Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIK1_HUMAN
GO:0004970 ionotropic glutamate receptor activity 37.5000 5 yes
GO:0005216 ion channel activity 37.5000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 37.5000 6 yes
GO:0005261 cation channel activity 37.5000 5 yes
GO:0005267 potassium channel activity 37.5000 6 yes
GO:0005272 sodium channel activity 37.5000 6 yes
GO:0008066 glutamate receptor activity 37.5000 4 yes
GO:0008324 cation transmembrane transporter activity 37.5000 4 yes
GO:0015079 potassium ion transmembrane transporter activity 37.5000 6 yes
GO:0015081 sodium ion transmembrane transporter activity 37.5000 6 yes
GO:0015267 channel activity 37.5000 4 yes
GO:0015276 ligand-gated ion channel activity 37.5000 5 yes
GO:0015277 kainate selective glutamate receptor activity 37.5000 6 yes
GO:0022824 transmitter-gated ion channel activity 37.5000 5 yes
GO:0022834 ligand-gated channel activity 37.5000 6 yes
GO:0022835 transmitter-gated channel activity 37.5000 4 yes
GO:0022836 gated channel activity 37.5000 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 37.5000 4 yes
GO:0046873 metal ion transmembrane transporter activity 37.5000 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 37.5000 4 yes
GO:0099094 ligand-gated cation channel activity 37.5000 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 37.5000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 37.5000 6 yes
GO:0001664 G protein-coupled receptor binding 37.5000 4 no
GO:0003779 actin binding 25.0000 4 no
GO:0005109 frizzled binding 25.0000 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0030165 PDZ domain binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRIK1_HUMAN
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0007268 chemical synaptic transmission 62.5000 6 yes
GO:0050804 modulation of chemical synaptic transmission 62.5000 5 yes
GO:0098916 anterograde trans-synaptic signaling 62.5000 5 yes
GO:0099177 regulation of trans-synaptic signaling 62.5000 4 yes
GO:0099537 trans-synaptic signaling 62.5000 4 yes
GO:0008104 protein localization 62.5000 4 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0072657 protein localization to membrane 62.5000 4 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 no
GO:0007215 glutamate receptor signaling pathway 37.5000 4 yes
GO:0007399 nervous system development 37.5000 4 yes
GO:0035249 synaptic transmission, glutamatergic 37.5000 7 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 37.5000 6 yes
GO:0006996 organelle organization 37.5000 4 no
GO:0002090 regulation of receptor internalization 37.5000 7 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0030100 regulation of endocytosis 37.5000 5 no
GO:0043113 receptor clustering 37.5000 5 no
GO:0048259 regulation of receptor-mediated endocytosis 37.5000 6 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051094 positive regulation of developmental process 37.5000 4 no
GO:0051129 negative regulation of cellular component organization 37.5000 5 no
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0006886 intracellular protein transport 37.5000 4 no
GO:0015031 protein transport 37.5000 4 no
GO:0071702 organic substance transport 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:0007417 central nervous system development 25.0000 4 yes
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0002091 negative regulation of receptor internalization 25.0000 7 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0035418 protein localization to synapse 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045806 negative regulation of endocytosis 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0048168 regulation of neuronal synaptic plasticity 25.0000 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 25.0000 5 no
GO:0048261 negative regulation of receptor-mediated endocytosis 25.0000 6 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0050806 positive regulation of synaptic transmission 25.0000 5 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0062237 protein localization to postsynapse 25.0000 7 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0097061 dendritic spine organization 25.0000 5 no
GO:0099173 postsynapse organization 25.0000 4 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:0150011 regulation of neuron projection arborization 25.0000 6 no
GO:0150012 positive regulation of neuron projection arborization 25.0000 5 no
GO:1902414 protein localization to cell junction 25.0000 5 no
GO:1903539 protein localization to postsynaptic membrane 25.0000 5 no
GO:1990778 protein localization to cell periphery 25.0000 5 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0090150 establishment of protein localization to membrane 25.0000 4 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0032872 regulation of stress-activated MAPK cascade 25.0000 6 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0046328 regulation of JNK cascade 25.0000 7 no
GO:0050805 negative regulation of synaptic transmission 25.0000 5 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:1903530 regulation of secretion by cell 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
KLH17_HUMAN [view entry] [view interactions] Low throughput yes no
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLTR2_HUMAN [view interactions] High throughput no no
TAAR1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] Computational no yes
GRIK2_HUMAN [view entry] [view interactions] Computational yes yes