Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNJ4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNJ4_HUMAN
GO:0030165 PDZ domain binding 25.0000 4 yes
GO:0097016 L27 domain binding 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0005216 ion channel activity 18.7500 4 yes
GO:0005244 voltage-gated ion channel activity 18.7500 4 yes
GO:0005249 voltage-gated potassium channel activity 18.7500 6 yes
GO:0005261 cation channel activity 18.7500 5 yes
GO:0005267 potassium channel activity 18.7500 6 yes
GO:0008324 cation transmembrane transporter activity 18.7500 4 yes
GO:0015079 potassium ion transmembrane transporter activity 18.7500 6 yes
GO:0015267 channel activity 18.7500 4 yes
GO:0022832 voltage-gated channel activity 18.7500 6 yes
GO:0022836 gated channel activity 18.7500 5 yes
GO:0022843 voltage-gated cation channel activity 18.7500 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 18.7500 4 yes
GO:0046873 metal ion transmembrane transporter activity 18.7500 5 yes
GO:0005242 inward rectifier potassium channel activity 12.5000 7 yes
GO:0015276 ligand-gated ion channel activity 12.5000 5 yes
GO:0022834 ligand-gated channel activity 12.5000 6 yes
GO:0099094 ligand-gated cation channel activity 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCNJ4_HUMAN
GO:0051049 regulation of transport 62.5000 4 yes
GO:0043269 regulation of ion transport 50.0000 5 yes
GO:0008104 protein localization 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0034762 regulation of transmembrane transport 43.7500 4 yes
GO:0034765 regulation of ion transmembrane transport 43.7500 5 yes
GO:0072657 protein localization to membrane 43.7500 4 no
GO:0031323 regulation of cellular metabolic process 43.7500 4 no
GO:0048522 positive regulation of cellular process 43.7500 4 no
GO:0048523 negative regulation of cellular process 43.7500 4 no
GO:0051171 regulation of nitrogen compound metabolic process 43.7500 4 no
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 37.5000 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 37.5000 5 no
GO:1990778 protein localization to cell periphery 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0044057 regulation of system process 37.5000 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0015031 protein transport 31.2500 4 no
GO:0016192 vesicle-mediated transport 31.2500 4 no
GO:0071702 organic substance transport 31.2500 4 no
GO:0071705 nitrogen compound transport 31.2500 4 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0010646 regulation of cell communication 31.2500 4 no
GO:0010959 regulation of metal ion transport 31.2500 6 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0007268 chemical synaptic transmission 31.2500 6 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0051128 regulation of cellular component organization 31.2500 4 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0098916 anterograde trans-synaptic signaling 31.2500 5 no
GO:0099537 trans-synaptic signaling 31.2500 4 no
GO:1904062 regulation of cation transmembrane transport 31.2500 6 no
GO:0009892 negative regulation of metabolic process 31.2500 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.2500 5 no
GO:0006811 ion transport 25.0000 4 yes
GO:0006812 cation transport 25.0000 5 yes
GO:0030001 metal ion transport 25.0000 6 yes
GO:0006887 exocytosis 25.0000 4 no
GO:0046903 secretion 25.0000 4 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0035418 protein localization to synapse 25.0000 6 no
GO:0043113 receptor clustering 25.0000 5 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:1902414 protein localization to cell junction 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0001508 action potential 25.0000 4 no
GO:0008016 regulation of heart contraction 25.0000 6 no
GO:1903522 regulation of blood circulation 25.0000 5 no
GO:0006813 potassium ion transport 18.7500 7 yes
GO:0071805 potassium ion transmembrane transport 18.7500 6 yes
GO:0098655 cation transmembrane transport 18.7500 4 yes
GO:0098660 inorganic ion transmembrane transport 18.7500 4 yes
GO:0098662 inorganic cation transmembrane transport 18.7500 5 yes
GO:0098657 import into cell 12.5000 4 yes
GO:0098659 inorganic cation import across plasma membrane 12.5000 5 yes
GO:0099587 inorganic ion import across plasma membrane 12.5000 4 yes
GO:1990573 potassium ion import across plasma membrane 12.5000 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCNJ4_HUMAN
DOID:0050700 cardiomyopathy 18.7500 4 no
DOID:0060036 intrinsic cardiomyopathy 18.7500 5 no
DOID:114 heart disease 18.7500 3 no
DOID:2843 long QT syndrome 12.5000 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LIN7B_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBGT2_HUMAN [view interactions] Low throughput no no
CAV3_HUMAN [view interactions] Low throughput no no
TX1B3_HUMAN [view interactions] Low throughput no no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
IL16_HUMAN [view interactions] High throughput no no
GPR35_HUMAN [view interactions] High throughput no no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG1_HUMAN [view interactions] High throughput no yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
KCJ14_HUMAN [view interactions] Computational no no
KCNQ1_HUMAN [view interactions] Computational no yes
KCNJ3_HUMAN [view interactions] Computational no yes
KCJ18_HUMAN [view interactions] Computational no no
KCNQ4_HUMAN [view interactions] Computational no yes
KCNQ5_HUMAN [view interactions] Computational no yes
KCNQ3_HUMAN [view interactions] Computational no no
KCNQ2_HUMAN [view entry] [view interactions] Computational yes yes
KCJ12_HUMAN [view interactions] Computational no no