CLAP1_HUMAN
Evidence for PS localization
Functions
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003501 | LIG_IBAR_NPY_1 | LIG | 1265 | 1267 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CLAP1_HUMAN |
|---|---|---|---|---|
| GO:0015631 | tubulin binding | 32.7869 | 4 | yes |
| GO:0008017 | microtubule binding | 31.1475 | 5 | yes |
| GO:0003723 | RNA binding | 29.5082 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.2295 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.2295 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.2295 | 4 | no |
| GO:0005524 | ATP binding | 22.9508 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.9508 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.9508 | 5 | no |
| GO:0051010 | microtubule plus-end binding | 16.3934 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CLAP1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 54.0984 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.8197 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.8197 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 44.2623 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 40.9836 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3443 | 4 | no |
| GO:0008104 | protein localization | 37.7049 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.0656 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0656 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.0656 | 4 | no |
| GO:0033043 | regulation of organelle organization | 31.1475 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.1475 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.1475 | 4 | no |
| GO:0071702 | organic substance transport | 31.1475 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.1475 | 4 | no |
| GO:0022607 | cellular component assembly | 31.1475 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.5082 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.2295 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.2295 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.2295 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.2295 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 24.5902 | 6 | yes |
| GO:0010468 | regulation of gene expression | 24.5902 | 5 | no |
| GO:0015031 | protein transport | 24.5902 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 22.9508 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 22.9508 | 5 | no |
| GO:0032886 | regulation of microtubule-based process | 21.3115 | 4 | yes |
| GO:0051049 | regulation of transport | 21.3115 | 4 | yes |
| GO:0030030 | cell projection organization | 21.3115 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.3115 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.3115 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.3115 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.3115 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 19.6721 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 18.0328 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 18.0328 | 5 | yes |
| GO:0070925 | organelle assembly | 18.0328 | 5 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 18.0328 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 18.0328 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 16.3934 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 14.7541 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 14.7541 | 4 | yes |
| GO:0051050 | positive regulation of transport | 14.7541 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 14.7541 | 4 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 13.1148 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 13.1148 | 6 | yes |
| GO:0051094 | positive regulation of developmental process | 13.1148 | 4 | yes |
| GO:0080134 | regulation of response to stress | 13.1148 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 13.1148 | 4 | yes |
| GO:2000145 | regulation of cell motility | 13.1148 | 4 | yes |
| GO:0007052 | mitotic spindle organization | 13.1148 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 13.1148 | 6 | yes |
| GO:0030334 | regulation of cell migration | 13.1148 | 5 | yes |
| GO:0031113 | regulation of microtubule polymerization | 11.4754 | 6 | yes |
| GO:0051293 | establishment of spindle localization | 11.4754 | 4 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 11.4754 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 11.4754 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 11.4754 | 4 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 9.8361 | 4 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 9.8361 | 6 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 9.8361 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 9.8361 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 9.8361 | 6 | yes |
| GO:0001952 | regulation of cell-matrix adhesion | 9.8361 | 6 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 9.8361 | 5 | yes |
| GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 8.1967 | 7 | yes |
| GO:0031116 | positive regulation of microtubule polymerization | 8.1967 | 7 | yes |
| GO:0032273 | positive regulation of protein polymerization | 8.1967 | 7 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 8.1967 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 8.1967 | 4 | yes |
| GO:0040001 | establishment of mitotic spindle localization | 8.1967 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 8.1967 | 4 | yes |
| GO:0051046 | regulation of secretion | 8.1967 | 5 | yes |
| GO:0051225 | spindle assembly | 8.1967 | 4 | yes |
| GO:0051294 | establishment of spindle orientation | 8.1967 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 8.1967 | 7 | yes |
| GO:0051893 | regulation of focal adhesion assembly | 8.1967 | 7 | yes |
| GO:0090109 | regulation of cell-substrate junction assembly | 8.1967 | 6 | yes |
| GO:0110053 | regulation of actin filament organization | 8.1967 | 6 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 8.1967 | 5 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 8.1967 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 8.1967 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 8.1967 | 5 | yes |
| GO:0007030 | Golgi organization | 8.1967 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 8.1967 | 6 | yes |
| GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 6.5574 | 7 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 6.5574 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 6.5574 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 6.5574 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 6.5574 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 6.5574 | 7 | yes |
| GO:1903532 | positive regulation of secretion by cell | 6.5574 | 5 | yes |
| GO:0010632 | regulation of epithelial cell migration | 6.5574 | 4 | yes |
| GO:0031114 | regulation of microtubule depolymerization | 4.9180 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 4.9180 | 4 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 4.9180 | 5 | yes |
| GO:0034453 | microtubule anchoring | 4.9180 | 4 | yes |
| GO:0040013 | negative regulation of locomotion | 4.9180 | 4 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 4.9180 | 4 | yes |
| GO:0045995 | regulation of embryonic development | 4.9180 | 5 | yes |
| GO:0051492 | regulation of stress fiber assembly | 4.9180 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 4.9180 | 4 | yes |
| GO:0090307 | mitotic spindle assembly | 4.9180 | 5 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 4.9180 | 6 | yes |
| GO:2000146 | negative regulation of cell motility | 4.9180 | 5 | yes |
| GO:0001578 | microtubule bundle formation | 4.9180 | 4 | yes |
| GO:0007026 | negative regulation of microtubule depolymerization | 4.9180 | 7 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 4.9180 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 4.9180 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 4.9180 | 6 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 3.2787 | 5 | yes |
| GO:0032232 | negative regulation of actin filament bundle assembly | 3.2787 | 6 | yes |
| GO:0045921 | positive regulation of exocytosis | 3.2787 | 6 | yes |
| GO:0051497 | negative regulation of stress fiber assembly | 3.2787 | 7 | yes |
| GO:0061041 | regulation of wound healing | 3.2787 | 6 | yes |
| GO:0061045 | negative regulation of wound healing | 3.2787 | 6 | yes |
| GO:0090091 | positive regulation of extracellular matrix disassembly | 3.2787 | 7 | yes |
| GO:0110011 | regulation of basement membrane organization | 3.2787 | 6 | yes |
| GO:1901201 | regulation of extracellular matrix assembly | 3.2787 | 5 | yes |
| GO:1901203 | positive regulation of extracellular matrix assembly | 3.2787 | 6 | yes |
| GO:1903034 | regulation of response to wounding | 3.2787 | 5 | yes |
| GO:1903035 | negative regulation of response to wounding | 3.2787 | 5 | yes |
| GO:1903053 | regulation of extracellular matrix organization | 3.2787 | 5 | yes |
| GO:1903055 | positive regulation of extracellular matrix organization | 3.2787 | 6 | yes |
| GO:1903689 | regulation of wound healing, spreading of epidermal cells | 3.2787 | 6 | yes |
| GO:1903690 | negative regulation of wound healing, spreading of epidermal cells | 3.2787 | 7 | yes |
| GO:1904259 | regulation of basement membrane assembly involved in embryonic body morphogenesis | 3.2787 | 6 | yes |
| GO:1904261 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis | 3.2787 | 5 | yes |
| GO:0007020 | microtubule nucleation | 3.2787 | 4 | yes |
| GO:0010458 | exit from mitosis | 3.2787 | 5 | yes |
| GO:0010470 | regulation of gastrulation | 3.2787 | 5 | yes |
| GO:0010715 | regulation of extracellular matrix disassembly | 3.2787 | 6 | yes |
| GO:0010717 | regulation of epithelial to mesenchymal transition | 3.2787 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CLAP1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.2787 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MACF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| SPAG5_HUMAN | [view interactions] | Low throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | Low throughput | no | yes |
| SNPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK3_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| SPICE_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| JKIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYBU_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| ARH38_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| C102A_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JKIP1_HUMAN | [view interactions] | High throughput | no | no |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED18_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCBT2_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT3_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CENPH_HUMAN | [view interactions] | High throughput | no | yes |
| CENPI_HUMAN | [view interactions] | High throughput | no | no |
| EAF6_HUMAN | [view interactions] | High throughput | no | no |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |