LIN7C_HUMAN
Evidence for PS localization
Functions
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIN7C_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 26.9841 | 4 | no |
| GO:0043168 | anion binding | 26.9841 | 4 | no |
| GO:0043169 | cation binding | 26.9841 | 4 | no |
| GO:0046872 | metal ion binding | 26.9841 | 5 | no |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 5 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.6349 | 4 | no |
| GO:0097016 | L27 domain binding | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIN7C_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.9683 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.7937 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.0317 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.0317 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.4444 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | no |
| GO:0022607 | cellular component assembly | 41.2698 | 4 | no |
| GO:0051049 | regulation of transport | 39.6825 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.9206 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.7460 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.7460 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.7460 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.7460 | 5 | no |
| GO:0008104 | protein localization | 30.1587 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 30.1587 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.9841 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.9841 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.3968 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.3968 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.3968 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.8095 | 6 | no |
| GO:0030030 | cell projection organization | 23.8095 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.8095 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.8095 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0034330 | cell junction organization | 22.2222 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.6349 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.6349 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.6349 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.6349 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 20.6349 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.6349 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6349 | 5 | no |
| GO:0006996 | organelle organization | 20.6349 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.6349 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.6349 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.6349 | 4 | no |
| GO:0071702 | organic substance transport | 12.6984 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 12.6984 | 4 | yes |
| GO:0072657 | protein localization to membrane | 12.6984 | 4 | yes |
| GO:0002009 | morphogenesis of an epithelium | 9.5238 | 4 | yes |
| GO:0015031 | protein transport | 9.5238 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 7.9365 | 4 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 7.9365 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 7.9365 | 5 | yes |
| GO:0007269 | neurotransmitter secretion | 6.3492 | 4 | yes |
| GO:0023061 | signal release | 6.3492 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 6.3492 | 5 | yes |
| GO:0046903 | secretion | 6.3492 | 4 | yes |
| GO:0099643 | signal release from synapse | 6.3492 | 5 | yes |
| GO:0035090 | maintenance of apical/basal cell polarity | 3.1746 | 4 | yes |
| GO:0045199 | maintenance of epithelial cell apical/basal polarity | 3.1746 | 5 | yes |
| GO:1903361 | protein localization to basolateral plasma membrane | 3.1746 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| KCJ12_HUMAN | [view interactions] | Low throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
| MARHB_HUMAN | [view interactions] | Low throughput | no | no |
| ARHG8_HUMAN | [view interactions] | Low throughput | no | yes |
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG5_HUMAN | [view interactions] | High throughput | no | yes |
| ARAP2_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| HERC4_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL7B_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| CA174_HUMAN | [view interactions] | High throughput | no | yes |
| INT12_HUMAN | [view interactions] | High throughput | no | yes |
| ANR49_HUMAN | [view interactions] | High throughput | no | yes |
| RIOX2_HUMAN | [view interactions] | High throughput | no | yes |
| STK25_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| CB39L_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATS1_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| UIMC1_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM1_HUMAN | [view interactions] | High throughput | no | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP37_HUMAN | [view interactions] | High throughput | no | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPCD_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD32_HUMAN | [view interactions] | High throughput | no | yes |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDC1_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI26B_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |