ACHA4_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA4_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | yes |
| GO:0015267 | channel activity | 30.3030 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 27.2727 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 24.2424 | 6 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 24.2424 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 24.2424 | 6 | yes |
| GO:0022836 | gated channel activity | 24.2424 | 5 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 21.2121 | 7 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 21.2121 | 5 | yes |
| GO:0022835 | transmitter-gated channel activity | 21.2121 | 4 | yes |
| GO:0046872 | metal ion binding | 21.2121 | 5 | no |
| GO:0005261 | monoatomic cation channel activity | 18.1818 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 18.1818 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 18.1818 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 18.1818 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 18.1818 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 18.1818 | 6 | yes |
| GO:0015464 | acetylcholine receptor activity | 15.1515 | 4 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 15.1515 | 7 | yes |
| GO:0042166 | acetylcholine binding | 9.0909 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA4_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 63.6364 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 57.5758 | 4 | no |
| GO:0051049 | regulation of transport | 51.5152 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.4545 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 45.4545 | 5 | no |
| GO:0008104 | protein localization | 42.4242 | 4 | no |
| GO:0023056 | positive regulation of signaling | 42.4242 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.3939 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.3636 | 5 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 36.3636 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 36.3636 | 6 | yes |
| GO:0099536 | synaptic signaling | 36.3636 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 36.3636 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.3636 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.3636 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | no |
| GO:0006811 | monoatomic ion transport | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0060341 | regulation of cellular localization | 30.3030 | 4 | no |
| GO:0071702 | organic substance transport | 30.3030 | 4 | no |
| GO:0051046 | regulation of secretion | 30.3030 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 30.3030 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 30.3030 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.3030 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.3030 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.3030 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 27.2727 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 27.2727 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
| GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.2727 | 6 | no |
| GO:0036211 | protein modification process | 27.2727 | 4 | no |
| GO:0043412 | macromolecule modification | 27.2727 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.2424 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.2424 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.2424 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.2424 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0030334 | regulation of cell migration | 24.2424 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.2424 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 24.2424 | 4 | no |
| GO:2000145 | regulation of cell motility | 24.2424 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.2424 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2121 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 21.2121 | 7 | no |
| GO:0014070 | response to organic cyclic compound | 21.2121 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.2121 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.2121 | 4 | no |
| GO:0051223 | regulation of protein transport | 21.2121 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.2121 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 21.2121 | 6 | no |
| GO:0071417 | cellular response to organonitrogen compound | 21.2121 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 21.2121 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.2121 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 21.2121 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.2121 | 4 | no |
| GO:0007271 | synaptic transmission, cholinergic | 21.2121 | 8 | yes |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:0006812 | monoatomic cation transport | 18.1818 | 5 | yes |
| GO:0007600 | sensory perception | 18.1818 | 4 | yes |
| GO:0030001 | metal ion transport | 18.1818 | 6 | yes |
| GO:0036293 | response to decreased oxygen levels | 18.1818 | 4 | yes |
| GO:0050890 | cognition | 18.1818 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 18.1818 | 4 | yes |
| GO:0006816 | calcium ion transport | 15.1515 | 7 | yes |
| GO:0035095 | behavioral response to nicotine | 15.1515 | 4 | yes |
| GO:0001508 | action potential | 12.1212 | 4 | yes |
| GO:0006259 | DNA metabolic process | 12.1212 | 5 | yes |
| GO:0006974 | DNA damage response | 12.1212 | 4 | yes |
| GO:0014059 | regulation of dopamine secretion | 12.1212 | 6 | yes |
| GO:0042113 | B cell activation | 12.1212 | 4 | yes |
| GO:0050433 | regulation of catecholamine secretion | 12.1212 | 5 | yes |
| GO:0051899 | membrane depolarization | 12.1212 | 4 | yes |
| GO:0051952 | regulation of amine transport | 12.1212 | 5 | yes |
| GO:0006281 | DNA repair | 9.0909 | 5 | yes |
| GO:0019233 | sensory perception of pain | 9.0909 | 5 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 6.0606 | 4 | yes |
| GO:0060080 | inhibitory postsynaptic potential | 6.0606 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LYPD1_HUMAN | [view interactions] | Low throughput | no | no |
| LY6H_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LY6E_HUMAN | [view interactions] | Low throughput | no | no |
| A0A0B4J1T7_HUMAN | [view interactions] | Low throughput | no | no |
| PSCA_HUMAN | [view interactions] | Low throughput | no | no |
| CREL2_HUMAN | [view interactions] | Low throughput | no | yes |
| LYNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAPSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| SLUR2_HUMAN | [view interactions] | Low throughput | no | no |
| P2RX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYPD6_HUMAN | [view interactions] | High throughput | no | no |
| SORL_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILDR2_HUMAN | [view interactions] | High throughput | no | yes |
| GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| ADCY6_HUMAN | [view interactions] | High throughput | no | yes |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC9_HUMAN | [view interactions] | High throughput | no | yes |
| COA1_HUMAN | [view interactions] | High throughput | no | yes |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| EREP3_HUMAN | [view interactions] | High throughput | no | no |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM219_HUMAN | [view interactions] | High throughput | no | yes |
| CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR3_HUMAN | [view interactions] | High throughput | no | no |
| XYLK_HUMAN | [view interactions] | High throughput | no | yes |
| POMT1_HUMAN | [view interactions] | High throughput | no | no |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| GHDC_HUMAN | [view interactions] | High throughput | no | yes |
| TM223_HUMAN | [view interactions] | High throughput | no | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| ENTP6_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| CF120_HUMAN | [view interactions] | High throughput | no | no |
| GL8D2_HUMAN | [view interactions] | High throughput | no | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| TMM62_HUMAN | [view interactions] | High throughput | no | yes |
| GPR27_HUMAN | [view interactions] | High throughput | no | yes |
| FZD6_HUMAN | [view interactions] | High throughput | no | yes |
| PLPR3_HUMAN | [view interactions] | High throughput | no | no |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| FZD3_HUMAN | [view interactions] | High throughput | no | yes |
| MARC1_HUMAN | [view interactions] | High throughput | no | yes |
| FUT10_HUMAN | [view interactions] | High throughput | no | yes |
| NAT14_HUMAN | [view interactions] | High throughput | no | no |
| MANEL_HUMAN | [view interactions] | High throughput | no | no |
| PIGO_HUMAN | [view interactions] | High throughput | no | no |
| GP1BB_HUMAN | [view interactions] | High throughput | no | no |
| GLRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLPP1_HUMAN | [view interactions] | High throughput | no | no |
| COX18_HUMAN | [view interactions] | High throughput | no | yes |
| MRP7_HUMAN | [view interactions] | High throughput | no | yes |
| S38AA_HUMAN | [view interactions] | High throughput | no | yes |
| D19L4_HUMAN | [view interactions] | High throughput | no | no |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| S15A4_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STEA3_HUMAN | [view interactions] | High throughput | no | yes |
| F219A_HUMAN | [view interactions] | High throughput | no | yes |
| TMED4_HUMAN | [view interactions] | High throughput | no | yes |
| MANEA_HUMAN | [view interactions] | High throughput | no | yes |
| PAR16_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| SIA10_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| NEMP2_HUMAN | [view interactions] | High throughput | no | no |
| MYORG_HUMAN | [view interactions] | High throughput | no | yes |
| SIA4C_HUMAN | [view interactions] | High throughput | no | yes |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| TM39B_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| SMO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| T179B_HUMAN | [view interactions] | High throughput | no | no |
| PIGG_HUMAN | [view interactions] | High throughput | no | yes |
| ALG12_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| C1GLC_HUMAN | [view interactions] | High throughput | no | yes |
| CTL5_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| PIGB_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPIL2_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| NMU_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT7_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| B4GN1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACR2_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| FKTN_HUMAN | [view interactions] | High throughput | no | no |
| ZDH21_HUMAN | [view interactions] | High throughput | no | yes |
| WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| SGCB_HUMAN | [view interactions] | High throughput | no | no |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| SIA7D_HUMAN | [view interactions] | High throughput | no | no |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| ALG9_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| TMTC4_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP1_HUMAN | [view interactions] | High throughput | no | no |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM2_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN167_HUMAN | [view interactions] | High throughput | no | yes |
| NRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| DMB_HUMAN | [view interactions] | High throughput | no | no |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| TMUB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMX4_HUMAN | [view interactions] | High throughput | no | yes |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| SIA7C_HUMAN | [view interactions] | High throughput | no | no |
| CERS6_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| CTL1_HUMAN | [view interactions] | High throughput | no | no |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8D_HUMAN | [view interactions] | High throughput | no | no |
| PIGN_HUMAN | [view interactions] | High throughput | no | yes |
| C1QRF_HUMAN | [view interactions] | High throughput | no | no |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
| NAGPA_HUMAN | [view interactions] | High throughput | no | no |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIEZ1_HUMAN | [view interactions] | High throughput | no | no |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM4_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |