Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LZTS3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LZTS3_HUMAN
GO:0035254 glutamate receptor binding 30.7692 4 no
GO:0043169 cation binding 30.7692 4 no
GO:0046872 metal ion binding 30.7692 5 no
GO:0030695 GTPase regulator activity 30.7692 4 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0004674 protein serine/threonine kinase activity 23.0769 4 no
GO:0005524 ATP binding 23.0769 5 no
GO:0016301 kinase activity 23.0769 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0030554 adenyl nucleotide binding 23.0769 6 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0032559 adenyl ribonucleotide binding 23.0769 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0043168 anion binding 23.0769 4 no
GO:0106310 protein serine kinase activity 23.0769 4 no
GO:0001664 G protein-coupled receptor binding 23.0769 4 no
GO:0005096 GTPase activator activity 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LZTS3_HUMAN
GO:0010646 regulation of cell communication 84.6154 4 no
GO:0031344 regulation of cell projection organization 69.2308 5 yes
GO:0051128 regulation of cellular component organization 69.2308 4 yes
GO:0009966 regulation of signal transduction 69.2308 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 61.5385 6 yes
GO:0048522 positive regulation of cellular process 61.5385 4 no
GO:0022603 regulation of anatomical structure morphogenesis 53.8462 4 yes
GO:0050807 regulation of synapse organization 53.8462 5 yes
GO:0099175 regulation of postsynapse organization 53.8462 6 yes
GO:0050804 modulation of chemical synaptic transmission 53.8462 5 no
GO:0099177 regulation of trans-synaptic signaling 53.8462 4 no
GO:0010975 regulation of neuron projection development 46.1538 7 yes
GO:0006996 organelle organization 46.1538 4 no
GO:1902531 regulation of intracellular signal transduction 46.1538 5 no
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0030030 cell projection organization 38.4615 4 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0031325 positive regulation of cellular metabolic process 38.4615 5 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 no
GO:0043085 positive regulation of catalytic activity 38.4615 4 no
GO:0048523 negative regulation of cellular process 38.4615 4 no
GO:0051049 regulation of transport 38.4615 4 no
GO:0061001 regulation of dendritic spine morphogenesis 30.7692 5 yes
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0001934 positive regulation of protein phosphorylation 30.7692 8 no
GO:0007010 cytoskeleton organization 30.7692 5 no
GO:0008104 protein localization 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0010562 positive regulation of phosphorus metabolic process 30.7692 6 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0019220 regulation of phosphate metabolic process 30.7692 6 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0031399 regulation of protein modification process 30.7692 6 no
GO:0031401 positive regulation of protein modification process 30.7692 7 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:0042327 positive regulation of phosphorylation 30.7692 8 no
GO:0045937 positive regulation of phosphate metabolic process 30.7692 7 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0051174 regulation of phosphorus metabolic process 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0080090 regulation of primary metabolic process 30.7692 4 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0043269 regulation of monoatomic ion transport 30.7692 5 no
GO:0050890 cognition 30.7692 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 30.7692 6 no
GO:0006468 protein phosphorylation 23.0769 5 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0048812 neuron projection morphogenesis 23.0769 5 no
GO:0072657 protein localization to membrane 23.0769 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.0769 4 no
GO:0007613 memory 23.0769 4 no
GO:0010038 response to metal ion 23.0769 4 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0034765 regulation of monoatomic ion transmembrane transport 23.0769 5 no
GO:0043549 regulation of kinase activity 23.0769 5 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0045859 regulation of protein kinase activity 23.0769 6 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.0769 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 23.0769 9 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051338 regulation of transferase activity 23.0769 4 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0061097 regulation of protein tyrosine kinase activity 23.0769 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 23.0769 8 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0097061 dendritic spine organization 23.0769 5 no
GO:0099173 postsynapse organization 23.0769 4 no
GO:0106027 neuron projection organization 23.0769 6 no
GO:0022898 regulation of transmembrane transporter activity 23.0769 4 no
GO:0031175 neuron projection development 23.0769 6 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 23.0769 5 no
GO:0043270 positive regulation of monoatomic ion transport 23.0769 5 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
SI1L1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCDC6_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
ODFP2_HUMAN [view interactions] High throughput no no
CK5P2_HUMAN [view interactions] High throughput no yes
DYR1B_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
FGF11_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SI1L3_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
H2B3B_HUMAN [view interactions] High throughput no yes
SI1L2_HUMAN [view entry] [view interactions] High throughput yes yes
BTBD1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
DCAF7_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes