5HT3C_HUMAN
Evidence for PS localization
Functions
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 5HT3C_HUMAN |
|---|---|---|---|---|
| GO:0015267 | channel activity | 36.3636 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 27.2727 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 18.1818 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 18.1818 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 18.1818 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 18.1818 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 18.1818 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 18.1818 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 18.1818 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 18.1818 | 4 | yes |
| GO:0022836 | gated channel activity | 18.1818 | 5 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 18.1818 | 7 | yes |
| GO:0022850 | serotonin-gated monoatomic cation channel activity | 18.1818 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 18.1818 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 18.1818 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 18.1818 | 5 | yes |
| GO:0099589 | serotonin receptor activity | 18.1818 | 4 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 18.1818 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT3C_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0008104 | protein localization | 45.4545 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | no |
| GO:0023056 | positive regulation of signaling | 36.3636 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 36.3636 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.3636 | 5 | no |
| GO:0032880 | regulation of protein localization | 36.3636 | 5 | no |
| GO:0060341 | regulation of cellular localization | 36.3636 | 4 | no |
| GO:0071702 | organic substance transport | 36.3636 | 4 | no |
| GO:0071705 | nitrogen compound transport | 36.3636 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.2727 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.2727 | 4 | no |
| GO:0030334 | regulation of cell migration | 27.2727 | 5 | no |
| GO:0040013 | negative regulation of locomotion | 27.2727 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.2727 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 27.2727 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 27.2727 | 4 | no |
| GO:2000145 | regulation of cell motility | 27.2727 | 4 | no |
| GO:0051046 | regulation of secretion | 27.2727 | 5 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 27.2727 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 27.2727 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 18.1818 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 5HT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TM223_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| ABHGA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| GL8D1_HUMAN | [view interactions] | High throughput | no | yes |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| IPRI_HUMAN | [view interactions] | High throughput | no | no |
| LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MET25_HUMAN | [view interactions] | High throughput | no | yes |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| TM186_HUMAN | [view interactions] | High throughput | no | no |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| PIGM_HUMAN | [view interactions] | High throughput | no | no |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| S38AA_HUMAN | [view interactions] | High throughput | no | yes |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| IMPA3_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MBOA7_HUMAN | [view interactions] | High throughput | no | no |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| PIGO_HUMAN | [view interactions] | High throughput | no | no |
| MGAT1_HUMAN | [view interactions] | High throughput | no | yes |
| ALG9_HUMAN | [view interactions] | High throughput | no | yes |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP6_HUMAN | [view interactions] | High throughput | no | yes |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
| MANEL_HUMAN | [view interactions] | High throughput | no | no |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| TMED4_HUMAN | [view interactions] | High throughput | no | yes |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| C1GLC_HUMAN | [view interactions] | High throughput | no | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP1_HUMAN | [view interactions] | High throughput | no | no |
| AT11C_HUMAN | [view interactions] | High throughput | no | no |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| FZD2_HUMAN | [view interactions] | High throughput | no | no |
| NHLC3_HUMAN | [view interactions] | High throughput | no | yes |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIK1B_HUMAN | [view interactions] | High throughput | no | no |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABHD3_HUMAN | [view interactions] | High throughput | no | yes |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| S38A9_HUMAN | [view interactions] | High throughput | no | yes |
| POMT1_HUMAN | [view interactions] | High throughput | no | no |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| LMF1_HUMAN | [view interactions] | High throughput | no | no |
| GET1_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| TM104_HUMAN | [view interactions] | High throughput | no | yes |
| T179B_HUMAN | [view interactions] | High throughput | no | no |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| EREP3_HUMAN | [view interactions] | High throughput | no | no |
| AG10A_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| GP1BB_HUMAN | [view interactions] | High throughput | no | no |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| S47A1_HUMAN | [view interactions] | High throughput | no | no |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| BRI3B_HUMAN | [view interactions] | High throughput | no | yes |
| RHG08_HUMAN | [view interactions] | High throughput | no | yes |
| SGCB_HUMAN | [view interactions] | High throughput | no | no |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM59L_HUMAN | [view interactions] | High throughput | no | yes |
| PLIN5_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |