EPHA7_HUMAN
Evidence for PS localization
Functions
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPHA7_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 35.5769 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.5769 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.6154 | 4 | yes |
| GO:0019900 | kinase binding | 26.9231 | 4 | no |
| GO:0019901 | protein kinase binding | 26.9231 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.1154 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.1154 | 5 | yes |
| GO:0005524 | ATP binding | 21.1538 | 5 | yes |
| GO:0016301 | kinase activity | 19.2308 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.2692 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 17.3077 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 12.5000 | 4 | yes |
| GO:0046875 | ephrin receptor binding | 9.6154 | 4 | yes |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 5.7692 | 5 | yes |
| GO:0019199 | transmembrane receptor protein kinase activity | 5.7692 | 4 | yes |
| GO:0005003 | ephrin receptor activity | 4.8077 | 6 | yes |
| GO:0005005 | transmembrane-ephrin receptor activity | 3.8462 | 7 | yes |
| GO:0005004 | GPI-linked ephrin receptor activity | 2.8846 | 7 | yes |
| GO:0008046 | axon guidance receptor activity | 2.8846 | 4 | yes |
| GO:0048018 | receptor ligand activity | 1.9231 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPHA7_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.5769 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.9231 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.9615 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 49.0385 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.1538 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.3846 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.4231 | 4 | yes |
| GO:0008104 | protein localization | 38.4615 | 4 | no |
| GO:0030030 | cell projection organization | 37.5000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 36.5385 | 4 | yes |
| GO:0051049 | regulation of transport | 36.5385 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.5769 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.6154 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.6154 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.6538 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.7308 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.7308 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.7692 | 5 | yes |
| GO:0006996 | organelle organization | 30.7692 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.8077 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 29.8077 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.8077 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.8462 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 28.8462 | 5 | yes |
| GO:0010468 | regulation of gene expression | 28.8462 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.8462 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.8462 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.8462 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 27.8846 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 27.8846 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 26.9231 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 25.9615 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.9615 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.9615 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.9615 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.9615 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | yes |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 25.0000 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 24.0385 | 4 | no |
| GO:0071702 | organic substance transport | 24.0385 | 4 | no |
| GO:0030334 | regulation of cell migration | 24.0385 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 24.0385 | 7 | yes |
| GO:0043085 | positive regulation of catalytic activity | 24.0385 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | yes |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.0769 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 23.0769 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 22.1154 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 22.1154 | 4 | yes |
| GO:0015031 | protein transport | 22.1154 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.1154 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.1154 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.1154 | 7 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 22.1154 | 6 | yes |
| GO:0031175 | neuron projection development | 22.1154 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 22.1154 | 7 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.1538 | 7 | yes |
| GO:0060284 | regulation of cell development | 21.1538 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 21.1538 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.1538 | 4 | no |
| GO:0034330 | cell junction organization | 21.1538 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 21.1538 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.1538 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.1538 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.1538 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 21.1538 | 8 | yes |
| GO:0009889 | regulation of biosynthetic process | 20.1923 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.1923 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.1923 | 6 | no |
| GO:0032880 | regulation of protein localization | 20.1923 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.1923 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.1923 | 8 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.1923 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.1923 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 19.2308 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 19.2308 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 19.2308 | 5 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 19.2308 | 5 | yes |
| GO:0010941 | regulation of cell death | 19.2308 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 18.2692 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 18.2692 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 17.3077 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 17.3077 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 17.3077 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 17.3077 | 6 | yes |
| GO:0016310 | phosphorylation | 16.3462 | 5 | yes |
| GO:0043549 | regulation of kinase activity | 15.3846 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 15.3846 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 15.3846 | 5 | yes |
| GO:0051347 | positive regulation of transferase activity | 15.3846 | 5 | yes |
| GO:0097485 | neuron projection guidance | 15.3846 | 7 | yes |
| GO:0007411 | axon guidance | 15.3846 | 8 | yes |
| GO:0010942 | positive regulation of cell death | 15.3846 | 5 | yes |
| GO:0033674 | positive regulation of kinase activity | 14.4231 | 6 | yes |
| GO:0043065 | positive regulation of apoptotic process | 14.4231 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 14.4231 | 6 | yes |
| GO:0002009 | morphogenesis of an epithelium | 13.4615 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 13.4615 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 11.5385 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 11.5385 | 6 | yes |
| GO:0099175 | regulation of postsynapse organization | 10.5769 | 6 | yes |
| GO:0001558 | regulation of cell growth | 10.5769 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 10.5769 | 7 | yes |
| GO:0030162 | regulation of proteolysis | 10.5769 | 6 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 9.6154 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 9.6154 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 9.6154 | 5 | yes |
| GO:1901214 | regulation of neuron death | 9.6154 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 9.6154 | 5 | yes |
| GO:0006915 | apoptotic process | 9.6154 | 4 | yes |
| GO:0010721 | negative regulation of cell development | 9.6154 | 6 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 7.6923 | 6 | yes |
| GO:0048638 | regulation of developmental growth | 7.6923 | 4 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 7.6923 | 8 | yes |
| GO:0052547 | regulation of peptidase activity | 7.6923 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 7.6923 | 6 | yes |
| GO:0061387 | regulation of extent of cell growth | 7.6923 | 5 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 7.6923 | 7 | yes |
| GO:0050771 | negative regulation of axonogenesis | 6.7308 | 6 | yes |
| GO:0060562 | epithelial tube morphogenesis | 6.7308 | 4 | yes |
| GO:1901216 | positive regulation of neuron death | 6.7308 | 6 | yes |
| GO:0007420 | brain development | 6.7308 | 4 | yes |
| GO:0051963 | regulation of synapse assembly | 5.7692 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 5.7692 | 7 | yes |
| GO:0043525 | positive regulation of neuron apoptotic process | 4.8077 | 7 | yes |
| GO:0045926 | negative regulation of growth | 4.8077 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 4.8077 | 5 | yes |
| GO:0030308 | negative regulation of cell growth | 4.8077 | 5 | yes |
| GO:0031952 | regulation of protein autophosphorylation | 4.8077 | 8 | yes |
| GO:0050919 | negative chemotaxis | 3.8462 | 4 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 3.8462 | 8 | yes |
| GO:1901889 | negative regulation of cell junction assembly | 2.8846 | 6 | yes |
| GO:0051964 | negative regulation of synapse assembly | 1.9231 | 6 | yes |
| GO:0072178 | nephric duct morphogenesis | 1.9231 | 5 | yes |
| GO:1905809 | negative regulation of synapse organization | 1.9231 | 6 | yes |
| GO:0031290 | retinal ganglion cell axon guidance | 1.9231 | 9 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EPHA7_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 1.9231 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 1.9231 | 5 | no |
| DOID:114 | heart disease | 1.9231 | 3 | no |
| DOID:2843 | long QT syndrome | 1.9231 | 6 | no |
| DOID:0060038 | specific developmental disorder | 1.9231 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 1.9231 | 5 | no |
| DOID:1059 | intellectual disability | 1.9231 | 4 | no |
| DOID:0111962 | combined immunodeficiency | 1.9231 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 1.9231 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RYK_HUMAN | [view interactions] | Low throughput | no | no |
| EFNA1_HUMAN | [view interactions] | Low throughput | no | no |
| EFNA5_HUMAN | [view interactions] | Low throughput | no | yes |
| EPHA3_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | Low throughput | no | no |
| EFNA2_HUMAN | [view interactions] | Low throughput | no | no |
| EFNA3_HUMAN | [view interactions] | Low throughput | no | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | Low throughput | no | no |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| PDIP3_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN267_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| DUS26_HUMAN | [view interactions] | High throughput | no | yes |
| DUS18_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EHBP1_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHB_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNNM3_HUMAN | [view interactions] | High throughput | no | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| TB10B_HUMAN | [view interactions] | High throughput | no | no |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| DSC2_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIRR1_HUMAN | [view interactions] | High throughput | no | no |
| MTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| STEA3_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| CCG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHAA_HUMAN | [view interactions] | High throughput | no | yes |
| MBLC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| BCAM_HUMAN | [view interactions] | High throughput | no | yes |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| NID2_HUMAN | [view interactions] | High throughput | no | yes |
| SMOC1_HUMAN | [view interactions] | High throughput | no | no |
| MICA_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRIQ1_HUMAN | [view interactions] | High throughput | no | no |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| NPTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BORA_HUMAN | [view interactions] | High throughput | no | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| I17RC_HUMAN | [view interactions] | High throughput | no | yes |
| I17RB_HUMAN | [view interactions] | High throughput | no | no |
| OAF_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE1E_HUMAN | [view interactions] | High throughput | no | no |
| WNT5A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| P3IP1_HUMAN | [view interactions] | High throughput | no | no |
| SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| V1BR_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| NXPH4_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| LTBP3_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| NPC2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| SEM3B_HUMAN | [view interactions] | High throughput | no | yes |
| CRLF1_HUMAN | [view interactions] | High throughput | no | no |
| SEM4G_HUMAN | [view interactions] | High throughput | no | yes |
| VWDE_HUMAN | [view interactions] | High throughput | no | no |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHPF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NAR5_HUMAN | [view interactions] | High throughput | no | no |
| AGRF1_HUMAN | [view interactions] | High throughput | no | no |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD_HUMAN | [view interactions] | High throughput | no | no |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| METRL_HUMAN | [view interactions] | High throughput | no | no |
| CO6A1_HUMAN | [view interactions] | High throughput | no | no |
| ATRN_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| T132A_HUMAN | [view interactions] | High throughput | no | yes |
| AGRG1_HUMAN | [view interactions] | High throughput | no | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| WNT16_HUMAN | [view interactions] | High throughput | no | no |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATS7_HUMAN | [view interactions] | High throughput | no | no |
| PCSK6_HUMAN | [view interactions] | High throughput | no | yes |
| SC65_HUMAN | [view interactions] | High throughput | no | no |
| PLXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSF1R_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB4_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| UBR2_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC6_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BLK_HUMAN | [view interactions] | Computational | no | no |
| EFNB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ABL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RASA1_HUMAN | [view interactions] | Computational | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FGR_HUMAN | [view interactions] | Computational | no | no |
| NGEF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |