GBRD_HUMAN
Evidence for PS localization
Functions
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRD_HUMAN |
|---|---|---|---|---|
| GO:0004890 | GABA-A receptor activity | 75.0000 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 75.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 75.0000 | 6 | yes |
| GO:0005253 | monoatomic anion channel activity | 75.0000 | 5 | yes |
| GO:0005254 | chloride channel activity | 75.0000 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 75.0000 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 75.0000 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 75.0000 | 5 | yes |
| GO:0015267 | channel activity | 75.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 75.0000 | 5 | yes |
| GO:0016917 | GABA receptor activity | 75.0000 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 75.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 75.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 75.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 75.0000 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 50.0000 | 6 | no |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 50.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRD_HUMAN |
|---|---|---|---|---|
| GO:0006811 | monoatomic ion transport | 75.0000 | 4 | yes |
| GO:0006820 | monoatomic anion transport | 75.0000 | 5 | yes |
| GO:0006821 | chloride transport | 75.0000 | 5 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 75.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 75.0000 | 7 | yes |
| GO:0015698 | inorganic anion transport | 75.0000 | 4 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 75.0000 | 8 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 75.0000 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 75.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 75.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 75.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 75.0000 | 5 | yes |
| GO:1902476 | chloride transmembrane transport | 75.0000 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
| GO:0034329 | cell junction assembly | 50.0000 | 5 | no |
| GO:0034330 | cell junction organization | 50.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 50.0000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 50.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 50.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GBRA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATF6A_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| RN115_HUMAN | [view interactions] | High throughput | no | yes |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| CCR8_HUMAN | [view interactions] | High throughput | no | no |
| ETS2_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| ST7L_HUMAN | [view interactions] | High throughput | no | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| BRI3B_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| A1AG1_HUMAN | [view interactions] | High throughput | no | no |
| TM201_HUMAN | [view interactions] | High throughput | no | no |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |