Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BORG4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BORG4_HUMAN
GO:0017076 purine nucleotide binding 56.2500 4 no
GO:0032555 purine ribonucleotide binding 56.2500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 56.2500 4 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0003924 GTPase activity 46.8750 7 no
GO:0005525 GTP binding 43.7500 5 no
GO:0019001 guanyl nucleotide binding 43.7500 5 no
GO:0032561 guanyl ribonucleotide binding 43.7500 5 no
GO:0019900 kinase binding 37.5000 4 no
GO:0019901 protein kinase binding 34.3750 5 no
GO:0019003 GDP binding 21.8750 4 no
GO:0003723 RNA binding 15.6250 4 yes
GO:0051020 GTPase binding 6.2500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BORG4_HUMAN
GO:0048522 positive regulation of cellular process 81.2500 4 yes
GO:0051128 regulation of cellular component organization 59.3750 4 yes
GO:0031323 regulation of cellular metabolic process 56.2500 4 no
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:0022607 cellular component assembly 53.1250 4 no
GO:0006996 organelle organization 53.1250 4 no
GO:0060255 regulation of macromolecule metabolic process 53.1250 4 no
GO:0080090 regulation of primary metabolic process 53.1250 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 46.8750 4 no
GO:0048584 positive regulation of response to stimulus 43.7500 4 no
GO:0009893 positive regulation of metabolic process 43.7500 4 no
GO:0031344 regulation of cell projection organization 40.6250 5 yes
GO:0033043 regulation of organelle organization 40.6250 5 yes
GO:0044087 regulation of cellular component biogenesis 40.6250 4 yes
GO:0051130 positive regulation of cellular component organization 40.6250 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.6250 6 yes
GO:0008104 protein localization 40.6250 4 no
GO:0010647 positive regulation of cell communication 40.6250 5 no
GO:0023056 positive regulation of signaling 40.6250 4 no
GO:0051049 regulation of transport 40.6250 4 no
GO:0010468 regulation of gene expression 40.6250 5 no
GO:0010604 positive regulation of macromolecule metabolic process 40.6250 5 no
GO:0031325 positive regulation of cellular metabolic process 40.6250 5 no
GO:0051246 regulation of protein metabolic process 40.6250 5 no
GO:1902531 regulation of intracellular signal transduction 40.6250 5 no
GO:0007264 small GTPase mediated signal transduction 37.5000 4 yes
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0007010 cytoskeleton organization 37.5000 5 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0030334 regulation of cell migration 37.5000 5 no
GO:0042127 regulation of cell population proliferation 37.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:2000145 regulation of cell motility 37.5000 4 no
GO:0007265 Ras protein signal transduction 34.3750 5 yes
GO:0071310 cellular response to organic substance 34.3750 4 yes
GO:0010941 regulation of cell death 34.3750 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.3750 5 no
GO:0019220 regulation of phosphate metabolic process 34.3750 6 no
GO:0042981 regulation of apoptotic process 34.3750 6 no
GO:0043067 regulation of programmed cell death 34.3750 5 no
GO:0051174 regulation of phosphorus metabolic process 34.3750 5 no
GO:0016192 vesicle-mediated transport 34.3750 4 no
GO:0032880 regulation of protein localization 34.3750 5 no
GO:0060341 regulation of cellular localization 34.3750 4 no
GO:0120036 plasma membrane bounded cell projection organization 34.3750 5 no
GO:0032956 regulation of actin cytoskeleton organization 31.2500 5 yes
GO:0032970 regulation of actin filament-based process 31.2500 4 yes
GO:0044089 positive regulation of cellular component biogenesis 31.2500 5 yes
GO:0051493 regulation of cytoskeleton organization 31.2500 6 yes
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0022603 regulation of anatomical structure morphogenesis 28.1250 4 yes
GO:0022604 regulation of cell morphogenesis 28.1250 5 yes
GO:0060491 regulation of cell projection assembly 28.1250 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 28.1250 6 yes
GO:0097435 supramolecular fiber organization 28.1250 4 no
GO:0001932 regulation of protein phosphorylation 28.1250 7 no
GO:0009892 negative regulation of metabolic process 28.1250 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.1250 6 no
GO:0043085 positive regulation of catalytic activity 28.1250 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.1250 7 no
GO:0051094 positive regulation of developmental process 28.1250 4 no
GO:0051247 positive regulation of protein metabolic process 28.1250 6 no
GO:0051252 regulation of RNA metabolic process 28.1250 5 no
GO:1902533 positive regulation of intracellular signal transduction 28.1250 6 no
GO:0031175 neuron projection development 28.1250 6 no
GO:0008284 positive regulation of cell population proliferation 28.1250 5 no
GO:0008360 regulation of cell shape 25.0000 6 yes
GO:0010638 positive regulation of organelle organization 25.0000 6 yes
GO:0031346 positive regulation of cell projection organization 25.0000 6 yes
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 21.8750 6 yes
GO:0001934 positive regulation of protein phosphorylation 21.8750 8 no
GO:0002684 positive regulation of immune system process 21.8750 4 no
GO:0006355 regulation of DNA-templated transcription 21.8750 6 no
GO:0009968 negative regulation of signal transduction 21.8750 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.8750 6 no
GO:0010648 negative regulation of cell communication 21.8750 5 no
GO:0010942 positive regulation of cell death 21.8750 5 no
GO:0023057 negative regulation of signaling 21.8750 4 no
GO:0030865 cortical cytoskeleton organization 21.8750 6 no
GO:0043065 positive regulation of apoptotic process 21.8750 7 no
GO:0043068 positive regulation of programmed cell death 21.8750 6 no
GO:0045597 positive regulation of cell differentiation 21.8750 5 no
GO:0048585 negative regulation of response to stimulus 21.8750 4 no
GO:0051240 positive regulation of multicellular organismal process 21.8750 4 no
GO:0051345 positive regulation of hydrolase activity 21.8750 5 no
GO:0051726 regulation of cell cycle 21.8750 4 no
GO:1901701 cellular response to oxygen-containing compound 21.8750 4 no
GO:1903506 regulation of nucleic acid-templated transcription 21.8750 7 no
GO:2001141 regulation of RNA biosynthetic process 21.8750 6 no
GO:0009894 regulation of catabolic process 21.8750 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.8750 5 no
GO:0015031 protein transport 21.8750 4 no
GO:0051223 regulation of protein transport 21.8750 5 no
GO:0060627 regulation of vesicle-mediated transport 21.8750 4 no
GO:0070201 regulation of establishment of protein localization 21.8750 6 no
GO:0030031 cell projection assembly 21.8750 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.8750 6 no
GO:0036211 protein modification process 21.8750 4 no
GO:0043254 regulation of protein-containing complex assembly 18.7500 5 yes
GO:0051495 positive regulation of cytoskeleton organization 18.7500 7 yes
GO:1902903 regulation of supramolecular fiber organization 18.7500 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 18.7500 6 yes
GO:0007266 Rho protein signal transduction 15.6250 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 15.6250 6 yes
GO:0110053 regulation of actin filament organization 15.6250 6 yes
GO:0032271 regulation of protein polymerization 12.5000 6 yes
GO:0032273 positive regulation of protein polymerization 12.5000 7 yes
GO:0032535 regulation of cellular component size 12.5000 4 yes
GO:0034097 response to cytokine 12.5000 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 9.3750 6 yes
GO:0030832 regulation of actin filament length 9.3750 5 yes
GO:0030833 regulation of actin filament polymerization 9.3750 7 yes
GO:0030838 positive regulation of actin filament polymerization 9.3750 7 yes
GO:0071345 cellular response to cytokine stimulus 9.3750 5 yes
GO:0031272 regulation of pseudopodium assembly 6.2500 7 yes
GO:0031274 positive regulation of pseudopodium assembly 6.2500 7 yes
GO:0034341 response to interferon-gamma 6.2500 5 yes
GO:0071346 cellular response to interferon-gamma 6.2500 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TGFR1_HUMAN [view interactions] High throughput no no
KCTD5_HUMAN [view interactions] High throughput no no
SEPT9_HUMAN [view interactions] High throughput no no
SEPT2_HUMAN [view interactions] High throughput no no
SEPT5_HUMAN [view interactions] High throughput no no
KLH15_HUMAN [view interactions] High throughput no yes
SEP14_HUMAN [view interactions] High throughput no no
FHL2_HUMAN [view interactions] High throughput no yes
RT4I1_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
STA5B_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes
FAM9B_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view interactions] High throughput no yes
RPC8_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT4_HUMAN [view interactions] High throughput no no
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT6_HUMAN [view interactions] High throughput no yes
SEPT8_HUMAN [view interactions] High throughput no no
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT3_HUMAN [view interactions] High throughput no no
SEP10_HUMAN [view interactions] High throughput no yes
YBEY_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
TGT_HUMAN [view interactions] High throughput no no
RN146_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
SPY2_HUMAN [view interactions] High throughput no yes
SURF6_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
CALL5_HUMAN [view entry] [view interactions] High throughput yes no
SNX12_HUMAN [view entry] [view interactions] High throughput yes yes
RBL2B_HUMAN [view interactions] High throughput no no
E41L5_HUMAN [view interactions] High throughput no no
RBFA_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
SBSN_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
RPAC2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CUL4B_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
AMPN_HUMAN [view interactions] High throughput no no