Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DCLK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DCLK2_HUMAN
GO:0017076 purine nucleotide binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0043168 anion binding 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0000166 nucleotide binding 33.3333 4 yes
GO:0005524 ATP binding 28.5714 5 yes
GO:0030554 adenyl nucleotide binding 28.5714 6 yes
GO:0032559 adenyl ribonucleotide binding 28.5714 5 yes
GO:0003723 RNA binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0016301 kinase activity 23.8095 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.8095 4 yes
GO:0019902 phosphatase binding 23.8095 4 no
GO:0045296 cadherin binding 23.8095 4 no
GO:0004674 protein serine/threonine kinase activity 19.0476 4 yes
GO:0008017 microtubule binding 19.0476 5 yes
GO:0015631 tubulin binding 19.0476 4 yes
GO:0106310 protein serine kinase activity 19.0476 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DCLK2_HUMAN
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0006996 organelle organization 52.3810 4 yes
GO:0019220 regulation of phosphate metabolic process 52.3810 6 no
GO:0051174 regulation of phosphorus metabolic process 52.3810 5 no
GO:0051246 regulation of protein metabolic process 52.3810 5 no
GO:0008104 protein localization 47.6190 4 yes
GO:0009889 regulation of biosynthetic process 47.6190 4 no
GO:0010556 regulation of macromolecule biosynthetic process 47.6190 5 no
GO:0031326 regulation of cellular biosynthetic process 47.6190 5 no
GO:0051128 regulation of cellular component organization 47.6190 4 no
GO:0009966 regulation of signal transduction 47.6190 4 no
GO:0031399 regulation of protein modification process 47.6190 6 no
GO:0045595 regulation of cell differentiation 42.8571 4 no
GO:0060341 regulation of cellular localization 38.0952 4 yes
GO:0009892 negative regulation of metabolic process 38.0952 4 no
GO:0010468 regulation of gene expression 38.0952 6 no
GO:0010605 negative regulation of macromolecule metabolic process 38.0952 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.0952 5 no
GO:0051049 regulation of transport 38.0952 4 no
GO:0050804 modulation of chemical synaptic transmission 38.0952 5 no
GO:0099177 regulation of trans-synaptic signaling 38.0952 4 no
GO:0042325 regulation of phosphorylation 38.0952 7 no
GO:0032880 regulation of protein localization 33.3333 5 yes
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0022607 cellular component assembly 28.5714 4 no
GO:0080134 regulation of response to stress 28.5714 4 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 yes
GO:0006355 regulation of DNA-templated transcription 23.8095 7 no
GO:0051252 regulation of RNA metabolic process 23.8095 5 no
GO:2001141 regulation of RNA biosynthetic process 23.8095 6 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0051050 positive regulation of transport 23.8095 4 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0097435 supramolecular fiber organization 23.8095 4 no
GO:0030030 cell projection organization 23.8095 4 no
GO:0043066 negative regulation of apoptotic process 23.8095 6 no
GO:0043069 negative regulation of programmed cell death 23.8095 5 no
GO:0050890 cognition 23.8095 4 no
GO:0051093 negative regulation of developmental process 23.8095 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 no
GO:0042327 positive regulation of phosphorylation 23.8095 8 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0043549 regulation of kinase activity 23.8095 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.8095 5 no
GO:0010563 negative regulation of phosphorus metabolic process 23.8095 6 no
GO:0031400 negative regulation of protein modification process 23.8095 7 no
GO:0045936 negative regulation of phosphate metabolic process 23.8095 7 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0016310 phosphorylation 19.0476 5 yes
GO:0033365 protein localization to organelle 19.0476 5 yes
GO:0021954 central nervous system neuron development 9.5238 5 yes
GO:0034504 protein localization to nucleus 9.5238 6 yes
GO:0048666 neuron development 9.5238 4 yes
GO:1900180 regulation of protein localization to nucleus 9.5238 6 yes
GO:1903828 negative regulation of protein localization 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLH15_HUMAN [view interactions] Low throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
ST32C_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB5_HUMAN [view interactions] High throughput no yes
SCO2_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
IMDH2_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD1_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF41_HUMAN [view interactions] High throughput no yes
NEB1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
T22D3_HUMAN [view interactions] High throughput no yes
BTG3_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD57_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
FBLI1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes