DCTN4_HUMAN
Evidence for PS localization
Functions
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DCTN4_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.7049 | 4 | no |
| GO:0000166 | nucleotide binding | 36.0656 | 4 | no |
| GO:0017076 | purine nucleotide binding | 34.4262 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 34.4262 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.7869 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.8689 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.8689 | 5 | no |
| GO:0005524 | ATP binding | 26.2295 | 5 | no |
| GO:0003723 | RNA binding | 22.9508 | 4 | no |
| GO:0019900 | kinase binding | 21.3115 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DCTN4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.7377 | 4 | no |
| GO:0006996 | organelle organization | 45.9016 | 4 | no |
| GO:0022607 | cellular component assembly | 45.9016 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.2623 | 4 | no |
| GO:0033043 | regulation of organelle organization | 42.6230 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 39.3443 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.4262 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.7869 | 4 | no |
| GO:0007010 | cytoskeleton organization | 31.1475 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.1475 | 4 | no |
| GO:0008104 | protein localization | 29.5082 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.8689 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.8689 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.8689 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 27.8689 | 6 | no |
| GO:0051049 | regulation of transport | 27.8689 | 4 | no |
| GO:0010646 | regulation of cell communication | 27.8689 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.2295 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.2295 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.2295 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.2295 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.5902 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.5902 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.9508 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 22.9508 | 5 | no |
| GO:0009966 | regulation of signal transduction | 22.9508 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.9508 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.3115 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.3115 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.3115 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 21.3115 | 5 | no |
| GO:0070925 | organelle assembly | 21.3115 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 21.3115 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 21.3115 | 6 | no |
| GO:0030030 | cell projection organization | 21.3115 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.3115 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.3115 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.3115 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.3115 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATP7B_HUMAN | [view interactions] | Low throughput | no | no |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED22_HUMAN | [view interactions] | High throughput | no | no |
| CCL4_HUMAN | [view interactions] | High throughput | no | no |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| N42L1_HUMAN | [view interactions] | High throughput | no | yes |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| BRDT_HUMAN | [view interactions] | High throughput | no | no |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CI114_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL36A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| SKI8_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NASP_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMA1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN6_HUMAN | [view interactions] | High throughput | no | no |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| CSPP1_HUMAN | [view interactions] | High throughput | no | no |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DS13A_HUMAN | [view interactions] | High throughput | no | no |
| KLHL2_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DB127_HUMAN | [view interactions] | High throughput | no | no |
| PDGFD_HUMAN | [view interactions] | High throughput | no | no |
| MERB1_HUMAN | [view interactions] | High throughput | no | yes |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| AROS_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |