SI1L3_HUMAN
Evidence for PS localization
Functions
Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SI1L3_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 31.0345 | 4 | no |
| GO:0045296 | cadherin binding | 31.0345 | 4 | no |
| GO:0043168 | anion binding | 25.8621 | 4 | no |
| GO:0019900 | kinase binding | 25.8621 | 4 | no |
| GO:0000166 | nucleotide binding | 24.1379 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.1379 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.1379 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.1379 | 4 | no |
| GO:0019901 | protein kinase binding | 24.1379 | 5 | no |
| GO:0003723 | RNA binding | 20.6897 | 4 | no |
| GO:0005524 | ATP binding | 20.6897 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.6897 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.6897 | 5 | no |
| GO:0030695 | GTPase regulator activity | 8.6207 | 4 | yes |
| GO:0005096 | GTPase activator activity | 6.8966 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SI1L3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.8966 | 4 | no |
| GO:0008104 | protein localization | 51.7241 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 51.7241 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.7241 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.7241 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.7241 | 4 | no |
| GO:0006996 | organelle organization | 48.2759 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.2759 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.1034 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.3793 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.3793 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.3793 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.6552 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.6552 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.2069 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.2069 | 5 | no |
| GO:0007010 | cytoskeleton organization | 32.7586 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 32.7586 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.7586 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.7586 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.3103 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.3103 | 4 | no |
| GO:0071702 | organic substance transport | 27.5862 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.5862 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.5862 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.5862 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.5862 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.5862 | 5 | no |
| GO:0071705 | nitrogen compound transport | 25.8621 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.8621 | 6 | no |
| GO:0015031 | protein transport | 24.1379 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.1379 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.1379 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.1379 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.1379 | 5 | no |
| GO:0051049 | regulation of transport | 24.1379 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.1379 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.4138 | 5 | yes |
| GO:0030030 | cell projection organization | 22.4138 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.4138 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 22.4138 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.4138 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 22.4138 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.4138 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.6897 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.6897 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.6897 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 20.6897 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.6897 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.6897 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6897 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.6897 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.6897 | 6 | no |
| GO:0051726 | regulation of cell cycle | 20.6897 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.6897 | 4 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 10.3448 | 6 | yes |
| GO:0090162 | establishment of epithelial cell polarity | 3.4483 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC26_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1B_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| GRIK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| LZTS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIPA1_HUMAN | [view interactions] | High throughput | no | yes |
| SPI2A_HUMAN | [view interactions] | High throughput | no | no |
| ITA6_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |