NETO2_HUMAN
Evidence for PS localization
Functions
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NETO2_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 40.0000 | 4 | no |
| GO:0005261 | cation channel activity | 40.0000 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0015267 | channel activity | 40.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 33.3333 | 6 | no |
| GO:0015276 | ligand-gated ion channel activity | 33.3333 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 33.3333 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 33.3333 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 33.3333 | 4 | no |
| GO:0022836 | gated channel activity | 33.3333 | 5 | no |
| GO:0099094 | ligand-gated cation channel activity | 33.3333 | 6 | no |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 26.6667 | 7 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 26.6667 | 4 | no |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 26.6667 | 5 | no |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 26.6667 | 6 | no |
| GO:0035254 | glutamate receptor binding | 20.0000 | 4 | yes |
| GO:0035255 | ionotropic glutamate receptor binding | 20.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NETO2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 53.3333 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.6667 | 4 | yes |
| GO:0051049 | regulation of transport | 46.6667 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 40.0000 | 6 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 40.0000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0006811 | ion transport | 33.3333 | 4 | no |
| GO:0043269 | regulation of ion transport | 26.6667 | 5 | yes |
| GO:0048878 | chemical homeostasis | 26.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.6667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 26.6667 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0051046 | regulation of secretion | 26.6667 | 5 | no |
| GO:0006812 | cation transport | 26.6667 | 5 | no |
| GO:0002028 | regulation of sodium ion transport | 13.3333 | 7 | yes |
| GO:0010959 | regulation of metal ion transport | 13.3333 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 13.3333 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 13.3333 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 13.3333 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 13.3333 | 7 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 13.3333 | 4 | yes |
| GO:1901016 | regulation of potassium ion transmembrane transporter activity | 13.3333 | 6 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 13.3333 | 7 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 13.3333 | 7 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 13.3333 | 6 | yes |
| GO:2000312 | regulation of kainate selective glutamate receptor activity | 13.3333 | 5 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 13.3333 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 13.3333 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NETO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDHD1_HUMAN | [view interactions] | High throughput | no | no |
| TRM6_HUMAN | [view interactions] | High throughput | no | yes |
| IRS2_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST2_HUMAN | [view interactions] | High throughput | no | no |
| TM168_HUMAN | [view interactions] | High throughput | no | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| CCD82_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT3C_HUMAN | [view interactions] | High throughput | no | no |
| BTNL8_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| TMED6_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| ADA33_HUMAN | [view interactions] | High throughput | no | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| IL9R_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD1B_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACHA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS3_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| LCTL_HUMAN | [view interactions] | High throughput | no | no |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| HFE_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| CRLF2_HUMAN | [view interactions] | High throughput | no | no |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAL10_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYK_HUMAN | [view interactions] | Computational | no | yes |
| S12A5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |