TWF1_HUMAN
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004172 | LIG_ActinCP_TwfCPI_2 | LIG | 323 | 333 | - |
| ELMI004172 | LIG_ActinCP_TwfCPI_2 | LIG | 323 | 333 | - |
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TWF1_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 36.7647 | 4 | yes |
| GO:0043168 | anion binding | 35.2941 | 4 | yes |
| GO:0000166 | nucleotide binding | 32.3529 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.8824 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.8824 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.8824 | 4 | yes |
| GO:0005524 | ATP binding | 27.9412 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.9412 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.9412 | 5 | yes |
| GO:0045296 | cadherin binding | 23.5294 | 4 | yes |
| GO:0043169 | cation binding | 20.5882 | 4 | no |
| GO:0046872 | metal ion binding | 20.5882 | 5 | no |
| GO:0035091 | phosphatidylinositol binding | 7.3529 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 5.8824 | 5 | yes |
| GO:0003785 | actin monomer binding | 4.4118 | 5 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 4.4118 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 4.4118 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TWF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.9412 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.5294 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.5294 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.5882 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.1176 | 4 | yes |
| GO:0006996 | organelle organization | 39.7059 | 4 | no |
| GO:0022607 | cellular component assembly | 38.2353 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.7647 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.7647 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 35.2941 | 4 | yes |
| GO:0010468 | regulation of gene expression | 35.2941 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.2941 | 5 | no |
| GO:0010646 | regulation of cell communication | 33.8235 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 33.8235 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.8235 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.8824 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.8824 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.8824 | 5 | no |
| GO:0030030 | cell projection organization | 30.8824 | 4 | no |
| GO:0071310 | cellular response to organic substance | 29.4118 | 4 | no |
| GO:0008104 | protein localization | 29.4118 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.4706 | 5 | no |
| GO:0007015 | actin filament organization | 26.4706 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 26.4706 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4706 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 25.0000 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.5294 | 6 | no |
| GO:0043933 | protein-containing complex organization | 23.5294 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 23.5294 | 7 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.0588 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.0588 | 4 | no |
| GO:0051049 | regulation of transport | 22.0588 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.0588 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 20.5882 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.5882 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.5882 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 20.5882 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 19.1176 | 6 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 19.1176 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 19.1176 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 16.1765 | 7 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.1765 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 14.7059 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 14.7059 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 14.7059 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 14.7059 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 14.7059 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 14.7059 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 13.2353 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 13.2353 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 11.7647 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 11.7647 | 5 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 11.7647 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 11.7647 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 11.7647 | 6 | yes |
| GO:0022411 | cellular component disassembly | 10.2941 | 4 | yes |
| GO:0030833 | regulation of actin filament polymerization | 10.2941 | 7 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 10.2941 | 7 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 10.2941 | 7 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 10.2941 | 6 | yes |
| GO:0044057 | regulation of system process | 10.2941 | 4 | yes |
| GO:0060491 | regulation of cell projection assembly | 10.2941 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 10.2941 | 6 | yes |
| GO:1901879 | regulation of protein depolymerization | 10.2941 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 10.2941 | 7 | yes |
| GO:0008154 | actin polymerization or depolymerization | 8.8235 | 6 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 8.8235 | 7 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 8.8235 | 6 | yes |
| GO:0032272 | negative regulation of protein polymerization | 8.8235 | 7 | yes |
| GO:0051016 | barbed-end actin filament capping | 8.8235 | 9 | yes |
| GO:0051693 | actin filament capping | 8.8235 | 8 | yes |
| GO:1902743 | regulation of lamellipodium organization | 8.8235 | 7 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 7.3529 | 7 | yes |
| GO:0010976 | positive regulation of neuron projection development | 7.3529 | 7 | yes |
| GO:0032984 | protein-containing complex disassembly | 7.3529 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 5.8824 | 5 | yes |
| GO:0030042 | actin filament depolymerization | 4.4118 | 7 | yes |
| GO:0042989 | sequestering of actin monomers | 4.4118 | 4 | yes |
| GO:0051261 | protein depolymerization | 4.4118 | 6 | yes |
| GO:0010611 | regulation of cardiac muscle hypertrophy | 2.9412 | 5 | yes |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | 2.9412 | 6 | yes |
| GO:0014742 | positive regulation of muscle hypertrophy | 2.9412 | 5 | yes |
| GO:0014743 | regulation of muscle hypertrophy | 2.9412 | 6 | yes |
| GO:0043502 | regulation of muscle adaptation | 2.9412 | 4 | yes |
| GO:0043538 | regulation of actin phosphorylation | 2.9412 | 6 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAZA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTPN_HUMAN | [view interactions] | Low throughput | no | yes |
| CP110_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| BPIB1_HUMAN | [view interactions] | High throughput | no | no |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| IGJ_HUMAN | [view interactions] | High throughput | no | no |
| BPIA1_HUMAN | [view interactions] | High throughput | no | no |
| LYSC_HUMAN | [view interactions] | High throughput | no | no |
| PAUF_HUMAN | [view interactions] | High throughput | no | no |
| AACT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MUC5B_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| DMBT1_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| TRM1_HUMAN | [view interactions] | High throughput | no | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP28_HUMAN | [view interactions] | High throughput | no | yes |
| UBA3_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| NCDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC3_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTK_HUMAN | [view interactions] | High throughput | no | no |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC7_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| CAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |