SI1L1_HUMAN
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI004046 | LIG_DLG_GKlike_1 | LIG | 1629 | 1637 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SI1L1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 27.4510 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 27.4510 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.4510 | 4 | no |
GO:0019900 | kinase binding | 21.5686 | 4 | no |
GO:0030695 | GTPase regulator activity | 19.6078 | 4 | yes |
GO:0005096 | GTPase activator activity | 11.7647 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SI1L1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 54.9020 | 4 | no |
GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | no |
GO:0051128 | regulation of cellular component organization | 50.9804 | 4 | yes |
GO:0010646 | regulation of cell communication | 49.0196 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 49.0196 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 47.0588 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 47.0588 | 4 | no |
GO:0008104 | protein localization | 45.0980 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 45.0980 | 4 | no |
GO:0009966 | regulation of signal transduction | 43.1373 | 4 | yes |
GO:0022607 | cellular component assembly | 37.2549 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 31.3725 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.3725 | 5 | no |
GO:0031399 | regulation of protein modification process | 29.4118 | 6 | no |
GO:0010647 | positive regulation of cell communication | 29.4118 | 5 | no |
GO:0023056 | positive regulation of signaling | 29.4118 | 4 | no |
GO:0006996 | organelle organization | 29.4118 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 29.4118 | 5 | yes |
GO:0071702 | organic substance transport | 29.4118 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 27.4510 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 27.4510 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 27.4510 | 5 | no |
GO:0071705 | nitrogen compound transport | 27.4510 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 27.4510 | 4 | no |
GO:0045595 | regulation of cell differentiation | 25.4902 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.4902 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.4902 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.4902 | 5 | no |
GO:0030030 | cell projection organization | 25.4902 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 25.4902 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 25.4902 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.4902 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.5294 | 5 | no |
GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.5294 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.5686 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 21.5686 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 21.5686 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.5686 | 6 | no |
GO:0051094 | positive regulation of developmental process | 21.5686 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 21.5686 | 4 | no |
GO:0032880 | regulation of protein localization | 21.5686 | 5 | no |
GO:0060341 | regulation of cellular localization | 21.5686 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 21.5686 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 21.5686 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.5686 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 21.5686 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 21.5686 | 5 | no |
GO:0015031 | protein transport | 21.5686 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.5686 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 21.5686 | 5 | no |
GO:0007010 | cytoskeleton organization | 19.6078 | 5 | yes |
GO:0010975 | regulation of neuron projection development | 17.6471 | 7 | yes |
GO:0050807 | regulation of synapse organization | 15.6863 | 5 | yes |
GO:0051336 | regulation of hydrolase activity | 15.6863 | 4 | yes |
GO:0043087 | regulation of GTPase activity | 13.7255 | 5 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 13.7255 | 6 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 11.7647 | 4 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 9.8039 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 9.8039 | 6 | yes |
GO:0051345 | positive regulation of hydrolase activity | 9.8039 | 5 | yes |
GO:0061001 | regulation of dendritic spine morphogenesis | 9.8039 | 5 | yes |
GO:0099175 | regulation of postsynapse organization | 9.8039 | 6 | yes |
GO:0031532 | actin cytoskeleton reorganization | 5.8824 | 4 | yes |
GO:0048013 | ephrin receptor signaling pathway | 5.8824 | 6 | yes |
GO:0048814 | regulation of dendrite morphogenesis | 5.8824 | 5 | yes |
GO:0050773 | regulation of dendrite development | 5.8824 | 4 | yes |
GO:0050770 | regulation of axonogenesis | 3.9216 | 5 | yes |
GO:0090630 | activation of GTPase activity | 3.9216 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SI1L1_HUMAN |
---|---|---|---|---|
DOID:0050155 | sensory system disease | 3.9216 | 3 | no |
DOID:0050563 | nonsyndromic deafness | 3.9216 | 5 | no |
DOID:0050564 | autosomal dominant nonsyndromic deafness | 3.9216 | 6 | no |
DOID:2742 | auditory system disease | 3.9216 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CEBPE_HUMAN | [view interactions] | Low throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LZTS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CENPU_HUMAN | [view interactions] | High throughput | no | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI67_HUMAN | [view interactions] | High throughput | no | no |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
MCM7_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
DYR1B_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LATS2_HUMAN | [view interactions] | High throughput | no | yes |
ODFP2_HUMAN | [view interactions] | High throughput | no | no |
CE128_HUMAN | [view interactions] | High throughput | no | yes |
CP135_HUMAN | [view interactions] | High throughput | no | no |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
TBC25_HUMAN | [view interactions] | High throughput | no | yes |
M3K21_HUMAN | [view interactions] | High throughput | no | yes |
ZN638_HUMAN | [view interactions] | High throughput | no | yes |
MELK_HUMAN | [view interactions] | High throughput | no | yes |
PTN13_HUMAN | [view interactions] | High throughput | no | yes |
CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
CDK16_HUMAN | [view interactions] | High throughput | no | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |
MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NADK_HUMAN | [view interactions] | High throughput | no | yes |
GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IF4E2_HUMAN | [view interactions] | High throughput | no | no |
MAST3_HUMAN | [view interactions] | High throughput | no | yes |
DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYCPP_HUMAN | [view interactions] | High throughput | no | no |
GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
LARP1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
AN34A_HUMAN | [view interactions] | High throughput | no | no |
DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN14_HUMAN | [view interactions] | High throughput | no | yes |
RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
DEN1A_HUMAN | [view interactions] | High throughput | no | no |
KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
STA13_HUMAN | [view interactions] | High throughput | no | yes |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
GAB2_HUMAN | [view interactions] | High throughput | no | yes |
AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
UBP21_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FA53C_HUMAN | [view interactions] | High throughput | no | yes |
INP5E_HUMAN | [view interactions] | High throughput | no | yes |
TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
RTKN_HUMAN | [view interactions] | High throughput | no | yes |
LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
SIN1_HUMAN | [view interactions] | High throughput | no | yes |
RAB3I_HUMAN | [view interactions] | High throughput | no | no |
EDC3_HUMAN | [view interactions] | High throughput | no | yes |
SRS12_HUMAN | [view interactions] | High throughput | no | no |
DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
NAV1_HUMAN | [view interactions] | High throughput | no | yes |
F110B_HUMAN | [view interactions] | High throughput | no | yes |
HDAC7_HUMAN | [view interactions] | High throughput | no | no |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
TESK2_HUMAN | [view interactions] | High throughput | no | yes |
F110A_HUMAN | [view interactions] | High throughput | no | yes |
KI13B_HUMAN | [view interactions] | High throughput | no | yes |
SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
CING_HUMAN | [view interactions] | High throughput | no | no |
NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
FOXP3_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
WDR83_HUMAN | [view interactions] | High throughput | no | yes |
FKBP6_HUMAN | [view interactions] | High throughput | no | no |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
KLHL2_HUMAN | [view interactions] | High throughput | no | no |
STALP_HUMAN | [view interactions] | High throughput | no | yes |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
TRI66_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
SI1L3_HUMAN | [view interactions] | High throughput | no | yes |
SI1L2_HUMAN | [view interactions] | High throughput | no | yes |
SPSB4_HUMAN | [view interactions] | High throughput | no | no |
PIP_HUMAN | [view interactions] | High throughput | no | no |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSSK2_HUMAN | [view interactions] | High throughput | no | no |
CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
CWC27_HUMAN | [view interactions] | High throughput | no | yes |
GARL3_HUMAN | [view interactions] | High throughput | no | yes |
ICE2_HUMAN | [view interactions] | High throughput | no | no |
RGPA2_HUMAN | [view interactions] | High throughput | no | yes |
CEP63_HUMAN | [view interactions] | High throughput | no | yes |
MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NIN_HUMAN | [view interactions] | High throughput | no | no |
SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMOT_HUMAN | [view interactions] | High throughput | no | no |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
K2C8_HUMAN | [view interactions] | High throughput | no | no |
LATS1_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SAS6_HUMAN | [view interactions] | High throughput | no | no |
SEP10_HUMAN | [view interactions] | High throughput | no | yes |
SYNE3_HUMAN | [view interactions] | High throughput | no | no |
ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VASP_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
VP33B_HUMAN | [view interactions] | High throughput | no | yes |
NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBP11_HUMAN | [view interactions] | High throughput | no | yes |
FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |