PLSL_HUMAN
Evidence for PS localization
Functions
Actin-binding protein (PubMed, PubMed, PubMed). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001420 | MOD_PKA_2 | MOD | 2 | 8 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLSL_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 48.2759 | 4 | yes |
| GO:0046872 | metal ion binding | 34.4828 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 24.1379 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.1379 | 4 | no |
| GO:0045296 | cadherin binding | 20.6897 | 4 | no |
| GO:0019900 | kinase binding | 20.6897 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.6897 | 4 | no |
| GO:0005509 | calcium ion binding | 13.7931 | 5 | yes |
| GO:0051020 | GTPase binding | 13.7931 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLSL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.0690 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.6207 | 4 | yes |
| GO:0006996 | organelle organization | 55.1724 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 55.1724 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 48.2759 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 48.2759 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 48.2759 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.3793 | 4 | no |
| GO:0022607 | cellular component assembly | 37.9310 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 37.9310 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 37.9310 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.9310 | 4 | no |
| GO:0032535 | regulation of cellular component size | 37.9310 | 4 | no |
| GO:0032880 | regulation of protein localization | 34.4828 | 5 | yes |
| GO:0051049 | regulation of transport | 34.4828 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 34.4828 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 34.4828 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.4828 | 5 | no |
| GO:0010646 | regulation of cell communication | 34.4828 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.4828 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.4828 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 34.4828 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.0345 | 5 | no |
| GO:0071310 | cellular response to organic substance | 31.0345 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 31.0345 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 31.0345 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5862 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 27.5862 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.5862 | 6 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 27.5862 | 6 | no |
| GO:0010468 | regulation of gene expression | 27.5862 | 5 | no |
| GO:0030832 | regulation of actin filament length | 27.5862 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 27.5862 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 27.5862 | 5 | no |
| GO:0032386 | regulation of intracellular transport | 24.1379 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 24.1379 | 4 | no |
| GO:0030030 | cell projection organization | 24.1379 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.1379 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.1379 | 5 | no |
| GO:0008104 | protein localization | 24.1379 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 24.1379 | 6 | no |
| GO:0030833 | regulation of actin filament polymerization | 24.1379 | 7 | no |
| GO:0032271 | regulation of protein polymerization | 24.1379 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 20.6897 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.6897 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 20.6897 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 20.6897 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.6897 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 20.6897 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.6897 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.6897 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 20.6897 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.6897 | 5 | no |
| GO:0030834 | regulation of actin filament depolymerization | 20.6897 | 7 | no |
| GO:0043244 | regulation of protein-containing complex disassembly | 20.6897 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.6897 | 4 | no |
| GO:1901879 | regulation of protein depolymerization | 20.6897 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.6897 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 20.6897 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.6897 | 4 | no |
| GO:0007015 | actin filament organization | 17.2414 | 5 | yes |
| GO:0010737 | protein kinase A signaling | 17.2414 | 4 | yes |
| GO:0051223 | regulation of protein transport | 17.2414 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 17.2414 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 17.2414 | 4 | yes |
| GO:0030865 | cortical cytoskeleton organization | 13.7931 | 6 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 13.7931 | 4 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 13.7931 | 6 | yes |
| GO:0033157 | regulation of intracellular protein transport | 13.7931 | 6 | yes |
| GO:0071801 | regulation of podosome assembly | 13.7931 | 6 | yes |
| GO:0022411 | cellular component disassembly | 10.3448 | 4 | yes |
| GO:0030198 | extracellular matrix organization | 10.3448 | 5 | yes |
| GO:0042110 | T cell activation | 10.3448 | 4 | yes |
| GO:0043062 | extracellular structure organization | 10.3448 | 4 | yes |
| GO:0045229 | external encapsulating structure organization | 10.3448 | 4 | yes |
| GO:0051017 | actin filament bundle assembly | 10.3448 | 5 | yes |
| GO:0061572 | actin filament bundle organization | 10.3448 | 6 | yes |
| GO:0071803 | positive regulation of podosome assembly | 10.3448 | 7 | yes |
| GO:1902117 | positive regulation of organelle assembly | 10.3448 | 6 | yes |
| GO:0002285 | lymphocyte activation involved in immune response | 6.8966 | 4 | yes |
| GO:0002286 | T cell activation involved in immune response | 6.8966 | 5 | yes |
| GO:0022617 | extracellular matrix disassembly | 6.8966 | 5 | yes |
| GO:0031100 | animal organ regeneration | 6.8966 | 4 | yes |
| GO:0051639 | actin filament network formation | 6.8966 | 6 | yes |
| GO:0051764 | actin crosslink formation | 6.8966 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ATX2_HUMAN | [view interactions] | Low throughput | no | yes |
| AIF1_HUMAN | [view interactions] | Low throughput | no | no |
| GRAN_HUMAN | [view interactions] | Low throughput | no | no |
| ITB2_HUMAN | [view interactions] | Low throughput | no | no |
| ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| FRMD1_HUMAN | [view interactions] | High throughput | no | no |
| LHPL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| COE2_HUMAN | [view interactions] | High throughput | no | no |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTSS1_HUMAN | [view interactions] | High throughput | no | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| DKK2_HUMAN | [view interactions] | High throughput | no | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL8_HUMAN | [view interactions] | High throughput | no | no |
| CP343_HUMAN | [view interactions] | High throughput | no | no |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| SMIM8_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKB14_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| TTL_HUMAN | [view interactions] | High throughput | no | no |
| PLSI_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| GLYR1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| GCYA1_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| PERM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SPI1_HUMAN | [view interactions] | Computational | no | no |
| STAT4_HUMAN | [view interactions] | Computational | no | yes |