TMOD2_HUMAN
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TMOD2_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 42.8571 | 4 | yes |
GO:0005524 | ATP binding | 22.8571 | 5 | no |
GO:0017076 | purine nucleotide binding | 22.8571 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 22.8571 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 22.8571 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 22.8571 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.8571 | 4 | no |
GO:0046872 | metal ion binding | 22.8571 | 4 | no |
GO:0005523 | tropomyosin binding | 5.7143 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TMOD2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 54.2857 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 51.4286 | 4 | no |
GO:0051128 | regulation of cellular component organization | 51.4286 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 48.5714 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 48.5714 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 48.5714 | 4 | no |
GO:0006996 | organelle organization | 48.5714 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 42.8571 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
GO:0051049 | regulation of transport | 40.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 40.0000 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 37.1429 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.1429 | 5 | no |
GO:0009966 | regulation of signal transduction | 37.1429 | 4 | yes |
GO:0033043 | regulation of organelle organization | 37.1429 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 37.1429 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 34.2857 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 34.2857 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.2857 | 5 | no |
GO:0007015 | actin filament organization | 34.2857 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.4286 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.4286 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 31.4286 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 31.4286 | 5 | no |
GO:0031399 | regulation of protein modification process | 31.4286 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.4286 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 31.4286 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 28.5714 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
GO:0051338 | regulation of transferase activity | 28.5714 | 4 | no |
GO:0071310 | cellular response to organic substance | 28.5714 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
GO:0030030 | cell projection organization | 28.5714 | 4 | no |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 28.5714 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 28.5714 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 28.5714 | 5 | yes |
GO:0110053 | regulation of actin filament organization | 28.5714 | 6 | yes |
GO:0008104 | protein localization | 25.7143 | 4 | no |
GO:0016192 | vesicle-mediated transport | 25.7143 | 4 | no |
GO:0036211 | protein modification process | 25.7143 | 4 | no |
GO:0043412 | macromolecule modification | 25.7143 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 25.7143 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 25.7143 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.7143 | 6 | no |
GO:0042325 | regulation of phosphorylation | 25.7143 | 7 | no |
GO:0043549 | regulation of kinase activity | 25.7143 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 25.7143 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.7143 | 5 | no |
GO:0010941 | regulation of cell death | 25.7143 | 4 | no |
GO:0042981 | regulation of apoptotic process | 25.7143 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.7143 | 5 | no |
GO:0032880 | regulation of protein localization | 25.7143 | 5 | no |
GO:0060341 | regulation of cellular localization | 25.7143 | 4 | no |
GO:0010647 | positive regulation of cell communication | 25.7143 | 5 | yes |
GO:0023056 | positive regulation of signaling | 25.7143 | 4 | yes |
GO:0009894 | regulation of catabolic process | 22.8571 | 4 | no |
GO:0030162 | regulation of proteolysis | 22.8571 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 22.8571 | 7 | no |
GO:1901701 | cellular response to oxygen-containing compound | 22.8571 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.8571 | 5 | no |
GO:0051050 | positive regulation of transport | 22.8571 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 22.8571 | 7 | no |
GO:0043254 | regulation of protein-containing complex assembly | 22.8571 | 5 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 20.0000 | 6 | yes |
GO:0009967 | positive regulation of signal transduction | 20.0000 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 20.0000 | 6 | yes |
GO:0030832 | regulation of actin filament length | 20.0000 | 5 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 20.0000 | 6 | yes |
GO:0032271 | regulation of protein polymerization | 20.0000 | 6 | yes |
GO:0032535 | regulation of cellular component size | 20.0000 | 4 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 17.1429 | 6 | yes |
GO:0030833 | regulation of actin filament polymerization | 17.1429 | 7 | yes |
GO:0032272 | negative regulation of protein polymerization | 17.1429 | 7 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 17.1429 | 7 | yes |
GO:0006936 | muscle contraction | 14.2857 | 4 | yes |
GO:0030834 | regulation of actin filament depolymerization | 14.2857 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 14.2857 | 7 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 14.2857 | 7 | yes |
GO:0031032 | actomyosin structure organization | 14.2857 | 4 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 14.2857 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 14.2857 | 5 | yes |
GO:0050890 | cognition | 14.2857 | 4 | yes |
GO:0051693 | actin filament capping | 14.2857 | 8 | yes |
GO:1901879 | regulation of protein depolymerization | 14.2857 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 14.2857 | 7 | yes |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 11.4286 | 5 | yes |
GO:0070925 | organelle assembly | 11.4286 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 8.5714 | 6 | yes |
GO:0007399 | nervous system development | 8.5714 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 8.5714 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 8.5714 | 4 | yes |
GO:0030239 | myofibril assembly | 5.7143 | 4 | yes |
GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway | 5.7143 | 6 | yes |
GO:0051694 | pointed-end actin filament capping | 5.7143 | 9 | yes |
GO:0140694 | non-membrane-bounded organelle assembly | 5.7143 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in TMOD2_HUMAN |
---|---|---|---|---|
DOID:0080000 | muscular disease | 5.7143 | 3 | no |
DOID:3191 | nemaline myopathy | 5.7143 | 7 | no |
DOID:422 | congenital structural myopathy | 5.7143 | 6 | no |
DOID:423 | myopathy | 5.7143 | 5 | no |
DOID:66 | muscle tissue disease | 5.7143 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSP1_HUMAN | [view interactions] | High throughput | no | no |
S2541_HUMAN | [view interactions] | High throughput | no | no |
SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PKHG6_HUMAN | [view interactions] | High throughput | no | yes |
SSH1_HUMAN | [view interactions] | High throughput | no | yes |
RBM18_HUMAN | [view interactions] | High throughput | no | no |
ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
ARHGH_HUMAN | [view interactions] | High throughput | no | yes |
PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYDGF_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FOS_HUMAN | [view interactions] | High throughput | no | yes |
FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LUZP4_HUMAN | [view interactions] | High throughput | no | no |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIR2B_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
AVIL_HUMAN | [view interactions] | High throughput | no | no |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PKHG1_HUMAN | [view interactions] | High throughput | no | yes |
VAV_HUMAN | [view interactions] | High throughput | no | no |
OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
ABRA_HUMAN | [view interactions] | High throughput | no | no |
GAGE5_HUMAN | [view interactions] | High throughput | no | no |
TP4A3_HUMAN | [view interactions] | High throughput | no | no |
CX001_HUMAN | [view interactions] | High throughput | no | no |
CXCL6_HUMAN | [view interactions] | High throughput | no | no |
MALL_HUMAN | [view interactions] | High throughput | no | no |
RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEAD1_HUMAN | [view interactions] | High throughput | no | no |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLK4_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
MRP1_HUMAN | [view interactions] | High throughput | no | no |
PABP3_HUMAN | [view interactions] | High throughput | no | yes |
TIM16_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
ST1C3_HUMAN | [view interactions] | High throughput | no | no |
VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHX9_HUMAN | [view interactions] | High throughput | no | yes |
SYVC_HUMAN | [view interactions] | High throughput | no | yes |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
CATB_HUMAN | [view interactions] | High throughput | no | yes |
CLC4D_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMOD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TPM1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TMOD3_HUMAN | [view interactions] | Computational | no | yes |
TMOD4_HUMAN | [view interactions] | Computational | no | no |
TPM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |