VCIP1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VCIP1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 39.3939 | 4 | no |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 30.3030 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 30.3030 | 4 | no |
| GO:0005524 | ATP binding | 24.2424 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.2424 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.2424 | 5 | no |
| GO:0043169 | cation binding | 24.2424 | 4 | no |
| GO:0046872 | metal ion binding | 24.2424 | 5 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.2121 | 6 | no |
| GO:0003723 | RNA binding | 21.2121 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.2121 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.2121 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VCIP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | no |
| GO:0008104 | protein localization | 48.4848 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | no |
| GO:0006996 | organelle organization | 42.4242 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.3939 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.3939 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.3030 | 5 | no |
| GO:0032880 | regulation of protein localization | 30.3030 | 5 | yes |
| GO:0036211 | protein modification process | 30.3030 | 4 | yes |
| GO:0043412 | macromolecule modification | 30.3030 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 30.3030 | 4 | yes |
| GO:0015031 | protein transport | 30.3030 | 4 | no |
| GO:0071702 | organic substance transport | 30.3030 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.3030 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.3030 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.3030 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.3030 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.2727 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.2727 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.2727 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.2727 | 4 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0006508 | proteolysis | 24.2424 | 4 | yes |
| GO:0006886 | intracellular protein transport | 24.2424 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.2424 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 24.2424 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.2424 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 24.2424 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.2424 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.2424 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 24.2424 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.2424 | 5 | no |
| GO:0051726 | regulation of cell cycle | 21.2121 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0016567 | protein ubiquitination | 21.2121 | 8 | yes |
| GO:0032446 | protein modification by small protein conjugation | 21.2121 | 7 | yes |
| GO:0043687 | post-translational protein modification | 21.2121 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 21.2121 | 6 | yes |
| GO:0009057 | macromolecule catabolic process | 21.2121 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.2121 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.2121 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.2121 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.2121 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.2121 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 21.2121 | 5 | no |
| GO:0061024 | membrane organization | 18.1818 | 4 | yes |
| GO:0006974 | DNA damage response | 15.1515 | 4 | yes |
| GO:0048284 | organelle fusion | 12.1212 | 5 | yes |
| GO:0061025 | membrane fusion | 12.1212 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 12.1212 | 4 | yes |
| GO:0006259 | DNA metabolic process | 9.0909 | 5 | yes |
| GO:0006281 | DNA repair | 9.0909 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 9.0909 | 6 | yes |
| GO:0007029 | endoplasmic reticulum organization | 6.0606 | 5 | yes |
| GO:0007030 | Golgi organization | 6.0606 | 5 | yes |
| GO:0106300 | protein-DNA covalent cross-linking repair | 6.0606 | 6 | yes |
| GO:1905634 | regulation of protein localization to chromatin | 6.0606 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NSF1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTT3_HUMAN | [view interactions] | Low throughput | no | no |
| WAC_HUMAN | [view interactions] | Low throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | Low throughput | no | yes |
| STX5_HUMAN | [view interactions] | Low throughput | no | yes |
| METK2_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCSD2_HUMAN | [view interactions] | High throughput | no | no |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
| UBX11_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| SVIP_HUMAN | [view interactions] | High throughput | no | yes |
| UBX2A_HUMAN | [view interactions] | High throughput | no | no |
| MRP9_HUMAN | [view interactions] | High throughput | no | no |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| UBX2B_HUMAN | [view interactions] | High throughput | no | no |
| KI20B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| ANM2_HUMAN | [view interactions] | High throughput | no | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAF1_HUMAN | [view interactions] | High throughput | no | no |
| TTLL1_HUMAN | [view interactions] | High throughput | no | yes |
| DND1_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR3_HUMAN | [view interactions] | High throughput | no | yes |
| PLAT5_HUMAN | [view interactions] | High throughput | no | no |
| NR0B2_HUMAN | [view interactions] | High throughput | no | no |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| RAB30_HUMAN | [view interactions] | High throughput | no | yes |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| ZSWM7_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| FIGL1_HUMAN | [view interactions] | High throughput | no | yes |
| AT131_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD20B_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FANCA_HUMAN | [view interactions] | High throughput | no | no |
| DDX11_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD4_HUMAN | [view interactions] | High throughput | no | no |
| SEN15_HUMAN | [view interactions] | High throughput | no | yes |
| DCC1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| APC5_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| KDM5C_HUMAN | [view interactions] | High throughput | no | no |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| DGKG_HUMAN | [view interactions] | High throughput | no | no |
| USP9Y_HUMAN | [view interactions] | High throughput | no | no |
| ZN318_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| N42L2_HUMAN | [view interactions] | High throughput | no | yes |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PX11A_HUMAN | [view interactions] | High throughput | no | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLBL1_HUMAN | [view interactions] | High throughput | no | no |
| NT5C_HUMAN | [view interactions] | High throughput | no | yes |
| SNX24_HUMAN | [view interactions] | High throughput | no | yes |
| IKBB_HUMAN | [view interactions] | High throughput | no | no |
| FA12_HUMAN | [view interactions] | High throughput | no | no |
| EID3_HUMAN | [view interactions] | High throughput | no | no |
| MCL1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| KCD14_HUMAN | [view interactions] | High throughput | no | no |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| ARL4D_HUMAN | [view interactions] | High throughput | no | no |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |