NOE2_HUMAN
Evidence for PS localization
Functions
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed). Plays a role in AMPAR complex organization . Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NOE2_HUMAN |
|---|---|---|---|---|
| GO:0001540 | amyloid-beta binding | 31.2500 | 4 | no |
| GO:0004970 | ionotropic glutamate receptor activity | 25.0000 | 5 | no |
| GO:0004971 | AMPA glutamate receptor activity | 25.0000 | 6 | no |
| GO:0005216 | ion channel activity | 25.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 25.0000 | 6 | no |
| GO:0005261 | cation channel activity | 25.0000 | 5 | no |
| GO:0008066 | glutamate receptor activity | 25.0000 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0015267 | channel activity | 25.0000 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 25.0000 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 25.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 25.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 25.0000 | 4 | no |
| GO:0022836 | gated channel activity | 25.0000 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 25.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NOE2_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0046903 | secretion | 18.7500 | 4 | yes |
| GO:0008104 | protein localization | 12.5000 | 4 | yes |
| GO:0009306 | protein secretion | 12.5000 | 4 | yes |
| GO:0015031 | protein transport | 12.5000 | 4 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 12.5000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 12.5000 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 12.5000 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 12.5000 | 4 | yes |
| GO:0071692 | protein localization to extracellular region | 12.5000 | 5 | yes |
| GO:0071702 | organic substance transport | 12.5000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 12.5000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| ROBO2_HUMAN | [view interactions] | High throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1_HUMAN | [view interactions] | High throughput | no | no |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| ZFHX4_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| NOE3_HUMAN | [view interactions] | High throughput | no | no |
| KDM5C_HUMAN | [view interactions] | High throughput | no | no |
| MSTO1_HUMAN | [view interactions] | High throughput | no | yes |
| ZSWM8_HUMAN | [view interactions] | High throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CO039_HUMAN | [view interactions] | High throughput | no | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| N42L2_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS8_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| NSE4A_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CXCL5_HUMAN | [view interactions] | High throughput | no | yes |
| GLHA_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGLL5_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| GIP_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| PPBI_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| BOC_HUMAN | [view interactions] | High throughput | no | yes |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| EDN3_HUMAN | [view interactions] | High throughput | no | no |
| PAEP_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| NXPH3_HUMAN | [view interactions] | High throughput | no | no |
| CGRE1_HUMAN | [view interactions] | High throughput | no | no |
| ATS4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| UD110_HUMAN | [view interactions] | High throughput | no | no |
| CST11_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| ATS12_HUMAN | [view interactions] | High throughput | no | no |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| CFC1_HUMAN | [view interactions] | High throughput | no | no |
| CAH6_HUMAN | [view interactions] | High throughput | no | no |
| ESPB1_HUMAN | [view interactions] | High throughput | no | no |
| TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| KLK1_HUMAN | [view interactions] | High throughput | no | yes |
| NCTR3_HUMAN | [view interactions] | High throughput | no | no |
| LY6H_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
| FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL7_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| TBB1_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN507_HUMAN | [view interactions] | High throughput | no | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX6_HUMAN | [view interactions] | High throughput | no | yes |
| GALNS_HUMAN | [view interactions] | High throughput | no | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| CNEP1_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOE1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NT2NC_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| FANCF_HUMAN | [view interactions] | High throughput | no | no |
| CNIH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |