MFN2_HUMAN
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed, PubMed, PubMed, PubMed). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed). Overexpression induces the formation of mitochondrial networks (PubMed). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes . Plays an important role in the regulation of vascular smooth muscle cell proliferation . Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress . Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MFN2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 34.4262 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 32.7869 | 4 | yes |
GO:0031625 | ubiquitin protein ligase binding | 29.5082 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.5082 | 4 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 29.5082 | 4 | yes |
GO:0003723 | RNA binding | 27.8689 | 4 | no |
GO:0016462 | pyrophosphatase activity | 22.9508 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.9508 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.9508 | 6 | yes |
GO:0030554 | adenyl nucleotide binding | 21.3115 | 5 | no |
GO:0005525 | GTP binding | 14.7541 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 14.7541 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 14.7541 | 5 | yes |
GO:0003924 | GTPase activity | 13.1148 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MFN2_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 40.9836 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 37.7049 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 37.7049 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 37.7049 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.7049 | 4 | no |
GO:0048523 | negative regulation of cellular process | 36.0656 | 4 | yes |
GO:0010646 | regulation of cell communication | 32.7869 | 4 | yes |
GO:0022607 | cellular component assembly | 31.1475 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 31.1475 | 5 | no |
GO:0009966 | regulation of signal transduction | 29.5082 | 4 | yes |
GO:0010941 | regulation of cell death | 29.5082 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 29.5082 | 4 | no |
GO:0042981 | regulation of apoptotic process | 27.8689 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 27.8689 | 5 | yes |
GO:0061024 | membrane organization | 27.8689 | 4 | yes |
GO:0006508 | proteolysis | 27.8689 | 4 | no |
GO:0009057 | macromolecule catabolic process | 27.8689 | 4 | no |
GO:0051128 | regulation of cellular component organization | 26.2295 | 4 | no |
GO:0044265 | cellular macromolecule catabolic process | 26.2295 | 4 | no |
GO:0008104 | protein localization | 26.2295 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 24.5902 | 4 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 24.5902 | 5 | no |
GO:0071702 | organic substance transport | 22.9508 | 4 | yes |
GO:0071705 | nitrogen compound transport | 22.9508 | 4 | yes |
GO:0019941 | modification-dependent protein catabolic process | 22.9508 | 6 | no |
GO:0043632 | modification-dependent macromolecule catabolic process | 22.9508 | 5 | no |
GO:0007005 | mitochondrion organization | 22.9508 | 5 | yes |
GO:0015031 | protein transport | 21.3115 | 4 | yes |
GO:0033043 | regulation of organelle organization | 21.3115 | 5 | no |
GO:0031399 | regulation of protein modification process | 21.3115 | 6 | no |
GO:0051049 | regulation of transport | 21.3115 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 21.3115 | 4 | no |
GO:0006886 | intracellular protein transport | 21.3115 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 19.6721 | 5 | yes |
GO:0033365 | protein localization to organelle | 18.0328 | 5 | yes |
GO:0070585 | protein localization to mitochondrion | 16.3934 | 6 | yes |
GO:0006839 | mitochondrial transport | 16.3934 | 4 | yes |
GO:0072594 | establishment of protein localization to organelle | 14.7541 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 13.1148 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 13.1148 | 5 | yes |
GO:0023057 | negative regulation of signaling | 13.1148 | 4 | yes |
GO:0048284 | organelle fusion | 13.1148 | 5 | yes |
GO:0048585 | negative regulation of response to stimulus | 13.1148 | 4 | yes |
GO:0072655 | establishment of protein localization to mitochondrion | 13.1148 | 5 | yes |
GO:0006605 | protein targeting | 13.1148 | 5 | yes |
GO:0007006 | mitochondrial membrane organization | 13.1148 | 5 | yes |
GO:0010942 | positive regulation of cell death | 11.4754 | 5 | yes |
GO:0043065 | positive regulation of apoptotic process | 11.4754 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 11.4754 | 6 | yes |
GO:0006626 | protein targeting to mitochondrion | 11.4754 | 5 | yes |
GO:0006915 | apoptotic process | 11.4754 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 9.8361 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 9.8361 | 4 | yes |
GO:0006986 | response to unfolded protein | 9.8361 | 4 | yes |
GO:0008053 | mitochondrial fusion | 9.8361 | 6 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 8.1967 | 6 | yes |
GO:0008284 | positive regulation of cell population proliferation | 6.5574 | 5 | yes |
GO:0008285 | negative regulation of cell population proliferation | 6.5574 | 5 | yes |
GO:0046578 | regulation of Ras protein signal transduction | 4.9180 | 7 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 4.9180 | 6 | yes |
GO:0061734 | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization | 4.9180 | 8 | yes |
GO:0098779 | positive regulation of mitophagy in response to mitochondrial depolarization | 4.9180 | 7 | yes |
GO:0098780 | response to mitochondrial depolarisation | 4.9180 | 4 | yes |
GO:1904923 | regulation of autophagy of mitochondrion in response to mitochondrial depolarization | 4.9180 | 5 | yes |
GO:1904925 | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | 4.9180 | 6 | yes |
GO:0010660 | regulation of muscle cell apoptotic process | 3.2787 | 7 | yes |
GO:0010661 | positive regulation of muscle cell apoptotic process | 3.2787 | 8 | yes |
GO:0034391 | regulation of smooth muscle cell apoptotic process | 3.2787 | 8 | yes |
GO:0034393 | positive regulation of smooth muscle cell apoptotic process | 3.2787 | 9 | yes |
GO:0034497 | protein localization to phagophore assembly site | 3.2787 | 5 | yes |
GO:0046580 | negative regulation of Ras protein signal transduction | 3.2787 | 8 | yes |
GO:0048592 | eye morphogenesis | 3.2787 | 5 | yes |
GO:0048593 | camera-type eye morphogenesis | 3.2787 | 6 | yes |
GO:0048660 | regulation of smooth muscle cell proliferation | 3.2787 | 5 | yes |
GO:0048661 | positive regulation of smooth muscle cell proliferation | 3.2787 | 6 | yes |
GO:0048662 | negative regulation of smooth muscle cell proliferation | 3.2787 | 6 | yes |
GO:0051058 | negative regulation of small GTPase mediated signal transduction | 3.2787 | 7 | yes |
GO:0090596 | sensory organ morphogenesis | 3.2787 | 4 | yes |
GO:0120162 | positive regulation of cold-induced thermogenesis | 3.2787 | 4 | yes |
GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 3.2787 | 6 | yes |
GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | 3.2787 | 7 | yes |
GO:1905459 | regulation of vascular associated smooth muscle cell apoptotic process | 3.2787 | 9 | yes |
GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process | 3.2787 | 10 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in MFN2_HUMAN |
---|---|---|---|---|
DOID:574 | peripheral nervous system disease | 8.1967 | 3 | yes |
DOID:870 | neuropathy | 8.1967 | 4 | yes |
DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 4.9180 | 7 | yes |
DOID:10595 | Charcot-Marie-Tooth disease | 4.9180 | 6 | yes |
DOID:440 | neuromuscular disease | 4.9180 | 5 | yes |
DOID:700 | mitochondrial metabolism disease | 3.2787 | 3 | no |
DOID:1891 | optic nerve disease | 3.2787 | 6 | no |
DOID:5656 | cranial nerve disease | 3.2787 | 5 | no |
DOID:5723 | optic atrophy | 3.2787 | 7 | no |
DOID:0080068 | Charcot-Marie-Tooth disease type 6 | 3.2787 | 7 | yes |
DOID:0110155 | Charcot-Marie-Tooth disease type 2A2A | 3.2787 | 8 | yes |
DOID:0111557 | Charcot-Marie-Tooth disease type 2A2B | 3.2787 | 8 | yes |
DOID:0070329 | mitochondrial DNA depletion syndrome | 3.2787 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MARH5_HUMAN | [view interactions] | Low throughput | no | no |
TCHP_HUMAN | [view interactions] | Low throughput | no | yes |
E2AK3_HUMAN | [view interactions] | Low throughput | no | yes |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SAM50_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MFN1_HUMAN | [view interactions] | Low throughput | no | yes |
BAK_HUMAN | [view interactions] | Low throughput | no | no |
BAX_HUMAN | [view interactions] | Low throughput | no | yes |
MFN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK09_HUMAN | [view interactions] | Low throughput | no | yes |
HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
S2538_HUMAN | [view interactions] | Low throughput | no | yes |
S2546_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DIK2A_HUMAN | [view interactions] | Low throughput | no | yes |
NNRE_HUMAN | [view interactions] | Low throughput | no | yes |
GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VSIG1_HUMAN | [view interactions] | High throughput | no | no |
GHITM_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KDF1_HUMAN | [view interactions] | High throughput | no | yes |
EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
CP2CJ_HUMAN | [view interactions] | High throughput | no | no |
THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC018_HUMAN | [view interactions] | High throughput | no | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLPA_HUMAN | [view interactions] | High throughput | no | no |
TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTBL_HUMAN | [view interactions] | High throughput | no | no |
PUR8_HUMAN | [view interactions] | High throughput | no | yes |
AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CK049_HUMAN | [view interactions] | High throughput | no | yes |
CI072_HUMAN | [view interactions] | High throughput | no | no |
CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
CFA36_HUMAN | [view interactions] | High throughput | no | yes |
CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRBG3_HUMAN | [view interactions] | High throughput | no | no |
DIP2A_HUMAN | [view interactions] | High throughput | no | no |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLMN_HUMAN | [view interactions] | High throughput | no | no |
GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
IBTK_HUMAN | [view interactions] | High throughput | no | yes |
IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KBP_HUMAN | [view interactions] | High throughput | no | yes |
LARP4_HUMAN | [view interactions] | High throughput | no | yes |
LRC49_HUMAN | [view interactions] | High throughput | no | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
NAA15_HUMAN | [view interactions] | High throughput | no | yes |
NBR1_HUMAN | [view interactions] | High throughput | no | yes |
NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUDC_HUMAN | [view interactions] | High throughput | no | yes |
NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
OCRL_HUMAN | [view interactions] | High throughput | no | yes |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA1_HUMAN | [view interactions] | High throughput | no | yes |
PSA2_HUMAN | [view interactions] | High throughput | no | yes |
PSA3_HUMAN | [view interactions] | High throughput | no | no |
PSA5_HUMAN | [view interactions] | High throughput | no | yes |
PSA6_HUMAN | [view interactions] | High throughput | no | yes |
PSA7_HUMAN | [view interactions] | High throughput | no | yes |
PSB1_HUMAN | [view interactions] | High throughput | no | yes |
PSB3_HUMAN | [view interactions] | High throughput | no | yes |
PSB4_HUMAN | [view interactions] | High throughput | no | yes |
PSB5_HUMAN | [view interactions] | High throughput | no | yes |
PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB7_HUMAN | [view interactions] | High throughput | no | yes |
PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS7_HUMAN | [view interactions] | High throughput | no | yes |
PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
PRS8_HUMAN | [view interactions] | High throughput | no | yes |
PRS10_HUMAN | [view interactions] | High throughput | no | yes |
PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMCR8_HUMAN | [view interactions] | High throughput | no | yes |
SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
F10A1_HUMAN | [view interactions] | High throughput | no | yes |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TDRKH_HUMAN | [view interactions] | High throughput | no | no |
TM160_HUMAN | [view interactions] | High throughput | no | no |
TPGS1_HUMAN | [view interactions] | High throughput | no | no |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTC1_HUMAN | [view interactions] | High throughput | no | yes |
TTC4_HUMAN | [view interactions] | High throughput | no | yes |
TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VP13D_HUMAN | [view interactions] | High throughput | no | no |
WDR41_HUMAN | [view interactions] | High throughput | no | yes |
YKT6_HUMAN | [view interactions] | High throughput | no | yes |
ZZEF1_HUMAN | [view interactions] | High throughput | no | no |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
TFAM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MIRO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MFF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GDAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
B2CL1_HUMAN | [view interactions] | Computational | no | yes |
PSN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PACS2_HUMAN | [view interactions] | Computational | no | no |
RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MLP3B_HUMAN | [view interactions] | Computational | no | yes |
GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FIS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TOM20_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
OPA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLIN1_HUMAN | [view interactions] | Computational | no | no |
DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATG5_HUMAN | [view interactions] | Computational | no | no |
MTEF3_HUMAN | [view interactions] | Computational | no | no |
SIR1_HUMAN | [view interactions] | Computational | no | yes |
PARL_HUMAN | [view interactions] | Computational | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |