Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STRAP_HUMAN

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in STRAP_HUMAN
GO:0017076 purine nucleotide binding 31.4815 4 no
GO:0032555 purine ribonucleotide binding 31.4815 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.4815 4 no
GO:0003723 RNA binding 29.6296 4 yes
GO:0005524 ATP binding 25.9259 5 no
GO:0030554 adenyl nucleotide binding 25.9259 5 no
GO:0032559 adenyl ribonucleotide binding 25.9259 5 no
GO:0003729 mRNA binding 12.9630 5 yes
GO:0070990 snRNP binding 3.7037 4 yes
GO:1990447 U2 snRNP binding 3.7037 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STRAP_HUMAN
GO:0048522 positive regulation of cellular process 64.8148 4 no
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 59.2593 4 yes
GO:0080090 regulation of primary metabolic process 59.2593 4 yes
GO:0031323 regulation of cellular metabolic process 57.4074 4 yes
GO:0048523 negative regulation of cellular process 55.5556 4 yes
GO:0009893 positive regulation of metabolic process 48.1481 4 no
GO:0051128 regulation of cellular component organization 48.1481 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.2963 5 no
GO:0031325 positive regulation of cellular metabolic process 46.2963 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 46.2963 5 no
GO:0010468 regulation of gene expression 44.4444 5 yes
GO:0009889 regulation of biosynthetic process 42.5926 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.5926 5 yes
GO:0010646 regulation of cell communication 42.5926 4 yes
GO:0031326 regulation of cellular biosynthetic process 42.5926 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.7407 5 yes
GO:0009892 negative regulation of metabolic process 38.8889 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 38.8889 5 yes
GO:0051246 regulation of protein metabolic process 38.8889 5 no
GO:0006996 organelle organization 38.8889 4 no
GO:0022607 cellular component assembly 37.0370 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 37.0370 5 yes
GO:0009966 regulation of signal transduction 35.1852 4 yes
GO:0031324 negative regulation of cellular metabolic process 35.1852 5 yes
GO:0051252 regulation of RNA metabolic process 35.1852 5 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0010648 negative regulation of cell communication 31.4815 5 yes
GO:0023057 negative regulation of signaling 31.4815 4 yes
GO:0009968 negative regulation of signal transduction 29.6296 5 yes
GO:0010941 regulation of cell death 29.6296 4 no
GO:0042981 regulation of apoptotic process 29.6296 6 no
GO:0043067 regulation of programmed cell death 29.6296 5 no
GO:0031399 regulation of protein modification process 29.6296 6 no
GO:0033043 regulation of organelle organization 29.6296 5 no
GO:0006355 regulation of DNA-templated transcription 27.7778 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 27.7778 7 yes
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 yes
GO:0051049 regulation of transport 27.7778 4 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0009891 positive regulation of biosynthetic process 25.9259 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.9259 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.9259 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.9259 6 no
GO:0036211 protein modification process 25.9259 4 no
GO:0043412 macromolecule modification 25.9259 4 no
GO:0031401 positive regulation of protein modification process 25.9259 7 no
GO:0060341 regulation of cellular localization 25.9259 4 no
GO:0006357 regulation of transcription by RNA polymerase II 24.0741 7 yes
GO:0044087 regulation of cellular component biogenesis 24.0741 4 no
GO:0051130 positive regulation of cellular component organization 24.0741 5 no
GO:0042127 regulation of cell population proliferation 24.0741 4 no
GO:0048584 positive regulation of response to stimulus 24.0741 4 no
GO:0019220 regulation of phosphate metabolic process 24.0741 6 no
GO:0051174 regulation of phosphorus metabolic process 24.0741 5 no
GO:0051248 negative regulation of protein metabolic process 24.0741 6 no
GO:0032880 regulation of protein localization 24.0741 5 no
GO:0007010 cytoskeleton organization 24.0741 5 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 yes
GO:0043933 protein-containing complex organization 22.2222 4 yes
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 7 no
GO:0043069 negative regulation of programmed cell death 22.2222 6 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0065003 protein-containing complex assembly 20.3704 5 yes
GO:0080134 regulation of response to stress 20.3704 4 no
GO:0010628 positive regulation of gene expression 20.3704 6 no
GO:0051129 negative regulation of cellular component organization 20.3704 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 18.5185 6 yes
GO:0090304 nucleic acid metabolic process 16.6667 4 yes
GO:0051253 negative regulation of RNA metabolic process 14.8148 6 yes
GO:0016070 RNA metabolic process 12.9630 5 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 11.1111 8 yes
GO:0006396 RNA processing 11.1111 6 yes
GO:0045892 negative regulation of DNA-templated transcription 11.1111 7 yes
GO:1902679 negative regulation of RNA biosynthetic process 11.1111 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 11.1111 8 yes
GO:0008380 RNA splicing 9.2593 7 yes
GO:0016071 mRNA metabolic process 9.2593 6 yes
GO:0030182 neuron differentiation 9.2593 4 yes
GO:0090287 regulation of cellular response to growth factor stimulus 9.2593 4 yes
GO:0001894 tissue homeostasis 7.4074 5 yes
GO:0006397 mRNA processing 7.4074 7 yes
GO:0060249 anatomical structure homeostasis 7.4074 4 yes
GO:0000375 RNA splicing, via transesterification reactions 5.5556 8 yes
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5.5556 9 yes
GO:0000398 mRNA splicing, via spliceosome 5.5556 8 yes
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 5.5556 6 yes
GO:0022618 ribonucleoprotein complex assembly 5.5556 6 yes
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 5.5556 7 yes
GO:0071826 ribonucleoprotein complex subunit organization 5.5556 5 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.5556 5 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.5556 6 yes
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 5.5556 5 yes
GO:0000380 alternative mRNA splicing, via spliceosome 3.7037 9 yes
GO:0000387 spliceosomal snRNP assembly 3.7037 7 yes
GO:0010669 epithelial structure maintenance 3.7037 6 yes
GO:0030277 maintenance of gastrointestinal epithelium 3.7037 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GEMI6_HUMAN [view interactions] Low throughput no yes
RSMB_HUMAN [view interactions] Low throughput no yes
SMD3_HUMAN [view interactions] Low throughput no yes
RUXE_HUMAN [view interactions] Low throughput no no
SMD2_HUMAN [view interactions] Low throughput no yes
STRAP_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFR1_HUMAN [view interactions] Low throughput no no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
CHK2_HUMAN [view interactions] Low throughput no yes
PBLD_HUMAN [view interactions] Low throughput no no
TGFR2_HUMAN [view interactions] Low throughput no no
SMAD7_HUMAN [view interactions] Low throughput no yes
SMAD2_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
AXIN1_HUMAN [view interactions] Low throughput no yes
NOTC3_HUMAN [view interactions] Low throughput no yes
PDPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
HSF1_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
SP1_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
NDKA_HUMAN [view entry] [view interactions] Low throughput yes yes
GEMI7_HUMAN [view interactions] Low throughput no no
CSDE1_HUMAN [view interactions] High throughput no yes
PLBL2_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
GEMI5_HUMAN [view interactions] High throughput no yes
EIF3I_HUMAN [view interactions] High throughput no yes
SYSC_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
TSNAX_HUMAN [view interactions] High throughput no yes
ZNFX1_HUMAN [view interactions] High throughput no yes
RPR1B_HUMAN [view interactions] High throughput no yes
CK068_HUMAN [view interactions] High throughput no yes
LARP6_HUMAN [view interactions] High throughput no yes
SPT6H_HUMAN [view interactions] High throughput no yes
TSN_HUMAN [view interactions] High throughput no yes
GEMI4_HUMAN [view interactions] High throughput no yes
PYC_HUMAN [view entry] [view interactions] High throughput yes yes
CDKA1_HUMAN [view interactions] High throughput no yes
GEMI8_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB3_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
KLF6_HUMAN [view interactions] High throughput no yes
KLF9_HUMAN [view interactions] High throughput no no
TLX2_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
EIF1B_HUMAN [view interactions] High throughput no no
RNPS1_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
ARP6_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view interactions] High throughput no yes
HUS1_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
MRES1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TIFAB_HUMAN [view interactions] High throughput no no
SGTA_HUMAN [view interactions] High throughput no yes
SZRD1_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
SMAD6_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC5_HUMAN [view interactions] High throughput no yes
UIF_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
GEMI2_HUMAN [view interactions] High throughput no yes
BARD1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
PAXI1_HUMAN [view interactions] High throughput no no
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
FOXP3_HUMAN [view interactions] High throughput no no
NOS2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
RAPH1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
PTN9_HUMAN [view interactions] High throughput no yes
RPRD2_HUMAN [view interactions] High throughput no yes
LS14A_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
CCND2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
FGF11_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
RUXF_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
MKRN3_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
RIPK2_HUMAN [view interactions] High throughput no yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
SNRPA_HUMAN [view interactions] High throughput no yes
RU1C_HUMAN [view interactions] High throughput no yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
LDLR_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
ACOHC_HUMAN [view interactions] High throughput no yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ACADM_HUMAN [view interactions] High throughput no yes
PYRG1_HUMAN [view interactions] High throughput no no
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
UBA6_HUMAN [view interactions] High throughput no no
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
ECI1_HUMAN [view interactions] High throughput no yes
OAT_HUMAN [view interactions] High throughput no yes
RUXG_HUMAN [view interactions] High throughput no yes
ZPR1_HUMAN [view interactions] High throughput no yes
SMD1_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
CELF1_HUMAN [view interactions] High throughput no yes
DAZL_HUMAN [view interactions] High throughput no no
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
F120A_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
IF2B1_HUMAN [view interactions] High throughput no no
IF2B2_HUMAN [view interactions] High throughput no yes
KIF1B_HUMAN [view interactions] High throughput no yes
PUM1_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
ZCCHV_HUMAN [view interactions] High throughput no yes
TDRD3_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
PAIRB_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
SLX1_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
RU17_HUMAN [view interactions] High throughput no yes
DDX20_HUMAN [view interactions] High throughput no no
LAR4B_HUMAN [view interactions] High throughput no yes
ZFYV9_HUMAN [view interactions] Computational no yes
NED4L_HUMAN [view interactions] Computational no yes
XIAP_HUMAN [view interactions] Computational no yes
M3K7_HUMAN [view interactions] Computational no yes
TAB2_HUMAN [view interactions] Computational no yes
TAB1_HUMAN [view interactions] Computational no yes
AP2B_HUMAN [view interactions] Computational no no
TGFB3_HUMAN [view interactions] Computational no no
PML_HUMAN [view interactions] Computational no yes
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes