PDE4B_HUMAN
Evidence for PS localization
Functions
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003067 | DOC_MAPK_JIP1_4 | DOC | 73 | 79 | - |
| ELMI003067 | DOC_MAPK_JIP1_4 | DOC | 73 | 79 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PDE4B_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 47.6190 | 4 | no |
| GO:0043169 | cation binding | 30.9524 | 4 | yes |
| GO:0046872 | metal ion binding | 30.9524 | 5 | yes |
| GO:0003779 | actin binding | 28.5714 | 4 | no |
| GO:0043168 | anion binding | 26.1905 | 4 | yes |
| GO:0000166 | nucleotide binding | 21.4286 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 21.4286 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 19.0476 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.0476 | 5 | yes |
| GO:0099106 | ion channel regulator activity | 9.5238 | 4 | yes |
| GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 7.1429 | 6 | yes |
| GO:0004114 | 3,5-cyclic-nucleotide phosphodiesterase activity | 7.1429 | 7 | yes |
| GO:0004115 | 3,5-cyclic-AMP phosphodiesterase activity | 7.1429 | 8 | yes |
| GO:0005246 | calcium channel regulator activity | 7.1429 | 5 | yes |
| GO:0008081 | phosphoric diester hydrolase activity | 7.1429 | 5 | yes |
| GO:0015631 | tubulin binding | 7.1429 | 4 | yes |
| GO:0030551 | cyclic nucleotide binding | 7.1429 | 5 | yes |
| GO:0030552 | cAMP binding | 7.1429 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 7.1429 | 4 | yes |
| GO:0043015 | gamma-tubulin binding | 4.7619 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PDE4B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.6190 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.6190 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.8571 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.4762 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.4762 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.4762 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.4762 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.4762 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.0952 | 4 | yes |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.9524 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.9524 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.9524 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.9524 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | yes |
| GO:0051049 | regulation of transport | 28.5714 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.1905 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.1905 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.1905 | 6 | yes |
| GO:0008104 | protein localization | 26.1905 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.1905 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 23.8095 | 7 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 21.4286 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 19.0476 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 19.0476 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 19.0476 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 19.0476 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 19.0476 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 19.0476 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 19.0476 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 16.6667 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 16.6667 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 16.6667 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 16.6667 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 14.2857 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 14.2857 | 6 | yes |
| GO:0044057 | regulation of system process | 14.2857 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 14.2857 | 5 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 14.2857 | 6 | yes |
| GO:0002684 | positive regulation of immune system process | 11.9048 | 4 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 11.9048 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 11.9048 | 7 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 11.9048 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 9.5238 | 4 | yes |
| GO:0001819 | positive regulation of cytokine production | 9.5238 | 5 | yes |
| GO:0006163 | purine nucleotide metabolic process | 9.5238 | 5 | yes |
| GO:0006195 | purine nucleotide catabolic process | 9.5238 | 6 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 9.5238 | 4 | yes |
| GO:0006942 | regulation of striated muscle contraction | 9.5238 | 7 | yes |
| GO:0008016 | regulation of heart contraction | 9.5238 | 6 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 9.5238 | 5 | yes |
| GO:0009117 | nucleotide metabolic process | 9.5238 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 9.5238 | 6 | yes |
| GO:0009154 | purine ribonucleotide catabolic process | 9.5238 | 6 | yes |
| GO:0009166 | nucleotide catabolic process | 9.5238 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 9.5238 | 5 | yes |
| GO:0009261 | ribonucleotide catabolic process | 9.5238 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 9.5238 | 4 | yes |
| GO:0032649 | regulation of type II interferon production | 9.5238 | 5 | yes |
| GO:0032729 | positive regulation of type II interferon production | 9.5238 | 6 | yes |
| GO:0046434 | organophosphate catabolic process | 9.5238 | 4 | yes |
| GO:0050776 | regulation of immune response | 9.5238 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 9.5238 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 9.5238 | 4 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 9.5238 | 7 | yes |
| GO:0072521 | purine-containing compound metabolic process | 9.5238 | 4 | yes |
| GO:0072523 | purine-containing compound catabolic process | 9.5238 | 5 | yes |
| GO:0086004 | regulation of cardiac muscle cell contraction | 9.5238 | 6 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 9.5238 | 4 | yes |
| GO:1901292 | nucleoside phosphate catabolic process | 9.5238 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 9.5238 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 9.5238 | 4 | yes |
| GO:1903115 | regulation of actin filament-based movement | 9.5238 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 9.5238 | 7 | yes |
| GO:1903522 | regulation of blood circulation | 9.5238 | 5 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 7.1429 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 7.1429 | 4 | yes |
| GO:0006198 | cAMP catabolic process | 7.1429 | 7 | yes |
| GO:0009187 | cyclic nucleotide metabolic process | 7.1429 | 6 | yes |
| GO:0009214 | cyclic nucleotide catabolic process | 7.1429 | 7 | yes |
| GO:0030593 | neutrophil chemotaxis | 7.1429 | 5 | yes |
| GO:0032663 | regulation of interleukin-2 production | 7.1429 | 5 | yes |
| GO:0032743 | positive regulation of interleukin-2 production | 7.1429 | 6 | yes |
| GO:0033993 | response to lipid | 7.1429 | 4 | yes |
| GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | 7.1429 | 6 | yes |
| GO:0046058 | cAMP metabolic process | 7.1429 | 7 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 7.1429 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 7.1429 | 6 | yes |
| GO:0052652 | cyclic purine nucleotide metabolic process | 7.1429 | 6 | yes |
| GO:0060326 | cell chemotaxis | 7.1429 | 4 | yes |
| GO:0071621 | granulocyte chemotaxis | 7.1429 | 4 | yes |
| GO:0071872 | cellular response to epinephrine stimulus | 7.1429 | 4 | yes |
| GO:0097530 | granulocyte migration | 7.1429 | 4 | yes |
| GO:1901077 | regulation of relaxation of muscle | 7.1429 | 6 | yes |
| GO:1901078 | negative regulation of relaxation of muscle | 7.1429 | 5 | yes |
| GO:1901897 | regulation of relaxation of cardiac muscle | 7.1429 | 7 | yes |
| GO:1901898 | negative regulation of relaxation of cardiac muscle | 7.1429 | 6 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 7.1429 | 8 | yes |
| GO:1990266 | neutrophil migration | 7.1429 | 5 | yes |
| GO:0002237 | response to molecule of bacterial origin | 4.7619 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 4.7619 | 4 | yes |
| GO:0071219 | cellular response to molecule of bacterial origin | 4.7619 | 4 | yes |
| GO:0071222 | cellular response to lipopolysaccharide | 4.7619 | 5 | yes |
| GO:0071396 | cellular response to lipid | 4.7619 | 5 | yes |
| GO:0071466 | cellular response to xenobiotic stimulus | 4.7619 | 4 | yes |
| GO:0071878 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway | 4.7619 | 8 | yes |
| GO:0106070 | regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway | 4.7619 | 6 | yes |
| GO:0106072 | negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway | 4.7619 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMUF2_HUMAN | [view interactions] | Low throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PDE4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| RCBT2_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C6B_HUMAN | [view interactions] | High throughput | no | no |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFRD1_HUMAN | [view interactions] | High throughput | no | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD11B_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN3_HUMAN | [view interactions] | High throughput | no | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI18_HUMAN | [view interactions] | High throughput | no | no |