NOE2_HUMAN
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed). Plays a role in AMPAR complex organization . Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
No data found.
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NOE2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 26.6667 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
GO:0045595 | regulation of cell differentiation | 20.0000 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 20.0000 | 5 | yes |
GO:0046903 | secretion | 20.0000 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 20.0000 | 4 | yes |
GO:0008104 | protein localization | 13.3333 | 4 | yes |
GO:0009306 | protein secretion | 13.3333 | 4 | yes |
GO:0015031 | protein transport | 13.3333 | 4 | yes |
GO:0035592 | establishment of protein localization to extracellular region | 13.3333 | 4 | yes |
GO:0071692 | protein localization to extracellular region | 13.3333 | 5 | yes |
GO:0071702 | organic substance transport | 13.3333 | 4 | yes |
GO:0071705 | nitrogen compound transport | 13.3333 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
NSE4A_HUMAN | [view interactions] | High throughput | no | yes |
SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
CXCL5_HUMAN | [view interactions] | High throughput | no | yes |
GLHA_HUMAN | [view interactions] | High throughput | no | no |
FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGLL5_HUMAN | [view interactions] | High throughput | no | no |
HDBP1_HUMAN | [view interactions] | High throughput | no | no |
GIP_HUMAN | [view interactions] | High throughput | no | no |
BTNL2_HUMAN | [view interactions] | High throughput | no | no |
GGH_HUMAN | [view interactions] | High throughput | no | yes |
FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
CA054_HUMAN | [view interactions] | High throughput | no | yes |
PPBI_HUMAN | [view interactions] | High throughput | no | no |
MFAP4_HUMAN | [view interactions] | High throughput | no | no |
SG1D1_HUMAN | [view interactions] | High throughput | no | no |
BOC_HUMAN | [view interactions] | High throughput | no | yes |
HLAG_HUMAN | [view interactions] | High throughput | no | no |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
EDN3_HUMAN | [view interactions] | High throughput | no | no |
PAEP_HUMAN | [view interactions] | High throughput | no | no |
CBLN4_HUMAN | [view interactions] | High throughput | no | no |
C4BPB_HUMAN | [view interactions] | High throughput | no | no |
NXPH3_HUMAN | [view interactions] | High throughput | no | no |
CGRE1_HUMAN | [view interactions] | High throughput | no | no |
ATS4_HUMAN | [view interactions] | High throughput | no | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
PRG2_HUMAN | [view interactions] | High throughput | no | no |
UD110_HUMAN | [view interactions] | High throughput | no | no |
CST11_HUMAN | [view interactions] | High throughput | no | no |
ISLR_HUMAN | [view interactions] | High throughput | no | no |
ATS12_HUMAN | [view interactions] | High throughput | no | no |
C1QB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IL5RA_HUMAN | [view interactions] | High throughput | no | no |
IDS_HUMAN | [view interactions] | High throughput | no | yes |
CFC1_HUMAN | [view interactions] | High throughput | no | no |
CAH6_HUMAN | [view interactions] | High throughput | no | no |
ESPB1_HUMAN | [view interactions] | High throughput | no | no |
TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
SLUR1_HUMAN | [view interactions] | High throughput | no | no |
TMM25_HUMAN | [view interactions] | High throughput | no | yes |
KLK1_HUMAN | [view interactions] | High throughput | no | yes |
NCTR3_HUMAN | [view interactions] | High throughput | no | no |
LY6H_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
LY86_HUMAN | [view interactions] | High throughput | no | no |
GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
CNEP1_HUMAN | [view interactions] | High throughput | no | yes |
BMP7_HUMAN | [view interactions] | High throughput | no | no |
GALNS_HUMAN | [view interactions] | High throughput | no | yes |
PEX6_HUMAN | [view interactions] | High throughput | no | yes |
LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
MTA70_HUMAN | [view interactions] | High throughput | no | no |
ZN507_HUMAN | [view interactions] | High throughput | no | no |
VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBB1_HUMAN | [view interactions] | High throughput | no | yes |
SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
EGFL7_HUMAN | [view interactions] | High throughput | no | yes |
FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
NOE1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NT2NC_HUMAN | [view interactions] | High throughput | no | no |
KRA13_HUMAN | [view interactions] | High throughput | no | no |
SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
F10A1_HUMAN | [view interactions] | High throughput | no | yes |
FANCF_HUMAN | [view interactions] | High throughput | no | no |
GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NBAS_HUMAN | [view interactions] | High throughput | no | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
ROBO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF1_HUMAN | [view interactions] | High throughput | no | no |
RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KR103_HUMAN | [view interactions] | High throughput | no | no |
NT2NA_HUMAN | [view interactions] | High throughput | no | no |
ZFHX4_HUMAN | [view interactions] | High throughput | no | yes |
BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
NOE3_HUMAN | [view interactions] | High throughput | no | no |
KDM5C_HUMAN | [view interactions] | High throughput | no | no |
MSTO1_HUMAN | [view interactions] | High throughput | no | yes |
ZSWM8_HUMAN | [view interactions] | High throughput | no | yes |
DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CO039_HUMAN | [view interactions] | High throughput | no | yes |
FUT11_HUMAN | [view interactions] | High throughput | no | yes |
BANP_HUMAN | [view interactions] | High throughput | no | yes |
UBP54_HUMAN | [view interactions] | High throughput | no | yes |
N42L2_HUMAN | [view interactions] | High throughput | no | yes |
HAUS8_HUMAN | [view interactions] | High throughput | no | yes |