Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRB3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed, PubMed, PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine (PubMed). Plays an important role in somatosensation and in the production of antinociception . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRB3_HUMAN
GO:0005216 ion channel activity 50.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 50.0000 6 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0015276 ligand-gated ion channel activity 50.0000 5 yes
GO:0022824 transmitter-gated ion channel activity 50.0000 5 yes
GO:0022834 ligand-gated channel activity 50.0000 6 yes
GO:0022835 transmitter-gated channel activity 50.0000 4 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0005253 anion channel activity 42.8571 5 yes
GO:0005254 chloride channel activity 42.8571 6 yes
GO:0008509 anion transmembrane transporter activity 42.8571 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 42.8571 4 yes
GO:0015108 chloride transmembrane transporter activity 42.8571 5 yes
GO:0016917 GABA receptor activity 42.8571 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 42.8571 4 no
GO:0004890 GABA-A receptor activity 39.2857 5 yes
GO:0099095 ligand-gated anion channel activity 39.2857 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 39.2857 5 no
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 39.2857 6 no
GO:0022851 GABA-gated chloride ion channel activity 35.7143 5 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 28.5714 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRB3_HUMAN
GO:0007268 chemical synaptic transmission 64.2857 6 yes
GO:0098916 anterograde trans-synaptic signaling 64.2857 5 yes
GO:0099537 trans-synaptic signaling 64.2857 4 yes
GO:0006811 ion transport 50.0000 4 yes
GO:0022607 cellular component assembly 46.4286 4 yes
GO:0006820 anion transport 42.8571 5 yes
GO:0006821 chloride transport 42.8571 7 yes
GO:0015698 inorganic anion transport 42.8571 6 yes
GO:0098656 anion transmembrane transport 42.8571 4 yes
GO:0098660 inorganic ion transmembrane transport 42.8571 4 yes
GO:0098661 inorganic anion transmembrane transport 42.8571 5 yes
GO:1902476 chloride transmembrane transport 42.8571 6 yes
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0010646 regulation of cell communication 39.2857 4 no
GO:0048522 positive regulation of cellular process 39.2857 4 no
GO:0009966 regulation of signal transduction 35.7143 4 no
GO:0034330 cell junction organization 32.1429 4 yes
GO:0010243 response to organonitrogen compound 28.5714 4 yes
GO:0034329 cell junction assembly 28.5714 5 yes
GO:0071310 cellular response to organic substance 28.5714 4 yes
GO:0051049 regulation of transport 28.5714 4 no
GO:0050808 synapse organization 25.0000 5 yes
GO:0071417 cellular response to organonitrogen compound 25.0000 4 yes
GO:1901699 cellular response to nitrogen compound 25.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0051932 synaptic transmission, GABAergic 25.0000 7 no
GO:0060078 regulation of postsynaptic membrane potential 25.0000 4 no
GO:0007416 synapse assembly 21.4286 6 yes
GO:0014070 response to organic cyclic compound 21.4286 4 yes
GO:0071407 cellular response to organic cyclic compound 21.4286 5 yes
GO:1904862 inhibitory synapse assembly 21.4286 7 yes
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0050804 modulation of chemical synaptic transmission 21.4286 5 no
GO:0099177 regulation of trans-synaptic signaling 21.4286 4 no
GO:0006996 organelle organization 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 5 no
GO:0010941 regulation of cell death 21.4286 4 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0031323 regulation of cellular metabolic process 21.4286 4 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0051171 regulation of nitrogen compound metabolic process 21.4286 4 no
GO:0080090 regulation of primary metabolic process 21.4286 4 no
GO:0051128 regulation of cellular component organization 21.4286 4 no
GO:0034776 response to histamine 17.8571 5 yes
GO:0071420 cellular response to histamine 17.8571 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CUL1_HUMAN [view interactions] Low throughput no yes
NGEF_HUMAN [view entry] [view interactions] Low throughput yes yes
KCD12_HUMAN [view entry] [view interactions] Low throughput yes no
MFN2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
RACK1_HUMAN [view interactions] Low throughput no yes
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRA5_HUMAN [view entry] [view interactions] Low throughput yes no
GBRD_HUMAN [view entry] [view interactions] Low throughput yes yes
BIG2_HUMAN [view entry] [view interactions] Low throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
HAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA4_HUMAN [view entry] [view interactions] Low throughput yes no
UBQL1_HUMAN [view interactions] Low throughput no yes
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA2_HUMAN [view entry] [view interactions] Low throughput yes no
MEOX2_HUMAN [view interactions] High throughput no no
MCLN3_HUMAN [view interactions] High throughput no no
GBRB2_HUMAN [view entry] [view interactions] High throughput yes no
GBRA6_HUMAN [view entry] [view interactions] High throughput yes no
ASIC4_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
GLRA3_HUMAN [view entry] [view interactions] High throughput yes no
ACHB4_HUMAN [view entry] [view interactions] High throughput yes no
OTUD4_HUMAN [view interactions] High throughput no yes
GABR2_HUMAN [view entry] [view interactions] Computational yes yes
GBRB1_HUMAN [view entry] [view interactions] Computational yes no