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SRGP2_HUMAN

GO
G2C
SynGO
SynaptomeDB

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SRGP2_HUMAN
GO:0017076 purine nucleotide binding 26.0870 4 no
GO:0032555 purine ribonucleotide binding 24.6377 4 no
GO:0030695 GTPase regulator activity 23.1884 4 yes
GO:0019900 kinase binding 23.1884 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.1884 4 no
GO:0019901 protein kinase binding 20.2899 5 no
GO:0046872 metal ion binding 20.2899 4 no
GO:0005096 GTPase activator activity 17.3913 4 yes
GO:0031267 small GTPase binding 13.0435 5 yes
GO:0051020 GTPase binding 13.0435 4 yes
GO:0042803 protein homodimerization activity 5.7971 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SRGP2_HUMAN
GO:0010646 regulation of cell communication 55.0725 4 yes
GO:0048523 negative regulation of cellular process 52.1739 4 yes
GO:0009966 regulation of signal transduction 50.7246 4 yes
GO:0048522 positive regulation of cellular process 50.7246 4 no
GO:0031323 regulation of cellular metabolic process 49.2754 4 no
GO:0080090 regulation of primary metabolic process 46.3768 4 no
GO:0051171 regulation of nitrogen compound metabolic process 44.9275 4 no
GO:0060255 regulation of macromolecule metabolic process 44.9275 4 no
GO:0006996 organelle organization 43.4783 4 yes
GO:0051128 regulation of cellular component organization 42.0290 4 no
GO:1902531 regulation of intracellular signal transduction 39.1304 5 yes
GO:0009893 positive regulation of metabolic process 34.7826 4 no
GO:0051246 regulation of protein metabolic process 34.7826 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0007010 cytoskeleton organization 31.8841 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.4348 5 no
GO:0019220 regulation of phosphate metabolic process 30.4348 6 no
GO:0031325 positive regulation of cellular metabolic process 30.4348 5 no
GO:0051174 regulation of phosphorus metabolic process 30.4348 5 no
GO:0022607 cellular component assembly 28.9855 4 yes
GO:0031399 regulation of protein modification process 28.9855 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.9855 5 no
GO:0008104 protein localization 27.5362 4 no
GO:0030030 cell projection organization 26.0870 4 yes
GO:0043085 positive regulation of catalytic activity 26.0870 4 yes
GO:0009892 negative regulation of metabolic process 26.0870 4 no
GO:0031344 regulation of cell projection organization 26.0870 5 no
GO:0042325 regulation of phosphorylation 26.0870 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.0870 6 no
GO:0051049 regulation of transport 26.0870 4 no
GO:0051336 regulation of hydrolase activity 24.6377 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 24.6377 5 no
GO:0031324 negative regulation of cellular metabolic process 24.6377 5 no
GO:0045595 regulation of cell differentiation 24.6377 4 no
GO:0010468 regulation of gene expression 23.1884 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.1884 5 no
GO:0001932 regulation of protein phosphorylation 23.1884 7 no
GO:0071702 organic substance transport 23.1884 4 no
GO:0010647 positive regulation of cell communication 23.1884 5 no
GO:0023056 positive regulation of signaling 23.1884 4 no
GO:0048584 positive regulation of response to stimulus 23.1884 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.7391 5 yes
GO:0036211 protein modification process 21.7391 4 no
GO:0043412 macromolecule modification 21.7391 4 no
GO:0051247 positive regulation of protein metabolic process 21.7391 6 no
GO:0051056 regulation of small GTPase mediated signal transduction 20.2899 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 20.2899 6 no
GO:0045937 positive regulation of phosphate metabolic process 20.2899 7 no
GO:0051094 positive regulation of developmental process 20.2899 4 no
GO:0071705 nitrogen compound transport 20.2899 4 no
GO:0009889 regulation of biosynthetic process 20.2899 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.2899 5 no
GO:0031326 regulation of cellular biosynthetic process 20.2899 5 no
GO:0009967 positive regulation of signal transduction 20.2899 5 no
GO:0030334 regulation of cell migration 17.3913 5 yes
GO:2000145 regulation of cell motility 17.3913 4 yes
GO:0051345 positive regulation of hydrolase activity 15.9420 5 yes
GO:0043087 regulation of GTPase activity 14.4928 5 yes
GO:0030031 cell projection assembly 11.5942 5 yes
GO:0032990 cell part morphogenesis 11.5942 4 yes
GO:0048858 cell projection morphogenesis 11.5942 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 11.5942 6 yes
GO:0043547 positive regulation of GTPase activity 10.1449 6 yes
GO:0048812 neuron projection morphogenesis 10.1449 7 yes
GO:0120031 plasma membrane bounded cell projection assembly 10.1449 6 yes
GO:0030336 negative regulation of cell migration 8.6957 6 yes
GO:0040013 negative regulation of locomotion 8.6957 4 yes
GO:2000146 negative regulation of cell motility 8.6957 5 yes
GO:0046847 filopodium assembly 7.2464 7 yes
GO:0097581 lamellipodium organization 5.7971 6 yes
GO:0000904 cell morphogenesis involved in differentiation 4.3478 4 yes
GO:0030032 lamellipodium assembly 4.3478 7 yes
GO:0034446 substrate adhesion-dependent cell spreading 4.3478 4 yes
GO:0003363 lamellipodium assembly involved in ameboidal cell migration 2.8986 8 yes
GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration 2.8986 4 yes
GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration 2.8986 5 yes
GO:0031268 pseudopodium organization 2.8986 6 yes
GO:0031269 pseudopodium assembly 2.8986 7 yes
GO:2001222 regulation of neuron migration 2.8986 6 yes
GO:2001223 negative regulation of neuron migration 2.8986 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in SRGP2_HUMAN
DOID:0050700 cardiomyopathy 2.8986 4 no
DOID:0060036 intrinsic cardiomyopathy 2.8986 5 no
DOID:114 heart disease 2.8986 3 no
DOID:2843 long QT syndrome 2.8986 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FMNL1_HUMAN [view entry] [view interactions] Low throughput yes no
ROBO2_HUMAN [view interactions] Low throughput no yes
FMNL3_HUMAN [view entry] [view interactions] Low throughput yes yes
SRG2C_HUMAN [view interactions] Low throughput no no
ANM5_HUMAN [view entry] [view interactions] Low throughput yes yes
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
SRGP2_HUMAN [view entry] [view interactions] Low throughput yes no
ROBO1_HUMAN [view interactions] Low throughput no yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
YLPM1_HUMAN [view interactions] Low throughput no yes
TNFL6_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
TRIMM_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
SCOC_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP19_HUMAN [view interactions] High throughput no no
PCM1_HUMAN [view interactions] High throughput no yes
AKIP_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1C_HUMAN [view interactions] High throughput no yes
KIF1B_HUMAN [view interactions] High throughput no yes
DEN4C_HUMAN [view interactions] High throughput no yes
SPD2A_HUMAN [view entry] [view interactions] High throughput yes yes
M3K21_HUMAN [view interactions] High throughput no yes
PTN14_HUMAN [view interactions] High throughput no yes
ZN638_HUMAN [view interactions] High throughput no yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
PTN13_HUMAN [view interactions] High throughput no yes
CAMP2_HUMAN [view interactions] High throughput no yes
CDK16_HUMAN [view interactions] High throughput no yes
MPIP3_HUMAN [view interactions] High throughput no yes
MPIP2_HUMAN [view interactions] High throughput no no
NF1_HUMAN [view entry] [view interactions] High throughput yes no
IF4E2_HUMAN [view interactions] High throughput no no
MAST3_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
PHLB2_HUMAN [view interactions] High throughput no yes
MYCPP_HUMAN [view interactions] High throughput no no
AN34A_HUMAN [view interactions] High throughput no no
LARP1_HUMAN [view interactions] High throughput no yes
RFIP2_HUMAN [view entry] [view interactions] High throughput yes yes
GGYF1_HUMAN [view interactions] High throughput no yes
KCTD3_HUMAN [view interactions] High throughput no yes
GAB2_HUMAN [view interactions] High throughput no yes
PPM1H_HUMAN [view interactions] High throughput no yes
FA53C_HUMAN [view interactions] High throughput no yes
INP5E_HUMAN [view interactions] High throughput no yes
TANC2_HUMAN [view entry] [view interactions] High throughput yes yes
OSBL6_HUMAN [view interactions] High throughput no yes
RTKN_HUMAN [view interactions] High throughput no yes
LPIN3_HUMAN [view interactions] High throughput no yes
SIN1_HUMAN [view interactions] High throughput no yes
RAB3I_HUMAN [view interactions] High throughput no no
EDC3_HUMAN [view interactions] High throughput no yes
SH3R3_HUMAN [view interactions] High throughput no yes
DEN1A_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
NADK_HUMAN [view interactions] High throughput no yes
AFAD_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
MELK_HUMAN [view interactions] High throughput no yes
TBC25_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
GGYF2_HUMAN [view interactions] High throughput no yes
SYDE1_HUMAN [view interactions] High throughput no yes
RGPS2_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
NAV1_HUMAN [view interactions] High throughput no yes
F110B_HUMAN [view interactions] High throughput no yes
HDAC7_HUMAN [view interactions] High throughput no no
DEP1B_HUMAN [view interactions] High throughput no yes
SRS12_HUMAN [view interactions] High throughput no no
MAGI1_HUMAN [view interactions] High throughput no no
TESK2_HUMAN [view interactions] High throughput no yes
F110A_HUMAN [view interactions] High throughput no yes
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
KI13B_HUMAN [view interactions] High throughput no yes
SH3B4_HUMAN [view interactions] High throughput no yes
LRFN1_HUMAN [view entry] [view interactions] High throughput yes no
CING_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
UBP21_HUMAN [view interactions] High throughput no no
ZBT21_HUMAN [view interactions] High throughput no yes
AGAP1_HUMAN [view entry] [view interactions] High throughput yes no
CBY1_HUMAN [view interactions] High throughput no no
STA13_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1G_HUMAN [view interactions] High throughput no no
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
WASP_HUMAN [view interactions] High throughput no yes
WIPF1_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
LUZP4_HUMAN [view interactions] High throughput no no
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
LNX2_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HECD1_HUMAN [view interactions] High throughput no yes
KDM6B_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
KPRP_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
ODAD1_HUMAN [view interactions] High throughput no no
KXDL1_HUMAN [view interactions] High throughput no yes
S100P_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
BSPRY_HUMAN [view interactions] High throughput no no
ZN414_HUMAN [view interactions] High throughput no yes
CCD96_HUMAN [view interactions] High throughput no no
PRPS2_HUMAN [view interactions] High throughput no no
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
NS1BP_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
RPGF4_HUMAN [view entry] [view interactions] High throughput yes yes
RHG15_HUMAN [view interactions] High throughput no no
RHG19_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG35_HUMAN [view interactions] High throughput no yes
RHG40_HUMAN [view interactions] High throughput no no
RHG42_HUMAN [view interactions] High throughput no yes
CHIO_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
GLI1_HUMAN [view interactions] High throughput no no
GLI2_HUMAN [view interactions] High throughput no yes
GNAL_HUMAN [view interactions] High throughput no yes
LHX5_HUMAN [view interactions] High throughput no no
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC1_HUMAN [view interactions] High throughput no yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RGF1B_HUMAN [view interactions] High throughput no no
S26A7_HUMAN [view interactions] High throughput no no
CTR2_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SPOPL_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
TIM44_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
TOM70_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
H2B2F_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
HYDIN_HUMAN [view interactions] Computational no no
GRIN2_HUMAN [view interactions] Computational no yes
WASF1_HUMAN [view entry] [view interactions] Computational yes yes