KI20B_HUMAN
Evidence for PS localization
Functions
Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed, PubMed). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth . Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002307 | DOC_WW_Pin1_4 | DOC | 1601 | 1606 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KI20B_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 36.8421 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 36.8421 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.8421 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.8421 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 36.8421 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.8421 | 4 | yes |
| GO:0019900 | kinase binding | 26.3158 | 4 | no |
| GO:0019901 | protein kinase binding | 26.3158 | 5 | no |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0046872 | metal ion binding | 21.0526 | 4 | no |
| GO:0008017 | microtubule binding | 21.0526 | 5 | yes |
| GO:0015631 | tubulin binding | 21.0526 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 15.7895 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.7895 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 15.7895 | 7 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.7895 | 6 | yes |
| GO:0042803 | protein homodimerization activity | 10.5263 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KI20B_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 57.8947 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 57.8947 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.6316 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.6316 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
| GO:0008104 | protein localization | 42.1053 | 4 | yes |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.1053 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.8421 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 36.8421 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 36.8421 | 5 | no |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0071702 | organic substance transport | 36.8421 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.8421 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.8421 | 5 | no |
| GO:0007346 | regulation of mitotic cell cycle | 31.5789 | 5 | yes |
| GO:0010564 | regulation of cell cycle process | 31.5789 | 5 | yes |
| GO:0015031 | protein transport | 31.5789 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.5789 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.5789 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.5789 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5789 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.5789 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.5789 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.3158 | 5 | yes |
| GO:0033365 | protein localization to organelle | 26.3158 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 26.3158 | 4 | yes |
| GO:0006886 | intracellular protein transport | 26.3158 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 26.3158 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 26.3158 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.3158 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.3158 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.3158 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.3158 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.3158 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.3158 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.3158 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.0526 | 5 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 21.0526 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.0526 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.0526 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
| GO:1901987 | regulation of cell cycle phase transition | 21.0526 | 6 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.0526 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.0526 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0007088 | regulation of mitotic nuclear division | 15.7895 | 6 | yes |
| GO:0030030 | cell projection organization | 15.7895 | 4 | yes |
| GO:0032465 | regulation of cytokinesis | 15.7895 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 15.7895 | 4 | yes |
| GO:0045787 | positive regulation of cell cycle | 15.7895 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 15.7895 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 15.7895 | 5 | yes |
| GO:0051049 | regulation of transport | 15.7895 | 4 | yes |
| GO:0051223 | regulation of protein transport | 15.7895 | 5 | yes |
| GO:0051302 | regulation of cell division | 15.7895 | 4 | yes |
| GO:0051783 | regulation of nuclear division | 15.7895 | 6 | yes |
| GO:0070201 | regulation of establishment of protein localization | 15.7895 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 15.7895 | 6 | yes |
| GO:0032386 | regulation of intracellular transport | 10.5263 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 10.5263 | 6 | yes |
| GO:0044380 | protein localization to cytoskeleton | 10.5263 | 6 | yes |
| GO:0051050 | positive regulation of transport | 10.5263 | 4 | yes |
| GO:0051222 | positive regulation of protein transport | 10.5263 | 5 | yes |
| GO:0072698 | protein localization to microtubule cytoskeleton | 10.5263 | 7 | yes |
| GO:0090068 | positive regulation of cell cycle process | 10.5263 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 10.5263 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 10.5263 | 6 | yes |
| GO:2000145 | regulation of cell motility | 10.5263 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB10B_HUMAN | [view interactions] | High throughput | no | no |
| ICE1_HUMAN | [view interactions] | High throughput | no | yes |
| TDIF2_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| DNLI3_HUMAN | [view interactions] | High throughput | no | yes |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| YJU2_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S38A2_HUMAN | [view interactions] | High throughput | no | yes |
| ASTE1_HUMAN | [view interactions] | High throughput | no | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CA052_HUMAN | [view interactions] | High throughput | no | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| KDM2A_HUMAN | [view interactions] | High throughput | no | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CBX6_HUMAN | [view interactions] | High throughput | no | yes |
| CBX8_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| NDE1_HUMAN | [view interactions] | High throughput | no | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| CCD89_HUMAN | [view interactions] | High throughput | no | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAD3_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ID2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX38_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| H2AJ_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRA_HUMAN | [view interactions] | High throughput | no | yes |
| CP141_HUMAN | [view interactions] | High throughput | no | no |
| EMB_HUMAN | [view interactions] | High throughput | no | no |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| SERF2_HUMAN | [view interactions] | High throughput | no | no |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN5_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| DGKZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTHD4_HUMAN | [view interactions] | High throughput | no | no |
| RTL9_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| TOPZ1_HUMAN | [view interactions] | High throughput | no | no |
| YTDC2_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM4_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3A_HUMAN | [view interactions] | High throughput | no | no |
| ULK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| TTK_HUMAN | [view interactions] | Computational | no | yes |
| ASPM_HUMAN | [view interactions] | Computational | no | no |
| KIF4A_HUMAN | [view interactions] | Computational | no | yes |
| KIF15_HUMAN | [view interactions] | Computational | no | no |
| KIF2C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KI18A_HUMAN | [view interactions] | Computational | no | yes |
| CCNB1_HUMAN | [view interactions] | Computational | no | no |
| KIF11_HUMAN | [view interactions] | Computational | no | yes |
| KI20A_HUMAN | [view interactions] | Computational | no | yes |
| CND3_HUMAN | [view interactions] | Computational | no | yes |
| RGAP1_HUMAN | [view interactions] | Computational | no | no |
| BUB1_HUMAN | [view interactions] | Computational | no | no |
| SMC2_HUMAN | [view interactions] | Computational | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCNB2_HUMAN | [view interactions] | Computational | no | yes |
| CENPE_HUMAN | [view interactions] | Computational | no | no |
| CCNA2_HUMAN | [view interactions] | Computational | no | no |
| DEP1A_HUMAN | [view interactions] | Computational | no | yes |
| BUB1B_HUMAN | [view interactions] | Computational | no | no |
| CDK1_HUMAN | [view interactions] | Computational | no | no |