Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHH_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed). Involved in the patterning of the anterior-posterior axis of the developing limb bud . Essential for axon guidance . Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
31 Gly Arg Holoprosencephaly3(HPE3) -
117 Trp Gly Holoprosencephaly3(HPE3) -
117 Trp Arg Holoprosencephaly3(HPE3) -
88 Asp Val Holoprosencephaly3(HPE3) -
100 Gln His Holoprosencephaly3(HPE3) -
115 Asn Lys Holoprosencephaly3(HPE3) -
188 Glu Gln Holoprosencephaly3(HPE3) -
222 Asp Asn Holoprosencephaly3(HPE3) -
224 Val Glu Holoprosencephaly3(HPE3) -
226 Ala Thr Holoprosencephaly3(HPE3) -
236 Ser Arg Holoprosencephaly3(HPE3) -
290 Gly Asp Holoprosencephaly3(HPE3) -
383 Ala Thr Holoprosencephaly3(HPE3) -
424 Pro Ala Holoprosencephaly3(HPE3) -
436 Ser Leu Holoprosencephaly3(HPE3) -
111 Ile Phe Solitarymedianmaxillarycentralincisor(SMMCI) -
6 Arg Thr Holoprosencephaly3(HPE3) -
110 Ala Asp Holoprosencephaly3(HPE3) -
150 Thr Arg Holoprosencephaly3(HPE3) -
271 Leu Pro Holoprosencephaly3(HPE3) -
332 Val Ala Holoprosencephaly3(HPE3) -
332 Val Ala Solitarymedianmaxillarycentralincisor(SMMCI) -
347 Pro Gln Holoprosencephaly3(HPE3) -
354 Ile Thr Holoprosencephaly3(HPE3) -
381 Arg Pro Holoprosencephaly3(HPE3) -
27 Gly Ala Holoprosencephaly3(HPE3) -
111 Ile Asn Holoprosencephaly3(HPE3) -
140 His Pro Holoprosencephaly3(HPE3) -
140 His Gln Holoprosencephaly3(HPE3) -
183 Cys Phe Holoprosencephaly3(HPE3) -
267 Thr Ile Holoprosencephaly3(HPE3) -
373 Ala Thr Holoprosencephaly3(HPE3) -
17 Leu Pro Holoprosencephaly3(HPE3) -
26 Pro Leu Holoprosencephaly3(HPE3) -
39 Leu Pro Holoprosencephaly3(HPE3) -
53 Glu Lys Holoprosencephaly3(HPE3) -
83 Asp Val Holoprosencephaly3(HPE3) -
84 Ile Phe Holoprosencephaly3(HPE3) -
102 Cys Arg Holoprosencephaly3(HPE3) -
102 Cys Tyr Holoprosencephaly3(HPE3) -
109 Leu Phe Holoprosencephaly3(HPE3) -
110 Ala Thr Holoprosencephaly3(HPE3) -
124 Val Met Holoprosencephaly3(HPE3) -
136 Glu Lys Holoprosencephaly3(HPE3) -
143 Gly Asp Holoprosencephaly3(HPE3) -
144 Arg Pro Holoprosencephaly3(HPE3) -
147 Asp Asn Holoprosencephaly3(HPE3) -
150 Thr Lys Holoprosencephaly3(HPE3) -
156 Ser Arg Holoprosencephaly3(HPE3) -
170 Phe Cys Holoprosencephaly3(HPE3) -
171 Asp His Holoprosencephaly3(HPE3) -
183 Cys Arg Holoprosencephaly3(HPE3) -
183 Cys Tyr Holoprosencephaly3(HPE3) -
184 Ser Leu Holoprosencephaly3(HPE3) -
196 Gly Glu Holoprosencephaly3(HPE3) -
197 Gly Val Holoprosencephaly3(HPE3) -
198 Cys Phe Holoprosencephaly3(HPE3) -
198 Cys Ser Holoprosencephaly3(HPE3) -
218 Leu Pro Holoprosencephaly3(HPE3) -
231 Gly Val Holoprosencephaly3(HPE3) -
232 Arg Gly Holoprosencephaly3(HPE3) -
234 Leu Pro Holoprosencephaly3(HPE3) -
236 Ser Asn Holoprosencephaly3(HPE3) -
241 Phe Leu Holoprosencephaly3(HPE3) -
241 Phe Val Holoprosencephaly3(HPE3) -
255 Ile Asn Holoprosencephaly3(HPE3) -
275 Ala Glu Holoprosencephaly3(HPE3) -
280 Ser Trp Holoprosencephaly3(HPE3) -
310 Arg Cys Holoprosencephaly3(HPE3) -
321 Arg Ser Holoprosencephaly3(HPE3) -
346 Ala Val Holoprosencephaly3(HPE3) -
347 Pro Leu Holoprosencephaly3(HPE3) -
347 Pro Arg Holoprosencephaly3(HPE3) -
362 Ser Leu Holoprosencephaly3(HPE3) -
363 Cys Tyr Holoprosencephaly3(HPE3) -
364 Tyr Cys Holoprosencephaly3(HPE3) -
374 His Arg Holoprosencephaly3(HPE3) -
376 Ala Asp Holoprosencephaly3(HPE3) -
377 Phe Ser Holoprosencephaly3(HPE3) -
382 Leu Pro Holoprosencephaly3(HPE3) -
435 Tyr Asn Holoprosencephaly3(HPE3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHH_HUMAN
GO:0005113 patched binding 100.0000 4 yes
GO:0004175 endopeptidase activity 66.6667 4 yes
GO:0005509 calcium ion binding 66.6667 6 yes
GO:0008270 zinc ion binding 66.6667 7 yes
GO:0016015 morphogen activity 66.6667 5 yes
GO:0043169 cation binding 66.6667 4 yes
GO:0043237 laminin-1 binding 66.6667 4 yes
GO:0046872 metal ion binding 66.6667 5 yes
GO:0046914 transition metal ion binding 66.6667 6 yes
GO:0048018 receptor ligand activity 66.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SHH_HUMAN
GO:0030850 prostate gland development 100.0000 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 100.0000 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 100.0000 7 yes
GO:0031175 neuron projection development 100.0000 6 yes
GO:0031323 regulation of cellular metabolic process 100.0000 4 yes
GO:0031324 negative regulation of cellular metabolic process 100.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 100.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 100.0000 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 100.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 100.0000 6 yes
GO:0032368 regulation of lipid transport 100.0000 5 yes
GO:0032371 regulation of sterol transport 100.0000 6 yes
GO:0032374 regulation of cholesterol transport 100.0000 7 yes
GO:1905952 regulation of lipid localization 100.0000 4 yes
GO:2000026 regulation of multicellular organismal development 100.0000 4 yes
GO:0032880 regulation of protein localization 100.0000 5 yes
GO:2001141 regulation of RNA biosynthetic process 100.0000 6 yes
GO:0035108 limb morphogenesis 100.0000 4 yes
GO:0035113 embryonic appendage morphogenesis 100.0000 4 yes
GO:0035137 hindlimb morphogenesis 100.0000 5 yes
GO:0042127 regulation of cell population proliferation 100.0000 4 yes
GO:0045595 regulation of cell differentiation 100.0000 4 yes
GO:0045596 negative regulation of cell differentiation 100.0000 5 yes
GO:0045597 positive regulation of cell differentiation 100.0000 5 yes
GO:0045892 negative regulation of DNA-templated transcription 100.0000 8 yes
GO:0045893 positive regulation of DNA-templated transcription 100.0000 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 100.0000 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 100.0000 5 yes
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0048585 negative regulation of response to stimulus 100.0000 4 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 100.0000 9 yes
GO:0048732 gland development 100.0000 4 yes
GO:0048745 smooth muscle tissue development 100.0000 5 yes
GO:0048754 branching morphogenesis of an epithelial tube 100.0000 4 yes
GO:0001658 branching involved in ureteric bud morphogenesis 100.0000 5 yes
GO:0050678 regulation of epithelial cell proliferation 100.0000 5 yes
GO:0002009 morphogenesis of an epithelium 100.0000 4 yes
GO:0051049 regulation of transport 100.0000 4 yes
GO:0051050 positive regulation of transport 100.0000 4 yes
GO:0051093 negative regulation of developmental process 100.0000 4 yes
GO:0051094 positive regulation of developmental process 100.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 100.0000 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 100.0000 8 yes
GO:0006508 proteolysis 100.0000 4 yes
GO:0007224 smoothened signaling pathway 100.0000 4 yes
GO:0051241 negative regulation of multicellular organismal process 100.0000 4 yes
GO:0007411 axon guidance 100.0000 8 yes
GO:0051252 regulation of RNA metabolic process 100.0000 5 yes
GO:0051253 negative regulation of RNA metabolic process 100.0000 6 yes
GO:0051254 positive regulation of RNA metabolic process 100.0000 6 yes
GO:0008104 protein localization 100.0000 4 yes
GO:0051302 regulation of cell division 100.0000 4 yes
GO:0051604 protein maturation 100.0000 4 yes
GO:0008285 negative regulation of cell population proliferation 100.0000 5 yes
GO:0008589 regulation of smoothened signaling pathway 100.0000 5 yes
GO:0009889 regulation of biosynthetic process 100.0000 4 yes
GO:0009890 negative regulation of biosynthetic process 100.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 100.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 100.0000 4 yes
GO:0009892 negative regulation of metabolic process 100.0000 4 yes
GO:0009893 positive regulation of metabolic process 100.0000 4 yes
GO:0060341 regulation of cellular localization 100.0000 4 yes
GO:0060429 epithelium development 100.0000 4 yes
GO:0009953 dorsal/ventral pattern formation 100.0000 4 yes
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0009968 negative regulation of signal transduction 100.0000 5 yes
GO:0010468 regulation of gene expression 100.0000 6 yes
GO:0060537 muscle tissue development 100.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 100.0000 5 yes
GO:0060562 epithelial tube morphogenesis 100.0000 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 100.0000 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 100.0000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 100.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 100.0000 5 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0010648 negative regulation of cell communication 100.0000 5 yes
GO:0010874 regulation of cholesterol efflux 100.0000 8 yes
GO:0061053 somite development 100.0000 5 yes
GO:0016485 protein processing 100.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 100.0000 5 yes
GO:0021515 cell differentiation in spinal cord 100.0000 4 yes
GO:0021522 spinal cord motor neuron differentiation 100.0000 5 yes
GO:0072044 collecting duct development 100.0000 4 yes
GO:0021904 dorsal/ventral neural tube patterning 100.0000 5 yes
GO:0072091 regulation of stem cell proliferation 100.0000 5 yes
GO:0072203 cell proliferation involved in metanephros development 100.0000 4 yes
GO:0021953 central nervous system neuron differentiation 100.0000 5 yes
GO:0072205 metanephric collecting duct development 100.0000 5 yes
GO:0080090 regulation of primary metabolic process 100.0000 4 yes
GO:0023057 negative regulation of signaling 100.0000 4 yes
GO:0030030 cell projection organization 100.0000 4 yes
GO:0097485 neuron projection guidance 100.0000 7 yes
GO:0120036 plasma membrane bounded cell projection organization 100.0000 5 yes
GO:0030182 neuron differentiation 100.0000 4 yes
GO:0030326 embryonic limb morphogenesis 100.0000 5 yes
GO:0030336 negative regulation of cell migration 66.6667 6 yes
GO:1902105 regulation of leukocyte differentiation 66.6667 5 yes
GO:0030539 male genitalia development 66.6667 5 yes
GO:1902106 negative regulation of leukocyte differentiation 66.6667 6 yes
GO:1902107 positive regulation of leukocyte differentiation 66.6667 6 yes
GO:0030878 thyroid gland development 66.6667 5 yes
GO:0030908 protein splicing 66.6667 6 yes
GO:0031016 pancreas development 66.6667 4 yes
GO:1902692 regulation of neuroblast proliferation 66.6667 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 66.6667 6 yes
GO:1903038 negative regulation of leukocyte cell-cell adhesion 66.6667 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 66.6667 7 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 66.6667 7 yes
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 66.6667 8 yes
GO:1903131 mononuclear cell differentiation 66.6667 5 yes
GO:1903706 regulation of hemopoiesis 66.6667 4 yes
GO:1903707 negative regulation of hemopoiesis 66.6667 5 yes
GO:0032369 negative regulation of lipid transport 66.6667 5 yes
GO:1903708 positive regulation of hemopoiesis 66.6667 5 yes
GO:1903829 positive regulation of protein localization 66.6667 5 yes
GO:0032372 negative regulation of sterol transport 66.6667 6 yes
GO:1904338 regulation of dopaminergic neuron differentiation 66.6667 6 yes
GO:1904339 negative regulation of dopaminergic neuron differentiation 66.6667 7 yes
GO:0032375 negative regulation of cholesterol transport 66.6667 7 yes
GO:1904951 positive regulation of establishment of protein localization 66.6667 6 yes
GO:0032386 regulation of intracellular transport 66.6667 5 yes
GO:1905330 regulation of morphogenesis of an epithelium 66.6667 5 yes
GO:0032388 positive regulation of intracellular transport 66.6667 5 yes
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 66.6667 6 yes
GO:1905953 negative regulation of lipid localization 66.6667 4 yes
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 66.6667 7 yes
GO:0032784 regulation of DNA-templated transcription elongation 66.6667 8 yes
GO:2000027 regulation of animal organ morphogenesis 66.6667 5 yes
GO:0032785 negative regulation of DNA-templated transcription, elongation 66.6667 9 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 66.6667 5 yes
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 66.6667 6 yes
GO:0032943 mononuclear cell proliferation 66.6667 4 yes
GO:2000061 regulation of ureter smooth muscle cell differentiation 66.6667 5 yes
GO:0032944 regulation of mononuclear cell proliferation 66.6667 6 yes
GO:2000062 negative regulation of ureter smooth muscle cell differentiation 66.6667 5 yes
GO:0032945 negative regulation of mononuclear cell proliferation 66.6667 7 yes
GO:2000063 positive regulation of ureter smooth muscle cell differentiation 66.6667 5 yes
GO:0032946 positive regulation of mononuclear cell proliferation 66.6667 7 yes
GO:2000145 regulation of cell motility 66.6667 4 yes
GO:0033077 T cell differentiation in thymus 66.6667 6 yes
GO:2000146 negative regulation of cell motility 66.6667 5 yes
GO:0033081 regulation of T cell differentiation in thymus 66.6667 8 yes
GO:2000177 regulation of neural precursor cell proliferation 66.6667 5 yes
GO:0033083 regulation of immature T cell proliferation 66.6667 8 yes
GO:2000179 positive regulation of neural precursor cell proliferation 66.6667 6 yes
GO:0033084 regulation of immature T cell proliferation in thymus 66.6667 9 yes
GO:2000243 positive regulation of reproductive process 66.6667 4 yes
GO:0033085 negative regulation of T cell differentiation in thymus 66.6667 9 yes
GO:2000356 regulation of kidney smooth muscle cell differentiation 66.6667 7 yes
GO:0033089 positive regulation of T cell differentiation in thymus 66.6667 9 yes
GO:2000357 negative regulation of kidney smooth muscle cell differentiation 66.6667 8 yes
GO:0033091 positive regulation of immature T cell proliferation 66.6667 9 yes
GO:2000358 positive regulation of kidney smooth muscle cell differentiation 66.6667 8 yes
GO:0033092 positive regulation of immature T cell proliferation in thymus 66.6667 10 yes
GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development 66.6667 5 yes
GO:0033157 regulation of intracellular protein transport 66.6667 6 yes
GO:2001053 regulation of mesenchymal cell apoptotic process 66.6667 6 yes
GO:0033365 protein localization to organelle 66.6667 5 yes
GO:2001054 negative regulation of mesenchymal cell apoptotic process 66.6667 7 yes
GO:0034243 regulation of transcription elongation by RNA polymerase II 66.6667 9 yes
GO:0034244 negative regulation of transcription elongation by RNA polymerase II 66.6667 10 yes
GO:0034504 protein localization to nucleus 66.6667 6 yes
GO:0035115 embryonic forelimb morphogenesis 66.6667 6 yes
GO:0035116 embryonic hindlimb morphogenesis 66.6667 6 yes
GO:0035136 forelimb morphogenesis 66.6667 5 yes
GO:0035914 skeletal muscle cell differentiation 66.6667 4 yes
GO:0036484 trunk neural crest cell migration 66.6667 7 yes
GO:0040013 negative regulation of locomotion 66.6667 4 yes
GO:0042098 T cell proliferation 66.6667 5 yes
GO:0042102 positive regulation of T cell proliferation 66.6667 8 yes
GO:0042110 T cell activation 66.6667 4 yes
GO:0042129 regulation of T cell proliferation 66.6667 7 yes
GO:0042130 negative regulation of T cell proliferation 66.6667 8 yes
GO:0042176 regulation of protein catabolic process 66.6667 5 yes
GO:0042177 negative regulation of protein catabolic process 66.6667 6 yes
GO:0042306 regulation of protein import into nucleus 66.6667 7 yes
GO:0042307 positive regulation of protein import into nucleus 66.6667 7 yes
GO:0042475 odontogenesis of dentin-containing tooth 66.6667 5 yes
GO:0042476 odontogenesis 66.6667 4 yes
GO:0042481 regulation of odontogenesis 66.6667 6 yes
GO:0042692 muscle cell differentiation 66.6667 4 yes
GO:0042733 embryonic digit morphogenesis 66.6667 4 yes
GO:0042981 regulation of apoptotic process 66.6667 5 yes
GO:0043010 camera-type eye development 66.6667 6 yes
GO:0043066 negative regulation of apoptotic process 66.6667 6 yes
GO:0043067 regulation of programmed cell death 66.6667 4 yes
GO:0043069 negative regulation of programmed cell death 66.6667 5 yes
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 66.6667 5 yes
GO:0045059 positive thymic T cell selection 66.6667 4 yes
GO:0045060 negative thymic T cell selection 66.6667 4 yes
GO:0045109 intermediate filament organization 66.6667 4 yes
GO:0045445 myoblast differentiation 66.6667 4 yes
GO:0045580 regulation of T cell differentiation 66.6667 7 yes
GO:0045581 negative regulation of T cell differentiation 66.6667 8 yes
GO:0045582 positive regulation of T cell differentiation 66.6667 8 yes
GO:0045619 regulation of lymphocyte differentiation 66.6667 6 yes
GO:0045620 negative regulation of lymphocyte differentiation 66.6667 7 yes
GO:0045621 positive regulation of lymphocyte differentiation 66.6667 7 yes
GO:0045664 regulation of neuron differentiation 66.6667 5 yes
GO:0045665 negative regulation of neuron differentiation 66.6667 6 yes
GO:0045685 regulation of glial cell differentiation 66.6667 5 yes
GO:0045687 positive regulation of glial cell differentiation 66.6667 6 yes
GO:0045785 positive regulation of cell adhesion 66.6667 5 yes
GO:0045861 negative regulation of proteolysis 66.6667 7 yes
GO:0045880 positive regulation of smoothened signaling pathway 66.6667 6 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 66.6667 9 yes
GO:0046631 alpha-beta T cell activation 66.6667 5 yes
GO:0046632 alpha-beta T cell differentiation 66.6667 6 yes
GO:0046634 regulation of alpha-beta T cell activation 66.6667 7 yes
GO:0046635 positive regulation of alpha-beta T cell activation 66.6667 8 yes
GO:0046636 negative regulation of alpha-beta T cell activation 66.6667 8 yes
GO:0046637 regulation of alpha-beta T cell differentiation 66.6667 8 yes
GO:0046638 positive regulation of alpha-beta T cell differentiation 66.6667 9 yes
GO:0046639 negative regulation of alpha-beta T cell differentiation 66.6667 9 yes
GO:0046651 lymphocyte proliferation 66.6667 4 yes
GO:0046822 regulation of nucleocytoplasmic transport 66.6667 6 yes
GO:0046824 positive regulation of nucleocytoplasmic transport 66.6667 6 yes
GO:0048534 hematopoietic or lymphoid organ development 66.6667 4 yes
GO:0048538 thymus development 66.6667 5 yes
GO:0048557 embryonic digestive tract morphogenesis 66.6667 5 yes
GO:0048562 embryonic organ morphogenesis 66.6667 4 yes
GO:0048584 positive regulation of response to stimulus 66.6667 4 yes
GO:0048617 embryonic foregut morphogenesis 66.6667 4 yes
GO:0048634 regulation of muscle organ development 66.6667 4 yes
GO:0048641 regulation of skeletal muscle tissue development 66.6667 5 yes
GO:0048643 positive regulation of skeletal muscle tissue development 66.6667 6 yes
GO:0048663 neuron fate commitment 66.6667 4 yes
GO:0048706 embryonic skeletal system development 66.6667 5 yes
GO:0048708 astrocyte differentiation 66.6667 5 yes
GO:0048709 oligodendrocyte differentiation 66.6667 5 yes
GO:0048710 regulation of astrocyte differentiation 66.6667 6 yes
GO:0048711 positive regulation of astrocyte differentiation 66.6667 7 yes
GO:0048713 regulation of oligodendrocyte differentiation 66.6667 6 yes
GO:0048714 positive regulation of oligodendrocyte differentiation 66.6667 7 yes
GO:0001501 skeletal system development 66.6667 4 yes
GO:0001569 branching involved in blood vessel morphogenesis 66.6667 5 yes
GO:0001570 vasculogenesis 66.6667 4 yes
GO:0001654 eye development 66.6667 5 yes
GO:0048806 genitalia development 66.6667 4 yes
GO:0001656 metanephros development 66.6667 5 yes
GO:0048864 stem cell development 66.6667 4 yes
GO:0050670 regulation of lymphocyte proliferation 66.6667 6 yes
GO:0001667 ameboidal-type cell migration 66.6667 4 yes
GO:0050671 positive regulation of lymphocyte proliferation 66.6667 7 yes
GO:0001755 neural crest cell migration 66.6667 6 yes
GO:0050672 negative regulation of lymphocyte proliferation 66.6667 7 yes
GO:0001822 kidney development 66.6667 4 yes
GO:0001947 heart looping 66.6667 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 66.6667 6 yes
GO:0050767 regulation of neurogenesis 66.6667 6 yes
GO:0002052 positive regulation of neuroblast proliferation 66.6667 7 yes
GO:0050769 positive regulation of neurogenesis 66.6667 6 yes
GO:0002053 positive regulation of mesenchymal cell proliferation 66.6667 6 yes
GO:0050863 regulation of T cell activation 66.6667 6 yes
GO:0002076 osteoblast development 66.6667 4 yes
GO:0050865 regulation of cell activation 66.6667 4 yes
GO:0002244 hematopoietic progenitor cell differentiation 66.6667 4 yes
GO:0050866 negative regulation of cell activation 66.6667 5 yes
GO:0002320 lymphoid progenitor cell differentiation 66.6667 5 yes
GO:0050867 positive regulation of cell activation 66.6667 5 yes
GO:0002360 T cell lineage commitment 66.6667 4 yes
GO:0050868 negative regulation of T cell activation 66.6667 7 yes
GO:0002521 leukocyte differentiation 66.6667 4 yes
GO:0050870 positive regulation of T cell activation 66.6667 7 yes
GO:0002683 negative regulation of immune system process 66.6667 4 yes
GO:0002684 positive regulation of immune system process 66.6667 4 yes
GO:0002694 regulation of leukocyte activation 66.6667 4 yes
GO:0051051 negative regulation of transport 66.6667 4 yes
GO:0002695 negative regulation of leukocyte activation 66.6667 5 yes
GO:0002696 positive regulation of leukocyte activation 66.6667 5 yes
GO:0003140 determination of left/right asymmetry in lateral mesoderm 66.6667 6 yes
GO:0051146 striated muscle cell differentiation 66.6667 5 yes
GO:0003143 embryonic heart tube morphogenesis 66.6667 4 yes
GO:0051147 regulation of muscle cell differentiation 66.6667 5 yes
GO:0003156 regulation of animal organ formation 66.6667 6 yes
GO:0051148 negative regulation of muscle cell differentiation 66.6667 6 yes
GO:0003401 axis elongation 66.6667 4 yes
GO:0051149 positive regulation of muscle cell differentiation 66.6667 6 yes
GO:0051150 regulation of smooth muscle cell differentiation 66.6667 6 yes
GO:0051151 negative regulation of smooth muscle cell differentiation 66.6667 7 yes
GO:0051152 positive regulation of smooth muscle cell differentiation 66.6667 7 yes
GO:0006606 protein import into nucleus 66.6667 5 yes
GO:0051153 regulation of striated muscle cell differentiation 66.6667 6 yes
GO:0006886 intracellular protein transport 66.6667 4 yes
GO:0051155 positive regulation of striated muscle cell differentiation 66.6667 7 yes
GO:0006913 nucleocytoplasmic transport 66.6667 5 yes
GO:0051169 nuclear transport 66.6667 4 yes
GO:0006915 apoptotic process 66.6667 4 yes
GO:0051170 import into nucleus 66.6667 6 yes
GO:0006996 organelle organization 66.6667 4 yes
GO:0051222 positive regulation of protein transport 66.6667 5 yes
GO:0007010 cytoskeleton organization 66.6667 5 yes
GO:0051223 regulation of protein transport 66.6667 5 yes
GO:0007162 negative regulation of cell adhesion 66.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 66.6667 4 yes
GO:0007368 determination of left/right symmetry 66.6667 5 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0007398 ectoderm development 66.6667 4 yes
GO:0051248 negative regulation of protein metabolic process 66.6667 6 yes
GO:0007405 neuroblast proliferation 66.6667 4 yes
GO:0051249 regulation of lymphocyte activation 66.6667 5 yes
GO:0051250 negative regulation of lymphocyte activation 66.6667 6 yes
GO:0007417 central nervous system development 66.6667 4 yes
GO:0051251 positive regulation of lymphocyte activation 66.6667 6 yes
GO:0007423 sensory organ development 66.6667 4 yes
GO:0007507 heart development 66.6667 4 yes
GO:0007599 hemostasis 66.6667 4 yes
GO:0008202 steroid metabolic process 66.6667 4 yes
GO:0008284 positive regulation of cell population proliferation 66.6667 5 yes
GO:0051781 positive regulation of cell division 66.6667 5 yes
GO:0051960 regulation of nervous system development 66.6667 5 yes
GO:0051962 positive regulation of nervous system development 66.6667 5 yes
GO:0009855 determination of bilateral symmetry 66.6667 4 yes
GO:0060020 Bergmann glial cell differentiation 66.6667 6 yes
GO:0060070 canonical Wnt signaling pathway 66.6667 5 yes
GO:0060251 regulation of glial cell proliferation 66.6667 5 yes
GO:0060284 regulation of cell development 66.6667 5 yes
GO:0009894 regulation of catabolic process 66.6667 4 yes
GO:0060428 lung epithelium development 66.6667 5 yes
GO:0009895 negative regulation of catabolic process 66.6667 5 yes
GO:0009949 polarity specification of anterior/posterior axis 66.6667 4 yes
GO:0060439 trachea morphogenesis 66.6667 4 yes
GO:0060445 branching involved in salivary gland morphogenesis 66.6667 4 yes
GO:0060447 bud outgrowth involved in lung branching 66.6667 6 yes
GO:0009967 positive regulation of signal transduction 66.6667 5 yes
GO:0060458 right lung development 66.6667 5 yes
GO:0060459 left lung development 66.6667 5 yes
GO:0010001 glial cell differentiation 66.6667 4 yes
GO:0060484 lung-associated mesenchyme development 66.6667 5 yes
GO:0010038 response to metal ion 66.6667 4 yes
GO:0060485 mesenchyme development 66.6667 4 yes
GO:0010226 response to lithium ion 66.6667 5 yes
GO:0060516 primary prostatic bud elongation 66.6667 4 yes
GO:0010464 regulation of mesenchymal cell proliferation 66.6667 5 yes
GO:0060523 prostate epithelial cord elongation 66.6667 4 yes
GO:0060602 branch elongation of an epithelium 66.6667 5 yes
GO:0060605 tube lumen cavitation 66.6667 4 yes
GO:0060662 salivary gland cavitation 66.6667 5 yes
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis 66.6667 4 yes
GO:0010628 positive regulation of gene expression 66.6667 7 yes
GO:0060684 epithelial-mesenchymal cell signaling 66.6667 4 yes
GO:0010629 negative regulation of gene expression 66.6667 7 yes
GO:0060685 regulation of prostatic bud formation 66.6667 4 yes
GO:0060688 regulation of morphogenesis of a branching structure 66.6667 4 yes
GO:0010647 positive regulation of cell communication 66.6667 5 yes
GO:0060737 prostate gland morphogenetic growth 66.6667 4 yes
GO:0060767 epithelial cell proliferation involved in prostate gland development 66.6667 4 yes
GO:0010720 positive regulation of cell development 66.6667 6 yes
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 66.6667 6 yes
GO:0010721 negative regulation of cell development 66.6667 6 yes
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development 66.6667 5 yes
GO:0060782 regulation of mesenchymal cell proliferation involved in prostate gland development 66.6667 6 yes
GO:0014003 oligodendrocyte development 66.6667 5 yes
GO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development 66.6667 5 yes
GO:0014013 regulation of gliogenesis 66.6667 7 yes
GO:0060828 regulation of canonical Wnt signaling pathway 66.6667 6 yes
GO:0014015 positive regulation of gliogenesis 66.6667 7 yes
GO:0060840 artery development 66.6667 4 yes
GO:0014706 striated muscle tissue development 66.6667 5 yes
GO:0060916 mesenchymal cell proliferation involved in lung development 66.6667 4 yes
GO:0014855 striated muscle cell proliferation 66.6667 4 yes
GO:0014856 skeletal muscle cell proliferation 66.6667 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 66.6667 6 yes
GO:0014857 regulation of skeletal muscle cell proliferation 66.6667 5 yes
GO:0061189 positive regulation of sclerotome development 66.6667 5 yes
GO:0014858 positive regulation of skeletal muscle cell proliferation 66.6667 6 yes
GO:0061190 regulation of sclerotome development 66.6667 4 yes
GO:0014902 myotube differentiation 66.6667 6 yes
GO:0061458 reproductive system development 66.6667 4 yes
GO:0015031 protein transport 66.6667 4 yes
GO:0070201 regulation of establishment of protein localization 66.6667 6 yes
GO:0016055 Wnt signaling pathway 66.6667 4 yes
GO:0070663 regulation of leukocyte proliferation 66.6667 5 yes
GO:0070664 negative regulation of leukocyte proliferation 66.6667 6 yes
GO:0016539 intein-mediated protein splicing 66.6667 7 yes
GO:0070665 positive regulation of leukocyte proliferation 66.6667 6 yes
GO:0016540 protein autoprocessing 66.6667 6 yes
GO:0071241 cellular response to inorganic substance 66.6667 4 yes
GO:0071248 cellular response to metal ion 66.6667 5 yes
GO:0021513 spinal cord dorsal/ventral patterning 66.6667 5 yes
GO:0071285 cellular response to lithium ion 66.6667 6 yes
GO:0071542 dopaminergic neuron differentiation 66.6667 5 yes
GO:0071702 organic substance transport 66.6667 4 yes
GO:0021534 cell proliferation in hindbrain 66.6667 4 yes
GO:0071705 nitrogen compound transport 66.6667 4 yes
GO:0021782 glial cell development 66.6667 4 yes
GO:0021924 cell proliferation in external granule layer 66.6667 5 yes
GO:0072135 kidney mesenchymal cell proliferation 66.6667 4 yes
GO:0021930 cerebellar granule cell precursor proliferation 66.6667 6 yes
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development 66.6667 5 yes
GO:0021936 regulation of cerebellar granule cell precursor proliferation 66.6667 6 yes
GO:0072199 regulation of mesenchymal cell proliferation involved in ureter development 66.6667 6 yes
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation 66.6667 7 yes
GO:0021978 telencephalon regionalization 66.6667 4 yes
GO:0072594 establishment of protein localization to organelle 66.6667 4 yes
GO:0022407 regulation of cell-cell adhesion 66.6667 5 yes
GO:0022408 negative regulation of cell-cell adhesion 66.6667 6 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 66.6667 7 yes
GO:0022409 positive regulation of cell-cell adhesion 66.6667 6 yes
GO:0090162 establishment of epithelial cell polarity 66.6667 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 66.6667 4 yes
GO:0090316 positive regulation of intracellular protein transport 66.6667 6 yes
GO:0023056 positive regulation of signaling 66.6667 4 yes
GO:0090370 negative regulation of cholesterol efflux 66.6667 8 yes
GO:0090497 mesenchymal cell migration 66.6667 5 yes
GO:0097152 mesenchymal cell apoptotic process 66.6667 5 yes
GO:0030098 lymphocyte differentiation 66.6667 4 yes
GO:0097264 self proteolysis 66.6667 5 yes
GO:0030111 regulation of Wnt signaling pathway 66.6667 5 yes
GO:0097435 supramolecular fiber organization 66.6667 4 yes
GO:0030155 regulation of cell adhesion 66.6667 4 yes
GO:0030162 regulation of proteolysis 66.6667 6 yes
GO:0098528 skeletal muscle fiber differentiation 66.6667 5 yes
GO:0030177 positive regulation of Wnt signaling pathway 66.6667 6 yes
GO:0098657 import into cell 66.6667 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 66.6667 6 yes
GO:1900180 regulation of protein localization to nucleus 66.6667 6 yes
GO:0030217 T cell differentiation 66.6667 5 yes
GO:1900182 positive regulation of protein localization to nucleus 66.6667 6 yes
GO:0030324 lung development 66.6667 4 yes
GO:1901799 negative regulation of proteasomal protein catabolic process 66.6667 7 yes
GO:1901861 regulation of muscle tissue development 66.6667 4 yes
GO:0030334 regulation of cell migration 66.6667 5 yes
GO:1901863 positive regulation of muscle tissue development 66.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDON_HUMAN [view interactions] Low throughput no no
BOC_HUMAN [view interactions] Low throughput no yes
GAS1_HUMAN [view interactions] Low throughput no yes
HHIP_HUMAN [view interactions] Low throughput no no
SHH_HUMAN [view entry] [view interactions] Low throughput yes no
SYVN1_HUMAN [view interactions] Low throughput no yes
GPC3_HUMAN [view interactions] Low throughput no no
EDEM1_HUMAN [view interactions] Low throughput no yes
EDEM2_HUMAN [view interactions] Low throughput no yes
EDEM3_HUMAN [view interactions] Low throughput no yes
TSN8_HUMAN [view interactions] Low throughput no no
DISP1_HUMAN [view interactions] Low throughput no no
HHAT_HUMAN [view interactions] Low throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
DERL2_HUMAN [view interactions] High throughput no yes
SE1L1_HUMAN [view interactions] High throughput no yes
GLI1_HUMAN [view interactions] High throughput no no
GLI3_HUMAN [view interactions] High throughput no yes
SAP18_HUMAN [view interactions] High throughput no yes
SUFU_HUMAN [view interactions] High throughput no yes
SIN3A_HUMAN [view interactions] High throughput no yes