ACHA5_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA5_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 50.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 50.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 50.0000 | 7 | yes |
| GO:0005261 | cation channel activity | 50.0000 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015267 | channel activity | 50.0000 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 50.0000 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 50.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | 50.0000 | 7 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
| GO:0099094 | ligand-gated cation channel activity | 50.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
| GO:0015464 | acetylcholine receptor activity | 41.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA5_HUMAN |
|---|---|---|---|---|
| GO:0006811 | ion transport | 58.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 58.3333 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 6 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0007271 | synaptic transmission, cholinergic | 41.6667 | 7 | yes |
| GO:0035095 | behavioral response to nicotine | 41.6667 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 41.6667 | 5 | yes |
| GO:0051046 | regulation of secretion | 41.6667 | 5 | yes |
| GO:0051899 | membrane depolarization | 41.6667 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 41.6667 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 41.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 33.3333 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | no |
| GO:0046928 | regulation of neurotransmitter secretion | 25.0000 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 25.0000 | 5 | yes |
| GO:0006936 | muscle contraction | 25.0000 | 4 | no |
| GO:0007274 | neuromuscular synaptic transmission | 25.0000 | 7 | no |
| GO:0060084 | synaptic transmission involved in micturition | 25.0000 | 8 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0033674 | positive regulation of kinase activity | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 25.0000 | 5 | no |
| GO:0051952 | regulation of amine transport | 25.0000 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 25.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:1901214 | regulation of neuron death | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0050807 | regulation of synapse organization | 25.0000 | 5 | no |
| GO:0051963 | regulation of synapse assembly | 25.0000 | 6 | no |
| GO:1901888 | regulation of cell junction assembly | 25.0000 | 5 | no |
| GO:0006812 | cation transport | 25.0000 | 5 | no |
| GO:0006816 | calcium ion transport | 25.0000 | 7 | no |
| GO:0030001 | metal ion transport | 25.0000 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| PIEZ1_HUMAN | [view interactions] | High throughput | no | no |
| IL17F_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| CATG_HUMAN | [view interactions] | High throughput | no | no |
| LIRA5_HUMAN | [view interactions] | High throughput | no | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| REL1_HUMAN | [view interactions] | High throughput | no | no |
| ATS4_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| P2RX2_HUMAN | [view interactions] | High throughput | no | no |
| CFC1_HUMAN | [view interactions] | High throughput | no | no |
| NCTR3_HUMAN | [view interactions] | High throughput | no | no |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| LYPD6_HUMAN | [view interactions] | High throughput | no | no |
| LYNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| F1892_HUMAN | [view interactions] | High throughput | no | yes |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| ACHD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P2RX5_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| NXPH3_HUMAN | [view interactions] | High throughput | no | no |
| EDN3_HUMAN | [view interactions] | High throughput | no | no |
| NDP_HUMAN | [view interactions] | High throughput | no | no |
| PPBN_HUMAN | [view interactions] | High throughput | no | no |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| LYPD1_HUMAN | [view interactions] | High throughput | no | no |
| VEGFD_HUMAN | [view interactions] | High throughput | no | no |
| WNT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WN10A_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| CMA1_HUMAN | [view interactions] | High throughput | no | no |
| EFNA2_HUMAN | [view interactions] | High throughput | no | no |
| FMOD_HUMAN | [view interactions] | High throughput | no | no |
| SIA4C_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |