BORG4_HUMAN
Evidence for PS localization
Functions
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BORG4_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 52.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 52.7778 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 52.7778 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 52.7778 | 4 | no |
| GO:0043168 | anion binding | 52.7778 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 44.4444 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 44.4444 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 44.4444 | 6 | no |
| GO:0003924 | GTPase activity | 41.6667 | 7 | no |
| GO:0005525 | GTP binding | 38.8889 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 38.8889 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 38.8889 | 5 | no |
| GO:0019900 | kinase binding | 30.5556 | 4 | no |
| GO:0019901 | protein kinase binding | 27.7778 | 5 | no |
| GO:0003723 | RNA binding | 13.8889 | 4 | yes |
| GO:0051020 | GTPase binding | 5.5556 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BORG4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.5556 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 63.8889 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.5556 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.7778 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.7778 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 47.2222 | 4 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 44.4444 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 41.6667 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 41.6667 | 5 | yes |
| GO:0010468 | regulation of gene expression | 38.8889 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.8889 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 38.8889 | 5 | no |
| GO:0023056 | positive regulation of signaling | 38.8889 | 4 | no |
| GO:0030334 | regulation of cell migration | 38.8889 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.8889 | 5 | no |
| GO:0051049 | regulation of transport | 38.8889 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 38.8889 | 5 | no |
| GO:2000145 | regulation of cell motility | 38.8889 | 4 | no |
| GO:0008104 | protein localization | 38.8889 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 38.8889 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 36.1111 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 36.1111 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 36.1111 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 36.1111 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 33.3333 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 30.5556 | 6 | no |
| GO:0030030 | cell projection organization | 30.5556 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.5556 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 30.5556 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.5556 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.5556 | 5 | no |
| GO:0032880 | regulation of protein localization | 30.5556 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.7778 | 7 | no |
| GO:0008284 | positive regulation of cell population proliferation | 27.7778 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 27.7778 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 27.7778 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 27.7778 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.7778 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 27.7778 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 27.7778 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 27.7778 | 5 | no |
| GO:0007010 | cytoskeleton organization | 27.7778 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 27.7778 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 27.7778 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 27.7778 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 25.0000 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0043408 | regulation of MAPK cascade | 25.0000 | 6 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | yes |
| GO:0060491 | regulation of cell projection assembly | 25.0000 | 5 | yes |
| GO:0006915 | apoptotic process | 22.2222 | 4 | no |
| GO:0007015 | actin filament organization | 22.2222 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
| GO:0002684 | positive regulation of immune system process | 22.2222 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 22.2222 | 4 | no |
| GO:0031175 | neuron projection development | 22.2222 | 6 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | no |
| GO:1903829 | positive regulation of protein localization | 22.2222 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.2222 | 7 | no |
| GO:0051726 | regulation of cell cycle | 22.2222 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.2222 | 6 | no |
| GO:0050807 | regulation of synapse organization | 22.2222 | 5 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.2222 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 22.2222 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 22.2222 | 6 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 19.4444 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 19.4444 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 16.6667 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 16.6667 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 16.6667 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.6667 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 13.8889 | 6 | yes |
| GO:0007266 | Rho protein signal transduction | 13.8889 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 13.8889 | 5 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 13.8889 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 13.8889 | 7 | yes |
| GO:0032535 | regulation of cellular component size | 11.1111 | 4 | yes |
| GO:0034097 | response to cytokine | 11.1111 | 4 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 8.3333 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 8.3333 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 8.3333 | 7 | yes |
| GO:0071346 | cellular response to type II interferon | 5.5556 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 5.5556 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 5.5556 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 5.5556 | 7 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 5.5556 | 7 | yes |
| GO:0031272 | regulation of pseudopodium assembly | 5.5556 | 7 | yes |
| GO:0031274 | positive regulation of pseudopodium assembly | 5.5556 | 7 | yes |
| GO:0034341 | response to type II interferon | 5.5556 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SEPT3_HUMAN | [view interactions] | High throughput | no | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGT_HUMAN | [view interactions] | High throughput | no | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBL2B_HUMAN | [view interactions] | High throughput | no | no |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| RBFA_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| SBSN_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| SEPT2_HUMAN | [view interactions] | High throughput | no | no |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| SEP14_HUMAN | [view interactions] | High throughput | no | no |
| KLH15_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT5_HUMAN | [view interactions] | High throughput | no | no |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPC8_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT4_HUMAN | [view interactions] | High throughput | no | no |
| SEPT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT8_HUMAN | [view interactions] | High throughput | no | no |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |