Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SEPT7_HUMAN

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SEPT7_HUMAN
GO:0000166 nucleotide binding 42.8571 4 yes
GO:0043168 anion binding 42.8571 4 yes
GO:0017076 purine nucleotide binding 40.0000 5 yes
GO:0032555 purine ribonucleotide binding 40.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.5714 4 yes
GO:0003723 RNA binding 27.1429 4 no
GO:0016462 pyrophosphatase activity 24.2857 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.2857 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.2857 6 yes
GO:0019900 kinase binding 22.8571 4 no
GO:0030554 adenyl nucleotide binding 22.8571 6 no
GO:0032559 adenyl ribonucleotide binding 22.8571 5 no
GO:0005524 ATP binding 21.4286 5 no
GO:0019001 guanyl nucleotide binding 20.0000 6 yes
GO:0032561 guanyl ribonucleotide binding 20.0000 5 yes
GO:0003924 GTPase activity 18.5714 7 yes
GO:0005525 GTP binding 18.5714 5 yes
GO:0045296 cadherin binding 15.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SEPT7_HUMAN
GO:0048522 positive regulation of cellular process 64.2857 4 yes
GO:0051128 regulation of cellular component organization 54.2857 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0010646 regulation of cell communication 48.5714 4 no
GO:0008104 protein localization 48.5714 4 no
GO:0006996 organelle organization 47.1429 4 yes
GO:0048523 negative regulation of cellular process 47.1429 4 no
GO:0080090 regulation of primary metabolic process 47.1429 4 no
GO:0031323 regulation of cellular metabolic process 44.2857 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0071702 organic substance transport 40.0000 4 no
GO:0051246 regulation of protein metabolic process 38.5714 5 no
GO:0071705 nitrogen compound transport 38.5714 4 no
GO:0022607 cellular component assembly 37.1429 4 yes
GO:0009889 regulation of biosynthetic process 37.1429 4 no
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010468 regulation of gene expression 35.7143 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 no
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 no
GO:0044087 regulation of cellular component biogenesis 34.2857 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 34.2857 5 no
GO:0048584 positive regulation of response to stimulus 32.8571 4 no
GO:1902531 regulation of intracellular signal transduction 32.8571 5 no
GO:0010647 positive regulation of cell communication 31.4286 5 no
GO:0023056 positive regulation of signaling 31.4286 4 no
GO:0051049 regulation of transport 31.4286 4 no
GO:0060341 regulation of cellular localization 30.0000 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 yes
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0015031 protein transport 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0031399 regulation of protein modification process 27.1429 6 no
GO:0043067 regulation of programmed cell death 27.1429 4 no
GO:0051247 positive regulation of protein metabolic process 27.1429 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.1429 5 no
GO:0030030 cell projection organization 25.7143 4 yes
GO:0009892 negative regulation of metabolic process 25.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.7143 5 no
GO:0042981 regulation of apoptotic process 25.7143 5 no
GO:0071310 cellular response to organic substance 25.7143 4 no
GO:0007010 cytoskeleton organization 25.7143 5 no
GO:0022603 regulation of anatomical structure morphogenesis 24.2857 4 yes
GO:0120036 plasma membrane bounded cell projection organization 24.2857 5 yes
GO:0031324 negative regulation of cellular metabolic process 24.2857 5 no
GO:0036211 protein modification process 24.2857 4 no
GO:0043412 macromolecule modification 24.2857 4 no
GO:0009894 regulation of catabolic process 24.2857 4 no
GO:0051252 regulation of RNA metabolic process 24.2857 5 no
GO:0031344 regulation of cell projection organization 22.8571 5 yes
GO:0033043 regulation of organelle organization 22.8571 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.8571 6 yes
GO:0019220 regulation of phosphate metabolic process 22.8571 6 no
GO:0051174 regulation of phosphorus metabolic process 22.8571 5 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 yes
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:2000026 regulation of multicellular organismal development 18.5714 4 yes
GO:0010638 positive regulation of organelle organization 17.1429 6 yes
GO:0031346 positive regulation of cell projection organization 17.1429 6 yes
GO:0070925 organelle assembly 14.2857 5 yes
GO:0060491 regulation of cell projection assembly 11.4286 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 11.4286 6 yes
GO:0022604 regulation of cell morphogenesis 10.0000 5 yes
GO:0030031 cell projection assembly 10.0000 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 10.0000 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 10.0000 6 yes
GO:0061640 cytoskeleton-dependent cytokinesis 8.5714 4 yes
GO:0044782 cilium organization 5.7143 5 yes
GO:0048232 male gamete generation 5.7143 4 yes
GO:0060271 cilium assembly 5.7143 6 yes
GO:0045724 positive regulation of cilium assembly 4.2857 7 yes
GO:1902017 regulation of cilium assembly 4.2857 6 yes
GO:1902115 regulation of organelle assembly 4.2857 5 yes
GO:1902117 positive regulation of organelle assembly 4.2857 6 yes
GO:0016476 regulation of embryonic cell shape 2.8571 4 yes
GO:0045995 regulation of embryonic development 2.8571 5 yes
GO:1902855 regulation of non-motile cilium assembly 2.8571 7 yes
GO:1902857 positive regulation of non-motile cilium assembly 2.8571 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CENPE_HUMAN [view interactions] Low throughput no no
RNF8_HUMAN [view interactions] Low throughput no yes
AP3B1_HUMAN [view entry] [view interactions] Low throughput yes yes
BAX_HUMAN [view interactions] Low throughput no yes
BORG3_HUMAN [view interactions] Low throughput no no
BORG1_HUMAN [view interactions] Low throughput no yes
BORG2_HUMAN [view interactions] Low throughput no yes
SEP14_HUMAN [view interactions] Low throughput no no
SEPT5_HUMAN [view interactions] Low throughput no no
SEPT9_HUMAN [view interactions] Low throughput no no
SEPT2_HUMAN [view interactions] Low throughput no no
SEP11_HUMAN [view entry] [view interactions] Low throughput yes yes
SEPT6_HUMAN [view interactions] Low throughput no yes
HDAC6_HUMAN [view interactions] Low throughput no yes
SEPT7_HUMAN [view entry] [view interactions] Low throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
PRCC_HUMAN [view interactions] High throughput no yes
GORS2_HUMAN [view interactions] High throughput no yes
CHRD1_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
SRRM2_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
ITA4_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BORG4_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT3_HUMAN [view interactions] High throughput no no
SEPT1_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
TGS1_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MKNK1_HUMAN [view interactions] High throughput no yes
SCMH1_HUMAN [view interactions] High throughput no no
CXXC1_HUMAN [view interactions] High throughput no yes
CPEB2_HUMAN [view entry] [view interactions] High throughput yes no
SEPT4_HUMAN [view interactions] High throughput no no
RM12_HUMAN [view interactions] High throughput no yes
CCND2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
UBR7_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK9_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
H2B1B_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ARM12_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
DOCK8_HUMAN [view interactions] High throughput no yes
PKHG4_HUMAN [view interactions] High throughput no no
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
ACAP3_HUMAN [view interactions] High throughput no no
FGD5_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
COPE_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ASXL3_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
TET5C_HUMAN [view interactions] High throughput no yes
MOB3C_HUMAN [view interactions] High throughput no no
MET14_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
TOP2B_HUMAN [view interactions] High throughput no yes
ACINU_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
RED_HUMAN [view interactions] High throughput no yes
SAP18_HUMAN [view interactions] High throughput no yes
TRI55_HUMAN [view interactions] High throughput no no
SRSF5_HUMAN [view interactions] High throughput no yes
ZN326_HUMAN [view interactions] High throughput no yes
HNRPC_HUMAN [view interactions] High throughput no yes
VTNC_HUMAN [view interactions] High throughput no no
NICA_HUMAN [view interactions] High throughput no yes
UT14A_HUMAN [view interactions] High throughput no yes
RU2A_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
SRSF7_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
TF3C1_HUMAN [view interactions] High throughput no yes
TPBG_HUMAN [view interactions] High throughput no yes
TRA2B_HUMAN [view interactions] High throughput no yes
SMCA5_HUMAN [view interactions] High throughput no yes
VASN_HUMAN [view interactions] High throughput no yes
SRP14_HUMAN [view interactions] High throughput no no
SURF4_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
U2AF1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
RBM25_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
TRA2A_HUMAN [view interactions] High throughput no yes
DHX36_HUMAN [view interactions] High throughput no yes
BUD31_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
SSRG_HUMAN [view interactions] High throughput no yes
SON_HUMAN [view interactions] High throughput no yes
PRPF3_HUMAN [view interactions] High throughput no yes
ENAH_HUMAN [view entry] [view interactions] High throughput yes yes
ESF1_HUMAN [view interactions] High throughput no yes
YTHD2_HUMAN [view interactions] High throughput no yes
ZWILC_HUMAN [view interactions] High throughput no no
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPR_HUMAN [view interactions] High throughput no yes
HEXA_HUMAN [view interactions] High throughput no yes
NMT1_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
CNBP_HUMAN [view interactions] High throughput no no
HMCS1_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
AIMP2_HUMAN [view interactions] High throughput no yes
DNJC3_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
NAB2_HUMAN [view interactions] High throughput no yes
TXND5_HUMAN [view interactions] High throughput no yes
STK39_HUMAN [view entry] [view interactions] High throughput yes yes
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
LRCH3_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
DCA15_HUMAN [view interactions] High throughput no no
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
BICD2_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
PER2_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
SEP12_HUMAN [view interactions] High throughput no no
RRP1B_HUMAN [view interactions] High throughput no yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
STAP2_HUMAN [view interactions] High throughput no yes
KMT2D_HUMAN [view interactions] High throughput no yes
M3K9_HUMAN [view interactions] High throughput no yes
SEP10_HUMAN [view interactions] High throughput no yes
SEPT8_HUMAN [view interactions] High throughput no no
AKIP_HUMAN [view interactions] High throughput no yes
SMHD1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PHAG1_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
GRIK1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
KCNK3_HUMAN [view interactions] High throughput no no
TCP4_HUMAN [view interactions] High throughput no yes
COPZ1_HUMAN [view interactions] High throughput no no
SARNP_HUMAN [view interactions] High throughput no yes
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
SCYL2_HUMAN [view interactions] High throughput no yes