Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TMOD2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TMOD2_HUMAN
GO:0003779 actin binding 35.1351 4 yes
GO:0043168 anion binding 35.1351 4 no
GO:0000166 nucleotide binding 27.0270 4 no
GO:0017076 purine nucleotide binding 27.0270 5 no
GO:0030554 adenyl nucleotide binding 27.0270 6 no
GO:0019900 kinase binding 27.0270 4 no
GO:0043169 cation binding 27.0270 4 no
GO:0046872 metal ion binding 27.0270 5 no
GO:0032555 purine ribonucleotide binding 24.3243 4 no
GO:0032559 adenyl ribonucleotide binding 24.3243 5 no
GO:0005524 ATP binding 21.6216 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.6216 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TMOD2_HUMAN
GO:0048522 positive regulation of cellular process 62.1622 4 yes
GO:0031323 regulation of cellular metabolic process 56.7568 4 no
GO:0048523 negative regulation of cellular process 56.7568 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.0541 4 no
GO:0051128 regulation of cellular component organization 54.0541 4 yes
GO:0010646 regulation of cell communication 51.3514 4 yes
GO:0080090 regulation of primary metabolic process 48.6486 4 no
GO:0009966 regulation of signal transduction 45.9459 4 yes
GO:0051246 regulation of protein metabolic process 43.2432 5 no
GO:0009889 regulation of biosynthetic process 43.2432 4 no
GO:0010468 regulation of gene expression 43.2432 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.2432 5 no
GO:0031326 regulation of cellular biosynthetic process 43.2432 5 no
GO:0009893 positive regulation of metabolic process 43.2432 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.2432 5 no
GO:0031325 positive regulation of cellular metabolic process 43.2432 5 no
GO:0006996 organelle organization 43.2432 4 yes
GO:0022607 cellular component assembly 43.2432 4 yes
GO:0051049 regulation of transport 37.8378 4 no
GO:0008104 protein localization 37.8378 4 no
GO:0048584 positive regulation of response to stimulus 35.1351 4 yes
GO:0009892 negative regulation of metabolic process 32.4324 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.4324 5 no
GO:0042981 regulation of apoptotic process 32.4324 5 no
GO:0043067 regulation of programmed cell death 32.4324 4 no
GO:0031399 regulation of protein modification process 32.4324 6 no
GO:0071310 cellular response to organic substance 32.4324 4 no
GO:0010647 positive regulation of cell communication 32.4324 5 yes
GO:0023056 positive regulation of signaling 32.4324 4 yes
GO:0044087 regulation of cellular component biogenesis 32.4324 4 yes
GO:0097435 supramolecular fiber organization 32.4324 4 yes
GO:0050804 modulation of chemical synaptic transmission 29.7297 5 no
GO:0099177 regulation of trans-synaptic signaling 29.7297 4 no
GO:1902531 regulation of intracellular signal transduction 29.7297 5 no
GO:0006355 regulation of DNA-templated transcription 29.7297 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.7297 5 no
GO:0031324 negative regulation of cellular metabolic process 29.7297 5 no
GO:0051252 regulation of RNA metabolic process 29.7297 5 no
GO:2001141 regulation of RNA biosynthetic process 29.7297 6 no
GO:0001932 regulation of protein phosphorylation 29.7297 7 no
GO:0009891 positive regulation of biosynthetic process 29.7297 5 no
GO:0019220 regulation of phosphate metabolic process 29.7297 6 no
GO:0031328 positive regulation of cellular biosynthetic process 29.7297 6 no
GO:0042325 regulation of phosphorylation 29.7297 7 no
GO:0051174 regulation of phosphorus metabolic process 29.7297 5 no
GO:0051247 positive regulation of protein metabolic process 29.7297 6 no
GO:0051338 regulation of transferase activity 29.7297 4 no
GO:0043933 protein-containing complex organization 29.7297 4 no
GO:0033043 regulation of organelle organization 29.7297 5 yes
GO:0051129 negative regulation of cellular component organization 29.7297 5 yes
GO:1902903 regulation of supramolecular fiber organization 27.0270 5 yes
GO:0030030 cell projection organization 27.0270 4 no
GO:0051248 negative regulation of protein metabolic process 27.0270 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.0270 6 no
GO:0043549 regulation of kinase activity 27.0270 5 no
GO:0051130 positive regulation of cellular component organization 27.0270 5 no
GO:0009967 positive regulation of signal transduction 27.0270 5 yes
GO:0009894 regulation of catabolic process 24.3243 4 no
GO:0071702 organic substance transport 24.3243 4 no
GO:0071705 nitrogen compound transport 24.3243 4 no
GO:0043066 negative regulation of apoptotic process 24.3243 6 no
GO:0043069 negative regulation of programmed cell death 24.3243 5 no
GO:0031401 positive regulation of protein modification process 24.3243 7 no
GO:0032880 regulation of protein localization 24.3243 5 no
GO:0045859 regulation of protein kinase activity 24.3243 6 no
GO:0060341 regulation of cellular localization 24.3243 4 no
GO:0007015 actin filament organization 24.3243 5 yes
GO:0030162 regulation of proteolysis 21.6216 6 no
GO:0098657 import into cell 21.6216 4 no
GO:0009968 negative regulation of signal transduction 21.6216 5 no
GO:0010648 negative regulation of cell communication 21.6216 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.6216 4 no
GO:0023057 negative regulation of signaling 21.6216 4 no
GO:0048585 negative regulation of response to stimulus 21.6216 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.6216 8 no
GO:0009890 negative regulation of biosynthetic process 21.6216 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.6216 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.6216 6 no
GO:0036211 protein modification process 21.6216 4 no
GO:0042127 regulation of cell population proliferation 21.6216 4 no
GO:0043412 macromolecule modification 21.6216 4 no
GO:0001934 positive regulation of protein phosphorylation 21.6216 8 no
GO:0010562 positive regulation of phosphorus metabolic process 21.6216 6 no
GO:0010628 positive regulation of gene expression 21.6216 7 no
GO:0031400 negative regulation of protein modification process 21.6216 7 no
GO:0042327 positive regulation of phosphorylation 21.6216 8 no
GO:0043085 positive regulation of catalytic activity 21.6216 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.6216 7 no
GO:1901701 cellular response to oxygen-containing compound 21.6216 4 no
GO:0051094 positive regulation of developmental process 21.6216 4 no
GO:0034097 response to cytokine 21.6216 4 no
GO:0065003 protein-containing complex assembly 21.6216 5 no
GO:0051493 regulation of cytoskeleton organization 21.6216 6 yes
GO:0007010 cytoskeleton organization 18.9189 5 yes
GO:0010639 negative regulation of organelle organization 18.9189 6 yes
GO:0032956 regulation of actin cytoskeleton organization 18.9189 5 yes
GO:0032970 regulation of actin filament-based process 18.9189 4 yes
GO:0043254 regulation of protein-containing complex assembly 18.9189 5 yes
GO:0050890 cognition 18.9189 4 yes
GO:0110053 regulation of actin filament organization 18.9189 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 16.2162 6 yes
GO:0031333 negative regulation of protein-containing complex assembly 16.2162 6 yes
GO:0051494 negative regulation of cytoskeleton organization 16.2162 7 yes
GO:0007268 chemical synaptic transmission 13.5135 7 yes
GO:0032271 regulation of protein polymerization 13.5135 6 yes
GO:0032272 negative regulation of protein polymerization 13.5135 7 yes
GO:0098916 anterograde trans-synaptic signaling 13.5135 6 yes
GO:0099536 synaptic signaling 13.5135 4 yes
GO:0099537 trans-synaptic signaling 13.5135 5 yes
GO:1901880 negative regulation of protein depolymerization 10.8108 7 yes
GO:0008064 regulation of actin polymerization or depolymerization 10.8108 6 yes
GO:0030832 regulation of actin filament length 10.8108 5 yes
GO:0030833 regulation of actin filament polymerization 10.8108 7 yes
GO:0030834 regulation of actin filament depolymerization 10.8108 7 yes
GO:0030835 negative regulation of actin filament depolymerization 10.8108 7 yes
GO:0030837 negative regulation of actin filament polymerization 10.8108 7 yes
GO:0032535 regulation of cellular component size 10.8108 4 yes
GO:0043242 negative regulation of protein-containing complex disassembly 10.8108 6 yes
GO:0043244 regulation of protein-containing complex disassembly 10.8108 5 yes
GO:0051693 actin filament capping 10.8108 8 yes
GO:1901879 regulation of protein depolymerization 10.8108 6 yes
GO:0007399 nervous system development 8.1081 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 8.1081 5 yes
GO:0070925 organelle assembly 8.1081 5 yes
GO:0006936 muscle contraction 5.4054 4 yes
GO:0031032 actomyosin structure organization 5.4054 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VATE1_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
SYVC_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CATB_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
LSP1_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
SCIN_HUMAN [view entry] [view interactions] High throughput yes no
PKHG6_HUMAN [view interactions] High throughput no yes
SSH1_HUMAN [view interactions] High throughput no yes
RBM18_HUMAN [view interactions] High throughput no no
ARHGB_HUMAN [view interactions] High throughput no yes
ARHGH_HUMAN [view interactions] High throughput no yes
PKHG3_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
MYDGF_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
AAPK1_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
LUZP4_HUMAN [view interactions] High throughput no no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RIR2B_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
AVIL_HUMAN [view interactions] High throughput no no
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
PKHG1_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
OPHN1_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
ABRA_HUMAN [view interactions] High throughput no no
GAGE5_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
CX001_HUMAN [view interactions] High throughput no no
CXCL6_HUMAN [view interactions] High throughput no no
MALL_HUMAN [view interactions] High throughput no no
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1D_HUMAN [view entry] [view interactions] High throughput yes yes
TEAD1_HUMAN [view interactions] High throughput no no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PLK4_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UBP53_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
SF3B2_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
SF3B3_HUMAN [view interactions] High throughput no yes
MRP1_HUMAN [view interactions] High throughput no no
PABP3_HUMAN [view interactions] High throughput no yes
TIM16_HUMAN [view entry] [view interactions] High throughput yes no
RUVB2_HUMAN [view interactions] High throughput no yes
ST1C3_HUMAN [view interactions] High throughput no no
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes