LIN7C_HUMAN
Evidence for PS localization
Functions
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIN7C_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.6377 | 4 | no |
| GO:0046872 | metal ion binding | 24.6377 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.1884 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.1884 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.1884 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | no |
| GO:0097016 | L27 domain binding | 5.7971 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIN7C_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.9710 | 4 | no |
| GO:0010646 | regulation of cell communication | 56.5217 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 49.2754 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.0290 | 4 | no |
| GO:0022607 | cellular component assembly | 42.0290 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.5797 | 4 | no |
| GO:0051049 | regulation of transport | 40.5797 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.1304 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.6812 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.2319 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 36.2319 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.2319 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 36.2319 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.8841 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.4348 | 5 | no |
| GO:0008104 | protein localization | 28.9855 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 27.5362 | 5 | no |
| GO:0043269 | regulation of ion transport | 27.5362 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.0870 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.0870 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.6377 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.6377 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.6377 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.6377 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.6377 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.6377 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.6377 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.1884 | 4 | yes |
| GO:0023061 | signal release | 23.1884 | 4 | yes |
| GO:0046903 | secretion | 23.1884 | 4 | yes |
| GO:0099643 | signal release from synapse | 23.1884 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 23.1884 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.1884 | 5 | no |
| GO:0071702 | organic substance transport | 21.7391 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.7391 | 7 | no |
| GO:0034330 | cell junction organization | 21.7391 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.7391 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.7391 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.2899 | 4 | no |
| GO:0030030 | cell projection organization | 20.2899 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.2899 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.2899 | 4 | no |
| GO:0051046 | regulation of secretion | 20.2899 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 20.2899 | 4 | no |
| GO:0044057 | regulation of system process | 20.2899 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.2899 | 4 | no |
| GO:0006836 | neurotransmitter transport | 18.8406 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 18.8406 | 4 | yes |
| GO:0006887 | exocytosis | 17.3913 | 4 | yes |
| GO:0072657 | protein localization to membrane | 17.3913 | 4 | yes |
| GO:0007269 | neurotransmitter secretion | 15.9420 | 4 | yes |
| GO:0015031 | protein transport | 15.9420 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 13.0435 | 5 | yes |
| GO:0002009 | morphogenesis of an epithelium | 7.2464 | 4 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 7.2464 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 5.7971 | 5 | yes |
| GO:0035090 | maintenance of apical/basal cell polarity | 4.3478 | 4 | yes |
| GO:0045199 | maintenance of epithelial cell apical/basal polarity | 4.3478 | 5 | yes |
| GO:1903361 | protein localization to basolateral plasma membrane | 4.3478 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LIN7C_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.3478 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.3478 | 5 | no |
| DOID:114 | heart disease | 4.3478 | 3 | no |
| DOID:2843 | long QT syndrome | 4.3478 | 6 | no |
| DOID:331 | central nervous system disease | 4.3478 | 3 | no |
| DOID:0050155 | sensory system disease | 2.8986 | 3 | no |
| DOID:5614 | eye disease | 2.8986 | 4 | no |
| DOID:10273 | heart conduction disease | 2.8986 | 4 | no |
| DOID:0050686 | organ system cancer | 2.8986 | 3 | no |
| DOID:936 | brain disease | 2.8986 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| KCJ12_HUMAN | [view interactions] | Low throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
| MARHB_HUMAN | [view interactions] | Low throughput | no | no |
| ARHG8_HUMAN | [view interactions] | Low throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| UIMC1_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM1_HUMAN | [view interactions] | High throughput | no | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD32_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| DPCD_HUMAN | [view interactions] | High throughput | no | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| NUP37_HUMAN | [view interactions] | High throughput | no | yes |
| PXDC1_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI26B_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG5_HUMAN | [view interactions] | High throughput | no | yes |
| ARAP2_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| HERC4_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL7B_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| CA174_HUMAN | [view interactions] | High throughput | no | yes |
| INT12_HUMAN | [view interactions] | High throughput | no | yes |
| ANR49_HUMAN | [view interactions] | High throughput | no | yes |
| RIOX2_HUMAN | [view interactions] | High throughput | no | yes |
| STK25_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| CB39L_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATS1_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| LIPA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SYN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMB1_HUMAN | [view interactions] | Computational | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |