Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LZTS3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LZTS3_HUMAN
GO:0046872 metal ion binding 37.5000 4 no
GO:0035254 glutamate receptor binding 25.0000 4 no
GO:0003779 actin binding 25.0000 4 no
GO:0004674 protein serine/threonine kinase activity 25.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0106310 protein serine kinase activity 25.0000 4 no
GO:0030695 GTPase regulator activity 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LZTS3_HUMAN
GO:0031344 regulation of cell projection organization 75.0000 5 yes
GO:0051128 regulation of cellular component organization 75.0000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 75.0000 6 yes
GO:0010646 regulation of cell communication 75.0000 4 no
GO:0010975 regulation of neuron projection development 62.5000 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 62.5000 4 yes
GO:0050807 regulation of synapse organization 62.5000 5 yes
GO:0099175 regulation of postsynapse organization 62.5000 6 yes
GO:0009966 regulation of signal transduction 62.5000 4 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0061001 regulation of dendritic spine morphogenesis 50.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0008104 protein localization 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0043270 positive regulation of ion transport 37.5000 5 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0006996 organelle organization 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 25.0000 6 no
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:0007613 memory 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0048854 brain morphogenesis 25.0000 4 no
GO:0050890 cognition 25.0000 4 no
GO:0000165 MAPK cascade 25.0000 4 no
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0031532 actin cytoskeleton reorganization 25.0000 4 no
GO:0032990 cell part morphogenesis 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0048814 regulation of dendrite morphogenesis 25.0000 5 no
GO:0048858 cell projection morphogenesis 25.0000 5 no
GO:0050773 regulation of dendrite development 25.0000 4 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0048013 ephrin receptor signaling pathway 25.0000 6 no
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 no
GO:0031175 neuron projection development 25.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
SI1L1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCDC6_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1B_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
FGF11_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SI1L3_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
H2B3B_HUMAN [view interactions] High throughput no yes
SI1L2_HUMAN [view interactions] High throughput no yes
BTBD1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
DCAF7_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes