EPHA7_HUMAN
Evidence for PS localization
Functions
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPHA7_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 38.3178 | 4 | yes |
| GO:0000166 | nucleotide binding | 34.5794 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 34.5794 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.5794 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.7103 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.4953 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.4953 | 5 | yes |
| GO:0043169 | cation binding | 20.5607 | 4 | no |
| GO:0005524 | ATP binding | 19.6262 | 5 | yes |
| GO:0016301 | kinase activity | 13.0841 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 12.1495 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.5421 | 4 | yes |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 4.6729 | 5 | yes |
| GO:0019199 | transmembrane receptor protein kinase activity | 4.6729 | 4 | yes |
| GO:0005003 | ephrin receptor activity | 2.8037 | 6 | yes |
| GO:0005005 | transmembrane-ephrin receptor activity | 2.8037 | 7 | yes |
| GO:0008046 | axon guidance receptor activity | 2.8037 | 4 | yes |
| GO:0048018 | receptor ligand activity | 2.8037 | 4 | yes |
| GO:0005004 | GPI-linked ephrin receptor activity | 1.8692 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPHA7_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.8785 | 4 | yes |
| GO:0010646 | regulation of cell communication | 49.5327 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 49.5327 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 43.9252 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.9907 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2523 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.2523 | 4 | yes |
| GO:0008104 | protein localization | 38.3178 | 4 | no |
| GO:0022607 | cellular component assembly | 33.6449 | 4 | no |
| GO:0030030 | cell projection organization | 33.6449 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 32.7103 | 4 | yes |
| GO:0051049 | regulation of transport | 32.7103 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.7757 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.8411 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 29.9065 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.9065 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.9720 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.9720 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 28.0374 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 28.0374 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0374 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.0374 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.0374 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.0374 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 27.1028 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.1682 | 5 | yes |
| GO:0006996 | organelle organization | 26.1682 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.2336 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.2336 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.2336 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.2991 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 24.2991 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.2991 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.3645 | 6 | yes |
| GO:2000145 | regulation of cell motility | 23.3645 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.4299 | 5 | yes |
| GO:0060284 | regulation of cell development | 22.4299 | 5 | yes |
| GO:0030334 | regulation of cell migration | 22.4299 | 5 | no |
| GO:0034330 | cell junction organization | 22.4299 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.4299 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.4953 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.4953 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.4953 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.4953 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4953 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.4953 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.4953 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 20.5607 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5607 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.5607 | 4 | no |
| GO:0071702 | organic substance transport | 20.5607 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.5607 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 20.5607 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 19.6262 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 19.6262 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 18.6916 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 18.6916 | 7 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 17.7570 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 17.7570 | 5 | yes |
| GO:0031175 | neuron projection development | 17.7570 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 16.8224 | 6 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 16.8224 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 15.8879 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 15.8879 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 15.8879 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 15.8879 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 14.9533 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 14.9533 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 14.9533 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 14.9533 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 14.9533 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 14.9533 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 14.9533 | 7 | yes |
| GO:0051336 | regulation of hydrolase activity | 14.0187 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 14.0187 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 14.0187 | 7 | yes |
| GO:0097485 | neuron projection guidance | 13.0841 | 7 | yes |
| GO:0002009 | morphogenesis of an epithelium | 13.0841 | 4 | yes |
| GO:0007411 | axon guidance | 13.0841 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 13.0841 | 6 | yes |
| GO:0016310 | phosphorylation | 13.0841 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 13.0841 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 13.0841 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 12.1495 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 12.1495 | 8 | yes |
| GO:0006915 | apoptotic process | 12.1495 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 12.1495 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 10.2804 | 5 | yes |
| GO:0001558 | regulation of cell growth | 10.2804 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 10.2804 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 9.3458 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 9.3458 | 5 | yes |
| GO:0010721 | negative regulation of cell development | 8.4112 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 7.4766 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 7.4766 | 5 | yes |
| GO:0060562 | epithelial tube morphogenesis | 7.4766 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 7.4766 | 7 | yes |
| GO:0031345 | negative regulation of cell projection organization | 7.4766 | 6 | yes |
| GO:0048638 | regulation of developmental growth | 6.5421 | 4 | yes |
| GO:0061387 | regulation of extent of cell growth | 6.5421 | 5 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 6.5421 | 7 | yes |
| GO:0099175 | regulation of postsynapse organization | 6.5421 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 6.5421 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 6.5421 | 6 | yes |
| GO:0030308 | negative regulation of cell growth | 6.5421 | 5 | yes |
| GO:0045926 | negative regulation of growth | 6.5421 | 4 | yes |
| GO:0050771 | negative regulation of axonogenesis | 5.6075 | 6 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 5.6075 | 6 | yes |
| GO:0048640 | negative regulation of developmental growth | 4.6729 | 5 | yes |
| GO:0050919 | negative chemotaxis | 4.6729 | 4 | yes |
| GO:0051963 | regulation of synapse assembly | 4.6729 | 6 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 4.6729 | 6 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 3.7383 | 8 | yes |
| GO:0051402 | neuron apoptotic process | 3.7383 | 5 | yes |
| GO:0052547 | regulation of peptidase activity | 3.7383 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 3.7383 | 6 | yes |
| GO:0007420 | brain development | 3.7383 | 4 | yes |
| GO:0031952 | regulation of protein autophosphorylation | 3.7383 | 8 | yes |
| GO:0051964 | negative regulation of synapse assembly | 1.8692 | 6 | yes |
| GO:0072178 | nephric duct morphogenesis | 1.8692 | 5 | yes |
| GO:1901889 | negative regulation of cell junction assembly | 1.8692 | 6 | yes |
| GO:1905809 | negative regulation of synapse organization | 1.8692 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 1.8692 | 7 | yes |
| GO:0031290 | retinal ganglion cell axon guidance | 1.8692 | 9 | yes |
| GO:0043525 | positive regulation of neuron apoptotic process | 1.8692 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EFNA2_HUMAN | [view interactions] | Low throughput | no | no |
| EFNA3_HUMAN | [view interactions] | Low throughput | no | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | Low throughput | no | no |
| RYK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EFNA1_HUMAN | [view interactions] | Low throughput | no | no |
| EPHA3_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNA5_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | Low throughput | no | no |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| CCG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHAA_HUMAN | [view interactions] | High throughput | no | yes |
| MBLC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| BCAM_HUMAN | [view interactions] | High throughput | no | yes |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| NID2_HUMAN | [view interactions] | High throughput | no | yes |
| SMOC1_HUMAN | [view interactions] | High throughput | no | no |
| MICA_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRIQ1_HUMAN | [view interactions] | High throughput | no | no |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| NPTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BORA_HUMAN | [view interactions] | High throughput | no | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| I17RC_HUMAN | [view interactions] | High throughput | no | yes |
| I17RB_HUMAN | [view interactions] | High throughput | no | no |
| OAF_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE1E_HUMAN | [view interactions] | High throughput | no | no |
| WNT5A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| P3IP1_HUMAN | [view interactions] | High throughput | no | no |
| SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| V1BR_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| NXPH4_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| LTBP3_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| NPC2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| SEM3B_HUMAN | [view interactions] | High throughput | no | yes |
| CRLF1_HUMAN | [view interactions] | High throughput | no | no |
| SEM4G_HUMAN | [view interactions] | High throughput | no | yes |
| VWDE_HUMAN | [view interactions] | High throughput | no | no |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHPF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NAR5_HUMAN | [view interactions] | High throughput | no | no |
| AGRF1_HUMAN | [view interactions] | High throughput | no | no |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD_HUMAN | [view interactions] | High throughput | no | no |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| METRL_HUMAN | [view interactions] | High throughput | no | no |
| CO6A1_HUMAN | [view interactions] | High throughput | no | no |
| ATRN_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| T132A_HUMAN | [view interactions] | High throughput | no | yes |
| AGRG1_HUMAN | [view interactions] | High throughput | no | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| WNT16_HUMAN | [view interactions] | High throughput | no | no |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATS7_HUMAN | [view interactions] | High throughput | no | no |
| PCSK6_HUMAN | [view interactions] | High throughput | no | yes |
| SC65_HUMAN | [view interactions] | High throughput | no | no |
| PLXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CSF1R_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| PANK1_HUMAN | [view interactions] | High throughput | no | no |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIP3_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC6_HUMAN | [view interactions] | High throughput | no | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| BAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR2_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| ZN267_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS18_HUMAN | [view interactions] | High throughput | no | yes |
| DUS26_HUMAN | [view interactions] | High throughput | no | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STEA3_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| MTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| KIRR1_HUMAN | [view interactions] | High throughput | no | no |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| DSC2_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| TB10B_HUMAN | [view interactions] | High throughput | no | no |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| CNNM3_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHB_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| EHBP1_HUMAN | [view interactions] | High throughput | no | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |