Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DC1L1_HUMAN

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DC1L1_HUMAN
GO:0017076 purine nucleotide binding 28.1250 4 yes
GO:0032555 purine ribonucleotide binding 27.0833 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 26.0417 4 yes
GO:0003723 RNA binding 25.0000 4 yes
GO:0019900 kinase binding 20.8333 4 no
GO:0019901 protein kinase binding 20.8333 5 no
GO:0046872 metal ion binding 20.8333 4 no
GO:0030554 adenyl nucleotide binding 19.7917 5 yes
GO:0032559 adenyl ribonucleotide binding 18.7500 5 yes
GO:0005524 ATP binding 17.7083 5 yes
GO:0019001 guanyl nucleotide binding 13.5417 5 yes
GO:0032561 guanyl ribonucleotide binding 13.5417 5 yes
GO:0019003 GDP binding 5.2083 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DC1L1_HUMAN
GO:0048522 positive regulation of cellular process 60.4167 4 yes
GO:0006996 organelle organization 51.0417 4 yes
GO:0051128 regulation of cellular component organization 45.8333 4 yes
GO:0048523 negative regulation of cellular process 43.7500 4 no
GO:0060255 regulation of macromolecule metabolic process 43.7500 4 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0022607 cellular component assembly 41.6667 4 no
GO:0080090 regulation of primary metabolic process 40.6250 4 no
GO:0010646 regulation of cell communication 39.5833 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 39.5833 4 no
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 35.4167 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 34.3750 5 no
GO:0007010 cytoskeleton organization 32.2917 5 yes
GO:0051049 regulation of transport 32.2917 4 no
GO:0044087 regulation of cellular component biogenesis 32.2917 4 no
GO:0008104 protein localization 32.2917 4 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0051246 regulation of protein metabolic process 29.1667 5 no
GO:1902531 regulation of intracellular signal transduction 28.1250 5 yes
GO:0031325 positive regulation of cellular metabolic process 28.1250 5 no
GO:0071702 organic substance transport 27.0833 4 no
GO:0009889 regulation of biosynthetic process 26.0417 4 no
GO:0010468 regulation of gene expression 26.0417 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0023056 positive regulation of signaling 23.9583 4 yes
GO:0051050 positive regulation of transport 23.9583 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.9583 5 no
GO:0016192 vesicle-mediated transport 23.9583 4 no
GO:0010647 positive regulation of cell communication 22.9167 5 yes
GO:0048584 positive regulation of response to stimulus 22.9167 4 yes
GO:0051493 regulation of cytoskeleton organization 22.9167 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.9167 5 no
GO:0071705 nitrogen compound transport 22.9167 4 no
GO:0009892 negative regulation of metabolic process 21.8750 4 no
GO:0051247 positive regulation of protein metabolic process 21.8750 6 no
GO:0010638 positive regulation of organelle organization 21.8750 6 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0031399 regulation of protein modification process 20.8333 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.8333 5 no
GO:0009894 regulation of catabolic process 20.8333 4 no
GO:0010941 regulation of cell death 20.8333 4 no
GO:0030030 cell projection organization 20.8333 4 no
GO:0043067 regulation of programmed cell death 20.8333 5 no
GO:0097435 supramolecular fiber organization 20.8333 4 no
GO:0009967 positive regulation of signal transduction 18.7500 5 yes
GO:0051726 regulation of cell cycle 15.6250 4 yes
GO:1902533 positive regulation of intracellular signal transduction 14.5833 6 yes
GO:0010564 regulation of cell cycle process 9.3750 5 yes
GO:0045787 positive regulation of cell cycle 8.3333 5 yes
GO:0007346 regulation of mitotic cell cycle 7.2917 5 yes
GO:0090068 positive regulation of cell cycle process 5.2083 6 yes
GO:0007088 regulation of mitotic nuclear division 4.1667 6 yes
GO:0033044 regulation of chromosome organization 4.1667 6 yes
GO:0051783 regulation of nuclear division 4.1667 6 yes
GO:0010965 regulation of mitotic sister chromatid separation 3.1250 6 yes
GO:0030071 regulation of mitotic metaphase/anaphase transition 3.1250 7 yes
GO:0033045 regulation of sister chromatid segregation 3.1250 5 yes
GO:0051983 regulation of chromosome segregation 3.1250 4 yes
GO:1901987 regulation of cell cycle phase transition 3.1250 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 3.1250 6 yes
GO:1902099 regulation of metaphase/anaphase transition of cell cycle 3.1250 6 yes
GO:1905818 regulation of chromosome separation 3.1250 5 yes
GO:0033047 regulation of mitotic sister chromatid segregation 2.0833 6 yes
GO:0090231 regulation of spindle checkpoint 2.0833 7 yes
GO:0090232 positive regulation of spindle checkpoint 2.0833 8 yes
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 2.0833 7 yes
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint 2.0833 7 yes
GO:1901976 regulation of cell cycle checkpoint 2.0833 6 yes
GO:1901978 positive regulation of cell cycle checkpoint 2.0833 7 yes
GO:1903504 regulation of mitotic spindle checkpoint 2.0833 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in DC1L1_HUMAN
DOID:114 heart disease 3.1250 3 no
DOID:0050700 cardiomyopathy 2.0833 4 no
DOID:0060036 intrinsic cardiomyopathy 2.0833 5 no
DOID:2843 long QT syndrome 2.0833 6 no
DOID:1289 neurodegenerative disease 2.0833 4 no
DOID:331 central nervous system disease 2.0833 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EFC4B_HUMAN [view interactions] Low throughput no no
MD2L1_HUMAN [view interactions] Low throughput no no
RAB4A_HUMAN [view entry] [view interactions] Low throughput yes no
PCNT_HUMAN [view interactions] Low throughput no yes
BICD2_HUMAN [view interactions] Low throughput no yes
DC1I1_HUMAN [view entry] [view interactions] Low throughput yes yes
BRCA2_HUMAN [view interactions] Low throughput no no
SPHK2_HUMAN [view interactions] Low throughput no no
NUDC_HUMAN [view interactions] Low throughput no yes
HOOK3_HUMAN [view entry] [view interactions] Low throughput yes yes
NEMO_HUMAN [view interactions] Low throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
RS12_HUMAN [view entry] [view interactions] High throughput yes yes
PAIRB_HUMAN [view interactions] High throughput no yes
CLU_HUMAN [view interactions] High throughput no yes
NU214_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC3_HUMAN [view interactions] High throughput no yes
NDE1_HUMAN [view interactions] High throughput no yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
ZN207_HUMAN [view interactions] High throughput no yes
CSN8_HUMAN [view interactions] High throughput no yes
CSN2_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CSN6_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
GOLP3_HUMAN [view interactions] High throughput no no
CT027_HUMAN [view interactions] High throughput no yes
KLH22_HUMAN [view interactions] High throughput no no
CASP8_HUMAN [view interactions] High throughput no yes
MACOI_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
PDZ11_HUMAN [view interactions] High throughput no yes
NUBP1_HUMAN [view interactions] High throughput no yes
PLSL_HUMAN [view entry] [view interactions] High throughput yes no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
MAVS_HUMAN [view interactions] High throughput no yes
TRDMT_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
MTMR9_HUMAN [view interactions] High throughput no no
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PAWR_HUMAN [view interactions] High throughput no yes
WDR11_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
AL1A2_HUMAN [view interactions] High throughput no yes
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R2_HUMAN [view interactions] High throughput no no
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
BSDC1_HUMAN [view interactions] High throughput no no
GRIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ELOB_HUMAN [view interactions] High throughput no no
PK1L1_HUMAN [view interactions] High throughput no no
MTAP_HUMAN [view interactions] High throughput no no
FAP20_HUMAN [view interactions] High throughput no no
STRN3_HUMAN [view interactions] High throughput no yes
SEPT9_HUMAN [view interactions] High throughput no no
F91A1_HUMAN [view interactions] High throughput no yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
AVEN_HUMAN [view interactions] High throughput no yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
CIP2A_HUMAN [view interactions] High throughput no yes
BI2L1_HUMAN [view interactions] High throughput no yes
PHAF1_HUMAN [view interactions] High throughput no yes
EDC3_HUMAN [view interactions] High throughput no yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
SC24A_HUMAN [view interactions] High throughput no no
BUB1B_HUMAN [view interactions] High throughput no no
CZIB_HUMAN [view interactions] High throughput no no
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1A_HUMAN [view interactions] High throughput no yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
GPN1_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
CBX8_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
RNC_HUMAN [view entry] [view interactions] High throughput yes no
ASB6_HUMAN [view interactions] High throughput no yes
BLMH_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
AAAT_HUMAN [view interactions] High throughput no no
SUGP1_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ANM9_HUMAN [view interactions] High throughput no no
BCL7B_HUMAN [view interactions] High throughput no yes
SCAM3_HUMAN [view interactions] High throughput no no
TTC9C_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
SI1L3_HUMAN [view interactions] High throughput no yes
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
F1142_HUMAN [view interactions] High throughput no yes
YJ005_HUMAN [view interactions] High throughput no no
PSMD6_HUMAN [view interactions] High throughput no yes
I5P2_HUMAN [view interactions] High throughput no yes
ASSY_HUMAN [view interactions] High throughput no yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
GOLI4_HUMAN [view interactions] High throughput no yes
MSH3_HUMAN [view interactions] High throughput no no
IMPCT_HUMAN [view interactions] High throughput no yes
MGAP_HUMAN [view interactions] High throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SPN1_HUMAN [view interactions] High throughput no yes
PIPNA_HUMAN [view entry] [view interactions] High throughput yes no
DNJC8_HUMAN [view interactions] High throughput no yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
LYST_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
DOCK6_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
PGAM2_HUMAN [view entry] [view interactions] High throughput yes no
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
SODM_HUMAN [view entry] [view interactions] High throughput yes no
DRC5_HUMAN [view interactions] High throughput no no
NIN_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
TIE2_HUMAN [view interactions] High throughput no no
FHI2B_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
NOP56_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
FOXP3_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
BPTF_HUMAN [view interactions] High throughput no yes
SSRG_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
KCAB2_HUMAN [view entry] [view interactions] High throughput yes yes
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
COBL1_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
TBC9B_HUMAN [view interactions] High throughput no yes
SR140_HUMAN [view interactions] High throughput no yes
HIG1A_HUMAN [view entry] [view interactions] High throughput yes yes
AGRE2_HUMAN [view interactions] High throughput no no
CENPE_HUMAN [view interactions] High throughput no no
TTC31_HUMAN [view interactions] High throughput no yes
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
MED25_HUMAN [view interactions] High throughput no yes
BCOR_HUMAN [view interactions] High throughput no no
PO5F1_HUMAN [view interactions] High throughput no yes
TRPT1_HUMAN [view interactions] High throughput no yes
C2CD2_HUMAN [view interactions] High throughput no yes
NFS1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RASEF_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
DYLT3_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
GLMN_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
BRDT_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOF_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARP10_HUMAN [view interactions] High throughput no no
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN5_HUMAN [view interactions] High throughput no yes
CCD39_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
WBP2_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TRXR1_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
ZFR_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ROA0_HUMAN [view interactions] High throughput no yes
DLRB2_HUMAN [view entry] [view interactions] Computational yes no
RAB7B_HUMAN [view interactions] Computational no no
HS90B_HUMAN [view entry] [view interactions] Computational yes yes
RB3GP_HUMAN [view entry] [view interactions] Computational yes yes
RAB7A_HUMAN [view entry] [view interactions] Computational yes yes
PRGR_HUMAN [view interactions] Computational no no
DC2L1_HUMAN [view interactions] Computational no no
DYT2B_HUMAN [view interactions] Computational no no
DC2I2_HUMAN [view interactions] Computational no yes
RAB18_HUMAN [view entry] [view interactions] Computational yes yes
TPR_HUMAN [view interactions] Computational no yes
MCR_HUMAN [view entry] [view interactions] Computational yes yes
FKBP4_HUMAN [view entry] [view interactions] Computational yes yes
RBGPR_HUMAN [view entry] [view interactions] Computational yes yes
DC2I1_HUMAN [view interactions] Computational no yes
GCR_HUMAN [view entry] [view interactions] Computational yes yes
RILP_HUMAN [view interactions] Computational no no
ANDR_HUMAN [view interactions] Computational no no
HS90A_HUMAN [view entry] [view interactions] Computational yes yes