ACHB4_HUMAN
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACHB4_HUMAN |
---|---|---|---|---|
GO:0005216 | monoatomic ion channel activity | 62.5000 | 4 | yes |
GO:0015267 | channel activity | 62.5000 | 4 | yes |
GO:0015276 | ligand-gated monoatomic ion channel activity | 62.5000 | 5 | yes |
GO:0022834 | ligand-gated channel activity | 62.5000 | 6 | yes |
GO:0022836 | gated channel activity | 62.5000 | 5 | yes |
GO:0008324 | monoatomic cation transmembrane transporter activity | 56.2500 | 4 | yes |
GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 6 | yes |
GO:0005261 | monoatomic cation channel activity | 50.0000 | 5 | yes |
GO:0022824 | transmitter-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
GO:0099094 | ligand-gated monoatomic cation channel activity | 50.0000 | 6 | yes |
GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 43.7500 | 7 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 43.7500 | 4 | yes |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 43.7500 | 5 | yes |
GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 43.7500 | 6 | yes |
GO:0043169 | cation binding | 43.7500 | 4 | no |
GO:0015464 | acetylcholine receptor activity | 37.5000 | 4 | yes |
GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 37.5000 | 7 | yes |
GO:0043168 | anion binding | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACHB4_HUMAN |
---|---|---|---|---|
GO:0006811 | monoatomic ion transport | 62.5000 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 56.2500 | 6 | yes |
GO:0099536 | synaptic signaling | 56.2500 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 56.2500 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 56.2500 | 7 | yes |
GO:0010646 | regulation of cell communication | 43.7500 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | yes |
GO:0007271 | synaptic transmission, cholinergic | 43.7500 | 8 | yes |
GO:0035095 | behavioral response to nicotine | 37.5000 | 4 | yes |
GO:0051049 | regulation of transport | 37.5000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 31.2500 | 5 | yes |
GO:0051046 | regulation of secretion | 31.2500 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 31.2500 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 31.2500 | 4 | yes |
GO:0006812 | monoatomic cation transport | 31.2500 | 5 | no |
GO:0030001 | metal ion transport | 31.2500 | 6 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | yes |
GO:0060084 | synaptic transmission involved in micturition | 25.0000 | 9 | yes |
GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
GO:0001508 | action potential | 25.0000 | 4 | yes |
GO:0007274 | neuromuscular synaptic transmission | 25.0000 | 8 | yes |
GO:0010647 | positive regulation of cell communication | 18.7500 | 5 | yes |
GO:0019228 | neuronal action potential | 18.7500 | 5 | yes |
GO:0044057 | regulation of system process | 18.7500 | 4 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 18.7500 | 5 | yes |
GO:0051588 | regulation of neurotransmitter transport | 18.7500 | 5 | yes |
GO:0090257 | regulation of muscle system process | 18.7500 | 5 | yes |
GO:0006936 | muscle contraction | 18.7500 | 4 | yes |
GO:0006937 | regulation of muscle contraction | 18.7500 | 6 | yes |
GO:0006939 | smooth muscle contraction | 18.7500 | 5 | yes |
GO:0006940 | regulation of smooth muscle contraction | 18.7500 | 7 | yes |
GO:0031644 | regulation of nervous system process | 12.5000 | 5 | yes |
GO:0031646 | positive regulation of nervous system process | 12.5000 | 5 | yes |
GO:0051969 | regulation of transmission of nerve impulse | 12.5000 | 5 | yes |
GO:0051971 | positive regulation of transmission of nerve impulse | 12.5000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACHA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACHA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACHB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
LYPD6_HUMAN | [view interactions] | High throughput | no | no |
LYNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
RHBD3_HUMAN | [view interactions] | High throughput | no | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEC20_HUMAN | [view interactions] | High throughput | no | yes |
H6ST2_HUMAN | [view interactions] | High throughput | no | no |
ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RN215_HUMAN | [view interactions] | High throughput | no | yes |
SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
PLD6_HUMAN | [view interactions] | High throughput | no | yes |
GP1BB_HUMAN | [view interactions] | High throughput | no | no |
TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
ASTRA_HUMAN | [view interactions] | High throughput | no | no |
ICAM4_HUMAN | [view interactions] | High throughput | no | no |
PIGB_HUMAN | [view interactions] | High throughput | no | yes |
UD3A2_HUMAN | [view interactions] | High throughput | no | no |
TPSN_HUMAN | [view interactions] | High throughput | no | yes |
TM131_HUMAN | [view interactions] | High throughput | no | yes |
PANX1_HUMAN | [view interactions] | High throughput | no | no |
SPAG4_HUMAN | [view interactions] | High throughput | no | no |
GOLI_HUMAN | [view interactions] | High throughput | no | yes |
PGAP1_HUMAN | [view interactions] | High throughput | no | no |
MFAP3_HUMAN | [view interactions] | High throughput | no | yes |
AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
GPHRA_HUMAN | [view interactions] | High throughput | no | no |
C1QRF_HUMAN | [view interactions] | High throughput | no | no |
ADCY3_HUMAN | [view interactions] | High throughput | no | yes |
TM87B_HUMAN | [view interactions] | High throughput | no | yes |
TTC17_HUMAN | [view interactions] | High throughput | no | yes |
CNNM1_HUMAN | [view interactions] | High throughput | no | yes |
GLT12_HUMAN | [view interactions] | High throughput | no | yes |
LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
EDA_HUMAN | [view interactions] | High throughput | no | no |
LSR_HUMAN | [view interactions] | High throughput | no | yes |
SGCB_HUMAN | [view interactions] | High throughput | no | no |
TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM59L_HUMAN | [view interactions] | High throughput | no | yes |
D19L4_HUMAN | [view interactions] | High throughput | no | no |
GLRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SEM4F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
MA1A2_HUMAN | [view interactions] | High throughput | no | yes |
AGRE5_HUMAN | [view interactions] | High throughput | no | no |
ERMP1_HUMAN | [view interactions] | High throughput | no | no |
MIB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT133_HUMAN | [view interactions] | High throughput | no | yes |
HLAF_HUMAN | [view interactions] | High throughput | no | no |
FKB14_HUMAN | [view interactions] | High throughput | no | yes |
GBRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SELT_HUMAN | [view interactions] | High throughput | no | yes |
AT132_HUMAN | [view interactions] | High throughput | no | yes |
LMF1_HUMAN | [view interactions] | High throughput | no | no |
TM39A_HUMAN | [view interactions] | High throughput | no | yes |
GL8D2_HUMAN | [view interactions] | High throughput | no | yes |
ALG9_HUMAN | [view interactions] | High throughput | no | yes |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
PCDGL_HUMAN | [view interactions] | High throughput | no | no |
LMF2_HUMAN | [view interactions] | High throughput | no | yes |