DCTN4_HUMAN
Evidence for PS localization
Functions
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DCTN4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 35.9375 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 35.9375 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.9375 | 4 | no |
| GO:0005524 | ATP binding | 28.1250 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 28.1250 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.1250 | 5 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 21.8750 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DCTN4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.1250 | 4 | no |
| GO:0006996 | organelle organization | 46.8750 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | no |
| GO:0022607 | cellular component assembly | 43.7500 | 4 | no |
| GO:0033043 | regulation of organelle organization | 39.0625 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 39.0625 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.3750 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.8125 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.8125 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.2500 | 4 | no |
| GO:0008104 | protein localization | 31.2500 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.6875 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.1250 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.1250 | 5 | no |
| GO:0010646 | regulation of cell communication | 28.1250 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.1250 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.5625 | 6 | no |
| GO:0051049 | regulation of transport | 26.5625 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.4375 | 5 | no |
| GO:0071702 | organic substance transport | 23.4375 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.4375 | 4 | no |
| GO:0030030 | cell projection organization | 23.4375 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.8750 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 21.8750 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.8750 | 5 | no |
| GO:0015031 | protein transport | 21.8750 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.8750 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.8750 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 21.8750 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.8750 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.8750 | 5 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.3125 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.3125 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.3125 | 5 | no |
| GO:0070925 | organelle assembly | 20.3125 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.3125 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.3125 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.3125 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATP7B_HUMAN | [view interactions] | Low throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN6_HUMAN | [view interactions] | High throughput | no | no |
| LAMA1_HUMAN | [view interactions] | High throughput | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| CSPP1_HUMAN | [view interactions] | High throughput | no | no |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL2_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DB127_HUMAN | [view interactions] | High throughput | no | no |
| PDGFD_HUMAN | [view interactions] | High throughput | no | no |
| MERB1_HUMAN | [view interactions] | High throughput | no | yes |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| AROS_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED22_HUMAN | [view interactions] | High throughput | no | no |
| CCL4_HUMAN | [view interactions] | High throughput | no | no |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| N42L1_HUMAN | [view interactions] | High throughput | no | yes |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| BRDT_HUMAN | [view interactions] | High throughput | no | no |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CI114_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL36A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| WDR61_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYH7_HUMAN | [view interactions] | Computational | no | no |
| DYH12_HUMAN | [view interactions] | Computational | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA3_HUMAN | [view interactions] | Computational | no | no |
| MCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH5_HUMAN | [view interactions] | Computational | no | no |
| GCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH2_HUMAN | [view interactions] | Computational | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH11_HUMAN | [view interactions] | Computational | no | no |
| ANDR_HUMAN | [view interactions] | Computational | no | no |
| DYH6_HUMAN | [view interactions] | Computational | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DNAI2_HUMAN | [view interactions] | Computational | no | no |
| DNAL1_HUMAN | [view interactions] | Computational | no | no |
| DYH3_HUMAN | [view interactions] | Computational | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH1_HUMAN | [view interactions] | Computational | no | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH14_HUMAN | [view interactions] | Computational | no | no |
| DYH9_HUMAN | [view interactions] | Computational | no | no |
| PRGR_HUMAN | [view interactions] | Computational | no | no |
| DNAL4_HUMAN | [view interactions] | Computational | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DYH17_HUMAN | [view interactions] | Computational | no | no |