Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAPSN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
14 Leu Pro Myasthenicsyndrome,congenital,11,associatedwithacetylcholinereceptordeficiency(CMS11) -
88 Asn Lys Myasthenicsyndrome,congenital,11,associatedwithacetylcholinereceptordeficiency(CMS11) -
45 Val Met Myasthenicsyndrome,congenital,11,associatedwithacetylcholinereceptordeficiency(CMS11) -
139 Phe Ser Fetalakinesiadeformationsequence2(FADS2) -
162 Glu Lys Myasthenicsyndrome,congenital,11,associatedwithacetylcholinereceptordeficiency(CMS11) -
164 Arg Cys Myasthenicsyndrome,congenital,11,associatedwithacetylcholinereceptordeficiency(CMS11) -
189 Ala Val Fetalakinesiadeformationsequence2(FADS2) -
283 Leu Pro Myasthenicsyndrome,congenital,11,associatedwithacetylcholinereceptordeficiency(CMS11) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAPSN_HUMAN
GO:0043169 cation binding 52.6316 4 yes
GO:0043168 anion binding 42.1053 4 no
GO:0017076 purine nucleotide binding 36.8421 5 no
GO:0030554 adenyl nucleotide binding 36.8421 6 no
GO:0032555 purine ribonucleotide binding 36.8421 4 no
GO:0032559 adenyl ribonucleotide binding 36.8421 5 no
GO:0035639 purine ribonucleoside triphosphate binding 36.8421 4 no
GO:0046872 metal ion binding 36.8421 5 yes
GO:0000166 nucleotide binding 36.8421 4 no
GO:0005524 ATP binding 36.8421 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.3158 4 no
GO:0016887 ATP hydrolysis activity 26.3158 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.3158 6 no
GO:0019900 kinase binding 26.3158 4 no
GO:0031625 ubiquitin protein ligase binding 26.3158 5 no
GO:0044389 ubiquitin-like protein ligase binding 26.3158 4 no
GO:0016462 pyrophosphatase activity 26.3158 5 no
GO:0045296 cadherin binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0098879 structural constituent of postsynaptic specialization 15.7895 4 yes
GO:0033130 acetylcholine receptor binding 10.5263 4 yes
GO:0035254 glutamate receptor binding 10.5263 4 yes
GO:0035255 ionotropic glutamate receptor binding 10.5263 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAPSN_HUMAN
GO:0048522 positive regulation of cellular process 78.9474 4 yes
GO:0051128 regulation of cellular component organization 68.4211 4 yes
GO:0031323 regulation of cellular metabolic process 63.1579 4 no
GO:0080090 regulation of primary metabolic process 57.8947 4 no
GO:0042981 regulation of apoptotic process 52.6316 5 yes
GO:0043067 regulation of programmed cell death 52.6316 4 yes
GO:0009893 positive regulation of metabolic process 52.6316 4 no
GO:0048523 negative regulation of cellular process 52.6316 4 no
GO:0060255 regulation of macromolecule metabolic process 52.6316 4 no
GO:0009889 regulation of biosynthetic process 52.6316 4 no
GO:0031326 regulation of cellular biosynthetic process 52.6316 5 no
GO:0032880 regulation of protein localization 52.6316 5 no
GO:0060341 regulation of cellular localization 52.6316 4 no
GO:0006996 organelle organization 47.3684 4 no
GO:0031325 positive regulation of cellular metabolic process 47.3684 5 no
GO:0010556 regulation of macromolecule biosynthetic process 47.3684 5 no
GO:0022607 cellular component assembly 47.3684 4 no
GO:0051130 positive regulation of cellular component organization 47.3684 5 no
GO:0008104 protein localization 42.1053 4 yes
GO:0010646 regulation of cell communication 42.1053 4 yes
GO:0099536 synaptic signaling 42.1053 4 yes
GO:0099537 trans-synaptic signaling 42.1053 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.1053 5 no
GO:1903829 positive regulation of protein localization 42.1053 5 no
GO:0007268 chemical synaptic transmission 36.8421 7 yes
GO:0098916 anterograde trans-synaptic signaling 36.8421 6 yes
GO:0051049 regulation of transport 36.8421 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 no
GO:0033043 regulation of organelle organization 36.8421 5 no
GO:0043933 protein-containing complex organization 36.8421 4 no
GO:0065003 protein-containing complex assembly 36.8421 5 no
GO:0050821 protein stabilization 36.8421 4 no
GO:0009891 positive regulation of biosynthetic process 36.8421 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.8421 6 no
GO:0010647 positive regulation of cell communication 31.5789 5 yes
GO:0023056 positive regulation of signaling 31.5789 4 yes
GO:0019220 regulation of phosphate metabolic process 31.5789 6 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0051174 regulation of phosphorus metabolic process 31.5789 5 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0009966 regulation of signal transduction 31.5789 4 no
GO:0010468 regulation of gene expression 31.5789 6 no
GO:0010638 positive regulation of organelle organization 31.5789 6 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.5789 6 no
GO:0051338 regulation of transferase activity 31.5789 4 no
GO:0070201 regulation of establishment of protein localization 31.5789 6 no
GO:0071310 cellular response to organic substance 31.5789 4 no
GO:0006915 apoptotic process 26.3158 4 yes
GO:0007271 synaptic transmission, cholinergic 26.3158 8 yes
GO:0033365 protein localization to organelle 26.3158 5 yes
GO:0072657 protein localization to membrane 26.3158 4 yes
GO:0006259 DNA metabolic process 26.3158 5 no
GO:0090304 nucleic acid metabolic process 26.3158 4 no
GO:0001932 regulation of protein phosphorylation 26.3158 7 no
GO:0006986 response to unfolded protein 26.3158 4 no
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0031401 positive regulation of protein modification process 26.3158 7 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0009968 negative regulation of signal transduction 26.3158 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.3158 5 no
GO:0010648 negative regulation of cell communication 26.3158 5 no
GO:0023057 negative regulation of signaling 26.3158 4 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 no
GO:0031327 negative regulation of cellular biosynthetic process 26.3158 6 no
GO:0048585 negative regulation of response to stimulus 26.3158 4 no
GO:0009894 regulation of catabolic process 26.3158 4 no
GO:0043066 negative regulation of apoptotic process 26.3158 6 no
GO:0043069 negative regulation of programmed cell death 26.3158 5 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0032386 regulation of intracellular transport 26.3158 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.3158 5 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 no
GO:0051052 regulation of DNA metabolic process 26.3158 5 no
GO:0051347 positive regulation of transferase activity 26.3158 5 no
GO:0051972 regulation of telomerase activity 26.3158 5 no
GO:1900180 regulation of protein localization to nucleus 26.3158 6 no
GO:1900182 positive regulation of protein localization to nucleus 26.3158 6 no
GO:1904951 positive regulation of establishment of protein localization 26.3158 6 no
GO:2000278 regulation of DNA biosynthetic process 26.3158 6 no
GO:0043065 positive regulation of apoptotic process 21.0526 6 yes
GO:0043068 positive regulation of programmed cell death 21.0526 5 yes
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 yes
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 yes
GO:1990778 protein localization to cell periphery 21.0526 5 yes
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:0006936 muscle contraction 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0022604 regulation of cell morphogenesis 21.0526 5 no
GO:0034330 cell junction organization 21.0526 4 no
GO:0043408 regulation of MAPK cascade 21.0526 6 no
GO:0044057 regulation of system process 21.0526 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.0526 5 no
GO:0051493 regulation of cytoskeleton organization 21.0526 6 no
GO:0097435 supramolecular fiber organization 21.0526 4 no
GO:1902531 regulation of intracellular signal transduction 21.0526 5 no
GO:1902532 negative regulation of intracellular signal transduction 21.0526 6 no
GO:0006508 proteolysis 21.0526 4 no
GO:0009057 macromolecule catabolic process 21.0526 4 no
GO:0036211 protein modification process 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0009896 positive regulation of catabolic process 21.0526 5 no
GO:0009967 positive regulation of signal transduction 21.0526 5 no
GO:0030162 regulation of proteolysis 21.0526 6 no
GO:0042176 regulation of protein catabolic process 21.0526 5 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:0032388 positive regulation of intracellular transport 21.0526 5 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0014070 response to organic cyclic compound 21.0526 4 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0051223 regulation of protein transport 21.0526 5 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:0051054 positive regulation of DNA metabolic process 21.0526 6 no
GO:0051973 positive regulation of telomerase activity 21.0526 6 no
GO:2000573 positive regulation of DNA biosynthetic process 21.0526 7 no
GO:0035418 protein localization to synapse 15.7895 6 yes
GO:0043113 receptor clustering 15.7895 5 yes
GO:0043523 regulation of neuron apoptotic process 15.7895 6 yes
GO:0062237 protein localization to postsynapse 15.7895 7 yes
GO:0090150 establishment of protein localization to membrane 15.7895 4 yes
GO:0099633 protein localization to postsynaptic specialization membrane 15.7895 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 15.7895 4 yes
GO:1902414 protein localization to cell junction 15.7895 5 yes
GO:1903539 protein localization to postsynaptic membrane 15.7895 5 yes
GO:0043525 positive regulation of neuron apoptotic process 10.5263 7 yes
GO:0050806 positive regulation of synaptic transmission 10.5263 5 yes
GO:0051402 neuron apoptotic process 10.5263 5 yes
GO:0071340 skeletal muscle acetylcholine-gated channel clustering 10.5263 6 yes
GO:0097049 motor neuron apoptotic process 10.5263 6 yes
GO:1900073 regulation of neuromuscular synaptic transmission 10.5263 6 yes
GO:1900075 positive regulation of neuromuscular synaptic transmission 10.5263 6 yes
GO:1901626 regulation of postsynaptic membrane organization 10.5263 5 yes
GO:1903540 establishment of protein localization to postsynaptic membrane 10.5263 5 yes
GO:2000671 regulation of motor neuron apoptotic process 10.5263 7 yes
GO:2000673 positive regulation of motor neuron apoptotic process 10.5263 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SODC_HUMAN [view interactions] Low throughput no yes
ACHB_HUMAN [view entry] [view interactions] Low throughput yes yes
KHDR1_HUMAN [view interactions] Low throughput no yes
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA4_HUMAN [view entry] [view interactions] Low throughput yes no
RAPSN_HUMAN [view entry] [view interactions] Low throughput yes no
KLHL8_HUMAN [view interactions] Low throughput no no
ACHA_HUMAN [view entry] [view interactions] Low throughput yes no
CAN2_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
UBE2Z_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
SMUF1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HERC1_HUMAN [view interactions] High throughput no no
KCMF1_HUMAN [view interactions] High throughput no yes
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
TUSC2_HUMAN [view interactions] High throughput no no
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
ZZEF1_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ACVL1_HUMAN [view interactions] High throughput no yes
TGFR2_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no