view interactions] | High throughput | no | no |
SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
EGFL8_HUMAN | [view interactions] | High throughput | no | no |
CP343_HUMAN | [view interactions] | High throughput | no | no |
PRKX_HUMAN | [view interactions] | High throughput | no | yes |
NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
SARAF_HUMAN | [view interactions] | High throughput | no | no |
CR021_HUMAN | [view interactions] | High throughput | no | no |
PLCA_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
KLK10_HUMAN | [view interactions] | High throughput | no | no |
MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
SMIM8_HUMAN | [view interactions] | High throughput | no | no |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
UBP11_HUMAN | [view interactions] | High throughput | no | yes |
UBP36_HUMAN | [view interactions] | High throughput | no | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FKB14_HUMAN | [view interactions] | High throughput | no | yes |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLIC1_HUMAN | [view interactions] | High throughput | no | no |
URP2_HUMAN | [view interactions] | High throughput | no | no |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PNPH_HUMAN | [view interactions] | High throughput | no | no |
KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLEK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COT2_HUMAN | [view interactions] | High throughput | no | no |
MET2B_HUMAN | [view interactions] | High throughput | no | no |
DPP9_HUMAN | [view interactions] | High throughput | no | yes |
NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SGT1_HUMAN | [view interactions] | High throughput | no | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BICD1_HUMAN | [view interactions] | High throughput | no | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STING_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |