Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHB4_HUMAN

GO
G2C
SynaptomeDB

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHB4_HUMAN
GO:0005216 monoatomic ion channel activity 62.5000 4 yes
GO:0015267 channel activity 62.5000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 62.5000 5 yes
GO:0022834 ligand-gated channel activity 62.5000 6 yes
GO:0022836 gated channel activity 62.5000 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 56.2500 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 50.0000 6 yes
GO:0005261 monoatomic cation channel activity 50.0000 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 50.0000 5 yes
GO:0022835 transmitter-gated channel activity 50.0000 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 50.0000 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 43.7500 7 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 43.7500 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 43.7500 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 43.7500 6 yes
GO:0043169 cation binding 43.7500 4 no
GO:0015464 acetylcholine receptor activity 37.5000 4 yes
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 37.5000 7 yes
GO:0043168 anion binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACHB4_HUMAN
GO:0006811 monoatomic ion transport 62.5000 4 yes
GO:0098916 anterograde trans-synaptic signaling 56.2500 6 yes
GO:0099536 synaptic signaling 56.2500 4 yes
GO:0099537 trans-synaptic signaling 56.2500 5 yes
GO:0007268 chemical synaptic transmission 56.2500 7 yes
GO:0010646 regulation of cell communication 43.7500 4 yes
GO:0048522 positive regulation of cellular process 43.7500 4 yes
GO:0007271 synaptic transmission, cholinergic 43.7500 8 yes
GO:0035095 behavioral response to nicotine 37.5000 4 yes
GO:0051049 regulation of transport 37.5000 4 yes
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 yes
GO:0051046 regulation of secretion 31.2500 5 yes
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 yes
GO:1903530 regulation of secretion by cell 31.2500 4 yes
GO:0006812 monoatomic cation transport 31.2500 5 no
GO:0030001 metal ion transport 31.2500 6 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:0060084 synaptic transmission involved in micturition 25.0000 9 yes
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0001508 action potential 25.0000 4 yes
GO:0007274 neuromuscular synaptic transmission 25.0000 8 yes
GO:0010647 positive regulation of cell communication 18.7500 5 yes
GO:0019228 neuronal action potential 18.7500 5 yes
GO:0044057 regulation of system process 18.7500 4 yes
GO:0046928 regulation of neurotransmitter secretion 18.7500 5 yes
GO:0051588 regulation of neurotransmitter transport 18.7500 5 yes
GO:0090257 regulation of muscle system process 18.7500 5 yes
GO:0006936 muscle contraction 18.7500 4 yes
GO:0006937 regulation of muscle contraction 18.7500 6 yes
GO:0006939 smooth muscle contraction 18.7500 5 yes
GO:0006940 regulation of smooth muscle contraction 18.7500 7 yes
GO:0031644 regulation of nervous system process 12.5000 5 yes
GO:0031646 positive regulation of nervous system process 12.5000 5 yes
GO:0051969 regulation of transmission of nerve impulse 12.5000 5 yes
GO:0051971 positive regulation of transmission of nerve impulse 12.5000 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA4_HUMAN [view entry] [view interactions] Low throughput yes no
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA5_HUMAN [view entry] [view interactions] Low throughput yes yes
ACHA3_HUMAN [view entry] [view interactions] Low throughput yes no
ACHB4_HUMAN [view entry] [view interactions] Low throughput yes no
UBQL1_HUMAN [view interactions] Low throughput no yes
LYPD6_HUMAN [view interactions] High throughput no no
LYNX1_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
ABHEA_HUMAN [view interactions] High throughput no yes
RHBD3_HUMAN [view interactions] High throughput no yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
SEC20_HUMAN [view interactions] High throughput no yes
H6ST2_HUMAN [view interactions] High throughput no no
ANO6_HUMAN [view entry] [view interactions] High throughput yes no
RN215_HUMAN [view interactions] High throughput no yes
SPP2B_HUMAN [view interactions] High throughput no yes
DNJB9_HUMAN [view interactions] High throughput no yes
PLD6_HUMAN [view interactions] High throughput no yes
GP1BB_HUMAN [view interactions] High throughput no no
TMM9B_HUMAN [view interactions] High throughput no yes
ASTRA_HUMAN [view interactions] High throughput no no
ICAM4_HUMAN [view interactions] High throughput no no
PIGB_HUMAN [view interactions] High throughput no yes
UD3A2_HUMAN [view interactions] High throughput no no
TPSN_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
PANX1_HUMAN [view interactions] High throughput no no
SPAG4_HUMAN [view interactions] High throughput no no
GOLI_HUMAN [view interactions] High throughput no yes
PGAP1_HUMAN [view interactions] High throughput no no
MFAP3_HUMAN [view interactions] High throughput no yes
AT12A_HUMAN [view entry] [view interactions] High throughput yes no
SIDT2_HUMAN [view interactions] High throughput no yes
GPHRA_HUMAN [view interactions] High throughput no no
C1QRF_HUMAN [view interactions] High throughput no no
ADCY3_HUMAN [view interactions] High throughput no yes
TM87B_HUMAN [view interactions] High throughput no yes
TTC17_HUMAN [view interactions] High throughput no yes
CNNM1_HUMAN [view interactions] High throughput no yes
GLT12_HUMAN [view interactions] High throughput no yes
LEMD2_HUMAN [view interactions] High throughput no yes
E2AK3_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
LSR_HUMAN [view interactions] High throughput no yes
SGCB_HUMAN [view interactions] High throughput no no
TMTC3_HUMAN [view interactions] High throughput no yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
TM59L_HUMAN [view interactions] High throughput no yes
D19L4_HUMAN [view interactions] High throughput no no
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
SEM4F_HUMAN [view entry] [view interactions] High throughput yes no
TUSC3_HUMAN [view interactions] High throughput no yes
MA1A2_HUMAN [view interactions] High throughput no yes
AGRE5_HUMAN [view interactions] High throughput no no
ERMP1_HUMAN [view interactions] High throughput no no
MIB2_HUMAN [view entry] [view interactions] High throughput yes yes
AT133_HUMAN [view interactions] High throughput no yes
HLAF_HUMAN [view interactions] High throughput no no
FKB14_HUMAN [view interactions] High throughput no yes
GBRB3_HUMAN [view entry] [view interactions] High throughput yes no
SELT_HUMAN [view interactions] High throughput no yes
AT132_HUMAN [view interactions] High throughput no yes
LMF1_HUMAN [view interactions] High throughput no no
TM39A_HUMAN [view interactions] High throughput no yes
GL8D2_HUMAN [view interactions] High throughput no yes
ALG9_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
PCDGL_HUMAN [view interactions] High throughput no no
LMF2_HUMAN [view interactions] High throughput no yes