PTC1_HUMAN
Evidence for PS localization
Functions
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehogs proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTC1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 24.0741 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.0741 | 5 | no |
| GO:0043168 | anion binding | 24.0741 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 5 | no |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.3704 | 6 | no |
| GO:0001664 | G protein-coupled receptor binding | 12.9630 | 4 | yes |
| GO:0005113 | patched binding | 7.4074 | 4 | yes |
| GO:0032934 | sterol binding | 5.5556 | 4 | yes |
| GO:0005119 | smoothened binding | 3.7037 | 5 | yes |
| GO:0008158 | hedgehog receptor activity | 3.7037 | 4 | yes |
| GO:0015485 | cholesterol binding | 3.7037 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.9630 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.8519 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.2963 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.2963 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.2963 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.5926 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 40.7407 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.7407 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 35.1852 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 35.1852 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.1852 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 35.1852 | 4 | yes |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 31.4815 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.4815 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.4815 | 6 | yes |
| GO:0051049 | regulation of transport | 29.6296 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 29.6296 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 29.6296 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.6296 | 7 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.6296 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.6296 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 27.7778 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 27.7778 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 25.9259 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.9259 | 8 | yes |
| GO:0006508 | proteolysis | 25.9259 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 25.9259 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.9259 | 6 | yes |
| GO:0030030 | cell projection organization | 25.9259 | 4 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.9259 | 6 | yes |
| GO:0051050 | positive regulation of transport | 24.0741 | 4 | yes |
| GO:0006996 | organelle organization | 24.0741 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.0741 | 5 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 22.2222 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 22.2222 | 7 | yes |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 22.2222 | 9 | yes |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 22.2222 | 8 | yes |
| GO:0071310 | cellular response to organic substance | 20.3704 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.3704 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.3704 | 4 | no |
| GO:0036211 | protein modification process | 20.3704 | 4 | no |
| GO:0043412 | macromolecule modification | 20.3704 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 20.3704 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.3704 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.3704 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.3704 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.3704 | 5 | no |
| GO:2000145 | regulation of cell motility | 20.3704 | 4 | no |
| GO:0071702 | organic substance transport | 20.3704 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.3704 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.3704 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.3704 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 20.3704 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 18.5185 | 4 | yes |
| GO:0031175 | neuron projection development | 18.5185 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 18.5185 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 16.6667 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 16.6667 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 16.6667 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 14.8148 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 14.8148 | 7 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 14.8148 | 8 | yes |
| GO:0051093 | negative regulation of developmental process | 12.9630 | 4 | yes |
| GO:0072657 | protein localization to membrane | 12.9630 | 4 | yes |
| GO:0097485 | neuron projection guidance | 12.9630 | 7 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 12.9630 | 4 | yes |
| GO:0007411 | axon guidance | 12.9630 | 8 | yes |
| GO:0030182 | neuron differentiation | 12.9630 | 4 | yes |
| GO:0033993 | response to lipid | 12.9630 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 12.9630 | 5 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 11.1111 | 5 | yes |
| GO:0060537 | muscle tissue development | 11.1111 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 11.1111 | 5 | yes |
| GO:0002009 | morphogenesis of an epithelium | 11.1111 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 11.1111 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 11.1111 | 4 | yes |
| GO:0040014 | regulation of multicellular organism growth | 11.1111 | 4 | yes |
| GO:0048745 | smooth muscle tissue development | 9.2593 | 5 | yes |
| GO:0051302 | regulation of cell division | 9.2593 | 4 | yes |
| GO:0071396 | cellular response to lipid | 9.2593 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 9.2593 | 5 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 9.2593 | 5 | yes |
| GO:0045926 | negative regulation of growth | 9.2593 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 7.4074 | 5 | yes |
| GO:0048732 | gland development | 7.4074 | 4 | yes |
| GO:0048754 | branching morphogenesis of an epithelial tube | 7.4074 | 4 | yes |
| GO:0060429 | epithelium development | 7.4074 | 4 | yes |
| GO:0060562 | epithelial tube morphogenesis | 7.4074 | 4 | yes |
| GO:0061053 | somite development | 7.4074 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 7.4074 | 5 | yes |
| GO:0097305 | response to alcohol | 7.4074 | 4 | yes |
| GO:0097306 | cellular response to alcohol | 7.4074 | 5 | yes |
| GO:0001658 | branching involved in ureteric bud morphogenesis | 7.4074 | 5 | yes |
| GO:0001701 | in utero embryonic development | 7.4074 | 6 | yes |
| GO:0007224 | smoothened signaling pathway | 7.4074 | 4 | yes |
| GO:0008589 | regulation of smoothened signaling pathway | 7.4074 | 5 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 7.4074 | 4 | yes |
| GO:0009953 | dorsal/ventral pattern formation | 7.4074 | 4 | yes |
| GO:0021904 | dorsal/ventral neural tube patterning | 7.4074 | 5 | yes |
| GO:0021953 | central nervous system neuron differentiation | 7.4074 | 5 | yes |
| GO:0042593 | glucose homeostasis | 7.4074 | 4 | yes |
| GO:0043009 | chordate embryonic development | 7.4074 | 5 | yes |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | 7.4074 | 4 | yes |
| GO:0051604 | protein maturation | 5.5556 | 4 | yes |
| GO:0060644 | mammary gland epithelial cell differentiation | 5.5556 | 5 | yes |
| GO:0061005 | cell differentiation involved in kidney development | 5.5556 | 4 | yes |
| GO:0070723 | response to cholesterol | 5.5556 | 5 | yes |
| GO:0071397 | cellular response to cholesterol | 5.5556 | 6 | yes |
| GO:0071679 | commissural neuron axon guidance | 5.5556 | 9 | yes |
| GO:0072044 | collecting duct development | 5.5556 | 4 | yes |
| GO:0072091 | regulation of stem cell proliferation | 5.5556 | 5 | yes |
| GO:0072203 | cell proliferation involved in metanephros development | 5.5556 | 4 | yes |
| GO:0072205 | metanephric collecting duct development | 5.5556 | 5 | yes |
| GO:0097421 | liver regeneration | 5.5556 | 5 | yes |
| GO:1905952 | regulation of lipid localization | 5.5556 | 4 | yes |
| GO:0001889 | liver development | 5.5556 | 5 | yes |
| GO:0007286 | spermatid development | 5.5556 | 4 | yes |
| GO:0010874 | regulation of cholesterol efflux | 5.5556 | 8 | yes |
| GO:0016485 | protein processing | 5.5556 | 5 | yes |
| GO:0021515 | cell differentiation in spinal cord | 5.5556 | 4 | yes |
| GO:0021522 | spinal cord motor neuron differentiation | 5.5556 | 5 | yes |
| GO:0030326 | embryonic limb morphogenesis | 5.5556 | 5 | yes |
| GO:0030850 | prostate gland development | 5.5556 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 5.5556 | 4 | yes |
| GO:0030856 | regulation of epithelial cell differentiation | 5.5556 | 5 | yes |
| GO:0031100 | animal organ regeneration | 5.5556 | 4 | yes |
| GO:0032355 | response to estradiol | 5.5556 | 4 | yes |
| GO:0032368 | regulation of lipid transport | 5.5556 | 5 | yes |
| GO:0032371 | regulation of sterol transport | 5.5556 | 6 | yes |
| GO:0032374 | regulation of cholesterol transport | 5.5556 | 7 | yes |
| GO:0035108 | limb morphogenesis | 5.5556 | 4 | yes |
| GO:0035113 | embryonic appendage morphogenesis | 5.5556 | 4 | yes |
| GO:0035137 | hindlimb morphogenesis | 5.5556 | 5 | yes |
| GO:0036314 | response to sterol | 5.5556 | 4 | yes |
| GO:0036315 | cellular response to sterol | 5.5556 | 5 | yes |
| GO:0048568 | embryonic organ development | 3.7037 | 4 | yes |
| GO:0050680 | negative regulation of epithelial cell proliferation | 3.7037 | 6 | yes |
| GO:0051782 | negative regulation of cell division | 3.7037 | 5 | yes |
| GO:0060037 | pharyngeal system development | 3.7037 | 4 | yes |
| GO:0060603 | mammary gland duct morphogenesis | 3.7037 | 5 | yes |
| GO:0060606 | tube closure | 3.7037 | 4 | yes |
| GO:1905954 | positive regulation of lipid localization | 3.7037 | 4 | yes |
| GO:2000647 | negative regulation of stem cell proliferation | 3.7037 | 6 | yes |
| GO:0000578 | embryonic axis specification | 3.7037 | 4 | yes |
| GO:0001843 | neural tube closure | 3.7037 | 5 | yes |
| GO:0003007 | heart morphogenesis | 3.7037 | 4 | yes |
| GO:0007420 | brain development | 3.7037 | 4 | yes |
| GO:0009957 | epidermal cell fate specification | 3.7037 | 4 | yes |
| GO:0010157 | response to chlorate | 3.7037 | 4 | yes |
| GO:0010837 | regulation of keratinocyte proliferation | 3.7037 | 6 | yes |
| GO:0010839 | negative regulation of keratinocyte proliferation | 3.7037 | 7 | yes |
| GO:0010875 | positive regulation of cholesterol efflux | 3.7037 | 8 | yes |
| GO:0021532 | neural tube patterning | 3.7037 | 4 | yes |
| GO:0021997 | neural plate axis specification | 3.7037 | 5 | yes |
| GO:0030858 | positive regulation of epithelial cell differentiation | 3.7037 | 6 | yes |
| GO:0032370 | positive regulation of lipid transport | 3.7037 | 5 | yes |
| GO:0032373 | positive regulation of sterol transport | 3.7037 | 6 | yes |
| GO:0032376 | positive regulation of cholesterol transport | 3.7037 | 7 | yes |
| GO:0032526 | response to retinoic acid | 3.7037 | 4 | yes |
| GO:0040015 | negative regulation of multicellular organism growth | 3.7037 | 5 | yes |
| GO:0043616 | keratinocyte proliferation | 3.7037 | 4 | yes |
| GO:0045604 | regulation of epidermal cell differentiation | 3.7037 | 5 | yes |
| GO:0045606 | positive regulation of epidermal cell differentiation | 3.7037 | 6 | yes |
| GO:0045667 | regulation of osteoblast differentiation | 3.7037 | 5 | yes |
| GO:0045668 | negative regulation of osteoblast differentiation | 3.7037 | 6 | yes |
| GO:0045682 | regulation of epidermis development | 3.7037 | 4 | yes |
| GO:0045684 | positive regulation of epidermis development | 3.7037 | 5 | yes |
| GO:0045879 | negative regulation of smoothened signaling pathway | 3.7037 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RBCC1_HUMAN | [view interactions] | Low throughput | no | no |
| ULK1_HUMAN | [view interactions] | Low throughput | no | no |
| ATG13_HUMAN | [view interactions] | Low throughput | no | no |
| TSN8_HUMAN | [view interactions] | Low throughput | no | no |
| ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
| ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDON_HUMAN | [view interactions] | Low throughput | no | no |
| SMO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HHIP_HUMAN | [view interactions] | Low throughput | no | no |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| IHH_HUMAN | [view interactions] | Low throughput | no | no |
| ATGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACA_HUMAN | [view interactions] | Low throughput | no | no |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| WWP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| ACD10_HUMAN | [view interactions] | High throughput | no | no |
| WNT16_HUMAN | [view interactions] | High throughput | no | no |
| PLXD1_HUMAN | [view interactions] | High throughput | no | yes |
| SIL1_HUMAN | [view interactions] | High throughput | no | yes |
| CELR1_HUMAN | [view interactions] | High throughput | no | no |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| ABH15_HUMAN | [view interactions] | High throughput | no | yes |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDUA_HUMAN | [view interactions] | High throughput | no | yes |
| UROK_HUMAN | [view interactions] | High throughput | no | no |
| OS9_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| TTC13_HUMAN | [view interactions] | High throughput | no | no |
| METRN_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| CADM4_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4G_HUMAN | [view interactions] | High throughput | no | yes |
| SEM3B_HUMAN | [view interactions] | High throughput | no | yes |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| ANR46_HUMAN | [view interactions] | High throughput | no | yes |
| MFGM_HUMAN | [view interactions] | High throughput | no | no |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| SEM3C_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM6B_HUMAN | [view interactions] | High throughput | no | yes |
| CRLF1_HUMAN | [view interactions] | High throughput | no | no |
| ABD12_HUMAN | [view interactions] | High throughput | no | no |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| BDNF_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLGT2_HUMAN | [view interactions] | High throughput | no | no |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMC2_HUMAN | [view interactions] | High throughput | no | no |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP6_HUMAN | [view interactions] | High throughput | no | yes |
| HYAL2_HUMAN | [view interactions] | High throughput | no | no |
| MGRN1_HUMAN | [view interactions] | High throughput | no | yes |
| SIA7D_HUMAN | [view interactions] | High throughput | no | no |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| PERF_HUMAN | [view interactions] | High throughput | no | no |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| PEX6_HUMAN | [view interactions] | High throughput | no | yes |
| GALT2_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A2_HUMAN | [view interactions] | High throughput | no | no |
| AGRG1_HUMAN | [view interactions] | High throughput | no | yes |
| CHPF2_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| MBTP1_HUMAN | [view interactions] | High throughput | no | yes |
| ECE1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MO2R1_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| SIG12_HUMAN | [view interactions] | High throughput | no | no |
| ITCH_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NED4L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| CASP9_HUMAN | [view interactions] | High throughput | no | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT7_HUMAN | [view interactions] | High throughput | no | yes |
| CA2D2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMPA3_HUMAN | [view interactions] | High throughput | no | yes |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| PLXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T132A_HUMAN | [view interactions] | High throughput | no | yes |
| AMD_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| NDST2_HUMAN | [view interactions] | High throughput | no | no |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM4_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM1_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| CHSTE_HUMAN | [view interactions] | High throughput | no | no |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| EXT1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| MUCL1_HUMAN | [view interactions] | High throughput | no | no |
| COCH_HUMAN | [view interactions] | High throughput | no | no |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MOXD1_HUMAN | [view interactions] | High throughput | no | no |
| CGT_HUMAN | [view interactions] | High throughput | no | no |
| ITA7_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST2_HUMAN | [view interactions] | High throughput | no | no |
| SLIT2_HUMAN | [view interactions] | High throughput | no | no |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| SULF2_HUMAN | [view interactions] | High throughput | no | yes |
| ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| ARSK_HUMAN | [view interactions] | High throughput | no | no |
| ITA6_HUMAN | [view interactions] | High throughput | no | yes |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
| SIA10_HUMAN | [view interactions] | High throughput | no | yes |
| CHSS1_HUMAN | [view interactions] | High throughput | no | no |
| CA2D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| MGT5A_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT3_HUMAN | [view interactions] | High throughput | no | yes |
| PXYP1_HUMAN | [view interactions] | High throughput | no | yes |
| GCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| TXD15_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GLT_HUMAN | [view interactions] | High throughput | no | no |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIA4C_HUMAN | [view interactions] | High throughput | no | yes |
| SIA7C_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CHSS2_HUMAN | [view interactions] | High throughput | no | yes |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GALT7_HUMAN | [view interactions] | High throughput | no | no |
| TGBR3_HUMAN | [view interactions] | High throughput | no | yes |
| MGAT1_HUMAN | [view interactions] | High throughput | no | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| MYORG_HUMAN | [view interactions] | High throughput | no | yes |
| GLT18_HUMAN | [view interactions] | High throughput | no | yes |
| CHST3_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITAV_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| ARBK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CIRBP_HUMAN | [view interactions] | High throughput | no | no |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| KC1AL_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F7_HUMAN | [view interactions] | High throughput | no | no |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| FIG4_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAR1_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR3_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LBR_HUMAN | [view interactions] | High throughput | no | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| LS14B_HUMAN | [view interactions] | High throughput | no | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYV1_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIL4_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| PSMA8_HUMAN | [view interactions] | High throughput | no | no |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| QPCTL_HUMAN | [view interactions] | High throughput | no | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| TPC6B_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |