Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NOE2_HUMAN

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed). Plays a role in AMPAR complex organization . Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

No data found.

Biological process

Term Name % Distance from top the of the tree Annotated in NOE2_HUMAN
GO:0048522 positive regulation of cellular process 40.0000 4 yes
GO:0048523 negative regulation of cellular process 40.0000 4 no
GO:0010646 regulation of cell communication 26.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 26.6667 4 no
GO:0045595 regulation of cell differentiation 20.0000 4 yes
GO:0045597 positive regulation of cell differentiation 20.0000 5 yes
GO:0046903 secretion 20.0000 4 yes
GO:0051094 positive regulation of developmental process 20.0000 4 yes
GO:0008104 protein localization 13.3333 4 yes
GO:0009306 protein secretion 13.3333 4 yes
GO:0015031 protein transport 13.3333 4 yes
GO:0035592 establishment of protein localization to extracellular region 13.3333 4 yes
GO:0071692 protein localization to extracellular region 13.3333 5 yes
GO:0071702 organic substance transport 13.3333 4 yes
GO:0071705 nitrogen compound transport 13.3333 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HNRPL_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
NSE4A_HUMAN [view interactions] High throughput no yes
SHKB1_HUMAN [view interactions] High throughput no yes
CXCL5_HUMAN [view interactions] High throughput no yes
GLHA_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
IGLL5_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
GIP_HUMAN [view interactions] High throughput no no
BTNL2_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
FIBIN_HUMAN [view interactions] High throughput no yes
CA054_HUMAN [view interactions] High throughput no yes
PPBI_HUMAN [view interactions] High throughput no no
MFAP4_HUMAN [view interactions] High throughput no no
SG1D1_HUMAN [view interactions] High throughput no no
BOC_HUMAN [view interactions] High throughput no yes
HLAG_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
EDN3_HUMAN [view interactions] High throughput no no
PAEP_HUMAN [view interactions] High throughput no no
CBLN4_HUMAN [view interactions] High throughput no no
C4BPB_HUMAN [view interactions] High throughput no no
NXPH3_HUMAN [view interactions] High throughput no no
CGRE1_HUMAN [view interactions] High throughput no no
ATS4_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
PRG2_HUMAN [view interactions] High throughput no no
UD110_HUMAN [view interactions] High throughput no no
CST11_HUMAN [view interactions] High throughput no no
ISLR_HUMAN [view interactions] High throughput no no
ATS12_HUMAN [view interactions] High throughput no no
C1QB_HUMAN [view entry] [view interactions] High throughput yes no
IL5RA_HUMAN [view interactions] High throughput no no
IDS_HUMAN [view interactions] High throughput no yes
CFC1_HUMAN [view interactions] High throughput no no
CAH6_HUMAN [view interactions] High throughput no no
ESPB1_HUMAN [view interactions] High throughput no no
TM2D3_HUMAN [view interactions] High throughput no yes
SLUR1_HUMAN [view interactions] High throughput no no
TMM25_HUMAN [view interactions] High throughput no yes
KLK1_HUMAN [view interactions] High throughput no yes
NCTR3_HUMAN [view interactions] High throughput no no
LY6H_HUMAN [view entry] [view interactions] High throughput yes no
DNSL1_HUMAN [view interactions] High throughput no yes
LY86_HUMAN [view interactions] High throughput no no
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
BL1S6_HUMAN [view interactions] High throughput no yes
DPYL4_HUMAN [view entry] [view interactions] High throughput yes yes
DVL2_HUMAN [view interactions] High throughput no yes
NCOR1_HUMAN [view interactions] High throughput no yes
CNEP1_HUMAN [view interactions] High throughput no yes
BMP7_HUMAN [view interactions] High throughput no no
GALNS_HUMAN [view interactions] High throughput no yes
PEX6_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
ZN507_HUMAN [view interactions] High throughput no no
VCIP1_HUMAN [view entry] [view interactions] High throughput yes no
TBB1_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
DNJB9_HUMAN [view interactions] High throughput no yes
EGFL7_HUMAN [view interactions] High throughput no yes
FEM1B_HUMAN [view interactions] High throughput no yes
GPTC8_HUMAN [view interactions] High throughput no yes
CBY1_HUMAN [view interactions] High throughput no no
NOE1_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
NT2NC_HUMAN [view interactions] High throughput no no
KRA13_HUMAN [view interactions] High throughput no no
SRSF5_HUMAN [view interactions] High throughput no yes
F10A1_HUMAN [view interactions] High throughput no yes
FANCF_HUMAN [view interactions] High throughput no no
GNB5_HUMAN [view entry] [view interactions] High throughput yes yes
NBAS_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
ROBO2_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
EIF1_HUMAN [view interactions] High throughput no no
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
KR103_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
ZFHX4_HUMAN [view interactions] High throughput no yes
BRE1B_HUMAN [view interactions] High throughput no yes
NOE3_HUMAN [view interactions] High throughput no no
KDM5C_HUMAN [view interactions] High throughput no no
MSTO1_HUMAN [view interactions] High throughput no yes
ZSWM8_HUMAN [view interactions] High throughput no yes
DTNB_HUMAN [view entry] [view interactions] High throughput yes no
CO039_HUMAN [view interactions] High throughput no yes
FUT11_HUMAN [view interactions] High throughput no yes
BANP_HUMAN [view interactions] High throughput no yes
UBP54_HUMAN [view interactions] High throughput no yes
N42L2_HUMAN [view interactions] High throughput no yes
HAUS8_HUMAN [view interactions] High throughput no yes