Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRC8A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2-3-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2-3-cGAMP, thereby promoting transfer of 2-3-cGAMP to bystander cells (PubMed). In contrast, complexes containing LRRC8D inhibit transport of 2-3-cGAMP (PubMed). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed, PubMed, PubMed). Can form functional channels by itself (in vitro) (PubMed). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed). Also required for T-cell development . Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption . Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRC8A_HUMAN
GO:0043168 anion binding 42.3077 4 no
GO:0000166 nucleotide binding 38.4615 4 no
GO:0017076 purine nucleotide binding 38.4615 5 no
GO:0032555 purine ribonucleotide binding 38.4615 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 no
GO:0016462 pyrophosphatase activity 34.6154 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 34.6154 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 34.6154 6 no
GO:0043169 cation binding 30.7692 4 no
GO:0003924 GTPase activity 30.7692 7 no
GO:0005525 GTP binding 30.7692 5 no
GO:0019001 guanyl nucleotide binding 30.7692 6 no
GO:0032561 guanyl ribonucleotide binding 30.7692 5 no
GO:0005216 monoatomic ion channel activity 26.9231 4 yes
GO:0015267 channel activity 26.9231 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 23.0769 4 no
GO:0019900 kinase binding 23.0769 4 no
GO:0019901 protein kinase binding 23.0769 5 no
GO:0005225 volume-sensitive anion channel activity 11.5385 6 yes
GO:0005253 monoatomic anion channel activity 11.5385 5 yes
GO:0008509 monoatomic anion transmembrane transporter activity 11.5385 4 yes
GO:0000295 adenine nucleotide transmembrane transporter activity 7.6923 6 yes
GO:0001409 guanine nucleotide transmembrane transporter activity 7.6923 6 yes
GO:0005346 purine ribonucleotide transmembrane transporter activity 7.6923 4 yes
GO:0015215 nucleotide transmembrane transporter activity 7.6923 4 yes
GO:0015216 purine nucleotide transmembrane transporter activity 7.6923 5 yes
GO:0140360 cyclic-GMP-AMP transmembrane transporter activity 7.6923 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LRC8A_HUMAN
GO:0048522 positive regulation of cellular process 65.3846 4 yes
GO:0022607 cellular component assembly 46.1538 4 yes
GO:0051128 regulation of cellular component organization 38.4615 4 no
GO:0010646 regulation of cell communication 34.6154 4 yes
GO:0010647 positive regulation of cell communication 34.6154 5 yes
GO:0023056 positive regulation of signaling 34.6154 4 yes
GO:0051049 regulation of transport 34.6154 4 yes
GO:0006996 organelle organization 34.6154 4 no
GO:0048584 positive regulation of response to stimulus 34.6154 4 no
GO:0141124 intracellular signaling cassette 34.6154 4 no
GO:0060341 regulation of cellular localization 30.7692 4 yes
GO:0007010 cytoskeleton organization 30.7692 5 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0048523 negative regulation of cellular process 30.7692 4 no
GO:0060255 regulation of macromolecule metabolic process 30.7692 4 no
GO:0080090 regulation of primary metabolic process 30.7692 4 no
GO:2000145 regulation of cell motility 30.7692 4 no
GO:0007264 small GTPase-mediated signal transduction 30.7692 5 no
GO:0045595 regulation of cell differentiation 26.9231 4 yes
GO:0051094 positive regulation of developmental process 26.9231 4 yes
GO:0008104 protein localization 26.9231 4 no
GO:0009966 regulation of signal transduction 26.9231 4 no
GO:0009967 positive regulation of signal transduction 26.9231 5 no
GO:0031323 regulation of cellular metabolic process 26.9231 4 no
GO:0042127 regulation of cell population proliferation 26.9231 4 no
GO:0044087 regulation of cellular component biogenesis 26.9231 4 no
GO:0007015 actin filament organization 26.9231 5 no
GO:0030030 cell projection organization 26.9231 4 no
GO:0030031 cell projection assembly 26.9231 5 no
GO:0030334 regulation of cell migration 26.9231 5 no
GO:0031344 regulation of cell projection organization 26.9231 5 no
GO:0032970 regulation of actin filament-based process 26.9231 4 no
GO:0097435 supramolecular fiber organization 26.9231 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.9231 6 no
GO:0006811 monoatomic ion transport 23.0769 4 yes
GO:0032880 regulation of protein localization 23.0769 5 yes
GO:0071702 organic substance transport 23.0769 4 yes
GO:0071705 nitrogen compound transport 23.0769 4 yes
GO:1903829 positive regulation of protein localization 23.0769 5 yes
GO:0009889 regulation of biosynthetic process 23.0769 4 no
GO:0010468 regulation of gene expression 23.0769 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031326 regulation of cellular biosynthetic process 23.0769 5 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:0010810 regulation of cell-substrate adhesion 23.0769 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0030155 regulation of cell adhesion 23.0769 4 no
GO:0030335 positive regulation of cell migration 23.0769 6 no
GO:0032956 regulation of actin cytoskeleton organization 23.0769 5 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0040017 positive regulation of locomotion 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.0769 5 no
GO:2000147 positive regulation of cell motility 23.0769 5 no
GO:0043933 protein-containing complex organization 19.2308 4 yes
GO:0045597 positive regulation of cell differentiation 19.2308 5 yes
GO:0051046 regulation of secretion 19.2308 5 yes
GO:0051050 positive regulation of transport 19.2308 4 yes
GO:0065003 protein-containing complex assembly 19.2308 5 yes
GO:0070201 regulation of establishment of protein localization 19.2308 6 yes
GO:1903530 regulation of secretion by cell 19.2308 4 yes
GO:1904951 positive regulation of establishment of protein localization 19.2308 6 yes
GO:0008361 regulation of cell size 15.3846 5 yes
GO:0032535 regulation of cellular component size 15.3846 4 yes
GO:0098657 import into cell 15.3846 4 yes
GO:0002521 leukocyte differentiation 11.5385 4 yes
GO:0006820 monoatomic anion transport 11.5385 5 yes
GO:0006821 chloride transport 11.5385 5 yes
GO:0015698 inorganic anion transport 11.5385 4 yes
GO:0042113 B cell activation 11.5385 4 yes
GO:0051047 positive regulation of secretion 11.5385 5 yes
GO:0051222 positive regulation of protein transport 11.5385 5 yes
GO:0051223 regulation of protein transport 11.5385 5 yes
GO:0051259 protein complex oligomerization 11.5385 6 yes
GO:1903131 mononuclear cell differentiation 11.5385 5 yes
GO:1903532 positive regulation of secretion by cell 11.5385 5 yes
GO:0001408 guanine nucleotide transport 7.6923 8 yes
GO:0001678 intracellular glucose homeostasis 7.6923 4 yes
GO:0002327 immature B cell differentiation 7.6923 6 yes
GO:0002329 pre-B cell differentiation 7.6923 7 yes
GO:0002791 regulation of peptide secretion 7.6923 6 yes
GO:0002793 positive regulation of peptide secretion 7.6923 6 yes
GO:0006835 dicarboxylic acid transport 7.6923 7 yes
GO:0006862 nucleotide transport 7.6923 6 yes
GO:0006865 amino acid transport 7.6923 5 yes
GO:0015711 organic anion transport 7.6923 5 yes
GO:0015734 taurine transmembrane transport 7.6923 5 yes
GO:0015740 C4-dicarboxylate transport 7.6923 8 yes
GO:0015748 organophosphate ester transport 7.6923 5 yes
GO:0015810 aspartate transmembrane transport 7.6923 4 yes
GO:0015849 organic acid transport 7.6923 5 yes
GO:0015865 purine nucleotide transport 7.6923 7 yes
GO:0015868 purine ribonucleotide transport 7.6923 6 yes
GO:0015931 nucleobase-containing compound transport 7.6923 5 yes
GO:0030098 lymphocyte differentiation 7.6923 4 yes
GO:0030183 B cell differentiation 7.6923 5 yes
GO:0032024 positive regulation of insulin secretion 7.6923 7 yes
GO:0034214 protein hexamerization 7.6923 7 yes
GO:0042593 glucose homeostasis 7.6923 4 yes
GO:0042918 alkanesulfonate transmembrane transport 7.6923 4 yes
GO:0045661 regulation of myoblast differentiation 7.6923 5 yes
GO:0045663 positive regulation of myoblast differentiation 7.6923 6 yes
GO:0046883 regulation of hormone secretion 7.6923 4 yes
GO:0046887 positive regulation of hormone secretion 7.6923 5 yes
GO:0046942 carboxylic acid transport 7.6923 6 yes
GO:0048232 male gamete generation 7.6923 4 yes
GO:0050708 regulation of protein secretion 7.6923 5 yes
GO:0050714 positive regulation of protein secretion 7.6923 6 yes
GO:0050796 regulation of insulin secretion 7.6923 6 yes
GO:0051503 adenine nucleotide transport 7.6923 8 yes
GO:0070729 cyclic nucleotide transport 7.6923 7 yes
GO:0072348 sulfur compound transport 7.6923 4 yes
GO:0090087 regulation of peptide transport 7.6923 5 yes
GO:0090276 regulation of peptide hormone secretion 7.6923 5 yes
GO:0090277 positive regulation of peptide hormone secretion 7.6923 6 yes
GO:0098656 monoatomic anion transmembrane transport 7.6923 4 yes
GO:0098661 inorganic anion transmembrane transport 7.6923 4 yes
GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane 7.6923 4 yes
GO:1901264 carbohydrate derivative transport 7.6923 5 yes
GO:1902476 chloride transmembrane transport 7.6923 5 yes
GO:1903790 guanine nucleotide transmembrane transport 7.6923 4 yes
GO:1905039 carboxylic acid transmembrane transport 7.6923 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRC8B_HUMAN [view interactions] Low throughput no yes
LRC8D_HUMAN [view interactions] Low throughput no no
LRC8E_HUMAN [view interactions] Low throughput no no
LRC8A_HUMAN [view entry] [view interactions] Low throughput yes no
LRC8C_HUMAN [view interactions] Low throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
5HT3C_HUMAN [view entry] [view interactions] High throughput yes no
IPPK_HUMAN [view interactions] High throughput no yes
C3AR_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
C5AR2_HUMAN [view interactions] High throughput no yes
5HT2C_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
GLPB_HUMAN [view interactions] High throughput no no
FADS3_HUMAN [view interactions] High throughput no no
STS_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
POPD2_HUMAN [view interactions] High throughput no no
GP183_HUMAN [view interactions] High throughput no yes
S39A4_HUMAN [view interactions] High throughput no no
ZACN_HUMAN [view interactions] High throughput no no
LPAR1_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
DLK2_HUMAN [view interactions] High throughput no no
5HT3A_HUMAN [view entry] [view interactions] High throughput yes no
VIR_HUMAN [view interactions] High throughput no yes
CXA8_HUMAN [view interactions] High throughput no no
ACHB_HUMAN [view entry] [view interactions] High throughput yes yes
BSCL2_HUMAN [view interactions] High throughput no yes
GPIX_HUMAN [view interactions] High throughput no no
O10H2_HUMAN [view interactions] High throughput no no
SMIM5_HUMAN [view interactions] High throughput no yes
TSN15_HUMAN [view interactions] High throughput no yes
CNGA4_HUMAN [view interactions] High throughput no no
LEG9B_HUMAN [view interactions] High throughput no no
CREL1_HUMAN [view interactions] High throughput no yes
D131A_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
ZDH12_HUMAN [view interactions] High throughput no yes
KCNKI_HUMAN [view interactions] High throughput no no
CLGN_HUMAN [view interactions] High throughput no no
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
DIK1A_HUMAN [view interactions] High throughput no yes
HCST_HUMAN [view interactions] High throughput no no
CKLF5_HUMAN [view interactions] High throughput no yes
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
NKAI1_HUMAN [view interactions] High throughput no no
CD3E_HUMAN [view interactions] High throughput no no
TYOBP_HUMAN [view interactions] High throughput no no
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
CAH9_HUMAN [view interactions] High throughput no no
OTULL_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TM11B_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes