TWF1_HUMAN
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI004172 | LIG_ActinCP_TwfCPI_2 | LIG | 323 | 333 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TWF1_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 44.0678 | 4 | yes |
GO:0005524 | ATP binding | 28.8136 | 5 | yes |
GO:0017076 | purine nucleotide binding | 28.8136 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 28.8136 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 28.8136 | 4 | yes |
GO:0032559 | adenyl ribonucleotide binding | 28.8136 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.8136 | 4 | yes |
GO:0045296 | cadherin binding | 25.4237 | 4 | yes |
GO:0046872 | metal ion binding | 20.3390 | 4 | no |
GO:0035091 | phosphatidylinositol binding | 8.4746 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 6.7797 | 5 | yes |
GO:0003785 | actin monomer binding | 5.0847 | 5 | yes |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 5.0847 | 4 | yes |
GO:1902936 | phosphatidylinositol bisphosphate binding | 5.0847 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TWF1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.5424 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 50.8475 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 45.7627 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 45.7627 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 44.0678 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 44.0678 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 42.3729 | 4 | yes |
GO:0006996 | organelle organization | 42.3729 | 4 | no |
GO:0022607 | cellular component assembly | 38.9831 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 33.8983 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 33.8983 | 4 | yes |
GO:0033043 | regulation of organelle organization | 33.8983 | 5 | yes |
GO:0051493 | regulation of cytoskeleton organization | 32.2034 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 32.2034 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 30.5085 | 5 | yes |
GO:0010468 | regulation of gene expression | 30.5085 | 5 | no |
GO:0007010 | cytoskeleton organization | 30.5085 | 5 | no |
GO:1902903 | regulation of supramolecular fiber organization | 28.8136 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.8136 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.8136 | 5 | no |
GO:0030030 | cell projection organization | 28.8136 | 4 | no |
GO:0007015 | actin filament organization | 28.8136 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 28.8136 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 27.1186 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 27.1186 | 5 | no |
GO:0071310 | cellular response to organic substance | 27.1186 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 27.1186 | 5 | yes |
GO:0110053 | regulation of actin filament organization | 25.4237 | 6 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.4237 | 6 | yes |
GO:0008104 | protein localization | 25.4237 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 25.4237 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.4237 | 5 | no |
GO:0031344 | regulation of cell projection organization | 25.4237 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 23.7288 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.7288 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.7288 | 5 | no |
GO:0043933 | protein-containing complex organization | 23.7288 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 22.0339 | 5 | yes |
GO:0010646 | regulation of cell communication | 22.0339 | 4 | no |
GO:0036211 | protein modification process | 22.0339 | 4 | no |
GO:0043412 | macromolecule modification | 22.0339 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 22.0339 | 4 | no |
GO:0016192 | vesicle-mediated transport | 22.0339 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 20.3390 | 4 | yes |
GO:0009894 | regulation of catabolic process | 20.3390 | 4 | no |
GO:0051049 | regulation of transport | 20.3390 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 20.3390 | 5 | no |
GO:0008064 | regulation of actin polymerization or depolymerization | 18.6441 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 18.6441 | 7 | yes |
GO:0030832 | regulation of actin filament length | 18.6441 | 5 | yes |
GO:0032535 | regulation of cellular component size | 18.6441 | 4 | yes |
GO:0032271 | regulation of protein polymerization | 16.9492 | 6 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 16.9492 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 15.2542 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 15.2542 | 6 | yes |
GO:0019220 | regulation of phosphate metabolic process | 15.2542 | 6 | yes |
GO:0030833 | regulation of actin filament polymerization | 15.2542 | 7 | yes |
GO:0031346 | positive regulation of cell projection organization | 15.2542 | 6 | yes |
GO:0031399 | regulation of protein modification process | 15.2542 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 15.2542 | 7 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 15.2542 | 5 | yes |
GO:1901879 | regulation of protein depolymerization | 13.5593 | 6 | yes |
GO:0001932 | regulation of protein phosphorylation | 13.5593 | 7 | yes |
GO:0008154 | actin polymerization or depolymerization | 13.5593 | 6 | yes |
GO:0030834 | regulation of actin filament depolymerization | 13.5593 | 7 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 11.8644 | 7 | yes |
GO:1901880 | negative regulation of protein depolymerization | 11.8644 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 11.8644 | 6 | yes |
GO:0022411 | cellular component disassembly | 11.8644 | 4 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 11.8644 | 7 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 11.8644 | 6 | yes |
GO:0044057 | regulation of system process | 11.8644 | 4 | yes |
GO:0051016 | barbed-end actin filament capping | 10.1695 | 9 | yes |
GO:0051693 | actin filament capping | 10.1695 | 8 | yes |
GO:0060491 | regulation of cell projection assembly | 10.1695 | 5 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 10.1695 | 6 | yes |
GO:1902743 | regulation of lamellipodium organization | 10.1695 | 7 | yes |
GO:0010976 | positive regulation of neuron projection development | 10.1695 | 7 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 10.1695 | 7 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 10.1695 | 6 | yes |
GO:0032272 | negative regulation of protein polymerization | 10.1695 | 7 | yes |
GO:0032984 | protein-containing complex disassembly | 10.1695 | 5 | yes |
GO:0010591 | regulation of lamellipodium assembly | 8.4746 | 7 | yes |
GO:0051261 | protein depolymerization | 6.7797 | 6 | yes |
GO:0090257 | regulation of muscle system process | 6.7797 | 5 | yes |
GO:0030042 | actin filament depolymerization | 6.7797 | 7 | yes |
GO:0042989 | sequestering of actin monomers | 5.0847 | 4 | yes |
GO:0010611 | regulation of cardiac muscle hypertrophy | 3.3898 | 5 | yes |
GO:0010613 | positive regulation of cardiac muscle hypertrophy | 3.3898 | 6 | yes |
GO:0014742 | positive regulation of muscle hypertrophy | 3.3898 | 5 | yes |
GO:0014743 | regulation of muscle hypertrophy | 3.3898 | 6 | yes |
GO:0043502 | regulation of muscle adaptation | 3.3898 | 4 | yes |
GO:0043538 | regulation of actin phosphorylation | 3.3898 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in TWF1_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 5.0847 | 3 | no |
DOID:0050155 | sensory system disease | 3.3898 | 3 | no |
DOID:0050563 | nonsyndromic deafness | 3.3898 | 5 | no |
DOID:2742 | auditory system disease | 3.3898 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CP110_HUMAN | [view interactions] | Low throughput | no | yes |
CAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAZA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TWF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MTPN_HUMAN | [view interactions] | Low throughput | no | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRIC3_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
RASA1_HUMAN | [view interactions] | High throughput | no | yes |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BTK_HUMAN | [view interactions] | High throughput | no | no |
NOD2_HUMAN | [view interactions] | High throughput | no | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC7_HUMAN | [view interactions] | High throughput | no | yes |
SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP10_HUMAN | [view interactions] | High throughput | no | no |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARC1B_HUMAN | [view interactions] | High throughput | no | no |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
STYX_HUMAN | [view interactions] | High throughput | no | yes |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
DCPS_HUMAN | [view interactions] | High throughput | no | yes |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
CUL9_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
BPIB1_HUMAN | [view interactions] | High throughput | no | no |
PIGR_HUMAN | [view interactions] | High throughput | no | no |
IGJ_HUMAN | [view interactions] | High throughput | no | no |
BPIA1_HUMAN | [view interactions] | High throughput | no | no |
LYSC_HUMAN | [view interactions] | High throughput | no | no |
ZG16B_HUMAN | [view interactions] | High throughput | no | no |
AACT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MUC5B_HUMAN | [view interactions] | High throughput | no | no |
TRFL_HUMAN | [view interactions] | High throughput | no | no |
DMBT1_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
CATB_HUMAN | [view interactions] | High throughput | no | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
RHBT2_HUMAN | [view interactions] | High throughput | no | no |
PLK4_HUMAN | [view interactions] | High throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITA2B_HUMAN | [view interactions] | High throughput | no | no |
FBX25_HUMAN | [view interactions] | High throughput | no | no |
TRM1_HUMAN | [view interactions] | High throughput | no | yes |
UN45A_HUMAN | [view interactions] | High throughput | no | yes |
XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBE2A_HUMAN | [view interactions] | High throughput | no | no |
UBXN1_HUMAN | [view interactions] | High throughput | no | no |
TXND5_HUMAN | [view interactions] | High throughput | no | yes |
XPP1_HUMAN | [view interactions] | High throughput | no | yes |
UBP28_HUMAN | [view interactions] | High throughput | no | yes |
UBA3_HUMAN | [view interactions] | High throughput | no | yes |
PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TPX2_HUMAN | [view interactions] | High throughput | no | yes |
ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
IPO9_HUMAN | [view interactions] | High throughput | no | no |
MCTS1_HUMAN | [view interactions] | High throughput | no | no |
PUR8_HUMAN | [view interactions] | High throughput | no | yes |
RRP44_HUMAN | [view interactions] | High throughput | no | yes |
UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYWC_HUMAN | [view interactions] | High throughput | no | yes |
AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
MCA3_HUMAN | [view interactions] | High throughput | no | yes |
HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
CPIN1_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
CATS_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
CLC4D_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
DEST_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BGAL_HUMAN | [view interactions] | Computational | no | yes |