Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNJ4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNJ4_HUMAN
GO:0019900 kinase binding 35.7143 4 no
GO:0030165 PDZ domain binding 28.5714 4 yes
GO:0097016 L27 domain binding 28.5714 4 no
GO:0004385 guanylate kinase activity 21.4286 6 no
GO:0016301 kinase activity 21.4286 4 no
GO:0016776 phosphotransferase activity, phosphate group as acceptor 21.4286 4 no
GO:0019205 nucleobase-containing compound kinase activity 21.4286 5 no
GO:0050145 nucleoside monophosphate kinase activity 21.4286 5 no
GO:0005216 monoatomic ion channel activity 14.2857 4 yes
GO:0005242 inward rectifier potassium channel activity 14.2857 7 yes
GO:0005244 voltage-gated monoatomic ion channel activity 14.2857 5 yes
GO:0005249 voltage-gated potassium channel activity 14.2857 7 yes
GO:0005261 monoatomic cation channel activity 14.2857 5 yes
GO:0005267 potassium channel activity 14.2857 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 14.2857 4 yes
GO:0015079 potassium ion transmembrane transporter activity 14.2857 6 yes
GO:0015267 channel activity 14.2857 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 14.2857 5 yes
GO:0022832 voltage-gated channel activity 14.2857 6 yes
GO:0022834 ligand-gated channel activity 14.2857 6 yes
GO:0022836 gated channel activity 14.2857 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 14.2857 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 14.2857 4 yes
GO:0046873 metal ion transmembrane transporter activity 14.2857 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 14.2857 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCNJ4_HUMAN
GO:0051049 regulation of transport 57.1429 4 yes
GO:0008104 protein localization 57.1429 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 50.0000 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 50.0000 5 no
GO:0072657 protein localization to membrane 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0034762 regulation of transmembrane transport 42.8571 4 yes
GO:0043269 regulation of monoatomic ion transport 42.8571 5 yes
GO:1990778 protein localization to cell periphery 42.8571 5 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 35.7143 5 yes
GO:0015031 protein transport 35.7143 4 no
GO:0071702 organic substance transport 35.7143 4 no
GO:0071705 nitrogen compound transport 35.7143 4 no
GO:0099536 synaptic signaling 35.7143 4 no
GO:0010959 regulation of metal ion transport 35.7143 6 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0043933 protein-containing complex organization 35.7143 4 no
GO:0044057 regulation of system process 35.7143 4 no
GO:0051128 regulation of cellular component organization 35.7143 4 no
GO:0065003 protein-containing complex assembly 35.7143 5 no
GO:0046903 secretion 28.5714 4 no
GO:0007268 chemical synaptic transmission 28.5714 7 no
GO:0098916 anterograde trans-synaptic signaling 28.5714 6 no
GO:0099537 trans-synaptic signaling 28.5714 5 no
GO:0006996 organelle organization 28.5714 4 no
GO:0008016 regulation of heart contraction 28.5714 6 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0035418 protein localization to synapse 28.5714 6 no
GO:0043113 receptor clustering 28.5714 5 no
GO:0043270 positive regulation of monoatomic ion transport 28.5714 5 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:1902414 protein localization to cell junction 28.5714 5 no
GO:1903522 regulation of blood circulation 28.5714 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 28.5714 6 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0006811 monoatomic ion transport 21.4286 4 yes
GO:0006812 monoatomic cation transport 21.4286 5 yes
GO:0030001 metal ion transport 21.4286 6 yes
GO:0098657 import into cell 21.4286 4 yes
GO:0002009 morphogenesis of an epithelium 21.4286 4 no
GO:0006836 neurotransmitter transport 21.4286 4 no
GO:0007269 neurotransmitter secretion 21.4286 4 no
GO:0023061 signal release 21.4286 4 no
GO:0035090 maintenance of apical/basal cell polarity 21.4286 4 no
GO:0045199 maintenance of epithelial cell apical/basal polarity 21.4286 5 no
GO:0099643 signal release from synapse 21.4286 5 no
GO:1903361 protein localization to basolateral plasma membrane 21.4286 5 no
GO:0002028 regulation of sodium ion transport 21.4286 7 no
GO:0006936 muscle contraction 21.4286 4 no
GO:0006937 regulation of muscle contraction 21.4286 6 no
GO:0006942 regulation of striated muscle contraction 21.4286 7 no
GO:0007162 negative regulation of cell adhesion 21.4286 5 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0010646 regulation of cell communication 21.4286 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0022898 regulation of transmembrane transporter activity 21.4286 4 no
GO:0030155 regulation of cell adhesion 21.4286 4 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 21.4286 5 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0055117 regulation of cardiac muscle contraction 21.4286 7 no
GO:0062237 protein localization to postsynapse 21.4286 7 no
GO:0090257 regulation of muscle system process 21.4286 5 no
GO:1902305 regulation of sodium ion transmembrane transport 21.4286 7 no
GO:1903539 protein localization to postsynaptic membrane 21.4286 5 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:0001508 action potential 21.4286 4 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0086001 cardiac muscle cell action potential 21.4286 5 no
GO:0006813 potassium ion transport 14.2857 7 yes
GO:0071805 potassium ion transmembrane transport 14.2857 5 yes
GO:0098655 monoatomic cation transmembrane transport 14.2857 4 yes
GO:0098659 inorganic cation import across plasma membrane 14.2857 5 yes
GO:0098662 inorganic cation transmembrane transport 14.2857 4 yes
GO:0099587 inorganic ion import across plasma membrane 14.2857 4 yes
GO:1990573 potassium ion import across plasma membrane 14.2857 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LIN7B_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBGT2_HUMAN [view interactions] Low throughput no no
CAV3_HUMAN [view interactions] Low throughput no no
TX1B3_HUMAN [view interactions] Low throughput no no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
IL16_HUMAN [view interactions] High throughput no no
GPR35_HUMAN [view interactions] High throughput no no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG1_HUMAN [view interactions] High throughput no yes