Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRN1_HUMAN
GO:0005216 ion channel activity 42.8571 4 no
GO:0015267 channel activity 42.8571 4 no
GO:0005253 anion channel activity 28.5714 5 no
GO:0008324 cation transmembrane transporter activity 28.5714 4 no
GO:0008509 anion transmembrane transporter activity 28.5714 4 no
GO:0015103 inorganic anion transmembrane transporter activity 28.5714 4 no
GO:0015108 chloride transmembrane transporter activity 28.5714 5 no
GO:0016597 amino acid binding 28.5714 4 no
GO:0022890 inorganic cation transmembrane transporter activity 28.5714 4 no
GO:0031406 carboxylic acid binding 28.5714 4 no
GO:0005230 extracellular ligand-gated ion channel activity 28.5714 6 no
GO:0005231 excitatory extracellular ligand-gated ion channel activity 28.5714 7 no
GO:0015276 ligand-gated ion channel activity 28.5714 5 no
GO:0022824 transmitter-gated ion channel activity 28.5714 5 no
GO:0022834 ligand-gated channel activity 28.5714 6 no
GO:0022835 transmitter-gated channel activity 28.5714 4 no
GO:0022836 gated channel activity 28.5714 5 no
GO:0098960 postsynaptic neurotransmitter receptor activity 28.5714 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 28.5714 5 no
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 28.5714 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in NRN1_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0051049 regulation of transport 57.1429 4 no
GO:0006811 ion transport 42.8571 4 no
GO:0007268 chemical synaptic transmission 42.8571 6 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010243 response to organonitrogen compound 42.8571 4 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0042327 positive regulation of phosphorylation 42.8571 8 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0098916 anterograde trans-synaptic signaling 42.8571 5 no
GO:0099537 trans-synaptic signaling 42.8571 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0006812 cation transport 28.5714 5 no
GO:0006820 anion transport 28.5714 5 no
GO:0006821 chloride transport 28.5714 7 no
GO:0008104 protein localization 28.5714 4 no
GO:0010467 gene expression 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0015698 inorganic anion transport 28.5714 6 no
GO:0016192 vesicle-mediated transport 28.5714 4 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0030001 metal ion transport 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0033674 positive regulation of kinase activity 28.5714 6 no
GO:0036293 response to decreased oxygen levels 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045860 positive regulation of protein kinase activity 28.5714 7 no
GO:0050890 cognition 28.5714 4 no
GO:0051171 regulation of nitrogen compound metabolic process 28.5714 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051223 regulation of protein transport 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0060013 righting reflex 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0098656 anion transmembrane transport 28.5714 4 no
GO:0098660 inorganic ion transmembrane transport 28.5714 4 no
GO:0098661 inorganic anion transmembrane transport 28.5714 5 no
GO:1902476 chloride transmembrane transport 28.5714 6 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0042326 negative regulation of phosphorylation 28.5714 8 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0050807 regulation of synapse organization 28.5714 5 no
GO:0051046 regulation of secretion 28.5714 5 no
GO:0051051 negative regulation of transport 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:1903530 regulation of secretion by cell 28.5714 4 no
GO:0007600 sensory perception 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CXB7_HUMAN [view interactions] High throughput no no
SIGL1_HUMAN [view interactions] High throughput no no
S12A7_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
SPP2B_HUMAN [view interactions] High throughput no yes
TM219_HUMAN [view interactions] High throughput no yes
MKS3_HUMAN [view interactions] High throughput no no
SPCS2_HUMAN [view interactions] High throughput no yes
FZD2_HUMAN [view interactions] High throughput no no
GPC3_HUMAN [view interactions] High throughput no no
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
HLAA_HUMAN [view interactions] High throughput no no
PCDGK_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
RAE1E_HUMAN [view interactions] High throughput no no
S12A6_HUMAN [view interactions] High throughput no yes
NCEH1_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
S12A4_HUMAN [view interactions] High throughput no yes
I23O2_HUMAN [view interactions] High throughput no no
AT11C_HUMAN [view interactions] High throughput no no
S47A1_HUMAN [view interactions] High throughput no no
AGRL1_HUMAN [view entry] [view interactions] High throughput yes no
HORM2_HUMAN [view interactions] High throughput no no
HGNAT_HUMAN [view interactions] High throughput no yes
LY86_HUMAN [view interactions] High throughput no no
B3GN7_HUMAN [view interactions] High throughput no no
MARH4_HUMAN [view interactions] High throughput no yes
LRC52_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
GSX1_HUMAN [view interactions] High throughput no no
SPCS1_HUMAN [view interactions] High throughput no yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
RPRM_HUMAN [view interactions] High throughput no no
B3GT5_HUMAN [view interactions] High throughput no no
HES3_HUMAN [view interactions] High throughput no no
CSF3_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes