Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPM4_HUMAN

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments . Binds calcium (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TPM4_HUMAN
GO:0003779 actin binding 36.3636 4 yes
GO:0046872 metal ion binding 29.8701 4 yes
GO:0045296 cadherin binding 24.6753 4 no
GO:0017076 purine nucleotide binding 23.3766 4 no
GO:0019900 kinase binding 22.0779 4 no
GO:0032555 purine ribonucleotide binding 22.0779 4 no
GO:0019901 protein kinase binding 20.7792 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.7792 4 no
GO:0042803 protein homodimerization activity 12.9870 4 yes
GO:0005509 calcium ion binding 11.6883 5 yes
GO:0046982 protein heterodimerization activity 6.4935 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPM4_HUMAN
GO:0048523 negative regulation of cellular process 55.8442 4 no
GO:0006996 organelle organization 54.5455 4 no
GO:0051128 regulation of cellular component organization 54.5455 4 no
GO:0048522 positive regulation of cellular process 51.9481 4 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0031323 regulation of cellular metabolic process 40.2597 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.2597 4 no
GO:0022607 cellular component assembly 40.2597 4 no
GO:0033043 regulation of organelle organization 38.9610 5 no
GO:0007010 cytoskeleton organization 36.3636 5 no
GO:0010646 regulation of cell communication 35.0649 4 no
GO:0008104 protein localization 35.0649 4 no
GO:0010468 regulation of gene expression 32.4675 5 no
GO:0051049 regulation of transport 32.4675 4 no
GO:0009966 regulation of signal transduction 32.4675 4 no
GO:0044087 regulation of cellular component biogenesis 32.4675 4 no
GO:0051246 regulation of protein metabolic process 32.4675 5 no
GO:0051130 positive regulation of cellular component organization 31.1688 5 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0097435 supramolecular fiber organization 27.2727 4 yes
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0051493 regulation of cytoskeleton organization 27.2727 6 no
GO:0010604 positive regulation of macromolecule metabolic process 25.9740 5 no
GO:0030030 cell projection organization 25.9740 4 no
GO:0007015 actin filament organization 24.6753 5 yes
GO:0036211 protein modification process 24.6753 4 no
GO:0043412 macromolecule modification 24.6753 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.6753 5 no
GO:0031324 negative regulation of cellular metabolic process 24.6753 5 no
GO:1902531 regulation of intracellular signal transduction 24.6753 5 no
GO:0009889 regulation of biosynthetic process 24.6753 4 no
GO:0031326 regulation of cellular biosynthetic process 24.6753 5 no
GO:1902903 regulation of supramolecular fiber organization 24.6753 5 no
GO:0032970 regulation of actin filament-based process 24.6753 4 no
GO:0060341 regulation of cellular localization 23.3766 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.3766 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.3766 5 no
GO:0051050 positive regulation of transport 23.3766 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.3766 5 no
GO:0051094 positive regulation of developmental process 22.0779 4 no
GO:0051240 positive regulation of multicellular organismal process 22.0779 4 no
GO:0010941 regulation of cell death 22.0779 4 no
GO:0042981 regulation of apoptotic process 22.0779 6 no
GO:0043067 regulation of programmed cell death 22.0779 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.0779 5 no
GO:0051252 regulation of RNA metabolic process 22.0779 5 no
GO:0032956 regulation of actin cytoskeleton organization 22.0779 5 no
GO:0010648 negative regulation of cell communication 20.7792 5 no
GO:0023057 negative regulation of signaling 20.7792 4 no
GO:0031399 regulation of protein modification process 20.7792 6 no
GO:0048585 negative regulation of response to stimulus 20.7792 4 no
GO:0031325 positive regulation of cellular metabolic process 20.7792 5 no
GO:1903506 regulation of nucleic acid-templated transcription 20.7792 7 no
GO:2001141 regulation of RNA biosynthetic process 20.7792 6 no
GO:0016192 vesicle-mediated transport 20.7792 4 no
GO:0110053 regulation of actin filament organization 20.7792 6 no
GO:0048584 positive regulation of response to stimulus 20.7792 4 no
GO:0006936 muscle contraction 7.7922 4 yes
GO:0001649 osteoblast differentiation 3.8961 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in TPM4_HUMAN
DOID:114 heart disease 3.8961 3 no
DOID:0080000 muscular disease 2.5974 3 no
DOID:3191 nemaline myopathy 2.5974 7 no
DOID:422 congenital structural myopathy 2.5974 6 no
DOID:423 myopathy 2.5974 5 no
DOID:66 muscle tissue disease 2.5974 4 no
DOID:574 peripheral nervous system disease 2.5974 3 no
DOID:870 neuropathy 2.5974 4 no
DOID:0050700 cardiomyopathy 2.5974 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5974 5 no
DOID:12930 dilated cardiomyopathy 2.5974 6 no
DOID:331 central nervous system disease 2.5974 3 no
DOID:1247 blood coagulation disease 2.5974 3 no
DOID:2218 blood platelet disease 2.5974 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRIP6_HUMAN [view interactions] Low throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
SRXN1_HUMAN [view interactions] High throughput no no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
PSA6_HUMAN [view interactions] High throughput no yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
ST1A1_HUMAN [view interactions] High throughput no no
SERPH_HUMAN [view interactions] High throughput no no
ILF3_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
RU17_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
SRSF2_HUMAN [view interactions] High throughput no yes
CAVN3_HUMAN [view interactions] High throughput no no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
PRS7_HUMAN [view interactions] High throughput no yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SHOT1_HUMAN [view interactions] High throughput no no
SIR1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
OSTF1_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
AT5F1_HUMAN [view interactions] High throughput no yes
CENPE_HUMAN [view interactions] High throughput no no
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
MYH7B_HUMAN [view interactions] High throughput no no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
PSA1_HUMAN [view interactions] High throughput no yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
URP2_HUMAN [view interactions] High throughput no no
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
UNK_HUMAN [view interactions] High throughput no yes
MFN2_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CATL1_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ATF2_HUMAN [view interactions] High throughput no yes
HDAC8_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
TBCK_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
KBP_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CFA97_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
ACATN_HUMAN [view interactions] High throughput no yes
MAST3_HUMAN [view interactions] High throughput no yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
FL2D_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
HACD1_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
PPM1D_HUMAN [view interactions] High throughput no no
MPIP3_HUMAN [view interactions] High throughput no yes
PTCA_HUMAN [view interactions] High throughput no no
DUS7_HUMAN [view interactions] High throughput no yes
PPTC7_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
ILKAP_HUMAN [view interactions] High throughput no yes
DUS21_HUMAN [view interactions] High throughput no no
PHP14_HUMAN [view interactions] High throughput no yes
DUS12_HUMAN [view interactions] High throughput no no
PPR3C_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
ATF3_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
DYRK3_HUMAN [view interactions] High throughput no no
PIM3_HUMAN [view interactions] High throughput no no
AAKG2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
KLF10_HUMAN [view interactions] High throughput no no
ELK3_HUMAN [view interactions] High throughput no yes
IRF8_HUMAN [view interactions] High throughput no no
STA5B_HUMAN [view interactions] High throughput no yes
VSX1_HUMAN [view interactions] High throughput no no
TEAD1_HUMAN [view interactions] High throughput no no
KLF6_HUMAN [view interactions] High throughput no yes
KLF12_HUMAN [view interactions] High throughput no yes
KLF3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
GATA4_HUMAN [view interactions] High throughput no no
ZIC3_HUMAN [view interactions] High throughput no no
SOX5_HUMAN [view interactions] High throughput no no
TLX1_HUMAN [view interactions] High throughput no no
NKX25_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
ASC_HUMAN [view interactions] High throughput no no
AAPK1_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
SNAPN_HUMAN [view interactions] High throughput no yes
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1A_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
FOS_HUMAN [view interactions] High throughput no yes
RON_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
NOD2_HUMAN [view interactions] High throughput no yes
TCRG1_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HACE1_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
STB5L_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
DPH1_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
APC13_HUMAN [view interactions] High throughput no no
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
MCM2_HUMAN [view interactions] High throughput no no
ZN131_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
PTN2_HUMAN [view interactions] High throughput no yes
PPM1M_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
RN181_HUMAN [view interactions] High throughput no no
R144A_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
NPC1_HUMAN [view interactions] High throughput no yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
ANDR_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
RM50_HUMAN [view interactions] High throughput no yes
LANC2_HUMAN [view entry] [view interactions] High throughput yes yes
HEM2_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
TRI26_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes