SRGP2_HUMAN
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SRGP2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 26.0870 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 24.6377 | 4 | no |
GO:0030695 | GTPase regulator activity | 23.1884 | 4 | yes |
GO:0019900 | kinase binding | 23.1884 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.1884 | 4 | no |
GO:0019901 | protein kinase binding | 20.2899 | 5 | no |
GO:0046872 | metal ion binding | 20.2899 | 4 | no |
GO:0005096 | GTPase activator activity | 17.3913 | 4 | yes |
GO:0031267 | small GTPase binding | 13.0435 | 5 | yes |
GO:0051020 | GTPase binding | 13.0435 | 4 | yes |
GO:0042803 | protein homodimerization activity | 5.7971 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SRGP2_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 55.0725 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 52.1739 | 4 | yes |
GO:0009966 | regulation of signal transduction | 50.7246 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.7246 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 49.2754 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 46.3768 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 44.9275 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.9275 | 4 | no |
GO:0006996 | organelle organization | 43.4783 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 42.0290 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 39.1304 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | no |
GO:0007010 | cytoskeleton organization | 31.8841 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 30.4348 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.4348 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 30.4348 | 5 | no |
GO:0022607 | cellular component assembly | 28.9855 | 4 | yes |
GO:0031399 | regulation of protein modification process | 28.9855 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.9855 | 5 | no |
GO:0008104 | protein localization | 27.5362 | 4 | no |
GO:0030030 | cell projection organization | 26.0870 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 26.0870 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
GO:0031344 | regulation of cell projection organization | 26.0870 | 5 | no |
GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.0870 | 6 | no |
GO:0051049 | regulation of transport | 26.0870 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 24.6377 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.6377 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 24.6377 | 5 | no |
GO:0045595 | regulation of cell differentiation | 24.6377 | 4 | no |
GO:0010468 | regulation of gene expression | 23.1884 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.1884 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 23.1884 | 7 | no |
GO:0071702 | organic substance transport | 23.1884 | 4 | no |
GO:0010647 | positive regulation of cell communication | 23.1884 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.1884 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 23.1884 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 21.7391 | 5 | yes |
GO:0036211 | protein modification process | 21.7391 | 4 | no |
GO:0043412 | macromolecule modification | 21.7391 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.7391 | 6 | no |
GO:0051056 | regulation of small GTPase mediated signal transduction | 20.2899 | 6 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 20.2899 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 20.2899 | 7 | no |
GO:0051094 | positive regulation of developmental process | 20.2899 | 4 | no |
GO:0071705 | nitrogen compound transport | 20.2899 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 20.2899 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.2899 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 20.2899 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 20.2899 | 5 | no |
GO:0030334 | regulation of cell migration | 17.3913 | 5 | yes |
GO:2000145 | regulation of cell motility | 17.3913 | 4 | yes |
GO:0051345 | positive regulation of hydrolase activity | 15.9420 | 5 | yes |
GO:0043087 | regulation of GTPase activity | 14.4928 | 5 | yes |
GO:0030031 | cell projection assembly | 11.5942 | 5 | yes |
GO:0032990 | cell part morphogenesis | 11.5942 | 4 | yes |
GO:0048858 | cell projection morphogenesis | 11.5942 | 5 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 11.5942 | 6 | yes |
GO:0043547 | positive regulation of GTPase activity | 10.1449 | 6 | yes |
GO:0048812 | neuron projection morphogenesis | 10.1449 | 7 | yes |
GO:0120031 | plasma membrane bounded cell projection assembly | 10.1449 | 6 | yes |
GO:0030336 | negative regulation of cell migration | 8.6957 | 6 | yes |
GO:0040013 | negative regulation of locomotion | 8.6957 | 4 | yes |
GO:2000146 | negative regulation of cell motility | 8.6957 | 5 | yes |
GO:0046847 | filopodium assembly | 7.2464 | 7 | yes |
GO:0097581 | lamellipodium organization | 5.7971 | 6 | yes |
GO:0000904 | cell morphogenesis involved in differentiation | 4.3478 | 4 | yes |
GO:0030032 | lamellipodium assembly | 4.3478 | 7 | yes |
GO:0034446 | substrate adhesion-dependent cell spreading | 4.3478 | 4 | yes |
GO:0003363 | lamellipodium assembly involved in ameboidal cell migration | 2.8986 | 8 | yes |
GO:0021815 | modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration | 2.8986 | 4 | yes |
GO:0021816 | extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration | 2.8986 | 5 | yes |
GO:0031268 | pseudopodium organization | 2.8986 | 6 | yes |
GO:0031269 | pseudopodium assembly | 2.8986 | 7 | yes |
GO:2001222 | regulation of neuron migration | 2.8986 | 6 | yes |
GO:2001223 | negative regulation of neuron migration | 2.8986 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SRGP2_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 2.8986 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 2.8986 | 5 | no |
DOID:114 | heart disease | 2.8986 | 3 | no |
DOID:2843 | long QT syndrome | 2.8986 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FMNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ROBO2_HUMAN | [view interactions] | Low throughput | no | yes |
FMNL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRG2C_HUMAN | [view interactions] | Low throughput | no | no |
ANM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SRGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ROBO1_HUMAN | [view interactions] | Low throughput | no | yes |
GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
YLPM1_HUMAN | [view interactions] | Low throughput | no | yes |
TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRIMM_HUMAN | [view interactions] | High throughput | no | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRGP1_HUMAN | [view interactions] | High throughput | no | no |
SCOC_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP19_HUMAN | [view interactions] | High throughput | no | no |
PCM1_HUMAN | [view interactions] | High throughput | no | yes |
AKIP_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K21_HUMAN | [view interactions] | High throughput | no | yes |
PTN14_HUMAN | [view interactions] | High throughput | no | yes |
ZN638_HUMAN | [view interactions] | High throughput | no | yes |
TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN13_HUMAN | [view interactions] | High throughput | no | yes |
CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
CDK16_HUMAN | [view interactions] | High throughput | no | yes |
MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IF4E2_HUMAN | [view interactions] | High throughput | no | no |
MAST3_HUMAN | [view interactions] | High throughput | no | yes |
CHK1_HUMAN | [view interactions] | High throughput | no | no |
PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
MYCPP_HUMAN | [view interactions] | High throughput | no | no |
AN34A_HUMAN | [view interactions] | High throughput | no | no |
LARP1_HUMAN | [view interactions] | High throughput | no | yes |
RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
GAB2_HUMAN | [view interactions] | High throughput | no | yes |
PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
FA53C_HUMAN | [view interactions] | High throughput | no | yes |
INP5E_HUMAN | [view interactions] | High throughput | no | yes |
TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
RTKN_HUMAN | [view interactions] | High throughput | no | yes |
LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
SIN1_HUMAN | [view interactions] | High throughput | no | yes |
RAB3I_HUMAN | [view interactions] | High throughput | no | no |
EDC3_HUMAN | [view interactions] | High throughput | no | yes |
SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
DEN1A_HUMAN | [view interactions] | High throughput | no | no |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
NADK_HUMAN | [view interactions] | High throughput | no | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
MELK_HUMAN | [view interactions] | High throughput | no | yes |
TBC25_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
NAV1_HUMAN | [view interactions] | High throughput | no | yes |
F110B_HUMAN | [view interactions] | High throughput | no | yes |
HDAC7_HUMAN | [view interactions] | High throughput | no | no |
DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
SRS12_HUMAN | [view interactions] | High throughput | no | no |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
TESK2_HUMAN | [view interactions] | High throughput | no | yes |
F110A_HUMAN | [view interactions] | High throughput | no | yes |
PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI13B_HUMAN | [view interactions] | High throughput | no | yes |
SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CING_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP21_HUMAN | [view interactions] | High throughput | no | no |
ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
STA13_HUMAN | [view interactions] | High throughput | no | yes |
ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1G_HUMAN | [view interactions] | High throughput | no | no |
CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASP_HUMAN | [view interactions] | High throughput | no | yes |
WIPF1_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LUZP4_HUMAN | [view interactions] | High throughput | no | no |
SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
LNX2_HUMAN | [view interactions] | High throughput | no | yes |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
KPRP_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
ODAD1_HUMAN | [view interactions] | High throughput | no | no |
KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
S100P_HUMAN | [view interactions] | High throughput | no | no |
DUS16_HUMAN | [view interactions] | High throughput | no | yes |
BSPRY_HUMAN | [view interactions] | High throughput | no | no |
ZN414_HUMAN | [view interactions] | High throughput | no | yes |
CCD96_HUMAN | [view interactions] | High throughput | no | no |
PRPS2_HUMAN | [view interactions] | High throughput | no | no |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
LPXN_HUMAN | [view interactions] | High throughput | no | yes |
RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG15_HUMAN | [view interactions] | High throughput | no | no |
RHG19_HUMAN | [view interactions] | High throughput | no | yes |
RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG35_HUMAN | [view interactions] | High throughput | no | yes |
RHG40_HUMAN | [view interactions] | High throughput | no | no |
RHG42_HUMAN | [view interactions] | High throughput | no | yes |
CHIO_HUMAN | [view interactions] | High throughput | no | yes |
DNMBP_HUMAN | [view interactions] | High throughput | no | no |
DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLI1_HUMAN | [view interactions] | High throughput | no | no |
GLI2_HUMAN | [view interactions] | High throughput | no | yes |
GNAL_HUMAN | [view interactions] | High throughput | no | yes |
LHX5_HUMAN | [view interactions] | High throughput | no | no |
PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRIC1_HUMAN | [view interactions] | High throughput | no | yes |
PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGF1B_HUMAN | [view interactions] | High throughput | no | no |
S26A7_HUMAN | [view interactions] | High throughput | no | no |
CTR2_HUMAN | [view interactions] | High throughput | no | no |
SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
TIM44_HUMAN | [view interactions] | High throughput | no | yes |
VAV_HUMAN | [view interactions] | High throughput | no | no |
TOM70_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
HYDIN_HUMAN | [view interactions] | Computational | no | no |
GRIN2_HUMAN | [view interactions] | Computational | no | yes |
WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |