Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRA4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRA4_HUMAN
GO:0016917 GABA receptor activity 64.2857 4 yes
GO:0022835 transmitter-gated channel activity 57.1429 4 yes
GO:0022836 gated channel activity 57.1429 5 yes
GO:0004890 GABA-A receptor activity 57.1429 5 yes
GO:0005216 ion channel activity 57.1429 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 57.1429 6 yes
GO:0005253 anion channel activity 57.1429 5 yes
GO:0005254 chloride channel activity 57.1429 6 yes
GO:0008509 anion transmembrane transporter activity 57.1429 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 57.1429 4 yes
GO:0015108 chloride transmembrane transporter activity 57.1429 5 yes
GO:0015267 channel activity 57.1429 4 yes
GO:0015276 ligand-gated ion channel activity 57.1429 5 yes
GO:0022824 transmitter-gated ion channel activity 57.1429 5 yes
GO:0022834 ligand-gated channel activity 57.1429 6 yes
GO:0022851 GABA-gated chloride ion channel activity 50.0000 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 50.0000 4 yes
GO:0099095 ligand-gated anion channel activity 50.0000 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 50.0000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 50.0000 6 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 42.8571 7 yes
GO:0017076 purine nucleotide binding 28.5714 4 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0046872 metal ion binding 28.5714 4 no
GO:0008503 benzodiazepine receptor activity 28.5714 4 yes
GO:0005524 ATP binding 21.4286 5 no
GO:0030554 adenyl nucleotide binding 21.4286 5 no
GO:0032559 adenyl ribonucleotide binding 21.4286 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRA4_HUMAN
GO:0007268 chemical synaptic transmission 71.4286 6 yes
GO:0098916 anterograde trans-synaptic signaling 71.4286 5 yes
GO:0099537 trans-synaptic signaling 71.4286 4 yes
GO:0006811 ion transport 64.2857 4 yes
GO:0006820 anion transport 57.1429 5 yes
GO:0006821 chloride transport 57.1429 7 yes
GO:0015698 inorganic anion transport 57.1429 6 yes
GO:0098656 anion transmembrane transport 57.1429 4 yes
GO:0098660 inorganic ion transmembrane transport 57.1429 4 yes
GO:0098661 inorganic anion transmembrane transport 57.1429 5 yes
GO:1902476 chloride transmembrane transport 57.1429 6 yes
GO:0051932 synaptic transmission, GABAergic 42.8571 7 yes
GO:0060078 regulation of postsynaptic membrane potential 42.8571 4 yes
GO:0034330 cell junction organization 35.7143 4 no
GO:0050808 synapse organization 35.7143 5 no
GO:0007416 synapse assembly 28.5714 6 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0034329 cell junction assembly 28.5714 5 no
GO:0060255 regulation of macromolecule metabolic process 21.4286 4 no
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 no
GO:0080090 regulation of primary metabolic process 21.4286 4 no
GO:0010646 regulation of cell communication 21.4286 4 no
GO:0050804 modulation of chemical synaptic transmission 21.4286 5 no
GO:0099177 regulation of trans-synaptic signaling 21.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010941 regulation of cell death 21.4286 4 no
GO:0014070 response to organic cyclic compound 21.4286 4 no
GO:0036211 protein modification process 21.4286 4 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0043523 regulation of neuron apoptotic process 21.4286 6 no
GO:0048523 negative regulation of cellular process 21.4286 4 no
GO:0050890 cognition 21.4286 4 no
GO:0060548 negative regulation of cell death 21.4286 5 no
GO:1901214 regulation of neuron death 21.4286 5 no
GO:1901215 negative regulation of neuron death 21.4286 6 no
GO:1904862 inhibitory synapse assembly 21.4286 7 no
GO:0009893 positive regulation of metabolic process 21.4286 4 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.4286 5 no
GO:0016192 vesicle-mediated transport 21.4286 4 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0031323 regulation of cellular metabolic process 21.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0042176 regulation of protein catabolic process 21.4286 5 no
GO:0048522 positive regulation of cellular process 21.4286 4 no
GO:0051049 regulation of transport 21.4286 4 no
GO:0051171 regulation of nitrogen compound metabolic process 21.4286 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0051246 regulation of protein metabolic process 21.4286 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
GBRD_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
DGAT1_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
UBQL1_HUMAN [view interactions] Computational no yes
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
GBRAP_HUMAN [view interactions] Computational no no
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
GBRA5_HUMAN [view entry] [view interactions] Computational yes no
GBRA3_HUMAN [view entry] [view interactions] Computational yes yes
NSF_HUMAN [view entry] [view interactions] Computational yes yes
GABR2_HUMAN [view entry] [view interactions] Computational yes yes
GEPH_HUMAN [view entry] [view interactions] Computational yes yes