GBRB3_HUMAN
Evidence for PS localization
Functions
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed, PubMed, PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine (PubMed). Plays an important role in somatosensation and in the production of antinociception . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRB3_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 46.4286 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 46.4286 | 6 | yes |
| GO:0015267 | channel activity | 46.4286 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 46.4286 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 46.4286 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 46.4286 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 46.4286 | 4 | yes |
| GO:0022836 | gated channel activity | 46.4286 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 42.8571 | 4 | no |
| GO:0005253 | monoatomic anion channel activity | 39.2857 | 5 | yes |
| GO:0005254 | chloride channel activity | 39.2857 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 39.2857 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 39.2857 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 39.2857 | 5 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 39.2857 | 5 | no |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 39.2857 | 6 | no |
| GO:0004890 | GABA-A receptor activity | 35.7143 | 5 | yes |
| GO:0016917 | GABA receptor activity | 35.7143 | 4 | yes |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 35.7143 | 6 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 32.1429 | 6 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated monoatomic ion channel activity | 25.0000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRB3_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 53.5714 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 53.5714 | 6 | yes |
| GO:0099536 | synaptic signaling | 53.5714 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 53.5714 | 5 | yes |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0006811 | monoatomic ion transport | 46.4286 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 46.4286 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0006820 | monoatomic anion transport | 39.2857 | 5 | yes |
| GO:0006821 | chloride transport | 39.2857 | 5 | yes |
| GO:0015698 | inorganic anion transport | 39.2857 | 4 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 39.2857 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 39.2857 | 4 | yes |
| GO:1902476 | chloride transmembrane transport | 39.2857 | 5 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 35.7143 | 4 | yes |
| GO:0034330 | cell junction organization | 35.7143 | 4 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 35.7143 | 8 | yes |
| GO:0048523 | negative regulation of cellular process | 35.7143 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.7143 | 5 | no |
| GO:0034329 | cell junction assembly | 32.1429 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:0050808 | synapse organization | 25.0000 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0060078 | regulation of postsynaptic membrane potential | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0007416 | synapse assembly | 21.4286 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 21.4286 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 21.4286 | 4 | yes |
| GO:1904862 | inhibitory synapse assembly | 21.4286 | 7 | yes |
| GO:0008104 | protein localization | 21.4286 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.4286 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.4286 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.4286 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 14.2857 | 4 | yes |
| GO:0034776 | response to histamine | 14.2857 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 14.2857 | 5 | yes |
| GO:0071420 | cellular response to histamine | 14.2857 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CUL1_HUMAN | [view interactions] | Low throughput | no | yes |
| NGEF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MFN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| GBRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLRA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |