Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DGKZ_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Does not regulate RASGRP1 activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DGKZ_HUMAN
GO:0016301 kinase activity 28.1250 4 yes
GO:0017076 purine nucleotide binding 28.1250 4 yes
GO:0032555 purine ribonucleotide binding 28.1250 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.1250 4 yes
GO:0019900 kinase binding 28.1250 4 no
GO:0005524 ATP binding 25.0000 5 yes
GO:0030554 adenyl nucleotide binding 25.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 25.0000 5 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.8750 4 yes
GO:0019901 protein kinase binding 21.8750 5 no
GO:0046872 metal ion binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DGKZ_HUMAN
GO:0048522 positive regulation of cellular process 68.7500 4 yes
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0080090 regulation of primary metabolic process 62.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 59.3750 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 59.3750 4 no
GO:0010646 regulation of cell communication 56.2500 4 yes
GO:0051246 regulation of protein metabolic process 53.1250 5 no
GO:0051049 regulation of transport 53.1250 4 no
GO:0051128 regulation of cellular component organization 53.1250 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.8750 5 no
GO:0031325 positive regulation of cellular metabolic process 43.7500 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 43.7500 5 no
GO:0019220 regulation of phosphate metabolic process 40.6250 6 yes
GO:0042325 regulation of phosphorylation 40.6250 7 yes
GO:0051174 regulation of phosphorus metabolic process 40.6250 5 yes
GO:0031399 regulation of protein modification process 40.6250 6 no
GO:0042127 regulation of cell population proliferation 40.6250 4 no
GO:0051247 positive regulation of protein metabolic process 40.6250 6 no
GO:0009892 negative regulation of metabolic process 40.6250 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.6250 5 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 34.3750 6 yes
GO:0010648 negative regulation of cell communication 34.3750 5 yes
GO:0023057 negative regulation of signaling 34.3750 4 yes
GO:0042327 positive regulation of phosphorylation 34.3750 8 yes
GO:0045937 positive regulation of phosphate metabolic process 34.3750 7 yes
GO:0048585 negative regulation of response to stimulus 34.3750 4 yes
GO:0050804 modulation of chemical synaptic transmission 34.3750 5 yes
GO:0051726 regulation of cell cycle 34.3750 4 yes
GO:0099177 regulation of trans-synaptic signaling 34.3750 4 yes
GO:0010647 positive regulation of cell communication 34.3750 5 no
GO:0023056 positive regulation of signaling 34.3750 4 no
GO:0031401 positive regulation of protein modification process 34.3750 7 no
GO:0008104 protein localization 34.3750 4 no
GO:0051050 positive regulation of transport 34.3750 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.3750 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.3750 5 no
GO:0006796 phosphate-containing compound metabolic process 31.2500 4 yes
GO:0009968 negative regulation of signal transduction 31.2500 5 yes
GO:0001934 positive regulation of protein phosphorylation 31.2500 8 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0033043 regulation of organelle organization 31.2500 5 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0042981 regulation of apoptotic process 31.2500 6 no
GO:0043067 regulation of programmed cell death 31.2500 5 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:1902531 regulation of intracellular signal transduction 31.2500 5 no
GO:0045595 regulation of cell differentiation 31.2500 4 no
GO:0022607 cellular component assembly 28.1250 4 no
GO:0036211 protein modification process 28.1250 4 no
GO:0043412 macromolecule modification 28.1250 4 no
GO:0008284 positive regulation of cell population proliferation 28.1250 5 no
GO:0060341 regulation of cellular localization 28.1250 4 no
GO:0006996 organelle organization 28.1250 4 no
GO:0043066 negative regulation of apoptotic process 28.1250 7 no
GO:0043069 negative regulation of programmed cell death 28.1250 6 no
GO:0060548 negative regulation of cell death 28.1250 5 no
GO:0009889 regulation of biosynthetic process 28.1250 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.1250 5 no
GO:0031326 regulation of cellular biosynthetic process 28.1250 5 no
GO:0051252 regulation of RNA metabolic process 28.1250 5 no
GO:0043408 regulation of MAPK cascade 28.1250 6 no
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0043085 positive regulation of catalytic activity 25.0000 4 yes
GO:0051338 regulation of transferase activity 25.0000 4 yes
GO:0051347 positive regulation of transferase activity 25.0000 5 yes
GO:0030334 regulation of cell migration 25.0000 5 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0016310 phosphorylation 21.8750 5 yes
GO:0043549 regulation of kinase activity 21.8750 5 yes
GO:0050776 regulation of immune response 21.8750 4 yes
GO:0008285 negative regulation of cell population proliferation 21.8750 5 no
GO:0051241 negative regulation of multicellular organismal process 21.8750 4 no
GO:0032386 regulation of intracellular transport 21.8750 5 no
GO:0016192 vesicle-mediated transport 21.8750 4 no
GO:0051129 negative regulation of cellular component organization 21.8750 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.8750 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.8750 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.8750 4 no
GO:0043269 regulation of ion transport 21.8750 5 no
GO:2000026 regulation of multicellular organismal development 21.8750 4 no
GO:0009891 positive regulation of biosynthetic process 21.8750 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.8750 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.8750 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.8750 6 no
GO:0002683 negative regulation of immune system process 18.7500 4 yes
GO:0033674 positive regulation of kinase activity 18.7500 6 yes
GO:0006644 phospholipid metabolic process 15.6250 4 yes
GO:0006650 glycerophospholipid metabolic process 15.6250 5 yes
GO:0007346 regulation of mitotic cell cycle 15.6250 5 yes
GO:0046486 glycerolipid metabolic process 15.6250 4 yes
GO:1901987 regulation of cell cycle phase transition 12.5000 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 12.5000 6 yes
GO:1902806 regulation of cell cycle G1/S phase transition 12.5000 7 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 12.5000 7 yes
GO:0008610 lipid biosynthetic process 9.3750 4 yes
GO:0008654 phospholipid biosynthetic process 9.3750 4 yes
GO:0010948 negative regulation of cell cycle process 9.3750 6 yes
GO:0045017 glycerolipid biosynthetic process 9.3750 4 yes
GO:0045786 negative regulation of cell cycle 9.3750 5 yes
GO:0045930 negative regulation of mitotic cell cycle 9.3750 6 yes
GO:0046474 glycerophospholipid biosynthetic process 9.3750 5 yes
GO:0090407 organophosphate biosynthetic process 9.3750 4 yes
GO:1901988 negative regulation of cell cycle phase transition 9.3750 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 9.3750 7 yes
GO:1902807 negative regulation of cell cycle G1/S phase transition 9.3750 8 yes
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 9.3750 8 yes
GO:0006974 cellular response to DNA damage stimulus 6.2500 4 yes
GO:0019216 regulation of lipid metabolic process 6.2500 5 yes
GO:0030258 lipid modification 6.2500 4 yes
GO:0043550 regulation of lipid kinase activity 6.2500 6 yes
GO:0045834 positive regulation of lipid metabolic process 6.2500 5 yes
GO:0090218 positive regulation of lipid kinase activity 6.2500 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in DGKZ_HUMAN
DOID:0050686 organ system cancer 6.2500 3 no
DOID:0050700 cardiomyopathy 6.2500 4 no
DOID:0060036 intrinsic cardiomyopathy 6.2500 5 no
DOID:114 heart disease 6.2500 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DMD_HUMAN [view entry] [view interactions] Low throughput yes no
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
GRP1_HUMAN [view interactions] Low throughput no no
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
PAR6A_HUMAN [view interactions] Low throughput no yes
RBL1_HUMAN [view interactions] Low throughput no yes
RBL2_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
SNX27_HUMAN [view entry] [view interactions] Low throughput yes no
SMO_HUMAN [view interactions] Low throughput no yes
SNTA1_HUMAN [view entry] [view interactions] Low throughput yes no
SNTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTB2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
RB_HUMAN [view interactions] Low throughput no yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
MYZAP_HUMAN [view interactions] High throughput no yes
GRL1A_HUMAN [view interactions] High throughput no no
SAT1_HUMAN [view interactions] High throughput no yes
CBX8_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
PTN3_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RBM28_HUMAN [view interactions] High throughput no yes
NOC2L_HUMAN [view interactions] High throughput no yes
H15_HUMAN [view interactions] High throughput no no
H12_HUMAN [view interactions] High throughput no yes
CEBPZ_HUMAN [view interactions] High throughput no no
ASCC3_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
NOL6_HUMAN [view interactions] High throughput no no
HNRLL_HUMAN [view interactions] High throughput no yes
NOL8_HUMAN [view interactions] High throughput no yes
FNTB_HUMAN [view interactions] High throughput no no
DDX27_HUMAN [view interactions] High throughput no no
HM20A_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
LRC15_HUMAN [view interactions] High throughput no no
RL36L_HUMAN [view interactions] High throughput no no
H2A1_HUMAN [view interactions] High throughput no yes
ZN629_HUMAN [view interactions] High throughput no no
FNBP4_HUMAN [view interactions] High throughput no yes
WDR36_HUMAN [view interactions] High throughput no yes
FNTA_HUMAN [view interactions] High throughput no yes
COX10_HUMAN [view interactions] High throughput no yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
RRP8_HUMAN [view interactions] High throughput no yes
ZKSC8_HUMAN [view interactions] High throughput no yes
CR025_HUMAN [view interactions] High throughput no yes
NOC3L_HUMAN [view interactions] High throughput no no
ZC3H1_HUMAN [view interactions] High throughput no yes
FRIL_HUMAN [view interactions] High throughput no yes
DDX51_HUMAN [view interactions] High throughput no no
BMS1_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
NPA1P_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
TRM1L_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
ECT2L_HUMAN [view interactions] High throughput no no
ASCC2_HUMAN [view interactions] High throughput no yes
FEZF1_HUMAN [view interactions] High throughput no yes
RRP5_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB7_HUMAN [view interactions] High throughput no yes
KBTB6_HUMAN [view interactions] High throughput no yes
NP1L4_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2O_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
JIP4_HUMAN [view interactions] High throughput no yes
OGA_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
HMGN5_HUMAN [view interactions] High throughput no no
KI20B_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
MECOM_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
PLD2_HUMAN [view interactions] Computational no yes
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
PLD1_HUMAN [view interactions] Computational no no
CDS2_HUMAN [view interactions] Computational no yes
PLCB2_HUMAN [view interactions] Computational no no