Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRN1_HUMAN
GO:0005216 monoatomic ion channel activity 50.0000 4 no
GO:0015267 channel activity 50.0000 4 no
GO:0043169 cation binding 50.0000 4 no
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 33.3333 6 no
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 33.3333 7 no
GO:0008324 monoatomic cation transmembrane transporter activity 33.3333 4 no
GO:0015276 ligand-gated monoatomic ion channel activity 33.3333 5 no
GO:0022824 transmitter-gated monoatomic ion channel activity 33.3333 5 no
GO:0022834 ligand-gated channel activity 33.3333 6 no
GO:0022835 transmitter-gated channel activity 33.3333 4 no
GO:0022836 gated channel activity 33.3333 5 no
GO:0098960 postsynaptic neurotransmitter receptor activity 33.3333 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 33.3333 5 no
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 33.3333 6 no
GO:0005253 monoatomic anion channel activity 33.3333 5 no
GO:0008509 monoatomic anion transmembrane transporter activity 33.3333 4 no
GO:0015103 inorganic anion transmembrane transporter activity 33.3333 4 no
GO:0015108 chloride transmembrane transporter activity 33.3333 5 no
GO:0031406 carboxylic acid binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NRN1_HUMAN
GO:0006811 monoatomic ion transport 50.0000 4 no
GO:0007268 chemical synaptic transmission 50.0000 7 no
GO:0098916 anterograde trans-synaptic signaling 50.0000 6 no
GO:0099536 synaptic signaling 50.0000 4 no
GO:0099537 trans-synaptic signaling 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006812 monoatomic cation transport 33.3333 5 no
GO:0007600 sensory perception 33.3333 4 no
GO:0030001 metal ion transport 33.3333 6 no
GO:0036293 response to decreased oxygen levels 33.3333 4 no
GO:0050890 cognition 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006820 monoatomic anion transport 33.3333 5 no
GO:0006821 chloride transport 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0009059 macromolecule biosynthetic process 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010467 gene expression 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0015698 inorganic anion transport 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0060013 righting reflex 33.3333 4 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0098656 monoatomic anion transmembrane transport 33.3333 4 no
GO:0098661 inorganic anion transmembrane transport 33.3333 4 no
GO:1902476 chloride transmembrane transport 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CXB7_HUMAN [view interactions] High throughput no no
SIGL1_HUMAN [view interactions] High throughput no no
HLAA_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
GPC3_HUMAN [view interactions] High throughput no no
FZD2_HUMAN [view interactions] High throughput no no
SPCS2_HUMAN [view interactions] High throughput no yes
MKS3_HUMAN [view interactions] High throughput no no
TM219_HUMAN [view interactions] High throughput no yes
SPP2B_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
S12A7_HUMAN [view interactions] High throughput no yes
PCDGK_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
RAE1E_HUMAN [view interactions] High throughput no no
S12A6_HUMAN [view interactions] High throughput no yes
NCEH1_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
S12A4_HUMAN [view interactions] High throughput no yes
I23O2_HUMAN [view interactions] High throughput no no
AT11C_HUMAN [view interactions] High throughput no no
S47A1_HUMAN [view interactions] High throughput no no
AGRL1_HUMAN [view interactions] High throughput no no
HORM2_HUMAN [view interactions] High throughput no no
HGNAT_HUMAN [view interactions] High throughput no yes
LY86_HUMAN [view interactions] High throughput no no
B3GN7_HUMAN [view interactions] High throughput no no
MARH4_HUMAN [view interactions] High throughput no yes
LRC52_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
GSX1_HUMAN [view interactions] High throughput no no
SPCS1_HUMAN [view interactions] High throughput no yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
RPRM_HUMAN [view interactions] High throughput no no
B3GT5_HUMAN [view interactions] High throughput no no
HES3_HUMAN [view interactions] High throughput no no
CSF3_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes