Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA5_HUMAN
GO:0005216 monoatomic ion channel activity 50.0000 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 50.0000 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 50.0000 7 yes
GO:0005261 monoatomic cation channel activity 50.0000 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 50.0000 4 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 50.0000 5 yes
GO:0022834 ligand-gated channel activity 50.0000 6 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 50.0000 6 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 42.8571 5 yes
GO:0022835 transmitter-gated channel activity 42.8571 4 yes
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 42.8571 7 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 42.8571 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 42.8571 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 42.8571 6 yes
GO:0043169 cation binding 42.8571 4 no
GO:0015464 acetylcholine receptor activity 35.7143 4 yes
GO:0042166 acetylcholine binding 28.5714 5 no
GO:0000166 nucleotide binding 21.4286 4 no
GO:0005524 ATP binding 21.4286 5 no
GO:0017076 purine nucleotide binding 21.4286 5 no
GO:0030554 adenyl nucleotide binding 21.4286 6 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0032559 adenyl ribonucleotide binding 21.4286 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0043168 anion binding 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA5_HUMAN
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0007268 chemical synaptic transmission 50.0000 7 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 6 yes
GO:0099536 synaptic signaling 50.0000 4 yes
GO:0099537 trans-synaptic signaling 50.0000 5 yes
GO:0007271 synaptic transmission, cholinergic 42.8571 8 yes
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 yes
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 yes
GO:0006811 monoatomic ion transport 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0080090 regulation of primary metabolic process 35.7143 4 no
GO:0035095 behavioral response to nicotine 35.7143 4 yes
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0006936 muscle contraction 28.5714 4 no
GO:0007274 neuromuscular synaptic transmission 28.5714 8 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0006812 monoatomic cation transport 28.5714 5 no
GO:0006816 calcium ion transport 28.5714 7 no
GO:0030001 metal ion transport 28.5714 6 no
GO:0051046 regulation of secretion 28.5714 5 no
GO:1903530 regulation of secretion by cell 28.5714 4 no
GO:0022607 cellular component assembly 21.4286 4 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0006939 smooth muscle contraction 21.4286 5 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0051963 regulation of synapse assembly 21.4286 6 no
GO:0060084 synaptic transmission involved in micturition 21.4286 9 no
GO:0095500 acetylcholine receptor signaling pathway 21.4286 4 no
GO:1901888 regulation of cell junction assembly 21.4286 5 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0031399 regulation of protein modification process 21.4286 6 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051246 regulation of protein metabolic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0007600 sensory perception 21.4286 4 no
GO:0036293 response to decreased oxygen levels 21.4286 4 no
GO:0042113 B cell activation 21.4286 4 no
GO:0051952 regulation of amine transport 21.4286 5 no
GO:0090304 nucleic acid metabolic process 21.4286 4 no
GO:0008284 positive regulation of cell population proliferation 21.4286 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA3_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA4_HUMAN [view entry] [view interactions] Low throughput yes no
ACHB4_HUMAN [view entry] [view interactions] Low throughput yes no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRG5_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
SLAF1_HUMAN [view interactions] High throughput no no
LYPD6_HUMAN [view interactions] High throughput no no
LYNX1_HUMAN [view entry] [view interactions] High throughput yes no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
CC50A_HUMAN [view interactions] High throughput no yes
EREP1_HUMAN [view interactions] High throughput no yes
DB135_HUMAN [view interactions] High throughput no no
CLGN_HUMAN [view interactions] High throughput no no
TAZ_HUMAN [view interactions] High throughput no yes
ACHD_HUMAN [view entry] [view interactions] High throughput yes no
P2RX5_HUMAN [view interactions] High throughput no no
BRID5_HUMAN [view interactions] High throughput no no
NXPH3_HUMAN [view interactions] High throughput no no
EDN3_HUMAN [view interactions] High throughput no no
NDP_HUMAN [view interactions] High throughput no no
PPBN_HUMAN [view interactions] High throughput no no
IL5RA_HUMAN [view interactions] High throughput no no
LYPD1_HUMAN [view interactions] High throughput no no
VEGFD_HUMAN [view interactions] High throughput no no
WNT3A_HUMAN [view entry] [view interactions] High throughput yes no
WN10A_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
CDHR4_HUMAN [view interactions] High throughput no no
CMA1_HUMAN [view interactions] High throughput no no
EFNA2_HUMAN [view interactions] High throughput no no
FMOD_HUMAN [view interactions] High throughput no no
SIA4C_HUMAN [view interactions] High throughput no yes
C1QB_HUMAN [view entry] [view interactions] High throughput yes no
PIEZ1_HUMAN [view interactions] High throughput no no
IL17F_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
CBLN4_HUMAN [view interactions] High throughput no no
KLK15_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
CATG_HUMAN [view interactions] High throughput no no
LIRA5_HUMAN [view interactions] High throughput no no
SIRPD_HUMAN [view interactions] High throughput no no
REL1_HUMAN [view interactions] High throughput no no
ATS4_HUMAN [view interactions] High throughput no yes
CNTP3_HUMAN [view interactions] High throughput no yes
OIT3_HUMAN [view interactions] High throughput no no
P2RX2_HUMAN [view entry] [view interactions] High throughput yes no
CFC1_HUMAN [view interactions] High throughput no no
NCTR3_HUMAN [view interactions] High throughput no no
TM87A_HUMAN [view interactions] High throughput no yes
LYZL1_HUMAN [view interactions] High throughput no no
PRG2_HUMAN [view interactions] High throughput no no
TSHR_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes