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TWF1_HUMAN

GO
G2C
SynGO

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles . [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI004172 LIG_ActinCP_TwfCPI_2 LIG 323 333 -
ELMI004172 LIG_ActinCP_TwfCPI_2 LIG 323 333 -

Molecular function

Term Name % Distance from the top of the tree Annotated in TWF1_HUMAN
GO:0003779 actin binding 36.7647 4 yes
GO:0043168 anion binding 35.2941 4 yes
GO:0000166 nucleotide binding 32.3529 4 yes
GO:0017076 purine nucleotide binding 30.8824 5 yes
GO:0032555 purine ribonucleotide binding 30.8824 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.8824 4 yes
GO:0005524 ATP binding 27.9412 5 yes
GO:0030554 adenyl nucleotide binding 27.9412 6 yes
GO:0032559 adenyl ribonucleotide binding 27.9412 5 yes
GO:0045296 cadherin binding 23.5294 4 yes
GO:0043169 cation binding 20.5882 4 no
GO:0046872 metal ion binding 20.5882 5 no
GO:0035091 phosphatidylinositol binding 7.3529 4 yes
GO:1901981 phosphatidylinositol phosphate binding 5.8824 5 yes
GO:0003785 actin monomer binding 4.4118 5 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4.4118 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 4.4118 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TWF1_HUMAN
GO:0048522 positive regulation of cellular process 52.9412 4 yes
GO:0051128 regulation of cellular component organization 52.9412 4 yes
GO:0031323 regulation of cellular metabolic process 48.5294 4 yes
GO:0048523 negative regulation of cellular process 48.5294 4 yes
GO:0060255 regulation of macromolecule metabolic process 45.5882 4 yes
GO:0080090 regulation of primary metabolic process 44.1176 4 yes
GO:0006996 organelle organization 39.7059 4 no
GO:0022607 cellular component assembly 38.2353 4 no
GO:0009889 regulation of biosynthetic process 36.7647 4 no
GO:0031326 regulation of cellular biosynthetic process 36.7647 5 no
GO:0044087 regulation of cellular component biogenesis 35.2941 4 yes
GO:0010468 regulation of gene expression 35.2941 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 no
GO:0010646 regulation of cell communication 33.8235 4 no
GO:0097435 supramolecular fiber organization 33.8235 4 yes
GO:0009893 positive regulation of metabolic process 33.8235 4 no
GO:0033043 regulation of organelle organization 30.8824 5 yes
GO:0051246 regulation of protein metabolic process 30.8824 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.8824 5 no
GO:0030030 cell projection organization 30.8824 4 no
GO:0071310 cellular response to organic substance 29.4118 4 no
GO:0008104 protein localization 29.4118 4 no
GO:0051130 positive regulation of cellular component organization 29.4118 5 yes
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0120036 plasma membrane bounded cell projection organization 26.4706 5 no
GO:0007015 actin filament organization 26.4706 5 yes
GO:0051493 regulation of cytoskeleton organization 26.4706 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.4706 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 yes
GO:0051129 negative regulation of cellular component organization 25.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 yes
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:0043933 protein-containing complex organization 23.5294 4 yes
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 yes
GO:0006355 regulation of DNA-templated transcription 23.5294 7 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0048584 positive regulation of response to stimulus 22.0588 4 no
GO:0009894 regulation of catabolic process 22.0588 4 no
GO:0051049 regulation of transport 22.0588 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.0588 6 no
GO:0042981 regulation of apoptotic process 20.5882 5 no
GO:0043067 regulation of programmed cell death 20.5882 4 no
GO:0009892 negative regulation of metabolic process 20.5882 4 no
GO:0032970 regulation of actin filament-based process 20.5882 4 yes
GO:0031399 regulation of protein modification process 19.1176 6 yes
GO:0032956 regulation of actin cytoskeleton organization 19.1176 5 yes
GO:0110053 regulation of actin filament organization 19.1176 6 yes
GO:0010975 regulation of neuron projection development 16.1765 7 yes
GO:0043254 regulation of protein-containing complex assembly 16.1765 5 yes
GO:0001932 regulation of protein phosphorylation 14.7059 7 yes
GO:0010639 negative regulation of organelle organization 14.7059 6 yes
GO:0019220 regulation of phosphate metabolic process 14.7059 6 yes
GO:0032271 regulation of protein polymerization 14.7059 6 yes
GO:0042325 regulation of phosphorylation 14.7059 7 yes
GO:0051174 regulation of phosphorus metabolic process 14.7059 5 yes
GO:0031346 positive regulation of cell projection organization 13.2353 6 yes
GO:0032535 regulation of cellular component size 13.2353 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 11.7647 6 yes
GO:0030832 regulation of actin filament length 11.7647 5 yes
GO:0043244 regulation of protein-containing complex disassembly 11.7647 5 yes
GO:0051494 negative regulation of cytoskeleton organization 11.7647 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 11.7647 6 yes
GO:0022411 cellular component disassembly 10.2941 4 yes
GO:0030833 regulation of actin filament polymerization 10.2941 7 yes
GO:0030834 regulation of actin filament depolymerization 10.2941 7 yes
GO:0030835 negative regulation of actin filament depolymerization 10.2941 7 yes
GO:0043242 negative regulation of protein-containing complex disassembly 10.2941 6 yes
GO:0044057 regulation of system process 10.2941 4 yes
GO:0060491 regulation of cell projection assembly 10.2941 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 10.2941 6 yes
GO:1901879 regulation of protein depolymerization 10.2941 6 yes
GO:1901880 negative regulation of protein depolymerization 10.2941 7 yes
GO:0008154 actin polymerization or depolymerization 8.8235 6 yes
GO:0030837 negative regulation of actin filament polymerization 8.8235 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 8.8235 6 yes
GO:0032272 negative regulation of protein polymerization 8.8235 7 yes
GO:0051016 barbed-end actin filament capping 8.8235 9 yes
GO:0051693 actin filament capping 8.8235 8 yes
GO:1902743 regulation of lamellipodium organization 8.8235 7 yes
GO:0010591 regulation of lamellipodium assembly 7.3529 7 yes
GO:0010976 positive regulation of neuron projection development 7.3529 7 yes
GO:0032984 protein-containing complex disassembly 7.3529 5 yes
GO:0090257 regulation of muscle system process 5.8824 5 yes
GO:0030042 actin filament depolymerization 4.4118 7 yes
GO:0042989 sequestering of actin monomers 4.4118 4 yes
GO:0051261 protein depolymerization 4.4118 6 yes
GO:0010611 regulation of cardiac muscle hypertrophy 2.9412 5 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 2.9412 6 yes
GO:0014742 positive regulation of muscle hypertrophy 2.9412 5 yes
GO:0014743 regulation of muscle hypertrophy 2.9412 6 yes
GO:0043502 regulation of muscle adaptation 2.9412 4 yes
GO:0043538 regulation of actin phosphorylation 2.9412 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAZA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
TWF1_HUMAN [view entry] [view interactions] Low throughput yes no
MTPN_HUMAN [view interactions] Low throughput no yes
CP110_HUMAN [view interactions] Low throughput no yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
ARP10_HUMAN [view interactions] High throughput no no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCIN_HUMAN [view entry] [view interactions] High throughput yes no
IKKE_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
LITD1_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ABCE1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
STYX_HUMAN [view interactions] High throughput no yes
ICAM1_HUMAN [view interactions] High throughput no no
BCL7C_HUMAN [view interactions] High throughput no yes
TIGAR_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
TNFA_HUMAN [view interactions] High throughput no no
DCPS_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
ATX1_HUMAN [view interactions] High throughput no yes
FBXW8_HUMAN [view interactions] High throughput no yes
CUL9_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KI20A_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
BPIB1_HUMAN [view interactions] High throughput no no
PIGR_HUMAN [view interactions] High throughput no no
IGJ_HUMAN [view interactions] High throughput no no
BPIA1_HUMAN [view interactions] High throughput no no
LYSC_HUMAN [view interactions] High throughput no no
PAUF_HUMAN [view interactions] High throughput no no
AACT_HUMAN [view entry] [view interactions] High throughput yes no
MUC5B_HUMAN [view interactions] High throughput no no
TRFL_HUMAN [view interactions] High throughput no no
DMBT1_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CATB_HUMAN [view interactions] High throughput no yes
DPP4_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
RHGBA_HUMAN [view interactions] High throughput no yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
COF1_HUMAN [view entry] [view interactions] High throughput yes no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
ANM1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
DDX24_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2B_HUMAN [view interactions] High throughput no no
FBX25_HUMAN [view interactions] High throughput no no
TRM1_HUMAN [view interactions] High throughput no yes
UN45A_HUMAN [view interactions] High throughput no yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
UBE2A_HUMAN [view interactions] High throughput no no
UBXN1_HUMAN [view interactions] High throughput no no
TXND5_HUMAN [view interactions] High throughput no yes
XPP1_HUMAN [view interactions] High throughput no yes
UBP28_HUMAN [view interactions] High throughput no yes
UBA3_HUMAN [view interactions] High throughput no yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
KINH_HUMAN [view entry] [view interactions] High throughput yes no
TPX2_HUMAN [view interactions] High throughput no yes
ZBED1_HUMAN [view interactions] High throughput no yes
IPO9_HUMAN [view interactions] High throughput no no
MCTS1_HUMAN [view interactions] High throughput no no
PUR8_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
UBP5_HUMAN [view entry] [view interactions] High throughput yes yes
SYWC_HUMAN [view interactions] High throughput no yes
AIMP1_HUMAN [view interactions] High throughput no yes
MCA3_HUMAN [view interactions] High throughput no yes
HNRPF_HUMAN [view interactions] High throughput no yes
AIMP2_HUMAN [view interactions] High throughput no yes
CPIN1_HUMAN [view interactions] High throughput no no
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
NUP98_HUMAN [view interactions] High throughput no no
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
PRIC3_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
SH3L1_HUMAN [view interactions] High throughput no yes
RASA1_HUMAN [view interactions] High throughput no yes
ZBT18_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
BMPR2_HUMAN [view entry] [view interactions] High throughput yes yes
BTK_HUMAN [view interactions] High throughput no no
NOD2_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
FGFR2_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
CDC7_HUMAN [view interactions] High throughput no yes
ARC1B_HUMAN [view interactions] High throughput no no
CAP2_HUMAN [view entry] [view interactions] High throughput yes yes