MYO6_HUMAN
Evidence for PS localization
Functions
Myosins are actin-based motor molecules with ATPase activity . Unconventional myosins serve in intracellular movements . Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed). Has slow rate of actin-activated ADP release due to weak ATP binding . Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration . Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed). May act as a regulator of F-actin dynamics . As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets . May play a role in the extension and network organization of neurites . Required for structural integrity of inner ear hair cells . Modulates RNA polymerase II-dependent transcription (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 442 | Cys | Tyr | Deafness,autosomaldominant,22(DFNA22) | - |
| 216 | Glu | Val | Deafness,autosomalrecessive,37(DFNB37) | - |
| 246 | His | Arg | Deafness,autosomaldominant22,withhypertrophiccardiomyopathy(DFNHCM) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYO6_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.2411 | 4 | no |
| GO:0043168 | anion binding | 25.5319 | 4 | yes |
| GO:0019900 | kinase binding | 25.5319 | 4 | no |
| GO:0000166 | nucleotide binding | 24.1135 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 24.1135 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.6950 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.6950 | 4 | yes |
| GO:0019901 | protein kinase binding | 22.6950 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 18.4397 | 6 | yes |
| GO:0003779 | actin binding | 17.0213 | 4 | yes |
| GO:0005524 | ATP binding | 17.0213 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.0213 | 5 | yes |
| GO:0043531 | ADP binding | 4.2553 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYO6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.2837 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.1915 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.7730 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.5177 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.8085 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.0993 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.8440 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.7163 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5887 | 5 | no |
| GO:0008104 | protein localization | 36.8794 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.8794 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.8794 | 4 | no |
| GO:0006996 | organelle organization | 35.4610 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.4610 | 5 | no |
| GO:0022607 | cellular component assembly | 35.4610 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.4610 | 5 | no |
| GO:0010468 | regulation of gene expression | 34.0426 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 32.6241 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.9149 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.4965 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.4965 | 5 | no |
| GO:0071702 | organic substance transport | 29.0780 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 28.3688 | 5 | no |
| GO:0071705 | nitrogen compound transport | 27.6596 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.2411 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.2411 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.5319 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.5319 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.5319 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.5319 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.8227 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1135 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.1135 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.4043 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.4043 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.4043 | 4 | no |
| GO:0015031 | protein transport | 22.6950 | 4 | yes |
| GO:0051049 | regulation of transport | 22.6950 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.6950 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.6950 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.6950 | 5 | no |
| GO:0098657 | import into cell | 21.9858 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 21.9858 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.2766 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.2766 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.2766 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.5674 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5674 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 17.7305 | 4 | yes |
| GO:0006886 | intracellular protein transport | 15.6028 | 4 | yes |
| GO:0007015 | actin filament organization | 14.8936 | 5 | yes |
| GO:0051046 | regulation of secretion | 7.8014 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 6.3830 | 4 | yes |
| GO:0006974 | DNA damage response | 5.6738 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 4.9645 | 4 | yes |
| GO:0030182 | neuron differentiation | 3.5461 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 3.5461 | 4 | yes |
| GO:0030050 | vesicle transport along actin filament | 2.8369 | 4 | yes |
| GO:0099515 | actin filament-based transport | 2.8369 | 5 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 2.8369 | 5 | yes |
| GO:0042490 | mechanoreceptor differentiation | 2.1277 | 5 | yes |
| GO:0042770 | signal transduction in response to DNA damage | 2.1277 | 4 | yes |
| GO:0007600 | sensory perception | 1.4184 | 4 | yes |
| GO:0007605 | sensory perception of sound | 1.4184 | 6 | yes |
| GO:0009913 | epidermal cell differentiation | 1.4184 | 5 | yes |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 1.4184 | 5 | yes |
| GO:0035315 | hair cell differentiation | 1.4184 | 5 | yes |
| GO:0042472 | inner ear morphogenesis | 1.4184 | 4 | yes |
| GO:0042491 | inner ear auditory receptor cell differentiation | 1.4184 | 6 | yes |
| GO:0050954 | sensory perception of mechanical stimulus | 1.4184 | 5 | yes |
| GO:0060113 | inner ear receptor cell differentiation | 1.4184 | 6 | yes |
| GO:0072331 | signal transduction by p53 class mediator | 1.4184 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| TM1L2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TOM1_HUMAN | [view interactions] | Low throughput | no | yes |
| LRCH3_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | Low throughput | no | no |
| GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHGC_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | Low throughput | no | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| LMTK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | Low throughput | no | yes |
| CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
| OPTN_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIPC2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| RN126_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| REPS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC2_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| RUXE_HUMAN | [view interactions] | High throughput | no | no |
| GEMI8_HUMAN | [view interactions] | High throughput | no | yes |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| EREP1_HUMAN | [view interactions] | High throughput | no | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| UBP25_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| PCGF3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| FBX34_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX30_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CAR10_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA13A_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| PPR3C_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF38_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| RPA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRS10_HUMAN | [view interactions] | High throughput | no | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RECQ1_HUMAN | [view interactions] | High throughput | no | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP36_HUMAN | [view interactions] | High throughput | no | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP9_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
| WRN_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| IRF8_HUMAN | [view interactions] | High throughput | no | no |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZIC3_HUMAN | [view interactions] | High throughput | no | no |
| TAF6_HUMAN | [view interactions] | High throughput | no | no |
| ELF3_HUMAN | [view interactions] | High throughput | no | no |
| HCFC1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHAA_HUMAN | [view interactions] | High throughput | no | yes |
| RPRD2_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF1_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| KANK1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| SHRM3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| WRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CSAG1_HUMAN | [view interactions] | High throughput | no | no |
| TRIMM_HUMAN | [view interactions] | High throughput | no | no |
| ANM2_HUMAN | [view interactions] | High throughput | no | yes |
| LCAP_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| MTCL1_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| KRI1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| LTV1_HUMAN | [view interactions] | High throughput | no | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| MOONR_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YETS2_HUMAN | [view interactions] | High throughput | no | no |
| ANR40_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIRR1_HUMAN | [view interactions] | High throughput | no | no |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRCH2_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRCH1_HUMAN | [view interactions] | High throughput | no | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH4_HUMAN | [view interactions] | High throughput | no | no |
| BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| DP13B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOL8_HUMAN | [view interactions] | High throughput | no | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| CE192_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| F1711_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| GULP1_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| FMNL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP4_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RPOM_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |