Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LY6H_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LY6H_HUMAN
GO:0016462 pyrophosphatase activity 28.5714 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.5714 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.5714 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in LY6H_HUMAN
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0045595 regulation of cell differentiation 57.1429 4 no
GO:0051094 positive regulation of developmental process 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051960 regulation of nervous system development 42.8571 5 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0060284 regulation of cell development 42.8571 5 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.8571 6 no
GO:1903506 regulation of nucleic acid-templated transcription 42.8571 7 no
GO:2000026 regulation of multicellular organismal development 42.8571 4 no
GO:2000145 regulation of cell motility 42.8571 4 no
GO:2001141 regulation of RNA biosynthetic process 42.8571 6 no
GO:0008104 protein localization 42.8571 4 no
GO:0045597 positive regulation of cell differentiation 42.8571 5 no
GO:0006355 regulation of DNA-templated transcription 42.8571 6 no
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0009968 negative regulation of signal transduction 42.8571 5 no
GO:0010468 regulation of gene expression 42.8571 5 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0010975 regulation of neuron projection development 42.8571 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0030334 regulation of cell migration 42.8571 5 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0031344 regulation of cell projection organization 42.8571 5 no
GO:0031346 positive regulation of cell projection organization 42.8571 6 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0043087 regulation of GTPase activity 42.8571 5 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:0050767 regulation of neurogenesis 42.8571 6 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051130 positive regulation of cellular component organization 42.8571 5 no
GO:0051171 regulation of nitrogen compound metabolic process 42.8571 4 no
GO:0051240 positive regulation of multicellular organismal process 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051252 regulation of RNA metabolic process 42.8571 5 no
GO:0051336 regulation of hydrolase activity 42.8571 4 no
GO:0060548 negative regulation of cell death 28.5714 5 no
GO:0070848 response to growth factor 28.5714 4 no
GO:0071241 cellular response to inorganic substance 28.5714 4 no
GO:0071248 cellular response to metal ion 28.5714 5 no
GO:0071277 cellular response to calcium ion 28.5714 6 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0071345 cellular response to cytokine stimulus 28.5714 5 no
GO:0071363 cellular response to growth factor stimulus 28.5714 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 28.5714 7 no
GO:0080134 regulation of response to stress 28.5714 4 no
GO:0080135 regulation of cellular response to stress 28.5714 4 no
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 28.5714 5 no
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 28.5714 6 no
GO:0090287 regulation of cellular response to growth factor stimulus 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 28.5714 8 no
GO:2000147 positive regulation of cell motility 28.5714 5 no
GO:0010720 positive regulation of cell development 28.5714 6 no
GO:0043620 regulation of DNA-templated transcription in response to stress 28.5714 4 no
GO:0050769 positive regulation of neurogenesis 28.5714 6 no
GO:0051962 positive regulation of nervous system development 28.5714 5 no
GO:0015031 protein transport 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0050890 cognition 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0002009 morphogenesis of an epithelium 28.5714 4 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 7 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0010976 positive regulation of neuron projection development 28.5714 7 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0022604 regulation of cell morphogenesis 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0030182 neuron differentiation 28.5714 4 no
GO:0030335 positive regulation of cell migration 28.5714 6 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0034097 response to cytokine 28.5714 4 no
GO:0040017 positive regulation of locomotion 28.5714 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043066 negative regulation of apoptotic process 28.5714 7 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0043069 negative regulation of programmed cell death 28.5714 6 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043405 regulation of MAP kinase activity 28.5714 8 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0043547 positive regulation of GTPase activity 28.5714 6 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045893 positive regulation of DNA-templated transcription 28.5714 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0050770 regulation of axonogenesis 28.5714 5 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051345 positive regulation of hydrolase activity 28.5714 5 no
GO:0051592 response to calcium ion 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA4_HUMAN [view entry] [view interactions] Low throughput yes no
KRA59_HUMAN [view interactions] High throughput no no
DVL3_HUMAN [view interactions] High throughput no yes
PP16A_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
ZN696_HUMAN [view interactions] High throughput no no
LRP11_HUMAN [view interactions] High throughput no no
ZN664_HUMAN [view interactions] High throughput no no
TXD16_HUMAN [view interactions] High throughput no yes
RBP10_HUMAN [view interactions] High throughput no no
MAEA_HUMAN [view interactions] High throughput no yes
CNTP3_HUMAN [view interactions] High throughput no yes
GDF11_HUMAN [view interactions] High throughput no yes
RMD5A_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CHLE_HUMAN [view interactions] High throughput no no
ARMC8_HUMAN [view interactions] High throughput no yes
PGLT1_HUMAN [view interactions] High throughput no no
GCNT1_HUMAN [view interactions] High throughput no yes
ARSK_HUMAN [view interactions] High throughput no no
WDR26_HUMAN [view interactions] High throughput no yes
TGFB2_HUMAN [view interactions] High throughput no no
TGFB1_HUMAN [view interactions] High throughput no no
ERO1B_HUMAN [view interactions] High throughput no yes
INHBE_HUMAN [view interactions] High throughput no no
ZN101_HUMAN [view interactions] High throughput no no
PCSK5_HUMAN [view interactions] High throughput no yes
MKLN1_HUMAN [view interactions] High throughput no yes
TIMP3_HUMAN [view interactions] High throughput no no
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
GLT18_HUMAN [view interactions] High throughput no yes
SULF1_HUMAN [view interactions] High throughput no no
PXDN_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
NXPH4_HUMAN [view interactions] High throughput no no
UGGG2_HUMAN [view interactions] High throughput no no
BGLR_HUMAN [view interactions] High throughput no yes
PLCA_HUMAN [view interactions] High throughput no yes
ADAM9_HUMAN [view interactions] High throughput no no
PCSK6_HUMAN [view interactions] High throughput no yes
SE1L3_HUMAN [view interactions] High throughput no yes
CTL1_HUMAN [view interactions] High throughput no no
METRN_HUMAN [view interactions] High throughput no yes
MA2A2_HUMAN [view interactions] High throughput no no
I17RA_HUMAN [view interactions] High throughput no yes
GID8_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
CHSTE_HUMAN [view interactions] High throughput no no
CHPF2_HUMAN [view interactions] High throughput no yes
ATS7_HUMAN [view interactions] High throughput no no
MGRN1_HUMAN [view interactions] High throughput no yes
ALG11_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
PLXA1_HUMAN [view entry] [view interactions] High throughput yes yes
PMGT2_HUMAN [view interactions] High throughput no yes
GT253_HUMAN [view interactions] High throughput no yes
CHRD_HUMAN [view interactions] High throughput no no
PLGT2_HUMAN [view interactions] High throughput no no
NOE2_HUMAN [view entry] [view interactions] High throughput yes yes
GID4_HUMAN [view interactions] High throughput no yes
SLUR1_HUMAN [view interactions] Computational no no
LYPD6_HUMAN [view interactions] Computational no no