ACHB4_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHB4_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 66.6667 | 4 | yes |
| GO:0015267 | channel activity | 66.6667 | 4 | yes |
| GO:0022836 | gated channel activity | 66.6667 | 5 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 61.9048 | 6 | yes |
| GO:0008324 | cation transmembrane transporter activity | 61.9048 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 61.9048 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 61.9048 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 61.9048 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 61.9048 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 61.9048 | 4 | yes |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 57.1429 | 7 | yes |
| GO:0005261 | cation channel activity | 57.1429 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 57.1429 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 57.1429 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 57.1429 | 6 | yes |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | 52.3810 | 7 | yes |
| GO:0099094 | ligand-gated cation channel activity | 52.3810 | 6 | yes |
| GO:0015464 | acetylcholine receptor activity | 42.8571 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHB4_HUMAN |
|---|---|---|---|---|
| GO:0006811 | ion transport | 76.1905 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 61.9048 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 61.9048 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 61.9048 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
| GO:0051049 | regulation of transport | 47.6190 | 4 | yes |
| GO:0051899 | membrane depolarization | 47.6190 | 4 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 42.8571 | 7 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 42.8571 | 5 | yes |
| GO:0051046 | regulation of secretion | 42.8571 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 42.8571 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 42.8571 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 38.0952 | 4 | yes |
| GO:0035095 | behavioral response to nicotine | 28.5714 | 4 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 28.5714 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 28.5714 | 5 | yes |
| GO:0044057 | regulation of system process | 23.8095 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 23.8095 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 23.8095 | 4 | no |
| GO:0043269 | regulation of ion transport | 23.8095 | 5 | no |
| GO:0006812 | cation transport | 23.8095 | 5 | no |
| GO:0030001 | metal ion transport | 23.8095 | 6 | no |
| GO:0030030 | cell projection organization | 23.8095 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.8095 | 4 | no |
| GO:0007274 | neuromuscular synaptic transmission | 19.0476 | 7 | yes |
| GO:0010647 | positive regulation of cell communication | 19.0476 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 19.0476 | 4 | yes |
| GO:0060084 | synaptic transmission involved in micturition | 19.0476 | 8 | yes |
| GO:0001508 | action potential | 14.2857 | 4 | yes |
| GO:0006936 | muscle contraction | 14.2857 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 14.2857 | 6 | yes |
| GO:0006939 | smooth muscle contraction | 14.2857 | 5 | yes |
| GO:0006940 | regulation of smooth muscle contraction | 14.2857 | 7 | yes |
| GO:0031644 | regulation of nervous system process | 14.2857 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 14.2857 | 5 | yes |
| GO:0031646 | positive regulation of nervous system process | 9.5238 | 5 | yes |
| GO:0051969 | regulation of transmission of nerve impulse | 9.5238 | 4 | yes |
| GO:0051971 | positive regulation of transmission of nerve impulse | 9.5238 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| LYPD6_HUMAN | [view interactions] | High throughput | no | no |
| LYNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| RHBD3_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST2_HUMAN | [view interactions] | High throughput | no | no |
| ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN215_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| GP1BB_HUMAN | [view interactions] | High throughput | no | no |
| TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| ICAM4_HUMAN | [view interactions] | High throughput | no | no |
| PIGB_HUMAN | [view interactions] | High throughput | no | yes |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| TPSN_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| SPAG4_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP1_HUMAN | [view interactions] | High throughput | no | no |
| MFAP3_HUMAN | [view interactions] | High throughput | no | yes |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| GPHRA_HUMAN | [view interactions] | High throughput | no | no |
| C1QRF_HUMAN | [view interactions] | High throughput | no | no |
| ADCY3_HUMAN | [view interactions] | High throughput | no | yes |
| TM87B_HUMAN | [view interactions] | High throughput | no | yes |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM1_HUMAN | [view interactions] | High throughput | no | yes |
| GLT12_HUMAN | [view interactions] | High throughput | no | yes |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| SGCB_HUMAN | [view interactions] | High throughput | no | no |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM59L_HUMAN | [view interactions] | High throughput | no | yes |
| D19L4_HUMAN | [view interactions] | High throughput | no | no |
| GLRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEM4F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| MA1A2_HUMAN | [view interactions] | High throughput | no | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| MIB2_HUMAN | [view interactions] | High throughput | no | yes |
| AT133_HUMAN | [view interactions] | High throughput | no | yes |
| HLAF_HUMAN | [view interactions] | High throughput | no | no |
| FKB14_HUMAN | [view interactions] | High throughput | no | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SELT_HUMAN | [view interactions] | High throughput | no | yes |
| AT132_HUMAN | [view interactions] | High throughput | no | yes |
| LMF1_HUMAN | [view interactions] | High throughput | no | no |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| GL8D2_HUMAN | [view interactions] | High throughput | no | yes |
| ALG9_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACHA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PSA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACHA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACHA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACHB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |