Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LY6H_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LY6H_HUMAN
GO:0043169 cation binding 22.2222 4 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0005096 GTPase activator activity 22.2222 4 no
GO:0030695 GTPase regulator activity 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LY6H_HUMAN
GO:0045595 regulation of cell differentiation 55.5556 4 no
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0022603 regulation of anatomical structure morphogenesis 44.4444 4 no
GO:0050767 regulation of neurogenesis 44.4444 6 no
GO:0051094 positive regulation of developmental process 44.4444 4 no
GO:0051960 regulation of nervous system development 44.4444 5 no
GO:0060284 regulation of cell development 44.4444 5 no
GO:2000026 regulation of multicellular organismal development 44.4444 4 no
GO:0006996 organelle organization 44.4444 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0009968 negative regulation of signal transduction 44.4444 5 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0010648 negative regulation of cell communication 44.4444 5 no
GO:0023057 negative regulation of signaling 44.4444 4 no
GO:0048585 negative regulation of response to stimulus 44.4444 4 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:0050890 cognition 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:0022604 regulation of cell morphogenesis 33.3333 5 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0050770 regulation of axonogenesis 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0002009 morphogenesis of an epithelium 22.2222 4 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0050769 positive regulation of neurogenesis 22.2222 6 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051962 positive regulation of nervous system development 22.2222 5 no
GO:1990138 neuron projection extension 22.2222 4 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0010721 negative regulation of cell development 22.2222 6 no
GO:0010977 negative regulation of neuron projection development 22.2222 7 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031345 negative regulation of cell projection organization 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0034097 response to cytokine 22.2222 4 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0043405 regulation of MAP kinase activity 22.2222 8 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0045596 negative regulation of cell differentiation 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0050768 negative regulation of neurogenesis 22.2222 6 no
GO:0050771 negative regulation of axonogenesis 22.2222 6 no
GO:0050808 synapse organization 22.2222 5 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051961 negative regulation of nervous system development 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0071345 cellular response to cytokine stimulus 22.2222 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.2222 7 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 22.2222 5 no
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 22.2222 6 no
GO:0090287 regulation of cellular response to growth factor stimulus 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:0015031 protein transport 22.2222 4 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0007612 learning 22.2222 4 no
GO:0008306 associative learning 22.2222 5 no
GO:0008542 visual learning 22.2222 4 no
GO:0009416 response to light stimulus 22.2222 4 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:0007010 cytoskeleton organization 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA4_HUMAN [view entry] [view interactions] Low throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
KRA59_HUMAN [view interactions] High throughput no no
DVL3_HUMAN [view interactions] High throughput no yes
PP16A_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
ZN696_HUMAN [view interactions] High throughput no no
LRP11_HUMAN [view interactions] High throughput no no
ZN664_HUMAN [view interactions] High throughput no no
TXD16_HUMAN [view interactions] High throughput no yes
RBP10_HUMAN [view interactions] High throughput no no
MAEA_HUMAN [view interactions] High throughput no yes
CNTP3_HUMAN [view interactions] High throughput no yes
GDF11_HUMAN [view interactions] High throughput no yes
RMD5A_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CHLE_HUMAN [view interactions] High throughput no no
ARMC8_HUMAN [view interactions] High throughput no yes
PGLT1_HUMAN [view interactions] High throughput no no
GCNT1_HUMAN [view interactions] High throughput no yes
ARSK_HUMAN [view interactions] High throughput no no
WDR26_HUMAN [view interactions] High throughput no yes
TGFB2_HUMAN [view interactions] High throughput no no
TGFB1_HUMAN [view interactions] High throughput no no
ERO1B_HUMAN [view interactions] High throughput no yes
INHBE_HUMAN [view interactions] High throughput no no
ZN101_HUMAN [view interactions] High throughput no no
PCSK5_HUMAN [view interactions] High throughput no yes
MKLN1_HUMAN [view entry] [view interactions] High throughput yes yes
TIMP3_HUMAN [view interactions] High throughput no no
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
GLT18_HUMAN [view interactions] High throughput no yes
SULF1_HUMAN [view interactions] High throughput no no
PXDN_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
NXPH4_HUMAN [view interactions] High throughput no no
UGGG2_HUMAN [view interactions] High throughput no no
BGLR_HUMAN [view interactions] High throughput no yes
PLCA_HUMAN [view interactions] High throughput no yes
ADAM9_HUMAN [view interactions] High throughput no no
PCSK6_HUMAN [view interactions] High throughput no yes
SE1L3_HUMAN [view interactions] High throughput no yes
CTL1_HUMAN [view interactions] High throughput no no
METRN_HUMAN [view interactions] High throughput no yes
MA2A2_HUMAN [view interactions] High throughput no no
I17RA_HUMAN [view interactions] High throughput no yes
GID8_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
CHSTE_HUMAN [view interactions] High throughput no no
CHPF2_HUMAN [view interactions] High throughput no yes
ATS7_HUMAN [view interactions] High throughput no no
MGRN1_HUMAN [view interactions] High throughput no yes
ALG11_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
PLXA1_HUMAN [view entry] [view interactions] High throughput yes yes
PMGT2_HUMAN [view interactions] High throughput no yes
GT253_HUMAN [view interactions] High throughput no yes
CHRD_HUMAN [view interactions] High throughput no no
PLGT2_HUMAN [view interactions] High throughput no no
NOE2_HUMAN [view entry] [view interactions] High throughput yes yes
GID4_HUMAN [view interactions] High throughput no yes