Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRD_HUMAN
GO:0008509 anion transmembrane transporter activity 83.3333 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 83.3333 4 yes
GO:0015108 chloride transmembrane transporter activity 83.3333 5 yes
GO:0004890 GABA-A receptor activity 66.6667 5 yes
GO:0005216 ion channel activity 66.6667 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 66.6667 6 yes
GO:0005253 anion channel activity 66.6667 5 yes
GO:0005254 chloride channel activity 66.6667 6 yes
GO:0015267 channel activity 66.6667 4 yes
GO:0015276 ligand-gated ion channel activity 66.6667 5 yes
GO:0016917 GABA receptor activity 66.6667 4 yes
GO:0022824 transmitter-gated ion channel activity 66.6667 5 yes
GO:0022834 ligand-gated channel activity 66.6667 6 yes
GO:0022835 transmitter-gated channel activity 66.6667 4 yes
GO:0022836 gated channel activity 66.6667 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 50.0000 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 50.0000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 50.0000 6 yes
GO:0022851 GABA-gated chloride ion channel activity 50.0000 5 no
GO:0099095 ligand-gated anion channel activity 50.0000 6 no
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 33.3333 7 no
GO:0008503 benzodiazepine receptor activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRD_HUMAN
GO:0006811 ion transport 83.3333 4 yes
GO:0006820 anion transport 83.3333 5 yes
GO:0006821 chloride transport 83.3333 7 yes
GO:0007268 chemical synaptic transmission 83.3333 6 yes
GO:0015698 inorganic anion transport 83.3333 6 yes
GO:0098656 anion transmembrane transport 83.3333 4 yes
GO:0098660 inorganic ion transmembrane transport 83.3333 4 yes
GO:0098661 inorganic anion transmembrane transport 83.3333 5 yes
GO:0098916 anterograde trans-synaptic signaling 83.3333 5 yes
GO:0099537 trans-synaptic signaling 83.3333 4 yes
GO:1902476 chloride transmembrane transport 83.3333 6 yes
GO:0010243 response to organonitrogen compound 50.0000 4 no
GO:0034330 cell junction organization 50.0000 4 no
GO:0051932 synaptic transmission, GABAergic 33.3333 7 no
GO:0060078 regulation of postsynaptic membrane potential 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0034329 cell junction assembly 33.3333 5 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0050808 synapse organization 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRA4_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
RN115_HUMAN [view interactions] High throughput no yes
DNJB9_HUMAN [view interactions] High throughput no yes
DJC18_HUMAN [view interactions] High throughput no yes
FUT8_HUMAN [view interactions] High throughput no yes
TTC17_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
ATF6A_HUMAN [view interactions] High throughput no yes
RAB13_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL4_HUMAN [view interactions] High throughput no yes
NT2NA_HUMAN [view interactions] High throughput no no
UBQL1_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
CCR8_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
ST7L_HUMAN [view interactions] High throughput no no
TUSC3_HUMAN [view interactions] High throughput no yes
CCPG1_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
BRI3B_HUMAN [view interactions] High throughput no yes
UBAC2_HUMAN [view interactions] High throughput no yes
A1AG1_HUMAN [view interactions] High throughput no no
TM201_HUMAN [view interactions] High throughput no no
GET4_HUMAN [view interactions] High throughput no yes
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
SC6A1_HUMAN [view entry] [view interactions] Computational yes no
CLCN2_HUMAN [view interactions] Computational no yes