KI20B_HUMAN
Evidence for PS localization
Functions
Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed, PubMed). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth . Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002307 | DOC_WW_Pin1_4 | DOC | 1601 | 1606 | - |
| ELMI002307 | DOC_WW_Pin1_4 | DOC | 1601 | 1606 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KI20B_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 26.3158 | 4 | yes |
| GO:0005524 | ATP binding | 26.3158 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 26.3158 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.3158 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 26.3158 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.3158 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.3158 | 4 | yes |
| GO:0043168 | anion binding | 26.3158 | 4 | yes |
| GO:0043169 | cation binding | 26.3158 | 4 | no |
| GO:0046872 | metal ion binding | 26.3158 | 5 | no |
| GO:0008017 | microtubule binding | 21.0526 | 5 | yes |
| GO:0015631 | tubulin binding | 21.0526 | 4 | yes |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0019900 | kinase binding | 21.0526 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 10.5263 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 10.5263 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 10.5263 | 7 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 10.5263 | 6 | yes |
| GO:0042803 | protein homodimerization activity | 10.5263 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KI20B_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 57.8947 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.6316 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.6316 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.6316 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.1053 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 42.1053 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 42.1053 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.1053 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.1053 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.1053 | 5 | no |
| GO:0008104 | protein localization | 36.8421 | 4 | yes |
| GO:0032880 | regulation of protein localization | 36.8421 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 36.8421 | 4 | yes |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.8421 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 36.8421 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.8421 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 36.8421 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 31.5789 | 5 | yes |
| GO:0030030 | cell projection organization | 31.5789 | 4 | yes |
| GO:0071702 | organic substance transport | 31.5789 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 31.5789 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 31.5789 | 5 | no |
| GO:0023057 | negative regulation of signaling | 31.5789 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.5789 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 31.5789 | 4 | no |
| GO:0006996 | organelle organization | 31.5789 | 4 | no |
| GO:0007346 | regulation of mitotic cell cycle | 26.3158 | 5 | yes |
| GO:0051049 | regulation of transport | 26.3158 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 26.3158 | 6 | yes |
| GO:0015031 | protein transport | 26.3158 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0071705 | nitrogen compound transport | 26.3158 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.3158 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 26.3158 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.3158 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.3158 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.3158 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.3158 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0007010 | cytoskeleton organization | 26.3158 | 5 | no |
| GO:0033365 | protein localization to organelle | 21.0526 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 21.0526 | 5 | yes |
| GO:0051223 | regulation of protein transport | 21.0526 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 21.0526 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 21.0526 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 21.0526 | 6 | yes |
| GO:0006886 | intracellular protein transport | 21.0526 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.0526 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 21.0526 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.0526 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.0526 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.0526 | 5 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 21.0526 | 6 | no |
| GO:1901987 | regulation of cell cycle phase transition | 21.0526 | 6 | no |
| GO:1902806 | regulation of cell cycle G1/S phase transition | 21.0526 | 7 | no |
| GO:0009894 | regulation of catabolic process | 21.0526 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0010975 | regulation of neuron projection development | 21.0526 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0033043 | regulation of organelle organization | 15.7895 | 5 | yes |
| GO:0051050 | positive regulation of transport | 15.7895 | 4 | yes |
| GO:0051222 | positive regulation of protein transport | 15.7895 | 5 | yes |
| GO:0007088 | regulation of mitotic nuclear division | 10.5263 | 6 | yes |
| GO:0032386 | regulation of intracellular transport | 10.5263 | 5 | yes |
| GO:0032465 | regulation of cytokinesis | 10.5263 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 10.5263 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 10.5263 | 4 | yes |
| GO:0045787 | positive regulation of cell cycle | 10.5263 | 5 | yes |
| GO:0051302 | regulation of cell division | 10.5263 | 4 | yes |
| GO:0051783 | regulation of nuclear division | 10.5263 | 6 | yes |
| GO:2000145 | regulation of cell motility | 10.5263 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KDM2A_HUMAN | [view interactions] | Low throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI3_HUMAN | [view interactions] | High throughput | no | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| TDIF2_HUMAN | [view interactions] | High throughput | no | yes |
| ICE1_HUMAN | [view interactions] | High throughput | no | yes |
| TB10B_HUMAN | [view interactions] | High throughput | no | no |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| CA052_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTE1_HUMAN | [view interactions] | High throughput | no | no |
| S38A2_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YJU2_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CBX6_HUMAN | [view interactions] | High throughput | no | yes |
| CBX8_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| NDE1_HUMAN | [view interactions] | High throughput | no | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| CCD89_HUMAN | [view interactions] | High throughput | no | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAD3_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ID2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX38_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| H2AJ_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRA_HUMAN | [view interactions] | High throughput | no | yes |
| CP141_HUMAN | [view interactions] | High throughput | no | no |
| EMB_HUMAN | [view interactions] | High throughput | no | no |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| SERF2_HUMAN | [view interactions] | High throughput | no | no |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| TBX5_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN5_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| DGKZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTHD4_HUMAN | [view interactions] | High throughput | no | no |
| RTL9_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| TOPZ1_HUMAN | [view interactions] | High throughput | no | no |
| YTDC2_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM4_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3A_HUMAN | [view interactions] | High throughput | no | no |
| ULK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA12_HUMAN | [view interactions] | High throughput | no | yes |
| NLE1_HUMAN | [view interactions] | High throughput | no | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |