VCIP1_HUMAN
(Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in VCIP1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 32.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 24.0000 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in VCIP1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.0000 | 4 | no |
GO:0022607 | cellular component assembly | 44.0000 | 4 | yes |
GO:0008104 | protein localization | 44.0000 | 4 | no |
GO:0006996 | organelle organization | 36.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 32.0000 | 5 | yes |
GO:0060341 | regulation of cellular localization | 32.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 32.0000 | 4 | no |
GO:0036211 | protein modification process | 28.0000 | 4 | yes |
GO:0043412 | macromolecule modification | 28.0000 | 4 | yes |
GO:0051049 | regulation of transport | 28.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 28.0000 | 4 | no |
GO:0015031 | protein transport | 28.0000 | 4 | no |
GO:0071702 | organic substance transport | 28.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 28.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 28.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 28.0000 | 4 | no |
GO:0006508 | proteolysis | 24.0000 | 4 | yes |
GO:0043933 | protein-containing complex organization | 24.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 24.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 24.0000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0000 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 24.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 24.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 24.0000 | 4 | no |
GO:0016567 | protein ubiquitination | 20.0000 | 7 | yes |
GO:0032446 | protein modification by small protein conjugation | 20.0000 | 6 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 20.0000 | 5 | yes |
GO:0048284 | organelle fusion | 12.0000 | 5 | yes |
GO:0061024 | membrane organization | 12.0000 | 4 | yes |
GO:0006259 | DNA metabolic process | 8.0000 | 4 | yes |
GO:0006281 | DNA repair | 8.0000 | 5 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 8.0000 | 4 | yes |
GO:0007030 | Golgi organization | 8.0000 | 5 | yes |
GO:0061025 | membrane fusion | 8.0000 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 8.0000 | 4 | yes |
GO:0106300 | protein-DNA covalent cross-linking repair | 8.0000 | 6 | yes |
GO:1905634 | regulation of protein localization to chromatin | 8.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NSF1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTT3_HUMAN | [view interactions] | Low throughput | no | no |
WAC_HUMAN | [view interactions] | Low throughput | no | yes |
SPRTN_HUMAN | [view interactions] | Low throughput | no | yes |
STX5_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FCSD2_HUMAN | [view interactions] | High throughput | no | no |
GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
FAF1_HUMAN | [view interactions] | High throughput | no | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
UBXN1_HUMAN | [view interactions] | High throughput | no | no |
UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
UBX11_HUMAN | [view interactions] | High throughput | no | yes |
UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPL4_HUMAN | [view interactions] | High throughput | no | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
UBX2B_HUMAN | [view interactions] | High throughput | no | no |
UFD1_HUMAN | [view interactions] | High throughput | no | no |
MRP9_HUMAN | [view interactions] | High throughput | no | no |
UBX2A_HUMAN | [view interactions] | High throughput | no | no |
SVIP_HUMAN | [view interactions] | High throughput | no | yes |
KI20B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LG3BP_HUMAN | [view interactions] | High throughput | no | no |
K2013_HUMAN | [view interactions] | High throughput | no | yes |
CE162_HUMAN | [view interactions] | High throughput | no | yes |
NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
ANM2_HUMAN | [view interactions] | High throughput | no | yes |
NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAF1_HUMAN | [view interactions] | High throughput | no | no |
TTLL1_HUMAN | [view interactions] | High throughput | no | yes |
DND1_HUMAN | [view interactions] | High throughput | no | no |
GAN_HUMAN | [view interactions] | High throughput | no | yes |
CNKR3_HUMAN | [view interactions] | High throughput | no | yes |
PLAT5_HUMAN | [view interactions] | High throughput | no | no |
NR0B2_HUMAN | [view interactions] | High throughput | no | no |
RAB38_HUMAN | [view interactions] | High throughput | no | no |
RAB30_HUMAN | [view interactions] | High throughput | no | yes |
RAB32_HUMAN | [view interactions] | High throughput | no | yes |
STIL_HUMAN | [view interactions] | High throughput | no | no |
CENPJ_HUMAN | [view interactions] | High throughput | no | no |
ADIP_HUMAN | [view interactions] | High throughput | no | yes |
MED23_HUMAN | [view interactions] | High throughput | no | no |
ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
ALMS1_HUMAN | [view interactions] | High throughput | no | no |
CCHCR_HUMAN | [view interactions] | High throughput | no | no |
UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
FIGL1_HUMAN | [view interactions] | High throughput | no | yes |
AT131_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CD20B_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
CBAR1_HUMAN | [view interactions] | High throughput | no | no |
TTC23_HUMAN | [view interactions] | High throughput | no | yes |
TEDC2_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
MDM2_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
TP4A3_HUMAN | [view interactions] | High throughput | no | no |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
FANCA_HUMAN | [view interactions] | High throughput | no | no |
DDX11_HUMAN | [view interactions] | High throughput | no | yes |
SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
JMJD4_HUMAN | [view interactions] | High throughput | no | no |
SEN15_HUMAN | [view interactions] | High throughput | no | yes |
DCC1_HUMAN | [view interactions] | High throughput | no | yes |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
APC5_HUMAN | [view interactions] | High throughput | no | yes |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
KDM5C_HUMAN | [view interactions] | High throughput | no | no |
S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
KRT38_HUMAN | [view interactions] | High throughput | no | no |
KRT37_HUMAN | [view interactions] | High throughput | no | no |
DGKG_HUMAN | [view interactions] | High throughput | no | no |
USP9Y_HUMAN | [view interactions] | High throughput | no | no |
ZN318_HUMAN | [view interactions] | High throughput | no | yes |
DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
CLH2_HUMAN | [view interactions] | High throughput | no | no |
VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
N42L2_HUMAN | [view interactions] | High throughput | no | yes |
PLD2_HUMAN | [view interactions] | High throughput | no | yes |
INSRR_HUMAN | [view interactions] | High throughput | no | no |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF41_HUMAN | [view interactions] | High throughput | no | yes |
TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PX11A_HUMAN | [view interactions] | High throughput | no | no |
D2HDH_HUMAN | [view interactions] | High throughput | no | no |
RFXK_HUMAN | [view interactions] | High throughput | no | yes |
DYR_HUMAN | [view interactions] | High throughput | no | yes |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLBL1_HUMAN | [view interactions] | High throughput | no | no |
NT5C_HUMAN | [view interactions] | High throughput | no | yes |
SNX24_HUMAN | [view interactions] | High throughput | no | yes |
IKBB_HUMAN | [view interactions] | High throughput | no | no |
FA12_HUMAN | [view interactions] | High throughput | no | no |
EID3_HUMAN | [view interactions] | High throughput | no | no |
MCL1_HUMAN | [view interactions] | High throughput | no | yes |
DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
KCD14_HUMAN | [view interactions] | High throughput | no | no |
PPARD_HUMAN | [view interactions] | High throughput | no | yes |
ARL4D_HUMAN | [view interactions] | High throughput | no | no |
NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
NPAS1_HUMAN | [view interactions] | High throughput | no | no |
UBP32_HUMAN | [view interactions] | High throughput | no | yes |
GGH_HUMAN | [view interactions] | High throughput | no | yes |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
PSG11_HUMAN | [view interactions] | High throughput | no | no |
SLN11_HUMAN | [view interactions] | High throughput | no | yes |
KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
PLAP_HUMAN | [view interactions] | High throughput | no | yes |
FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
RFFL_HUMAN | [view interactions] | High throughput | no | yes |
BICD1_HUMAN | [view interactions] | High throughput | no | yes |
NIN_HUMAN | [view interactions] | High throughput | no | no |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
EDC3_HUMAN | [view interactions] | High throughput | no | yes |
MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PXMP2_HUMAN | [view interactions] | High throughput | no | no |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
CDK1_HUMAN | [view interactions] | Computational | no | no |