Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPM4_HUMAN

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments . Binds calcium (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TPM4_HUMAN
GO:0043169 cation binding 33.7079 4 yes
GO:0046872 metal ion binding 33.7079 5 yes
GO:0003779 actin binding 30.3371 4 yes
GO:0043168 anion binding 29.2135 4 no
GO:0000166 nucleotide binding 24.7191 4 no
GO:0017076 purine nucleotide binding 24.7191 5 no
GO:0032555 purine ribonucleotide binding 23.5955 4 no
GO:0045296 cadherin binding 23.5955 4 no
GO:0019900 kinase binding 23.5955 4 no
GO:0019901 protein kinase binding 22.4719 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.3483 4 no
GO:0005509 calcium ion binding 14.6067 6 yes
GO:0042803 protein homodimerization activity 11.2360 4 yes
GO:0046982 protein heterodimerization activity 5.6180 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPM4_HUMAN
GO:0048522 positive regulation of cellular process 52.8090 4 no
GO:0048523 negative regulation of cellular process 52.8090 4 no
GO:0051128 regulation of cellular component organization 49.4382 4 no
GO:0060255 regulation of macromolecule metabolic process 48.3146 4 no
GO:0006996 organelle organization 47.1910 4 no
GO:0031323 regulation of cellular metabolic process 44.9438 4 no
GO:0080090 regulation of primary metabolic process 43.8202 4 no
GO:0009889 regulation of biosynthetic process 37.0787 4 no
GO:0031326 regulation of cellular biosynthetic process 37.0787 5 no
GO:0022607 cellular component assembly 37.0787 4 no
GO:0010468 regulation of gene expression 35.9551 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.9551 5 no
GO:0008104 protein localization 35.9551 4 no
GO:0010646 regulation of cell communication 34.8315 4 no
GO:0009966 regulation of signal transduction 32.5843 4 no
GO:0051246 regulation of protein metabolic process 31.4607 5 no
GO:0009893 positive regulation of metabolic process 31.4607 4 no
GO:0033043 regulation of organelle organization 31.4607 5 no
GO:0044087 regulation of cellular component biogenesis 30.3371 4 no
GO:0051049 regulation of transport 30.3371 4 no
GO:0007010 cytoskeleton organization 29.2135 5 no
GO:0031325 positive regulation of cellular metabolic process 29.2135 5 no
GO:0009892 negative regulation of metabolic process 28.0899 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.0899 5 no
GO:0051130 positive regulation of cellular component organization 28.0899 5 no
GO:0097435 supramolecular fiber organization 26.9663 4 yes
GO:0051129 negative regulation of cellular component organization 26.9663 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.8427 5 no
GO:1902531 regulation of intracellular signal transduction 25.8427 5 no
GO:0031324 negative regulation of cellular metabolic process 24.7191 5 no
GO:0007015 actin filament organization 23.5955 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.5955 5 no
GO:0051252 regulation of RNA metabolic process 22.4719 5 no
GO:0042981 regulation of apoptotic process 22.4719 5 no
GO:0043067 regulation of programmed cell death 22.4719 4 no
GO:0060341 regulation of cellular localization 22.4719 4 no
GO:0006355 regulation of DNA-templated transcription 21.3483 7 no
GO:0048584 positive regulation of response to stimulus 21.3483 4 no
GO:2001141 regulation of RNA biosynthetic process 21.3483 6 no
GO:0009891 positive regulation of biosynthetic process 21.3483 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.3483 6 no
GO:0031399 regulation of protein modification process 21.3483 6 no
GO:0051493 regulation of cytoskeleton organization 21.3483 6 no
GO:0030030 cell projection organization 21.3483 4 no
GO:0051050 positive regulation of transport 21.3483 4 no
GO:0023056 positive regulation of signaling 20.2247 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.2247 6 no
GO:0036211 protein modification process 20.2247 4 no
GO:0043412 macromolecule modification 20.2247 4 no
GO:0043933 protein-containing complex organization 20.2247 4 no
GO:0051247 positive regulation of protein metabolic process 20.2247 6 no
GO:0051240 positive regulation of multicellular organismal process 20.2247 4 no
GO:0071310 cellular response to organic substance 20.2247 4 no
GO:0006936 muscle contraction 5.6180 4 yes
GO:0001649 osteoblast differentiation 4.4944 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRIP6_HUMAN [view interactions] Low throughput no yes
TCRG1_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HACE1_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
STB5L_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
DPH1_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
APC13_HUMAN [view interactions] High throughput no no
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
MCM2_HUMAN [view interactions] High throughput no no
ZN131_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
PTN2_HUMAN [view interactions] High throughput no yes
PPM1M_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
RN181_HUMAN [view interactions] High throughput no no
R144A_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
ANDR_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
RM50_HUMAN [view interactions] High throughput no yes
LANC2_HUMAN [view entry] [view interactions] High throughput yes yes
HEM2_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
TRI26_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
FOLR1_HUMAN [view interactions] High throughput no no
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CDK7_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
DDX24_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RN207_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
SRXN1_HUMAN [view interactions] High throughput no no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
PSA6_HUMAN [view interactions] High throughput no yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
ST1A1_HUMAN [view interactions] High throughput no no
SERPH_HUMAN [view interactions] High throughput no no
ILF3_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
RU17_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
SRSF2_HUMAN [view interactions] High throughput no yes
CAVN3_HUMAN [view interactions] High throughput no no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
PRS7_HUMAN [view interactions] High throughput no yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SHOT1_HUMAN [view interactions] High throughput no no
SIR1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
OSTF1_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
AT5F1_HUMAN [view interactions] High throughput no yes
CENPE_HUMAN [view interactions] High throughput no no
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
MYH7B_HUMAN [view interactions] High throughput no no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
PSA1_HUMAN [view interactions] High throughput no yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
URP2_HUMAN [view interactions] High throughput no no
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
HMGB1_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
ACSL1_HUMAN [view interactions] High throughput no no
HDGF_HUMAN [view interactions] High throughput no yes
RBGP1_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
MFN2_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CATL1_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
CLC4D_HUMAN [view interactions] High throughput no no
ATF2_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
HDAC8_HUMAN [view interactions] High throughput no yes
PCDH7_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
FOXO1_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
HYOU1_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
SVIL_HUMAN [view interactions] High throughput no yes
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
TBCK_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
KBP_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CFA97_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
ACATN_HUMAN [view interactions] High throughput no yes
MAST3_HUMAN [view interactions] High throughput no yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
FL2D_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
HACD1_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
PPM1D_HUMAN [view interactions] High throughput no no
MPIP3_HUMAN [view interactions] High throughput no yes
PTCA_HUMAN [view interactions] High throughput no no
DUS7_HUMAN [view interactions] High throughput no yes
PPTC7_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
ILKAP_HUMAN [view interactions] High throughput no yes
DUS21_HUMAN [view interactions] High throughput no no
PHP14_HUMAN [view interactions] High throughput no yes
DUS12_HUMAN [view interactions] High throughput no no
PPR3C_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
ATF3_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
DYRK3_HUMAN [view interactions] High throughput no no
PIM3_HUMAN [view interactions] High throughput no no
AAKG2_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ELK3_HUMAN [view interactions] High throughput no yes
KLF10_HUMAN [view interactions] High throughput no no
IRF8_HUMAN [view interactions] High throughput no no
STA5B_HUMAN [view interactions] High throughput no yes
KLF3_HUMAN [view interactions] High throughput no yes
KLF12_HUMAN [view interactions] High throughput no yes
KLF6_HUMAN [view interactions] High throughput no yes
TEAD1_HUMAN [view interactions] High throughput no no
VSX1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
GATA4_HUMAN [view interactions] High throughput no no
ZIC3_HUMAN [view interactions] High throughput no no
SOX5_HUMAN [view interactions] High throughput no no
TLX1_HUMAN [view interactions] High throughput no no
NKX25_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
ASC_HUMAN [view interactions] High throughput no no
AAPK1_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
SNAPN_HUMAN [view interactions] High throughput no yes
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1A_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
FOS_HUMAN [view interactions] High throughput no yes
RON_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
NOD2_HUMAN [view interactions] High throughput no yes