Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DCLK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DCLK2_HUMAN
GO:0017076 purine nucleotide binding 38.8889 4 yes
GO:0032555 purine ribonucleotide binding 38.8889 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.8889 4 yes
GO:0005524 ATP binding 33.3333 5 yes
GO:0030554 adenyl nucleotide binding 33.3333 5 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0003723 RNA binding 33.3333 4 no
GO:0016301 kinase activity 27.7778 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 27.7778 4 yes
GO:0019901 protein kinase binding 27.7778 5 no
GO:0004674 protein serine/threonine kinase activity 22.2222 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 22.2222 4 yes
GO:0008017 microtubule binding 22.2222 5 yes
GO:0015631 tubulin binding 22.2222 4 yes
GO:0106310 protein serine kinase activity 22.2222 4 yes
GO:0003779 actin binding 22.2222 4 no
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0019902 phosphatase binding 22.2222 4 no
GO:0042826 histone deacetylase binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DCLK2_HUMAN
GO:0048523 negative regulation of cellular process 72.2222 4 yes
GO:0031323 regulation of cellular metabolic process 72.2222 4 no
GO:0051171 regulation of nitrogen compound metabolic process 72.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 72.2222 4 no
GO:0080090 regulation of primary metabolic process 72.2222 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0019220 regulation of phosphate metabolic process 55.5556 6 no
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 no
GO:0051246 regulation of protein metabolic process 55.5556 5 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0006996 organelle organization 44.4444 4 yes
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 no
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 no
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0060341 regulation of cellular localization 38.8889 4 yes
GO:0008104 protein localization 38.8889 4 no
GO:0009889 regulation of biosynthetic process 38.8889 4 no
GO:0009893 positive regulation of metabolic process 38.8889 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.8889 5 no
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.8889 5 no
GO:0031325 positive regulation of cellular metabolic process 38.8889 5 no
GO:0031326 regulation of cellular biosynthetic process 38.8889 5 no
GO:0045595 regulation of cell differentiation 38.8889 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.8889 5 no
GO:0042325 regulation of phosphorylation 38.8889 7 no
GO:0032880 regulation of protein localization 33.3333 5 yes
GO:0022607 cellular component assembly 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0015031 protein transport 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006796 phosphate-containing compound metabolic process 27.7778 4 yes
GO:0007010 cytoskeleton organization 27.7778 5 yes
GO:0016310 phosphorylation 27.7778 5 yes
GO:0036211 protein modification process 27.7778 4 yes
GO:0043412 macromolecule modification 27.7778 4 yes
GO:0051130 positive regulation of cellular component organization 27.7778 5 no
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.7778 6 no
GO:0042981 regulation of apoptotic process 27.7778 6 no
GO:0043067 regulation of programmed cell death 27.7778 5 no
GO:0010563 negative regulation of phosphorus metabolic process 27.7778 6 no
GO:0031400 negative regulation of protein modification process 27.7778 7 no
GO:0045936 negative regulation of phosphate metabolic process 27.7778 7 no
GO:0042327 positive regulation of phosphorylation 27.7778 8 no
GO:0043085 positive regulation of catalytic activity 27.7778 4 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0071310 cellular response to organic substance 27.7778 4 no
GO:0006468 protein phosphorylation 22.2222 5 yes
GO:0018105 peptidyl-serine phosphorylation 22.2222 6 yes
GO:0018193 peptidyl-amino acid modification 22.2222 5 yes
GO:0018209 peptidyl-serine modification 22.2222 6 yes
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0031334 positive regulation of protein-containing complex assembly 22.2222 6 no
GO:0032271 regulation of protein polymerization 22.2222 6 no
GO:0032273 positive regulation of protein polymerization 22.2222 7 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0043254 regulation of protein-containing complex assembly 22.2222 5 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0006605 protein targeting 22.2222 5 no
GO:0034605 cellular response to heat 22.2222 4 no
GO:0035303 regulation of dephosphorylation 22.2222 7 no
GO:0035304 regulation of protein dephosphorylation 22.2222 7 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0050890 cognition 22.2222 4 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0021954 central nervous system neuron development 11.1111 5 yes
GO:0048666 neuron development 11.1111 4 yes
GO:1900180 regulation of protein localization to nucleus 11.1111 6 yes
GO:1903828 negative regulation of protein localization 11.1111 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLH15_HUMAN [view interactions] Low throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
ST32C_HUMAN [view entry] [view interactions] High throughput yes yes
NEB1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF41_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
SCO2_HUMAN [view interactions] High throughput no no
ZBTB5_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
T22D3_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD57_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
FBLI1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no