SI1L1_HUMAN
Evidence for PS localization
Functions
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004046 | LIG_DLG_GKlike_1 | LIG | 1629 | 1637 | - |
| ELMI004046 | LIG_DLG_GKlike_1 | LIG | 1629 | 1637 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SI1L1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.6452 | 4 | no |
| GO:0000166 | nucleotide binding | 27.4194 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.4194 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.8065 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.1935 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.5806 | 6 | no |
| GO:0003779 | actin binding | 20.9677 | 4 | no |
| GO:0045296 | cadherin binding | 20.9677 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.9677 | 5 | no |
| GO:0019900 | kinase binding | 20.9677 | 4 | no |
| GO:0030695 | GTPase regulator activity | 19.3548 | 4 | yes |
| GO:0005096 | GTPase activator activity | 14.5161 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SI1L1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 56.4516 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 54.8387 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 53.2258 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.6129 | 4 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.3871 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.7742 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.1613 | 4 | no |
| GO:0006996 | organelle organization | 40.3226 | 4 | yes |
| GO:0022607 | cellular component assembly | 38.7097 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.4839 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.4839 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.4839 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.4839 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.8710 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 33.8710 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 29.0323 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.0323 | 5 | no |
| GO:0031399 | regulation of protein modification process | 29.0323 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 29.0323 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.0323 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.4194 | 4 | yes |
| GO:0030030 | cell projection organization | 27.4194 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.4194 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.4194 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.4194 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.4194 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.4194 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.8065 | 4 | no |
| GO:0051049 | regulation of transport | 25.8065 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.8065 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.8065 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.1935 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.1935 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.1935 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.1935 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 24.1935 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.5806 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 22.5806 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 22.5806 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 22.5806 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 22.5806 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5806 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.5806 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 22.5806 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.5806 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.5806 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | no |
| GO:0050807 | regulation of synapse organization | 20.9677 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.9677 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 20.9677 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.9677 | 4 | no |
| GO:0034330 | cell junction organization | 20.9677 | 4 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 17.7419 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 16.1290 | 7 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 14.5161 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 14.5161 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 12.9032 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 12.9032 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 9.6774 | 4 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 9.6774 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 8.0645 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 8.0645 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 8.0645 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 6.4516 | 5 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 4.8387 | 6 | yes |
| GO:0090630 | activation of GTPase activity | 3.2258 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CEBPE_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LZTS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL2_HUMAN | [view interactions] | High throughput | no | no |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SI1L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL6_HUMAN | [view interactions] | High throughput | no | no |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TSSK2_HUMAN | [view interactions] | High throughput | no | no |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| CWC27_HUMAN | [view interactions] | High throughput | no | yes |
| GARL3_HUMAN | [view interactions] | High throughput | no | yes |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| RGPA2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CENPU_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMIG1_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1B_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |