ACHA4_HUMAN
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACHA4_HUMAN |
---|---|---|---|---|
GO:0015267 | channel activity | 44.4444 | 4 | yes |
GO:0005216 | ion channel activity | 41.6667 | 4 | yes |
GO:0022836 | gated channel activity | 38.8889 | 5 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 36.1111 | 6 | yes |
GO:0015276 | ligand-gated ion channel activity | 36.1111 | 5 | yes |
GO:0022824 | transmitter-gated ion channel activity | 36.1111 | 5 | yes |
GO:0022834 | ligand-gated channel activity | 36.1111 | 6 | yes |
GO:0022835 | transmitter-gated channel activity | 36.1111 | 4 | yes |
GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 33.3333 | 7 | yes |
GO:0005261 | cation channel activity | 33.3333 | 5 | yes |
GO:0008324 | cation transmembrane transporter activity | 33.3333 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 33.3333 | 4 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 33.3333 | 4 | yes |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 33.3333 | 5 | yes |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 33.3333 | 6 | yes |
GO:0022848 | acetylcholine-gated cation-selective channel activity | 30.5556 | 7 | yes |
GO:0099094 | ligand-gated cation channel activity | 30.5556 | 6 | yes |
GO:0015464 | acetylcholine receptor activity | 25.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACHA4_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 63.8889 | 4 | no |
GO:0051049 | regulation of transport | 55.5556 | 4 | yes |
GO:0006811 | ion transport | 52.7778 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0007268 | chemical synaptic transmission | 41.6667 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 41.6667 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 41.6667 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 38.8889 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 38.8889 | 4 | no |
GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 38.8889 | 4 | no |
GO:0051046 | regulation of secretion | 36.1111 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 36.1111 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 36.1111 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | no |
GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
GO:0043269 | regulation of ion transport | 30.5556 | 5 | yes |
GO:0051899 | membrane depolarization | 30.5556 | 4 | yes |
GO:0022607 | cellular component assembly | 30.5556 | 4 | no |
GO:0007271 | synaptic transmission, cholinergic | 27.7778 | 7 | yes |
GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.7778 | 5 | no |
GO:0010243 | response to organonitrogen compound | 27.7778 | 4 | no |
GO:0010468 | regulation of gene expression | 27.7778 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:0044057 | regulation of system process | 22.2222 | 4 | no |
GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | no |
GO:0036211 | protein modification process | 22.2222 | 4 | no |
GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 22.2222 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | no |
GO:0008104 | protein localization | 22.2222 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
GO:0006812 | cation transport | 19.4444 | 5 | yes |
GO:0030001 | metal ion transport | 19.4444 | 6 | yes |
GO:0035095 | behavioral response to nicotine | 16.6667 | 4 | yes |
GO:0006816 | calcium ion transport | 13.8889 | 7 | yes |
GO:0036293 | response to decreased oxygen levels | 13.8889 | 4 | yes |
GO:0050890 | cognition | 13.8889 | 4 | yes |
GO:0051952 | regulation of amine transport | 13.8889 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 13.8889 | 4 | yes |
GO:0001508 | action potential | 11.1111 | 4 | yes |
GO:0007600 | sensory perception | 11.1111 | 4 | yes |
GO:0014059 | regulation of dopamine secretion | 11.1111 | 6 | yes |
GO:0042113 | B cell activation | 11.1111 | 4 | yes |
GO:0050433 | regulation of catecholamine secretion | 11.1111 | 5 | yes |
GO:0006259 | DNA metabolic process | 8.3333 | 4 | yes |
GO:0006281 | DNA repair | 8.3333 | 5 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 8.3333 | 4 | yes |
GO:0019233 | sensory perception of pain | 8.3333 | 5 | yes |
GO:0060078 | regulation of postsynaptic membrane potential | 8.3333 | 4 | yes |
GO:0060080 | inhibitory postsynaptic potential | 5.5556 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LYPD1_HUMAN | [view interactions] | Low throughput | no | no |
ACHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LY6H_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LY6E_HUMAN | [view interactions] | Low throughput | no | no |
A0A0B4J1T7_HUMAN | [view interactions] | Low throughput | no | no |
PSCA_HUMAN | [view interactions] | Low throughput | no | no |
CREL2_HUMAN | [view interactions] | Low throughput | no | yes |
LYNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACHA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACHB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAPSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
SLUR2_HUMAN | [view interactions] | Low throughput | no | no |
P2RX2_HUMAN | [view interactions] | Low throughput | no | no |
CERS6_HUMAN | [view interactions] | High throughput | no | yes |
EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
CTL1_HUMAN | [view interactions] | High throughput | no | no |
SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
LRC8D_HUMAN | [view interactions] | High throughput | no | no |
PIGN_HUMAN | [view interactions] | High throughput | no | yes |
C1QRF_HUMAN | [view interactions] | High throughput | no | no |
ALG8_HUMAN | [view interactions] | High throughput | no | yes |
DJC18_HUMAN | [view interactions] | High throughput | no | yes |
TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
NAGPA_HUMAN | [view interactions] | High throughput | no | no |
NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIEZ1_HUMAN | [view interactions] | High throughput | no | no |
DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
ICAM4_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYPD6_HUMAN | [view interactions] | High throughput | no | no |
LRP1B_HUMAN | [view interactions] | High throughput | no | yes |
CBX1_HUMAN | [view interactions] | High throughput | no | yes |
IF2B_HUMAN | [view interactions] | High throughput | no | yes |
SORL_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ILDR2_HUMAN | [view interactions] | High throughput | no | yes |
GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
PTPRK_HUMAN | [view interactions] | High throughput | no | no |
ADCY6_HUMAN | [view interactions] | High throughput | no | yes |
ERMP1_HUMAN | [view interactions] | High throughput | no | no |
SL9A8_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC9_HUMAN | [view interactions] | High throughput | no | yes |
COA1_HUMAN | [view interactions] | High throughput | no | yes |
SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
F189B_HUMAN | [view interactions] | High throughput | no | no |
NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM219_HUMAN | [view interactions] | High throughput | no | yes |
CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
LPAR3_HUMAN | [view interactions] | High throughput | no | no |
XYLK_HUMAN | [view interactions] | High throughput | no | yes |
POMT1_HUMAN | [view interactions] | High throughput | no | no |
CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
GHDC_HUMAN | [view interactions] | High throughput | no | yes |
TM223_HUMAN | [view interactions] | High throughput | no | yes |
LSR_HUMAN | [view interactions] | High throughput | no | yes |
LRC8E_HUMAN | [view interactions] | High throughput | no | no |
ENTP6_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
CF120_HUMAN | [view interactions] | High throughput | no | no |
GL8D2_HUMAN | [view interactions] | High throughput | no | yes |
GBRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CA043_HUMAN | [view interactions] | High throughput | no | yes |
TMM62_HUMAN | [view interactions] | High throughput | no | yes |
GPR27_HUMAN | [view interactions] | High throughput | no | yes |
FZD6_HUMAN | [view interactions] | High throughput | no | yes |
PLPR3_HUMAN | [view interactions] | High throughput | no | no |
LMF2_HUMAN | [view interactions] | High throughput | no | yes |
PACC1_HUMAN | [view interactions] | High throughput | no | no |
FZD3_HUMAN | [view interactions] | High throughput | no | yes |
MARC1_HUMAN | [view interactions] | High throughput | no | yes |
FUT10_HUMAN | [view interactions] | High throughput | no | yes |
NAT14_HUMAN | [view interactions] | High throughput | no | no |
MANEL_HUMAN | [view interactions] | High throughput | no | no |
PIGO_HUMAN | [view interactions] | High throughput | no | no |
GP1BB_HUMAN | [view interactions] | High throughput | no | no |
GLRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PLPP1_HUMAN | [view interactions] | High throughput | no | no |
COX18_HUMAN | [view interactions] | High throughput | no | yes |
MRP7_HUMAN | [view interactions] | High throughput | no | yes |
S38AA_HUMAN | [view interactions] | High throughput | no | yes |
D19L4_HUMAN | [view interactions] | High throughput | no | no |
KLRG2_HUMAN | [view interactions] | High throughput | no | no |
UD3A2_HUMAN | [view interactions] | High throughput | no | no |
S15A4_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STEA3_HUMAN | [view interactions] | High throughput | no | yes |
F219A_HUMAN | [view interactions] | High throughput | no | yes |
TMED4_HUMAN | [view interactions] | High throughput | no | yes |
MANEA_HUMAN | [view interactions] | High throughput | no | yes |
PAR16_HUMAN | [view interactions] | High throughput | no | yes |
GBRAP_HUMAN | [view interactions] | High throughput | no | no |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
SIA10_HUMAN | [view interactions] | High throughput | no | yes |
TM39A_HUMAN | [view interactions] | High throughput | no | yes |
NEMP2_HUMAN | [view interactions] | High throughput | no | no |
MYORG_HUMAN | [view interactions] | High throughput | no | yes |
SIA4C_HUMAN | [view interactions] | High throughput | no | yes |
TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
TM39B_HUMAN | [view interactions] | High throughput | no | yes |
TMX2_HUMAN | [view interactions] | High throughput | no | yes |
SMO_HUMAN | [view interactions] | High throughput | no | yes |
MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
SC11C_HUMAN | [view interactions] | High throughput | no | no |
T179B_HUMAN | [view interactions] | High throughput | no | no |
PIGG_HUMAN | [view interactions] | High throughput | no | yes |
ALG12_HUMAN | [view interactions] | High throughput | no | yes |
5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
C1GLC_HUMAN | [view interactions] | High throughput | no | yes |
CTL5_HUMAN | [view interactions] | High throughput | no | no |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASTRA_HUMAN | [view interactions] | High throughput | no | no |
PIGB_HUMAN | [view interactions] | High throughput | no | yes |
SEM4F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IPIL2_HUMAN | [view interactions] | High throughput | no | no |
DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
NMU_HUMAN | [view interactions] | High throughput | no | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
B4GT7_HUMAN | [view interactions] | High throughput | no | yes |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
B4GN1_HUMAN | [view interactions] | High throughput | no | yes |
LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FACR2_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
EDA_HUMAN | [view interactions] | High throughput | no | no |
FKTN_HUMAN | [view interactions] | High throughput | no | no |
ZDH21_HUMAN | [view interactions] | High throughput | no | yes |
WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
SGCB_HUMAN | [view interactions] | High throughput | no | no |
EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
FUT8_HUMAN | [view interactions] | High throughput | no | yes |
CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
TM131_HUMAN | [view interactions] | High throughput | no | yes |
SIA7D_HUMAN | [view interactions] | High throughput | no | no |
K2013_HUMAN | [view interactions] | High throughput | no | yes |
LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
ALG9_HUMAN | [view interactions] | High throughput | no | yes |
ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
TMTC4_HUMAN | [view interactions] | High throughput | no | yes |
PGAP1_HUMAN | [view interactions] | High throughput | no | no |
PLD6_HUMAN | [view interactions] | High throughput | no | yes |
GOLM2_HUMAN | [view interactions] | High throughput | no | yes |
CISD2_HUMAN | [view interactions] | High throughput | no | yes |
RN167_HUMAN | [view interactions] | High throughput | no | yes |
NRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
DMB_HUMAN | [view interactions] | High throughput | no | no |
LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
TMUB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMX4_HUMAN | [view interactions] | High throughput | no | yes |
POMT2_HUMAN | [view interactions] | High throughput | no | yes |
SIA7C_HUMAN | [view interactions] | High throughput | no | no |
KCNQ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACHB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACHA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACHA3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |