Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SCIN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed, PubMed). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts . Regulates chondrocyte proliferation and differentiation . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SCIN_HUMAN
GO:0017076 purine nucleotide binding 56.2500 4 no
GO:0030554 adenyl nucleotide binding 43.7500 5 no
GO:0032555 purine ribonucleotide binding 43.7500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 43.7500 4 no
GO:0003779 actin binding 37.5000 4 yes
GO:0005524 ATP binding 31.2500 5 no
GO:0032559 adenyl ribonucleotide binding 31.2500 5 no
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 25.0000 4 yes
GO:0035091 phosphatidylinositol binding 25.0000 4 yes
GO:1901981 phosphatidylinositol phosphate binding 25.0000 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 25.0000 6 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0005509 calcium ion binding 18.7500 5 yes
GO:0046872 metal ion binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SCIN_HUMAN
GO:0048522 positive regulation of cellular process 81.2500 4 yes
GO:0051128 regulation of cellular component organization 68.7500 4 yes
GO:0033043 regulation of organelle organization 62.5000 5 yes
GO:0044087 regulation of cellular component biogenesis 62.5000 4 yes
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0006996 organelle organization 62.5000 4 no
GO:0022607 cellular component assembly 56.2500 4 yes
GO:0032956 regulation of actin cytoskeleton organization 56.2500 5 yes
GO:0032970 regulation of actin filament-based process 56.2500 4 yes
GO:0051493 regulation of cytoskeleton organization 56.2500 6 yes
GO:0110053 regulation of actin filament organization 56.2500 6 yes
GO:1902903 regulation of supramolecular fiber organization 56.2500 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 56.2500 4 no
GO:0080090 regulation of primary metabolic process 56.2500 4 no
GO:0009893 positive regulation of metabolic process 56.2500 4 no
GO:0043254 regulation of protein-containing complex assembly 50.0000 5 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0051129 negative regulation of cellular component organization 50.0000 5 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0008064 regulation of actin polymerization or depolymerization 43.7500 6 yes
GO:0010639 negative regulation of organelle organization 43.7500 6 yes
GO:0016192 vesicle-mediated transport 43.7500 4 yes
GO:0030832 regulation of actin filament length 43.7500 5 yes
GO:0030833 regulation of actin filament polymerization 43.7500 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 43.7500 6 yes
GO:0032271 regulation of protein polymerization 43.7500 6 yes
GO:0032535 regulation of cellular component size 43.7500 4 yes
GO:0051130 positive regulation of cellular component organization 43.7500 5 yes
GO:0007010 cytoskeleton organization 43.7500 5 no
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:0007015 actin filament organization 37.5000 5 yes
GO:0030837 negative regulation of actin filament polymerization 37.5000 7 yes
GO:0032272 negative regulation of protein polymerization 37.5000 7 yes
GO:0051050 positive regulation of transport 37.5000 4 yes
GO:0051494 negative regulation of cytoskeleton organization 37.5000 7 yes
GO:0097435 supramolecular fiber organization 37.5000 4 yes
GO:1902904 negative regulation of supramolecular fiber organization 37.5000 6 yes
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0006897 endocytosis 37.5000 5 no
GO:0008104 protein localization 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0010638 positive regulation of organelle organization 31.2500 6 yes
GO:0010941 regulation of cell death 31.2500 4 yes
GO:0030834 regulation of actin filament depolymerization 31.2500 7 yes
GO:0030835 negative regulation of actin filament depolymerization 31.2500 7 yes
GO:0042981 regulation of apoptotic process 31.2500 6 yes
GO:0043067 regulation of programmed cell death 31.2500 5 yes
GO:0043242 negative regulation of protein-containing complex disassembly 31.2500 6 yes
GO:0043244 regulation of protein-containing complex disassembly 31.2500 5 yes
GO:0051495 positive regulation of cytoskeleton organization 31.2500 7 yes
GO:0051693 actin filament capping 31.2500 8 yes
GO:1901879 regulation of protein depolymerization 31.2500 6 yes
GO:1901880 negative regulation of protein depolymerization 31.2500 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 31.2500 6 yes
GO:0034330 cell junction organization 31.2500 4 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:0070925 organelle assembly 31.2500 5 no
GO:0010942 positive regulation of cell death 25.0000 5 yes
GO:0030030 cell projection organization 25.0000 4 yes
GO:0043065 positive regulation of apoptotic process 25.0000 7 yes
GO:0043068 positive regulation of programmed cell death 25.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0060249 anatomical structure homeostasis 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0034097 response to cytokine 25.0000 4 no
GO:0034341 response to interferon-gamma 25.0000 5 no
GO:0071345 cellular response to cytokine stimulus 25.0000 5 no
GO:0071346 cellular response to interferon-gamma 25.0000 6 no
GO:0008154 actin polymerization or depolymerization 18.7500 6 yes
GO:0030031 cell projection assembly 18.7500 5 yes
GO:0042989 sequestering of actin monomers 18.7500 4 yes
GO:0051016 barbed-end actin filament capping 18.7500 9 yes
GO:0051094 positive regulation of developmental process 18.7500 4 yes
GO:0007417 central nervous system development 12.5000 4 yes
GO:0042127 regulation of cell population proliferation 12.5000 4 yes
GO:0045010 actin nucleation 12.5000 6 yes
GO:0045595 regulation of cell differentiation 12.5000 4 yes
GO:0045597 positive regulation of cell differentiation 12.5000 5 yes
GO:0046903 secretion 12.5000 4 yes
GO:0051046 regulation of secretion 12.5000 5 yes
GO:0051047 positive regulation of secretion 12.5000 5 yes
GO:0051125 regulation of actin nucleation 12.5000 7 yes
GO:0051127 positive regulation of actin nucleation 12.5000 7 yes
GO:2000026 regulation of multicellular organismal development 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACTS_HUMAN [view interactions] Low throughput no no
LSP1_HUMAN [view interactions] High throughput no no
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
SSH1_HUMAN [view interactions] High throughput no yes
OCAD2_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no
HASP_HUMAN [view interactions] High throughput no yes
M3K3_HUMAN [view interactions] High throughput no no
RIPK3_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1B_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
ELF5_HUMAN [view interactions] High throughput no no
BCL7C_HUMAN [view interactions] High throughput no yes
BCL7A_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
POTEF_HUMAN [view interactions] High throughput no no
FBX30_HUMAN [view interactions] High throughput no yes
GRCR1_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
GPAT1_HUMAN [view interactions] High throughput no no
POTEI_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT5_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CO3_HUMAN [view entry] [view interactions] Computational yes no
GELS_HUMAN [view entry] [view interactions] Computational yes no