Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CLAP1_HUMAN

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI003501 LIG_IBAR_NPY_1 LIG 1265 1267 -
ELMI003501 LIG_IBAR_NPY_1 LIG 1265 1267 -

Molecular function

Term Name % Distance from the top of the tree Annotated in CLAP1_HUMAN
GO:0015631 tubulin binding 29.5775 4 yes
GO:0003723 RNA binding 29.5775 4 no
GO:0000166 nucleotide binding 28.1690 4 no
GO:0017076 purine nucleotide binding 28.1690 5 no
GO:0032555 purine ribonucleotide binding 28.1690 4 no
GO:0043168 anion binding 28.1690 4 no
GO:0008017 microtubule binding 26.7606 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 26.7606 4 no
GO:0030554 adenyl nucleotide binding 25.3521 6 no
GO:0032559 adenyl ribonucleotide binding 25.3521 5 no
GO:0005524 ATP binding 23.9437 5 no
GO:0051010 microtubule plus-end binding 12.6761 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CLAP1_HUMAN
GO:0048522 positive regulation of cellular process 53.5211 4 yes
GO:0051128 regulation of cellular component organization 52.1127 4 yes
GO:0006996 organelle organization 50.7042 4 yes
GO:0048523 negative regulation of cellular process 43.6620 4 yes
GO:0008104 protein localization 43.6620 4 no
GO:0060255 regulation of macromolecule metabolic process 42.2535 4 no
GO:0031323 regulation of cellular metabolic process 40.8451 4 no
GO:0080090 regulation of primary metabolic process 38.0282 4 no
GO:0007010 cytoskeleton organization 36.6197 5 yes
GO:0022607 cellular component assembly 36.6197 4 yes
GO:0010646 regulation of cell communication 35.2113 4 no
GO:0044087 regulation of cellular component biogenesis 33.8028 4 yes
GO:0009889 regulation of biosynthetic process 32.3944 4 no
GO:0009893 positive regulation of metabolic process 30.9859 4 no
GO:0051049 regulation of transport 29.5775 4 yes
GO:0010468 regulation of gene expression 29.5775 6 no
GO:0010556 regulation of macromolecule biosynthetic process 29.5775 5 no
GO:0031326 regulation of cellular biosynthetic process 29.5775 5 no
GO:0009966 regulation of signal transduction 29.5775 4 no
GO:0071702 organic substance transport 29.5775 4 no
GO:0033043 regulation of organelle organization 29.5775 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 28.1690 5 no
GO:0051246 regulation of protein metabolic process 28.1690 5 no
GO:0051130 positive regulation of cellular component organization 26.7606 5 yes
GO:0031325 positive regulation of cellular metabolic process 26.7606 5 no
GO:0060341 regulation of cellular localization 26.7606 4 no
GO:0071705 nitrogen compound transport 25.3521 4 no
GO:0019220 regulation of phosphate metabolic process 23.9437 6 no
GO:0031399 regulation of protein modification process 23.9437 6 no
GO:0051174 regulation of phosphorus metabolic process 23.9437 5 no
GO:0043933 protein-containing complex organization 23.9437 4 no
GO:0051493 regulation of cytoskeleton organization 22.5352 6 yes
GO:0009891 positive regulation of biosynthetic process 22.5352 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.5352 5 no
GO:0048584 positive regulation of response to stimulus 22.5352 4 no
GO:0032880 regulation of protein localization 22.5352 5 no
GO:0032886 regulation of microtubule-based process 22.5352 4 yes
GO:0044089 positive regulation of cellular component biogenesis 21.1268 5 yes
GO:0048585 negative regulation of response to stimulus 21.1268 4 yes
GO:0097435 supramolecular fiber organization 21.1268 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 21.1268 6 no
GO:0051252 regulation of RNA metabolic process 21.1268 5 no
GO:0010647 positive regulation of cell communication 21.1268 5 no
GO:0023056 positive regulation of signaling 21.1268 4 no
GO:0009892 negative regulation of metabolic process 21.1268 4 no
GO:0043254 regulation of protein-containing complex assembly 18.3099 5 yes
GO:0045595 regulation of cell differentiation 18.3099 4 yes
GO:0051050 positive regulation of transport 18.3099 4 yes
GO:0051129 negative regulation of cellular component organization 18.3099 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 18.3099 5 yes
GO:0070925 organelle assembly 16.9014 5 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 16.9014 4 yes
GO:1902903 regulation of supramolecular fiber organization 16.9014 5 yes
GO:0051094 positive regulation of developmental process 14.0845 4 yes
GO:0080134 regulation of response to stress 14.0845 4 yes
GO:0010638 positive regulation of organelle organization 14.0845 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 14.0845 4 yes
GO:0051046 regulation of secretion 12.6761 5 yes
GO:1903530 regulation of secretion by cell 12.6761 4 yes
GO:2000145 regulation of cell motility 12.6761 4 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 12.6761 6 yes
GO:0032271 regulation of protein polymerization 12.6761 6 yes
GO:0051293 establishment of spindle localization 11.2676 4 yes
GO:1901888 regulation of cell junction assembly 11.2676 5 yes
GO:2000026 regulation of multicellular organismal development 11.2676 4 yes
GO:0007052 mitotic spindle organization 11.2676 4 yes
GO:0010639 negative regulation of organelle organization 11.2676 6 yes
GO:0030155 regulation of cell adhesion 11.2676 4 yes
GO:0030334 regulation of cell migration 11.2676 5 yes
GO:0031113 regulation of microtubule polymerization 11.2676 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 11.2676 6 yes
GO:0032101 regulation of response to external stimulus 11.2676 4 yes
GO:0051047 positive regulation of secretion 9.8592 5 yes
GO:0060627 regulation of vesicle-mediated transport 9.8592 4 yes
GO:0140694 non-membrane-bounded organelle assembly 9.8592 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 9.8592 6 yes
GO:1903532 positive regulation of secretion by cell 9.8592 5 yes
GO:0001952 regulation of cell-matrix adhesion 9.8592 6 yes
GO:0010810 regulation of cell-substrate adhesion 9.8592 5 yes
GO:0051294 establishment of spindle orientation 8.4507 5 yes
GO:0051494 negative regulation of cytoskeleton organization 8.4507 7 yes
GO:0051495 positive regulation of cytoskeleton organization 8.4507 7 yes
GO:0017157 regulation of exocytosis 8.4507 5 yes
GO:0040001 establishment of mitotic spindle localization 8.4507 5 yes
GO:0051225 spindle assembly 7.0423 4 yes
GO:0051893 regulation of focal adhesion assembly 7.0423 7 yes
GO:0090109 regulation of cell-substrate junction assembly 7.0423 6 yes
GO:0150116 regulation of cell-substrate junction organization 7.0423 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 7.0423 6 yes
GO:2000147 positive regulation of cell motility 7.0423 5 yes
GO:0030335 positive regulation of cell migration 7.0423 6 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 7.0423 7 yes
GO:0031112 positive regulation of microtubule polymerization or depolymerization 7.0423 7 yes
GO:0031116 positive regulation of microtubule polymerization 7.0423 7 yes
GO:0031122 cytoplasmic microtubule organization 7.0423 4 yes
GO:0032273 positive regulation of protein polymerization 7.0423 7 yes
GO:0040017 positive regulation of locomotion 7.0423 4 yes
GO:0043244 regulation of protein-containing complex disassembly 5.6338 5 yes
GO:0045921 positive regulation of exocytosis 5.6338 6 yes
GO:0110053 regulation of actin filament organization 5.6338 6 yes
GO:1901879 regulation of protein depolymerization 5.6338 6 yes
GO:1901880 negative regulation of protein depolymerization 5.6338 7 yes
GO:0007030 Golgi organization 5.6338 5 yes
GO:0010632 regulation of epithelial cell migration 5.6338 4 yes
GO:0032956 regulation of actin cytoskeleton organization 5.6338 5 yes
GO:0032970 regulation of actin filament-based process 5.6338 4 yes
GO:0043242 negative regulation of protein-containing complex disassembly 5.6338 6 yes
GO:0045995 regulation of embryonic development 4.2254 5 yes
GO:0051492 regulation of stress fiber assembly 4.2254 6 yes
GO:0090307 mitotic spindle assembly 4.2254 5 yes
GO:0110020 regulation of actomyosin structure organization 4.2254 6 yes
GO:2000146 negative regulation of cell motility 4.2254 5 yes
GO:0001578 microtubule bundle formation 4.2254 4 yes
GO:0007026 negative regulation of microtubule depolymerization 4.2254 7 yes
GO:0010634 positive regulation of epithelial cell migration 4.2254 5 yes
GO:0030336 negative regulation of cell migration 4.2254 6 yes
GO:0031114 regulation of microtubule depolymerization 4.2254 6 yes
GO:0032102 negative regulation of response to external stimulus 4.2254 5 yes
GO:0032231 regulation of actin filament bundle assembly 4.2254 5 yes
GO:0034453 microtubule anchoring 4.2254 4 yes
GO:0040013 negative regulation of locomotion 4.2254 4 yes
GO:0044772 mitotic cell cycle phase transition 2.8169 4 yes
GO:0051497 negative regulation of stress fiber assembly 2.8169 7 yes
GO:0061041 regulation of wound healing 2.8169 6 yes
GO:0061045 negative regulation of wound healing 2.8169 6 yes
GO:0090091 positive regulation of extracellular matrix disassembly 2.8169 7 yes
GO:0110011 regulation of basement membrane organization 2.8169 6 yes
GO:1901201 regulation of extracellular matrix assembly 2.8169 5 yes
GO:1901203 positive regulation of extracellular matrix assembly 2.8169 6 yes
GO:1903034 regulation of response to wounding 2.8169 5 yes
GO:1903035 negative regulation of response to wounding 2.8169 5 yes
GO:1903053 regulation of extracellular matrix organization 2.8169 5 yes
GO:1903055 positive regulation of extracellular matrix organization 2.8169 6 yes
GO:1903689 regulation of wound healing, spreading of epidermal cells 2.8169 6 yes
GO:1903690 negative regulation of wound healing, spreading of epidermal cells 2.8169 7 yes
GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis 2.8169 6 yes
GO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis 2.8169 5 yes
GO:0007020 microtubule nucleation 2.8169 4 yes
GO:0010458 exit from mitosis 2.8169 5 yes
GO:0010470 regulation of gastrulation 2.8169 5 yes
GO:0010715 regulation of extracellular matrix disassembly 2.8169 6 yes
GO:0010717 regulation of epithelial to mesenchymal transition 2.8169 5 yes
GO:0032232 negative regulation of actin filament bundle assembly 2.8169 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CLIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
CLIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
MACF1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPAG5_HUMAN [view interactions] Low throughput no yes
KIF1B_HUMAN [view entry] [view interactions] Low throughput yes yes
PHLB2_HUMAN [view interactions] Low throughput no yes
SNPH_HUMAN [view entry] [view interactions] Low throughput yes yes
MARK3_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF41_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
MTCL2_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
CENPJ_HUMAN [view interactions] High throughput no no
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
PHKG2_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SRP14_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
DCLK2_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CENPE_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTRL_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
SPICE_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CBY1_HUMAN [view interactions] High throughput no no
JKIP2_HUMAN [view entry] [view interactions] High throughput yes no
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
SYBU_HUMAN [view interactions] High throughput no yes
4ET_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
GAN_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
ARH38_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CC14A_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
FZR1_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
FAXC_HUMAN [view interactions] High throughput no no
HYPM_HUMAN [view interactions] High throughput no no
C102A_HUMAN [view interactions] High throughput no yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
AR6P6_HUMAN [view interactions] High throughput no yes
ARL8A_HUMAN [view interactions] High throughput no no
GCC2_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
JKIP1_HUMAN [view interactions] High throughput no no
KIF2C_HUMAN [view entry] [view interactions] High throughput yes no
MED18_HUMAN [view interactions] High throughput no yes
CLIP4_HUMAN [view interactions] High throughput no yes
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
RCBT2_HUMAN [view interactions] High throughput no yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
MIS12_HUMAN [view interactions] High throughput no yes
TPC2A_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
WEE1_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
ZW10_HUMAN [view interactions] High throughput no yes
DYLT3_HUMAN [view interactions] High throughput no yes
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
ZN207_HUMAN [view interactions] High throughput no yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
CENPH_HUMAN [view interactions] High throughput no yes
CENPI_HUMAN [view interactions] High throughput no no
EAF6_HUMAN [view interactions] High throughput no no
TPR_HUMAN [view interactions] High throughput no yes
SEH1_HUMAN [view interactions] High throughput no no
SGO1_HUMAN [view interactions] High throughput no no
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CAMP2_HUMAN [view interactions] High throughput no yes
K2C8_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI36_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
CCNF_HUMAN [view interactions] High throughput no no
GSK3A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
CNPY3_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes