SNTB2_HUMAN
Evidence for PS localization
Functions
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNTB2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 34.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 32.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 28.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
| GO:0046872 | metal ion binding | 26.0000 | 4 | no |
| GO:0003723 | RNA binding | 18.0000 | 4 | yes |
| GO:0003779 | actin binding | 18.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNTB2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.0000 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 38.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 36.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.0000 | 4 | no |
| GO:0030030 | cell projection organization | 36.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 34.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.0000 | 5 | no |
| GO:0008104 | protein localization | 32.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 32.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 32.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 28.0000 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0000 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 26.0000 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.0000 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.0000 | 7 | no |
| GO:0023056 | positive regulation of signaling | 26.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.0000 | 5 | no |
| GO:0071702 | organic substance transport | 24.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.0000 | 7 | no |
| GO:0030155 | regulation of cell adhesion | 24.0000 | 4 | no |
| GO:0031175 | neuron projection development | 24.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.0000 | 8 | no |
| GO:0060341 | regulation of cellular localization | 24.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.0000 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 22.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 22.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.0000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.0000 | 5 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SNTB2_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 10.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 10.0000 | 5 | no |
| DOID:114 | heart disease | 10.0000 | 3 | no |
| DOID:423 | myopathy | 6.0000 | 5 | no |
| DOID:66 | muscle tissue disease | 6.0000 | 4 | no |
| DOID:9884 | muscular dystrophy | 6.0000 | 6 | no |
| DOID:0080000 | muscular disease | 6.0000 | 3 | no |
| DOID:11724 | limb-girdle muscular dystrophy | 4.0000 | 7 | no |
| DOID:12930 | dilated cardiomyopathy | 4.0000 | 6 | no |
| DOID:2843 | long QT syndrome | 4.0000 | 6 | no |
| DOID:0111962 | combined immunodeficiency | 4.0000 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 4.0000 | 3 | no |
| DOID:0110274 | autosomal recessive limb-girdle muscular dystrophy | 4.0000 | 8 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAST1_HUMAN | [view interactions] | Low throughput | no | yes |
| MAST2_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADA1D_HUMAN | [view interactions] | Low throughput | no | no |
| UTRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRN_HUMAN | [view interactions] | Low throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCN5A_HUMAN | [view interactions] | Low throughput | no | no |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZMYM1_HUMAN | [view interactions] | High throughput | no | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDC1_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| FCGR1_HUMAN | [view interactions] | High throughput | no | no |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| SPZ1_HUMAN | [view interactions] | High throughput | no | no |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| CPNE5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA36_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| TENS1_HUMAN | [view interactions] | High throughput | no | no |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHB3_HUMAN | [view interactions] | High throughput | no | yes |
| FRK_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNL1_HUMAN | [view interactions] | High throughput | no | no |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| SNTG2_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| SKAP2_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| SNTG1_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| RP25L_HUMAN | [view interactions] | High throughput | no | yes |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBD2B_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| AJUBA_HUMAN | [view interactions] | High throughput | no | yes |
| T3HPD_HUMAN | [view interactions] | High throughput | no | yes |
| SEGN_HUMAN | [view interactions] | High throughput | no | no |
| SEMG2_HUMAN | [view interactions] | High throughput | no | no |
| SEMG1_HUMAN | [view interactions] | High throughput | no | no |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGCE_HUMAN | [view interactions] | Computational | no | no |
| SSPN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SGCA_HUMAN | [view interactions] | Computational | no | yes |
| UTP4_HUMAN | [view interactions] | Computational | no | yes |
| SGCD_HUMAN | [view entry] [view interactions] | Computational | yes | no |