Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHB_HUMAN
GO:0046872 metal ion binding 41.6667 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 33.3333 4 no
GO:0004713 protein tyrosine kinase activity 33.3333 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0016301 kinase activity 33.3333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0005216 ion channel activity 25.0000 4 yes
GO:0015267 channel activity 25.0000 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 25.0000 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0042169 SH2 domain binding 25.0000 4 no
GO:0005509 calcium ion binding 25.0000 5 no
GO:0005230 extracellular ligand-gated ion channel activity 16.6667 6 yes
GO:0005261 cation channel activity 16.6667 5 yes
GO:0008324 cation transmembrane transporter activity 16.6667 4 yes
GO:0015276 ligand-gated ion channel activity 16.6667 5 yes
GO:0022824 transmitter-gated ion channel activity 16.6667 5 yes
GO:0022834 ligand-gated channel activity 16.6667 6 yes
GO:0022835 transmitter-gated channel activity 16.6667 4 yes
GO:0022836 gated channel activity 16.6667 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 16.6667 4 yes
GO:0099094 ligand-gated cation channel activity 16.6667 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHB_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0010646 regulation of cell communication 58.3333 4 no
GO:0051128 regulation of cellular component organization 58.3333 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0001932 regulation of protein phosphorylation 41.6667 7 no
GO:0001934 positive regulation of protein phosphorylation 41.6667 8 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0010562 positive regulation of phosphorus metabolic process 41.6667 6 no
GO:0019220 regulation of phosphate metabolic process 41.6667 6 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0031401 positive regulation of protein modification process 41.6667 7 no
GO:0033674 positive regulation of kinase activity 41.6667 6 no
GO:0042325 regulation of phosphorylation 41.6667 7 no
GO:0042327 positive regulation of phosphorylation 41.6667 8 no
GO:0043549 regulation of kinase activity 41.6667 5 no
GO:0045937 positive regulation of phosphate metabolic process 41.6667 7 no
GO:0051174 regulation of phosphorus metabolic process 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0051338 regulation of transferase activity 41.6667 4 no
GO:0051347 positive regulation of transferase activity 41.6667 5 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0051094 positive regulation of developmental process 41.6667 4 no
GO:0008104 protein localization 41.6667 4 no
GO:0001952 regulation of cell-matrix adhesion 33.3333 6 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 33.3333 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010810 regulation of cell-substrate adhesion 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0022604 regulation of cell morphogenesis 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0046777 protein autophosphorylation 33.3333 6 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:1901888 regulation of cell junction assembly 33.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0099537 trans-synaptic signaling 25.0000 4 yes
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0007172 signal complex assembly 25.0000 5 no
GO:0007173 epidermal growth factor receptor signaling pathway 25.0000 7 no
GO:0007229 integrin-mediated signaling pathway 25.0000 4 no
GO:0008360 regulation of cell shape 25.0000 6 no
GO:0010632 regulation of epithelial cell migration 25.0000 4 no
GO:0018108 peptidyl-tyrosine phosphorylation 25.0000 6 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0018212 peptidyl-tyrosine modification 25.0000 6 no
GO:0019216 regulation of lipid metabolic process 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032103 positive regulation of response to external stimulus 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0038127 ERBB signaling pathway 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0043087 regulation of GTPase activity 25.0000 5 no
GO:0043550 regulation of lipid kinase activity 25.0000 6 no
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 25.0000 7 no
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 25.0000 7 no
GO:0045834 positive regulation of lipid metabolic process 25.0000 5 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0048010 vascular endothelial growth factor receptor signaling pathway 25.0000 6 no
GO:0051896 regulation of protein kinase B signaling 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0090218 positive regulation of lipid kinase activity 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051222 positive regulation of protein transport 25.0000 5 no
GO:0051223 regulation of protein transport 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1904951 positive regulation of establishment of protein localization 25.0000 6 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0033993 response to lipid 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071396 cellular response to lipid 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0006811 ion transport 16.6667 4 yes
GO:0007268 chemical synaptic transmission 16.6667 6 yes
GO:0007271 synaptic transmission, cholinergic 16.6667 7 yes
GO:0061024 membrane organization 16.6667 4 yes
GO:0098916 anterograde trans-synaptic signaling 16.6667 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ACHB_HUMAN
DOID:3635 congenital myasthenic syndrome 16.6667 7 no
DOID:439 neuromuscular junction disease 16.6667 6 no
DOID:440 neuromuscular disease 16.6667 5 no
DOID:574 peripheral nervous system disease 16.6667 3 no
DOID:870 neuropathy 16.6667 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
MUSK_HUMAN [view entry] [view interactions] Low throughput yes no
RAPSN_HUMAN [view entry] [view interactions] Low throughput yes no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
PCX3_HUMAN [view interactions] High throughput no no
VWA1_HUMAN [view interactions] High throughput no no
ATRAP_HUMAN [view interactions] High throughput no yes
SEC20_HUMAN [view interactions] High throughput no yes
P121A_HUMAN [view interactions] High throughput no yes
MFAP3_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
MINY1_HUMAN [view interactions] High throughput no yes
CSCL1_HUMAN [view interactions] High throughput no no
ATF6A_HUMAN [view interactions] High throughput no yes
LRP12_HUMAN [view interactions] High throughput no yes
WLS_HUMAN [view entry] [view interactions] High throughput yes no
ASB6_HUMAN [view interactions] High throughput no yes
CSN6_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
GHDC_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
LRC8A_HUMAN [view entry] [view interactions] High throughput yes no
CA043_HUMAN [view interactions] High throughput no yes
APOL2_HUMAN [view entry] [view interactions] High throughput yes yes
DJC30_HUMAN [view interactions] High throughput no no
SPP2B_HUMAN [view interactions] High throughput no yes
PDZD8_HUMAN [view interactions] High throughput no yes
LEMD2_HUMAN [view interactions] High throughput no yes
KAISO_HUMAN [view interactions] High throughput no yes
DJC18_HUMAN [view interactions] High throughput no yes
CISD2_HUMAN [view interactions] High throughput no yes
FAK2_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes